ApoCanD

#	Name/ID	Cell Line/Tumor sample	Tissue of Origin	Reference ID	cDNA change	Protein change	Source	FATHMM Prediction	PolyPhen2 Prediction
1	1946219	Tumour	LUNG	NM_004347.1	c.477_478insA	p.N162fs*3	COSMIC	NP	NP
2	585223	Tumour	LUNG	NM_004347.1	c.117G>T	p.K39N	COSMIC	NP	NP
3	587222	Tumour	LARGE INTESTINE	NM_004347.1	c.1153C>T	p.R385W	COSMIC	NP	NP
4	587342	Tumour	LARGE INTESTINE	NM_004347.1	c.286G>C	p.A96P	COSMIC	NP	NP
5	587376	Tumour	LARGE INTESTINE	NM_004347.1	c.975G>T	p.E325D	COSMIC	NP	NP
6	631084	Tumour	LUNG	NM_004347.1	c.67G>T	p.V23L	COSMIC	NP	NP
7	ESO-0013	Tumour	OESOPHAGUS	NM_004347.1	c.135A>C	p.K45N	COSMIC	NP	NP
8	HCC104T	Tumour	LIVER	NM_004347.1	c.474G>T	p.L158L	COSMIC	NP	NP
9	HCC4T	Tumour	LIVER	NM_004347.1	c.1159-8T>C	p.?	COSMIC	NP	NP
10	HCC4T	Tumour	LIVER	NM_004347.1	c.154delA	p.T52fs*26	COSMIC	NP	NP
11	HX13T	Tumour	LIVER	NM_004347.1	c.1159-8T>C	p.?	COSMIC	NP	NP
12	K3	Tumour	KIDNEY	NM_004347.1	c.195T>A	p.H65Q	COSMIC	NP	NP
13	LUAD-CHTN-3090416	Tumour	LUNG	NM_004347.1	c.664G>A	p.A222T	COSMIC	NP	NP
14	LUAD-CHTN-Z4716A	Tumour	LUNG	NM_004347.1	c.600C>A	p.I200I	COSMIC	NP	NP
15	LUAD-RT-S01818	Tumour	LUNG	NM_004347.1	c.468G>C	p.L156L	COSMIC	NP	NP
16	LUAD-S01478	Tumour	LUNG	NM_004347.1	c.875A>T	p.K292M	COSMIC	NP	NP
17	LUAD-YINHD	Tumour	LUNG	NM_004347.1	c.1256G>C	p.*419S	COSMIC	NP	NP
18	NCI-H128	Cell Line	LUNG	NM_004347.1	c.388C>G	p.L130V	COSMIC	NP	NP
19	PD4596a	Tumour	NS	NM_004347.1	c.305C>T	p.S102F	COSMIC	NP	NP
20	RK112	Tumour	C01 LIVER	NM_004347.1	c.137A>G	p.D46G	COSMIC	NP	NP
21	SW620	Cell Line	LARGE INTESTINE	NM_004347.1	c.1043C>A	p.T348K	COSMIC	NP	NP
22	TCGA-13-0924-01	Tumour	OVARY	NM_004347.1	c.519G>C	p.E173D	COSMIC	NP	NP
23	TCGA-13-1407-01	Tumour	OVARY	NM_004347.1	c.154delA	p.T52fs*26	COSMIC	NP	NP
24	TCGA-22-5473-01	Tumour	LUNG	NM_004347.1	c.493G>A	p.E165K	COSMIC	NP	NP
25	TCGA-24-2293-01	Tumour	OVARY	NM_004347.1	c.385C>T	p.P129S	COSMIC	NP	NP
26	TCGA-34-5927-01	Tumour	LUNG	NM_004347.1	c.975G>A	p.E325E	COSMIC	NP	NP
27	TCGA-43-6771-01	Tumour	LUNG	NM_004347.1	c.19C>T	p.Q7*	COSMIC	NP	NP
28	TCGA-44-3398-01	Tumour	LUNG	NM_004347.1	c.543C>T	p.I181I	COSMIC	NP	NP
