ApoCanD

Mutation Data (+)

#	Name/ID	Cell Line/Tumor sample	Tissue of Origin	Reference ID	cDNA change	Protein change	Source	FATHMM Prediction	PolyPhen2 Prediction
1	DND41	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_116784	c.410C>A	p.T137K	CCLE	PASSENGER/OTHER	Probably Damaging
2	EBC1	Cell Line	LUNG	NP_116784	c.85G>A	p.D29N	CCLE	PASSENGER/OTHER	Probably Damaging
3	GP2D	Cell Line	LARGE INTESTINE	NP_116784	c.483G>T	p.R161S	CCLE	PASSENGER/OTHER	Possibly Damaging
4	HEC265	Cell Line	ENDOMETRIUM	NP_116784	c.208C>T	p.R70W	CCLE	PASSENGER/OTHER	Probably Damaging
5	JHOM1	Cell Line	OVARY	NP_116784	c.95C>T	p.S32L	CCLE	PASSENGER/OTHER	Benign
6	VMCUB1	Cell Line	URINARY TRACT	NP_116784	c.491C>T	p.S164F	CCLE	PASSENGER/OTHER	Benign
7	587278	Tumour	LARGE INTESTINE	ENST00000394532	c.301C>T	p.P101S	COSMIC	NP	NP
8	Br27P	Tumour	CENTRAL NERVOUS SYSTEM	ENST00000394532	c.371C>T	p.S124F	COSMIC	NP	NP
9	ESO-539	Tumour	OESOPHAGUS	ENST00000394532	c.379-4C>T	p.?	COSMIC	NP	NP
10	LUAD-YINHD	Tumour	LUNG	ENST00000394532	c.450C>G	p.V150V	COSMIC	NP	NP
11	TCGA-AA-3811-01	Tumour	LARGE INTESTINE	ENST00000394532	c.306delC	p.N103fs*15	COSMIC	NP	NP
12	TCGA-AO-A03U-01	Tumour	BREAST	ENST00000394532	c.288C>T	p.R96R	COSMIC	NP	NP
13	TCGA-D1-A167-01	Tumour	ENDOMETRIUM	ENST00000394532	c.243G>A	p.E81E	COSMIC	NP	NP
14	TCGA-D1-A17R-01	Tumour	ENDOMETRIUM	ENST00000394532	c.298G>A	p.A100T	COSMIC	NP	NP
15	A2058	Cell Line	SKIN	ENST00000394532	c.102C>T	p.S34S	COSMIC	NP	NP
16	DND41	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000394532	c.385C>T	p.L129F	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
17	DND41	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000394532	c.410C>A	p.T137K	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
18	GP5D	Cell Line	LARGE_INTESTINE	ENST00000394532	c.483G>T	p.R161S	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
19	OPM2	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000394532	c.453C>A	p.F151L	COSMIC	PASSENGER/OTHER	BENIGN
20	VMCUB1	Cell Line	URINARY_TRACT	ENST00000394532	c.491C>T	p.S164F	COSMIC	PASSENGER/OTHER	BENIGN
21	WIL2NS	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000394532	c.427_428insA	p.S144fs*>26	COSMIC	NP	NP

*NP: Not Predicted

Copy number variation and expression profile (+)

Tissue Type	Mean Expression Value	Median Expression Value	Mean CNV	Median CNV

AUTONOMIC GANGLIA	7.0166	6.8539	-0.0433	-0.05465
BILIARY TRACT	6.9254	7.0312	0.1033	0.0395
BONE	7.5503	7.5986	0.0545	-0.002568
BREAST	7.6416	7.57705	0.0749	0.06745
CENTRAL NERVOUS SYSTEM	7.7032	7.8199	-0.0155	-0.024
ENDOMETRIUM	7.1822	7.3069	-0.0007	-0.004906
HAEMATOPOIETIC AND LYMPHOID TISSUE	6.7499	6.7774	0.0252	0.0025
KIDNEY	7.3673	7.4883	-0.0582	0.0515
LARGE INTESTINE	6.8302	6.82435	-0.0024	0.01055
LIVER	7.0967	7.2398	0.0152	0.0217
LUNG	7.4376	7.51965	0.0924	0.11685
OESOPHAGUS	7.3452	7.30745	0.1667	0.18635
OVARY	7.5270	7.4864	0.1739	0.09036
PANCREAS	7.3985	7.4312	0.1981	0.2363
PLEURA	8.0548	8.1639	-0.0044	-0.09416
PROSTATE	7.9950	8.09455	0.0940	0.0470778
SALIVARY GLAND	7.3127	7.3127	0.5219	0.5219
SKIN	7.0379	7.14	-0.1081	-0.01235
SMALL INTESTINE	6.9004	6.9004	0.0222	0.0222
SOFT TISSUE	7.1890	7.40245	0.0092	0.01365
STOMACH	7.3403	7.2841	0.1500	0.15655
THYROID	7.3676	7.5872	0.1312	0.18965
UPPER AERODIGESTIVE TRACT	7.6370	7.74945	0.2988	0.30435
URINARY TRACT	7.7824	7.84425	0.1636	0.26805

Gene Essentiality Data (+)

Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.

test

Tertiary structure (+)

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Modelled Structure	Structures available in PDB
	1G5J

Structure Domains (+)

1. PFAM Domains:

Domain ID	Domain Name	Start Site	End Site	E-value
PF10514	Bcl-2_BAD	1	168	6.3e-93
PF08945	Bclx_interact	101	125	0.003

2. Superfaimly domains are not present!!

Sequence Alignment (+)

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1. Variants are not present in 1000 Genomes!!

2. Sequence alignment with CCLE mutants:

3. Sequence alignment with COSMIC mutants:

Click on button to get Sequence alignment with Coverage, Consensus and Quality

4. Sequence alignment with homologus proteins:

Sequence Profiles (+)

HMM
With Uniprot database	With Mutants	With 1000 Genome Variants

PSSM
With Uniprot database	With Mutants	With 1000 Genome Variant

Post Translational Modifications (+)

Post translational modifications are not found!!

Proteomics DB	COSMIC	Gene Atlas	STRING	PIR
BAD	BAD	BAD
QuickGO	HGNC	Ensembl Genome Browser	TreeFam	UniProt
	BAD		BAD
Expression Atlas	Protein Atlas	OMIM	IntAct	PharmGKB
BAD

Protein: BAD