ApoCanD

#	Name/ID	Cell Line/Tumor sample	Tissue of Origin	Reference ID	cDNA change	Protein change	Source	FATHMM Prediction	PolyPhen2 Prediction
1	A2058	Cell Line	SKIN	NP_004199	c.1379T>G	p.V460G	CCLE	PASSENGER/OTHER	Possibly Damaging
2	CAL148	Cell Line	BREAST	NP_004199	c.1831C>T	p.H611Y	CCLE	PASSENGER/OTHER	Possibly Damaging
3	CALU1	Cell Line	LUNG	NP_004199	c.141A>C	p.E47D	CCLE	PASSENGER/OTHER	Benign
4	COLO792	Cell Line	SKIN	NP_004199	c.299C>T	p.S100L	CCLE	PASSENGER/OTHER	Benign
5	CORL24	Cell Line	LUNG	NP_004199	c.1424C>T	p.P475L	CCLE	PASSENGER/OTHER	Possibly Damaging
6	CW2	Cell Line	LARGE INTESTINE	NP_004199	c.1696T>C	p.F566L	CCLE	CANCER	Probably Damaging
7	HCC202	Cell Line	BREAST	NP_004199	c.1437_1440delGTCA	p.Q479fs	CCLE	NP	NP
8	IGROV1	Cell Line	OVARY	NP_004199	c.421A>G	p.T141A	CCLE	PASSENGER/OTHER	Probably Damaging
9	JHUEM1	Cell Line	ENDOMETRIUM	NP_004199	c.172G>T	p.G58C	CCLE	PASSENGER/OTHER	Probably Damaging
10	JHUEM7	Cell Line	ENDOMETRIUM	NP_004199	c.1100C>T	p.A367V	CCLE	PASSENGER/OTHER	Possibly Damaging
11	JHUEM7	Cell Line	ENDOMETRIUM	NP_004199	c.761A>G	p.E254G	CCLE	PASSENGER/OTHER	Benign
12	MFE296	Cell Line	ENDOMETRIUM	NP_004199	c.1410T>C	p.T470T	CCLE	NP	NP
13	MOLM13	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_004199	c.1707G>A	p.R569R	CCLE	NP	NP
14	MOLM16	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_004199	c.1707G>A	p.R569R	CCLE	NP	NP
15	MOLT16	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_004199	c.1005C>T	p.P335P	CCLE	NP	NP
16	NCIH2073	Cell Line	LUNG	NP_004199	c.1595G>A	p.S532N	CCLE	PASSENGER/OTHER	Benign
17	NCIH2347	Cell Line	LUNG	NP_004199	c.839G>C	p.R280T	CCLE	PASSENGER/OTHER	Probably Damaging
18	SNGM	Cell Line	ENDOMETRIUM	NP_004199	c.781G>T	p.G261*	CCLE	NP	NP
19	SNU1040	Cell Line	LARGE INTESTINE	NP_004199	c.1005C>T	p.P335P	CCLE	NP	NP
20	SNU407	Cell Line	LARGE INTESTINE	NP_004199	c.1073G>A	p.R358Q	CCLE	PASSENGER/OTHER	Benign
21	14D	Tumour	HAEMATOPOIETIC AND LYMPHOID TISSUE	ENST00000319908	c.195_197delCTT	p.F65delF	COSMIC	NP	NP
22	BN17T	Tumour	LIVER	ENST00000319908	c.20T>C	p.L7P	COSMIC	NP	NP
23	CHC429T	Tumour	LIVER	ENST00000319908	c.988T>C	p.F330L	COSMIC	NP	NP
24	CHC433T	Tumour	LIVER	ENST00000319908	c.1336A>T	p.R446W	COSMIC	NP	NP
25	ESO-837	Tumour	OESOPHAGUS	ENST00000319908	c.1236A>C	p.S412S	COSMIC	NP	NP
26	HCC2998	Cell Line	LARGE INTESTINE	ENST00000319908	c.524T>C	p.L175P	COSMIC	NP	NP
27	LUAD-E01014	Tumour	LUNG	ENST00000319908	c.1771G>T	p.G591C	COSMIC	NP	NP
28	PR-00-160	Tumour	PROSTATE	ENST00000319908	c.1573C>T	p.R525*	COSMIC	NP	NP