29	TCGA-49-4488-01	Tumour	LUNG	NM_004347.1	c.845G>A	p.R282H	COSMIC	NP	NP
30	TCGA-49-6744-01	Tumour	LUNG	NM_004347.1	c.495G>T	p.E165D	COSMIC	NP	NP
31	TCGA-50-5066-01	Tumour	LUNG	NM_004347.1	c.221A>T	p.H74L	COSMIC	NP	NP
32	TCGA-50-5066-02	Tumour	LUNG	NM_004347.1	c.221A>T	p.H74L	COSMIC	NP	NP
33	TCGA-50-5930-01	Tumour	LUNG	NM_004347.1	c.498C>A	p.I166I	COSMIC	NP	NP
34	TCGA-50-6590-01	Tumour	LUNG	NM_004347.1	c.562G>C	p.D188H	COSMIC	NP	NP
35	TCGA-50-6590-01	Tumour	LUNG	NM_004347.1	c.872C>G	p.P291R	COSMIC	NP	NP
36	TCGA-85-6175-01	Tumour	LUNG	NM_004347.1	c.743T>C	p.L248P	COSMIC	NP	NP
37	TCGA-86-6851-01	Tumour	LUNG	NM_004347.1	c.402G>T	p.E134D	COSMIC	NP	NP
38	TCGA-A5-A0GH-01	Tumour	ENDOMETRIUM	NM_004347.1	c.1048C>T	p.H350Y	COSMIC	NP	NP
39	TCGA-A6-5662-01	Tumour	LARGE INTESTINE	NM_004347.1	c.518A>G	p.E173G	COSMIC	NP	NP
40	TCGA-A6-5665-01	Tumour	LARGE INTESTINE	NM_004347.1	c.154delA	p.T52fs*26	COSMIC	NP	NP
41	TCGA-AA-3510-01	Tumour	LARGE INTESTINE	NM_004347.1	c.460G>T	p.E154*	COSMIC	NP	NP
42	TCGA-AA-3713-01	Tumour	LARGE INTESTINE	NM_004347.1	c.154delA	p.T52fs*26	COSMIC	NP	NP
43	TCGA-AA-3715-01	Tumour	LARGE INTESTINE	NM_004347.1	c.108G>A	p.T36T	COSMIC	NP	NP
44	TCGA-AA-3833-01	Tumour	LARGE INTESTINE	NM_004347.1	c.775G>A	p.G259R	COSMIC	NP	NP
45	TCGA-AA-3977-01	Tumour	LARGE INTESTINE	NM_004347.1	c.812T>G	p.L271R	COSMIC	NP	NP
46	TCGA-AA-3984-01	Tumour	LARGE INTESTINE	NM_004347.1	c.481A>C	p.K161Q	COSMIC	NP	NP
47	TCGA-AA-A00N-01	Tumour	LARGE INTESTINE	NM_004347.1	c.223G>A	p.D75N	COSMIC	NP	NP
48	TCGA-AD-6889-01	Tumour	LARGE INTESTINE	NM_004347.1	c.485delA	p.N162fs*8	COSMIC	NP	NP
49	TCGA-AD-6895-01	Tumour	LARGE INTESTINE	NM_004347.1	c.40G>A	p.V14M	COSMIC	NP	NP
50	TCGA-AD-6964-01	Tumour	LARGE INTESTINE	NM_004347.1	c.154delA	p.T52fs*26	COSMIC	NP	NP
51	TCGA-AG-3732-01	Tumour	LARGE INTESTINE	NM_004347.1	c.154delA	p.T52fs*26	COSMIC	NP	NP
52	TCGA-AG-3885-01	Tumour	LARGE INTESTINE	NM_004347.1	c.1028C>A	p.A343D	COSMIC	NP	NP
53	TCGA-AP-A051-01	Tumour	ENDOMETRIUM	NM_004347.1	c.404C>T	p.A135V	COSMIC	NP	NP
54	TCGA-AP-A051-01	Tumour	ENDOMETRIUM	NM_004347.1	c.684G>A	p.V228V	COSMIC	NP	NP
55	TCGA-AP-A056-01	Tumour	ENDOMETRIUM	NM_004347.1	c.107C>T	p.T36M	COSMIC	NP	NP
