5TSS	Toxin	date	Dec 11, 1996
title	Toxic Shock Syndrome Toxin-1: Orthorhombic P222(1) Crystal Form
authors	G.S.Prasad, R.Radhakrishnan, D.T.Mitchell, C.A.Earhart, M.M.Dinges, W.J.Cook, P.M.Schlivert, D.H.Ohlendorf
compound		source
Molecule: Toxic Shock Syndrome Toxin-1 Chain: A, B Synonym: Tsst-1		Organism_scientific: Staphylococcus Aureus Strain: Mn 8 Cellular_location: Secreted
symmetry	Space Group: P 2 2 21	R_factor	0.148
crystal cell	length a length b length c angle alpha angle beta angle gamma 49.100 75.100 115.200 90.00 90.00 90.00
method	X-Ray Diffraction	resolution	2.90 Å
related structures	by homologous chain: 4TSS
similarity	Belongs to the staphylococcal/streptococcal toxin family.[Stap_Strp_toxin]
subcellular loc.	Secreted protein.
Gene	TST (S. aureus)
function	Responsible for the symptoms of toxic shock syndrome.
Gene Ontology	Chain Function Process Component A, B pathogenesis extracellular region
Primary reference	Refined structures of three crystal forms of toxic shock syndrome toxin-1 and of a tetramutant with reduced activity., Prasad GS, Radhakrishnan R, Mitchell DT, Earhart CA, Dinges MM, Cook WJ, Schlievert PM, Ohlendorf DH, Protein Sci 1997 Jun;6(6):1220-7. PMID:9194182

Data retrieval

Asymmetric unit, PDB entry: [header only] [complete with coordinates] (67 Kb) [Save to disk] Biological Unit Coordinates (5tss.pdb1.gz) 33 Kb Biological Unit Coordinates (5tss.pdb2.gz) 33 Kb CSU: Contacts of Structural Units for 5TSS Likely Quarternary Molecular Structure file(s) for 5TSS Retrieve 5TSS in mmCIF format [Save to disk]

View 5TSS in 3D

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Structure-derived information

Dipole moment, from Dipole Server at Weizmann Institute Crystal Contacts, from CryCo at Weizmann Institute 3D motif for 5TSS, from MSDmotif at EBI Genome occurence of 5TSS's fold from GeneCensus Classification of representative domains in scop (Structural Classification of Proteins)     - Domain d5tssa1, region A:1-93 [Jmol] [rasmolscript] [script source]     - Domain d5tssa2, region A:94-194 [Jmol] [rasmolscript] [script source]     - Domain d5tssb1, region B:1-93 [Jmol] [rasmolscript] [script source]     - Domain d5tssb2, region B:94-194 [Jmol] [rasmolscript] [script source] Fold representative 5tss from FSSP and Dali (Families of Structurally Similar Proteins) Class (fold), Architecture (subfold), Topology, Homologous superfamily from CATH Summaries and structural analyses of PDB data files from PDBSum Identification of Protein Pockets & Cavities at CASTp

Sequence-derived information

View one-letter amino acid or nucleotide sequence for each chain: [5tss_B] [5tss_A]

Other resources with information on 5TSS

InterPro: IPR006125 , IPR006123 , IPR006173 , IPR006126 PDBREPORT (protein verification by WHAT_CHECK procedures) MMDB (Entrez's Structure Database)

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