29	S00833	Tumour	LUNG	ENST00000319908	c.1427C>T	p.S476L	COSMIC	NP	NP
30	SWE-1B	Tumour	PROSTATE	ENST00000319908	c.485C>T	p.P162L	COSMIC	NP	NP
31	T92	Tumour	PROSTATE	ENST00000319908	c.1277G>A	p.R426H	COSMIC	NP	NP
32	TCGA-02-0114-01	Tumour	CENTRAL NERVOUS SYSTEM	ENST00000319908	c.259G>A	p.D87N	COSMIC	NP	NP
33	TCGA-04-1361-01	Tumour	OVARY	ENST00000319908	c.1452C>A	p.P484P	COSMIC	NP	NP
34	TCGA-13-0800-01	Tumour	OVARY	ENST00000319908	c.993C>G	p.P331P	COSMIC	NP	NP
35	TCGA-29-2427-01	Tumour	OVARY	ENST00000319908	c.1767G>C	p.K589N	COSMIC	NP	NP
36	TCGA-34-5234-01	Tumour	LUNG	ENST00000319908	c.1080G>A	p.M360I	COSMIC	NP	NP
37	TCGA-38-4631-01	Tumour	LUNG	ENST00000319908	c.940G>T	p.A314S	COSMIC	NP	NP
38	TCGA-44-6774-01	Tumour	LUNG	ENST00000319908	c.1028A>T	p.Y343F	COSMIC	NP	NP
39	TCGA-50-6594-01	Tumour	LUNG	ENST00000319908	c.1277G>T	p.R426L	COSMIC	NP	NP
40	TCGA-59-2351-01	Tumour	OVARY	ENST00000319908	c.567C>A	p.F189L	COSMIC	NP	NP
41	TCGA-67-3770-01	Tumour	LUNG	ENST00000319908	c.1631C>T	p.P544L	COSMIC	NP	NP
42	TCGA-69-7974-01	Tumour	LUNG	ENST00000319908	c.956C>A	p.A319D	COSMIC	NP	NP
43	TCGA-95-7043-01	Tumour	LUNG	ENST00000319908	c.401G>T	p.G134V	COSMIC	NP	NP
44	TCGA-97-7938-01	Tumour	LUNG	ENST00000319908	c.559C>A	p.L187M	COSMIC	NP	NP
45	TCGA-A2-A25A-01	Tumour	BREAST	ENST00000319908	c.1731C>G	p.I577M	COSMIC	NP	NP
46	TCGA-A3-3316-01	Tumour	KIDNEY	ENST00000319908	c.1120A>G	p.K374E	COSMIC	NP	NP
47	TCGA-A5-A0GW-01	Tumour	ENDOMETRIUM	ENST00000319908	c.269G>A	p.R90K	COSMIC	NP	NP
48	TCGA-A5-A0VQ-01	Tumour	ENDOMETRIUM	ENST00000319908	c.111G>A	p.V37V	COSMIC	NP	NP
49	TCGA-A6-5659-01	Tumour	LARGE INTESTINE	ENST00000319908	c.1765A>T	p.K589*	COSMIC	NP	NP
50	TCGA-A6-6141-01	Tumour	LARGE INTESTINE	ENST00000319908	c.261T>C	p.D87D	COSMIC	NP	NP
51	TCGA-AA-3660-01	Tumour	LARGE INTESTINE	ENST00000319908	c.261T>C	p.D87D	COSMIC	NP	NP
52	TCGA-AA-3949-01	Tumour	LARGE INTESTINE	ENST00000319908	c.327C>T	p.A109A	COSMIC	NP	NP
53	TCGA-AA-3968-01	Tumour	LARGE INTESTINE	ENST00000319908	c.33T>G	p.A11A	COSMIC	NP	NP
54	TCGA-AA-3984-01	Tumour	LARGE INTESTINE	ENST00000319908	c.927C>T	p.S309S	COSMIC	NP	NP
55	TCGA-AA-A00J-01	Tumour	LARGE INTESTINE	ENST00000319908	c.706G>C	p.D236H	COSMIC	NP	NP
56	TCGA-AB-2830-03	Tumour	HAEMATOPOIETIC AND LYMPHOID TISSUE	ENST00000319908	c.240C>T	p.A80A	COSMIC	NP	NP
57	TCGA-AD-6889-01	Tumour	LARGE INTESTINE	ENST00000319908	c.261T>C	p.D87D	COSMIC	NP	NP
58	TCGA-AD-6895-01	Tumour	LARGE INTESTINE	ENST00000319908	c.1708G>A	p.V570M	COSMIC	NP	NP
59	TCGA-AG-3892-01	Tumour	LARGE INTESTINE	ENST00000319908	c.822G>T	p.K274N	COSMIC	NP	NP