56	TCGA-AP-A056-01	Tumour	ENDOMETRIUM	NM_004347.1	c.1169C>A	p.S390*	COSMIC	NP	NP
57	TCGA-AP-A059-01	Tumour	ENDOMETRIUM	NM_004347.1	c.261T>G	p.Y87*	COSMIC	NP	NP
58	TCGA-AP-A0LG-01	Tumour	ENDOMETRIUM	NM_004347.1	c.10G>A	p.G4S	COSMIC	NP	NP
59	TCGA-AR-A0U4-01	Tumour	BREAST	NM_004347.1	c.581A>T	p.N194I	COSMIC	NP	NP
60	TCGA-AU-6004-01	Tumour	LARGE INTESTINE	NM_004347.1	c.485delA	p.N162fs*8	COSMIC	NP	NP
61	TCGA-AX-A0J0-01	Tumour	ENDOMETRIUM	NM_004347.1	c.252G>T	p.K84N	COSMIC	NP	NP
62	TCGA-AX-A0J0-01	Tumour	ENDOMETRIUM	NM_004347.1	c.311G>A	p.R104Q	COSMIC	NP	NP
63	TCGA-AX-A0J0-01	Tumour	ENDOMETRIUM	NM_004347.1	c.451C>A	p.P151T	COSMIC	NP	NP
64	TCGA-AY-6386-01	Tumour	LARGE INTESTINE	NM_004347.1	c.154delA	p.T52fs*26	COSMIC	NP	NP
65	TCGA-AZ-5403-01	Tumour	LARGE INTESTINE	NM_004347.1	c.518A>G	p.E173G	COSMIC	NP	NP
66	TCGA-AZ-6598-01	Tumour	LARGE INTESTINE	NM_004347.1	c.154delA	p.T52fs*26	COSMIC	NP	NP
67	TCGA-AZ-6598-01	Tumour	LARGE INTESTINE	NM_004347.1	c.325G>A	p.A109T	COSMIC	NP	NP
68	TCGA-AZ-6608-01	Tumour	LARGE INTESTINE	NM_004347.1	c.518A>G	p.E173G	COSMIC	NP	NP
69	TCGA-B0-4706-01	Tumour	KIDNEY	NM_004347.1	c.648C>T	p.D216D	COSMIC	NP	NP
70	TCGA-BI-A0VR-01	Tumour	CERVIX	NM_004347.1	c.1245T>C	p.F415F	COSMIC	NP	NP
71	TCGA-BK-A0CA-01	Tumour	ENDOMETRIUM	NM_004347.1	c.63C>A	p.N21K	COSMIC	NP	NP
72	TCGA-BP-4975-01	Tumour	KIDNEY	NM_004347.1	c.223G>A	p.D75N	COSMIC	NP	NP
73	TCGA-BS-A0UV-01	Tumour	ENDOMETRIUM	NM_004347.1	c.15C>A	p.I5I	COSMIC	NP	NP
74	TCGA-BT-A20O-01	Tumour	URINARY TRACT	NM_004347.1	c.1087T>G	p.F363V	COSMIC	NP	NP
75	TCGA-CK-5913-01	Tumour	LARGE INTESTINE	NM_004347.1	c.154delA	p.T52fs*26	COSMIC	NP	NP
76	TCGA-CM-5348-01	Tumour	LARGE INTESTINE	NM_004347.1	c.154delA	p.T52fs*26	COSMIC	NP	NP
77	TCGA-CM-6165-01	Tumour	LARGE INTESTINE	NM_004347.1	c.154delA	p.T52fs*26	COSMIC	NP	NP
78	TCGA-CM-6171-01	Tumour	LARGE INTESTINE	NM_004347.1	c.153_154delAA	p.K51fs*3	COSMIC	NP	NP
79	TCGA-CM-6674-01	Tumour	LARGE INTESTINE	NM_004347.1	c.485delA	p.N162fs*8	COSMIC	NP	NP
80	TCGA-CM-6676-01	Tumour	LARGE INTESTINE	NM_004347.1	c.518A>G	p.E173G	COSMIC	NP	NP
81	TCGA-D1-A16Y-01	Tumour	ENDOMETRIUM	NM_004347.1	c.1169C>A	p.S390*	COSMIC	NP	NP