60	TCGA-AP-A056-01	Tumour	ENDOMETRIUM	ENST00000319908	c.328G>A	p.A110T	COSMIC	NP	NP
61	TCGA-AP-A0LM-01	Tumour	ENDOMETRIUM	ENST00000319908	c.1141G>T	p.D381Y	COSMIC	NP	NP
62	TCGA-AP-A0LM-01	Tumour	ENDOMETRIUM	ENST00000319908	c.1744C>T	p.P582S	COSMIC	NP	NP
63	TCGA-AX-A0J0-01	Tumour	ENDOMETRIUM	ENST00000319908	c.1237G>T	p.D413Y	COSMIC	NP	NP
64	TCGA-AY-5543-01	Tumour	LARGE INTESTINE	ENST00000319908	c.1452C>T	p.P484P	COSMIC	NP	NP
65	TCGA-AZ-6598-01	Tumour	LARGE INTESTINE	ENST00000319908	c.993C>T	p.P331P	COSMIC	NP	NP
66	TCGA-B5-A0JY-01	Tumour	ENDOMETRIUM	ENST00000319908	c.399T>G	p.I133M	COSMIC	NP	NP
67	TCGA-B5-A0JY-01	Tumour	ENDOMETRIUM	ENST00000319908	c.594-1G>T	p.?	COSMIC	NP	NP
68	TCGA-B5-A11E-01	Tumour	ENDOMETRIUM	ENST00000319908	c.1645G>A	p.A549T	COSMIC	NP	NP
69	TCGA-B5-A11H-01	Tumour	ENDOMETRIUM	ENST00000319908	c.1759-2A>G	p.?	COSMIC	NP	NP
70	TCGA-BG-A0MQ-01	Tumour	ENDOMETRIUM	ENST00000319908	c.1780C>T	p.H594Y	COSMIC	NP	NP
71	TCGA-BS-A0TC-01	Tumour	ENDOMETRIUM	ENST00000319908	c.164C>T	p.S55F	COSMIC	NP	NP
72	TCGA-CA-6718-01	Tumour	LARGE INTESTINE	ENST00000319908	c.260A>G	p.D87G	COSMIC	NP	NP
73	TCGA-CM-5348-01	Tumour	LARGE INTESTINE	ENST00000319908	c.992C>A	p.P331H	COSMIC	NP	NP
74	TCGA-CM-5862-01	Tumour	LARGE INTESTINE	ENST00000319908	c.1766A>G	p.K589R	COSMIC	NP	NP
75	TCGA-CM-5863-01	Tumour	LARGE INTESTINE	ENST00000319908	c.260A>G	p.D87G	COSMIC	NP	NP
76	TCGA-CM-6168-01	Tumour	LARGE INTESTINE	ENST00000319908	c.993C>A	p.P331P	COSMIC	NP	NP
77	TCGA-D1-A103-01	Tumour	ENDOMETRIUM	ENST00000319908	c.996G>T	p.E332D	COSMIC	NP	NP
78	TCGA-D1-A17Q-01	Tumour	ENDOMETRIUM	ENST00000319908	c.140G>T	p.R47I	COSMIC	NP	NP
79	TCGA-D1-A17Q-01	Tumour	ENDOMETRIUM	ENST00000319908	c.842G>T	p.R281I	COSMIC	NP	NP
80	TCGA-D5-5538-01	Tumour	LARGE INTESTINE	ENST00000319908	c.993C>T	p.P331P	COSMIC	NP	NP
81	TCGA-D5-6931-01	Tumour	LARGE INTESTINE	ENST00000319908	c.1766A>G	p.K589R	COSMIC	NP	NP
82	TCGA-DI-A0WH-01	Tumour	ENDOMETRIUM	ENST00000319908	c.1046T>C	p.M349T	COSMIC	NP	NP
83	TCGA-DM-A1D0-01	Tumour	LARGE INTESTINE	ENST00000319908	c.261T>C	p.D87D	COSMIC	NP	NP
84	TCGA-DM-A1D9-01	Tumour	LARGE INTESTINE	ENST00000319908	c.993C>T	p.P331P	COSMIC	NP	NP
85	TCGA-DY-A0XA-01	Tumour	LARGE INTESTINE	ENST00000319908	c.260A>G	p.D87G	COSMIC	NP	NP
86	TCGA-E9-A22E-01	Tumour	BREAST	ENST00000319908	c.1773T>A	p.G591G	COSMIC	NP	NP
87	TCGA-F5-6811-01	Tumour	LARGE INTESTINE	ENST00000319908	c.993C>A	p.P331P	COSMIC	NP	NP
88	TCGA-G4-6315-01	Tumour	LARGE INTESTINE	ENST00000319908	c.782G>T	p.R261I	COSMIC	NP	NP
89	TCGA-G4-6315-01	Tumour	LARGE INTESTINE	ENST00000319908	c.993C>T	p.P331P	COSMIC	NP	NP
90	TCGA-G4-6321-01	Tumour	LARGE INTESTINE	ENST00000319908	c.1767G>T	p.K589N	COSMIC	NP	NP
91	YUKLAB	Tumour	SKIN	ENST00000319908	c.1195A>C	p.N399H	COSMIC	NP	NP
92	A2058	Cell Line	SKIN	ENST00000319908	c.1367T>G	p.V456G	COSMIC	NP	NP
93	BALL1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000319908	c.250A>G	p.M84V	COSMIC	NP	NP
94	CAL148	Cell Line	BREAST	ENST00000319908	c.1819C>T	p.H607Y	COSMIC	NP	NP
95	COLO792	Cell Line	SKIN	ENST00000319908	c.287C>T	p.S96L	COSMIC	NP	NP
96	CW2	Cell Line	LARGE_INTESTINE	ENST00000319908	c.1684T>C	p.F562L	COSMIC	NP	NP
97	CW2	Cell Line	LARGE_INTESTINE	ENST00000319908	c.462+8G>A	p.?	COSMIC	NP	NP
98	ETK1	Cell Line	BILIARY_TRACT	ENST00000319908	c.1695G>A	p.R565R	COSMIC	NP	NP
99	G401	Cell Line	SOFT_TISSUE	ENST00000319908	c.354A>G	p.E118E	COSMIC	NP	NP
100	HAL01	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000319908	c.1695G>A	p.R565R	COSMIC	NP	NP
101	HCC202	Cell Line	BREAST	ENST00000319908	c.1425_1428delGTCA	p.S476fs*107	COSMIC	NP	NP
102	HCC2998	Cell Line	LARGE_INTESTINE	ENST00000319908	c.524T>C	p.L175P	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
103	IGROV1	Cell Line	OVARY	ENST00000319908	c.409A>G	p.T137A	COSMIC	NP	NP
104	KNS42	Cell Line	CENTRAL_NERVOUS_SYSTEM	ENST00000319908	c.834G>A	p.T278T	COSMIC	NP	NP
105	LAMA84	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000319908	c.1413G>A	p.P471P	COSMIC	NP	NP
106	MCC13	Cell Line	SKIN	ENST00000319908	c.1335G>A	p.R445R	COSMIC	NP	NP
107	MFM223	Cell Line	BREAST	ENST00000319908	c.791C>T	p.S264F	COSMIC	NP	NP
108	MOLM13	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000319908	c.1695G>A	p.R565R	COSMIC	NP	NP
109	MOLM16	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000319908	c.1695G>A	p.R565R	COSMIC	NP	NP
110	MOLT16	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000319908	c.993C>T	p.P331P	COSMIC	NP	NP
111	MRKNU1	Cell Line	BREAST	ENST00000319908	c.192C>T	p.Y64Y	COSMIC	NP	NP
112	NCIH1993	Cell Line	LUNG	ENST00000319908	c.1583G>A	p.S528N	COSMIC	NP	NP
113	NCIH2347	Cell Line	LUNG	ENST00000319908	c.827G>C	p.R276T	COSMIC	NP	NP
114	SNU407	Cell Line	LARGE_INTESTINE	ENST00000319908	c.1061G>A	p.R354Q	COSMIC	NP	NP
115	SW13	Cell Line	ADRENAL_GLAND	ENST00000319908	c.461G>A	p.R154K	COSMIC	NP	NP
116	SW684	Cell Line	SOFT_TISSUE	ENST00000319908	c.1035C>T	p.S345S	COSMIC	NP	NP
117	SW982	Cell Line	SOFT_TISSUE	ENST00000319908	c.882G>A	p.R294R	COSMIC	NP	NP
118	TGBC1TKB	Cell Line	BILIARY_TRACT	ENST00000319908	c.327C>T	p.A109A	COSMIC	NP	NP