82	TCGA-D1-A17U-01	Tumour	ENDOMETRIUM	NM_004347.1	c.352C>T	p.L118F	COSMIC	NP	NP
83	TCGA-D5-6541-01	Tumour	LARGE INTESTINE	NM_004347.1	c.154delA	p.T52fs*26	COSMIC	NP	NP
84	TCGA-D5-6927-01	Tumour	LARGE INTESTINE	NM_004347.1	c.95T>C	p.L32P	COSMIC	NP	NP
85	TCGA-DC-6157-01	Tumour	LARGE INTESTINE	NM_004347.1	c.154delA	p.T52fs*26	COSMIC	NP	NP
86	TCGA-DK-A3IT-01	Tumour	URINARY TRACT	NM_004347.1	c.749C>T	p.S250F	COSMIC	NP	NP
87	TCGA-DM-A0XF-01	Tumour	LARGE INTESTINE	NM_004347.1	c.154delA	p.T52fs*26	COSMIC	NP	NP
88	TCGA-DY-A0XA-01	Tumour	LARGE INTESTINE	NM_004347.1	c.869A>T	p.K290I	COSMIC	NP	NP
89	TCGA-G4-6299-01	Tumour	LARGE INTESTINE	NM_004347.1	c.1086C>T	p.I362I	COSMIC	NP	NP
90	TCGA-G4-6299-01	Tumour	LARGE INTESTINE	NM_004347.1	c.1089C>T	p.F363F	COSMIC	NP	NP
91	TCGA-G4-6303-01	Tumour	LARGE INTESTINE	NM_004347.1	c.154delA	p.T52fs*26	COSMIC	NP	NP
92	TCGA-G4-6586-01	Tumour	LARGE INTESTINE	NM_004347.1	c.154delA	p.T52fs*26	COSMIC	NP	NP
93	TCGA-G4-6588-01	Tumour	LARGE INTESTINE	NM_004347.1	c.512delA	p.K171fs*33	COSMIC	NP	NP
94	TCGA-G4-6626-01	Tumour	LARGE INTESTINE	NM_004347.1	c.154delA	p.T52fs*26	COSMIC	NP	NP
95	TCGA-H4-A2HQ-01	Tumour	URINARY TRACT	NM_004347.1	c.291G>A	p.L97L	COSMIC	NP	NP
96	YUDUTY	Tumour	SKIN	NM_004347.1	c.85A>G	p.I29V	COSMIC	NP	NP
97	YUGAFFE	Tumour	SKIN	NM_004347.1	c.241G>A	p.E81K	COSMIC	NP	NP
98	YUKLAB	Tumour	SKIN	NM_004347.1	c.1180C>T	p.P394S	COSMIC	NP	NP
99	YUMER	Tumour	SKIN	NM_004347.1	c.346A>G	p.T116A	COSMIC	NP	NP
100	cSCCP7	Tumour	SKIN	NM_004347.1	c.959C>T	p.S320F	COSMIC	NP	NP
101	A673	Cell Line	BONE	NM_004347.1	c.293T>C	p.I98T	COSMIC	NP	NP
102	BC1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	NM_004347.1	c.496-15_496-1delCTCCATCTCCTGCAG	p.?	COSMIC	NP	NP
103	CP66MEL	Cell Line	SKIN	NM_004347.1	c.116A>C	p.K39T	COSMIC	NP	NP
104	DU4475	Cell Line	BREAST	NM_004347.1	c.414T>C	p.P138P	COSMIC	NP	NP
105	EW16	Cell Line	BONE	NM_004347.1	c.1208T>C	p.I403T	COSMIC	NP	NP
106	FARAGE	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	NM_004347.1	c.321C>T	p.R107R	COSMIC	NP	NP
107	GRST	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	NM_004347.1	c.1070G>A	p.R357H	COSMIC	NP	NP