*NP: Not Predicted

Tissue Type	Mean Expression Value	Median Expression Value	Mean CNV	Median CNV

AUTONOMIC GANGLIA	8.7174	8.5814	0.0010	0.0046
BILIARY TRACT	9.8540	9.8121	0.3519	0.4297
BONE	8.9568	8.9377	-0.0009	0.0077
BREAST	9.5155	9.6741	0.0876	0.0077
CENTRAL NERVOUS SYSTEM	9.1196	9.1161	0.0189	0.007613
ENDOMETRIUM	9.6494	9.4983	0.0182	-0.001048
HAEMATOPOIETIC AND LYMPHOID TISSUE	9.7895	9.7734	0.0540	0.0138
KIDNEY	9.1847	9.3679	0.0150	0.004057
LARGE INTESTINE	9.6689	9.67075	0.0563	0.006278
LIVER	9.7613	9.8037	0.0161	0.0155
LUNG	9.3539	9.36705	0.0823	0.01495
OESOPHAGUS	9.1562	9.07955	0.1192	0.013041
OVARY	9.5011	9.4156	0.0575	-0.0011
PANCREAS	9.1710	9.1961	0.0926	0.0081
PLEURA	9.1442	9.0345	0.0068	0.0019
PROSTATE	9.7425	9.68535	0.0162	0.01095
SALIVARY GLAND	9.2044	9.2044	0.0271	0.0271
SKIN	9.5897	9.7132	-0.0197	0.0058
SMALL INTESTINE	9.6605	9.6605	0.0521	0.0521
SOFT TISSUE	9.3164	9.29215	0.0377	0.0146
STOMACH	9.6758	9.71025	0.0527	0.0131
THYROID	9.6383	9.61625	0.2512	0.01159
UPPER AERODIGESTIVE TRACT	8.8126	8.87195	0.1269	0.0204
URINARY TRACT	9.2160	9.16935	0.1676	0.02434

Domain ID	Domain Name	Start Site	End Site	E-value
PF14962	AIF-MLS	11	112	5.6e-13
PF07992	Pyr_redox_2	136	443	7.3e-24
PF00070	Pyr_redox	302	385	1.9e-10
PF14721	AIF_C	465	594	2.8e-59
PF14759	Reductase_C	561	597	0.57

Domain ID	Start Site	End Site	E-value
0040820	478	608	3.74e-55
0047068	127	347	1.36e-37
0047270	299	475	2.54e-21

S. No.	Position	Amino acid	Type	Description
1	105	T	Phosphorylation	Phosphothreonine
2	105	T	Phosphorylation	Phosphothreonine.
3	109	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
4	189	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
5	255	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin).
6	268	S	Phosphorylation	Phosphoserine
7	268	S	Phosphorylation	Phosphoserine.
8	295	K	Acetylation	N6-acetyllysine
9	295	K	Acetylation	N6-acetyllysine.
10	328	T	Phosphorylation	Phosphothreonine

Proteomics DB	COSMIC	Gene Atlas	STRING	PIR
AIFM1	AIFM1	AIFM1	ENSP00000287295	O95831
QuickGO	HGNC	Ensembl Genome Browser	TreeFam	UniProt
O95831	AIFM1	ENSP00000287295	AIFM1	O95831
Expression Atlas	Protein Atlas	OMIM	IntAct	PharmGKB
AIFM1	ENSP00000287295	300169	O95831	PA162376129

Protein: AIFM1

Mutation Data (+)

Copy number variation and expression profile (+)

Gene Essentiality Data (+)

Tertiary structure (+)

Structure Domains (+)

Sequence Alignment (+)

Sequence Profiles (+)

Post Translational Modifications (+)

Other Databases Link (+)

Modelled Structure	Structures available in PDB
	1M6I, 4FDC, 4LII