108	GRST	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	NM_004347.1	c.485delA	p.N162fs*8	COSMIC	NP	NP
109	HCC2998	Cell Line	LARGE_INTESTINE	NM_004347.1	c.1251C>A	p.G417G	COSMIC	NP	NP
110	HCC2998	Cell Line	LARGE_INTESTINE	NM_004347.1	c.39C>T	p.F13F	COSMIC	NP	NP
111	HCC33	Cell Line	LUNG	NM_004347.1	c.904G>T	p.E302*	COSMIC	NP	NP
112	KCL22	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	NM_004347.1	c.267T>C	p.D89D	COSMIC	NP	NP
113	KM12	Cell Line	LARGE_INTESTINE	NM_004347.1	c.822C>A	p.T274T	COSMIC	NP	NP
114	KM12	Cell Line	LARGE_INTESTINE	NM_004347.1	c.892G>A	p.A298T	COSMIC	NP	NP
115	L540	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	NM_004347.1	c.872C>A	p.P291H	COSMIC	NP	NP
116	LNZTA3WT4	Cell Line	CENTRAL_NERVOUS_SYSTEM	NM_004347.1	c.11G>T	p.G4V	COSMIC	NP	NP
117	MEWO	Cell Line	SKIN	NM_004347.1	c.109G>A	p.D37N	COSMIC	NP	NP
118	MKN28	Cell Line	STOMACH	NM_004347.1	c.1033T>A	p.C345S	COSMIC	NP	NP
119	MKN45	Cell Line	STOMACH	NM_004347.1	c.267T>C	p.D89D	COSMIC	NP	NP
120	MOLT13	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	NM_004347.1	c.164T>G	p.M55R	COSMIC	NP	NP
121	NALM6	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	NM_004347.1	c.485delA	p.N162fs*8	COSMIC	NP	NP
122	NCC021	Cell Line	KIDNEY	NM_004347.1	c.532C>T	p.L178L	COSMIC	NP	NP
123	NCIH128	Cell Line	LUNG	NM_004347.1	c.388C>G	p.L130V	COSMIC	NP	NP
124	NCIH2009	Cell Line	LUNG	NM_004347.1	c.264T>C	p.Y88Y	COSMIC	NP	NP
125	NCIH650	Cell Line	LUNG	NM_004347.1	c.1109G>C	p.C370S	COSMIC	NP	NP
126	NCIH810	Cell Line	LUNG	NM_004347.1	c.407G>A	p.G136E	COSMIC	NP	NP
127	NCIH835	Cell Line	LUNG	NM_004347.1	c.551A>T	p.N184I	COSMIC	NP	NP
128	RERFLCFM	Cell Line	LUNG	NM_004347.1	c.321C>T	p.R107R	COSMIC	NP	NP
129	RL952	Cell Line	ENDOMETRIUM	NM_004347.1	c.786T>C	p.H262H	COSMIC	NP	NP
130	SNU182	Cell Line	LIVER	NM_004347.1	c.267T>C	p.D89D	COSMIC	NP	NP
131	SNU81	Cell Line	LARGE_INTESTINE	NM_004347.1	c.277G>T	p.E93*	COSMIC	NP	NP
132	SNUC5	Cell Line	LARGE_INTESTINE	NM_004347.1	c.35A>C	p.N12T	COSMIC	NP	NP
133	SUDHL16	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	NM_004347.1	c.1052A>C	p.N351T	COSMIC	NP	NP
134	SW620	Cell Line	LARGE_INTESTINE	NM_004347.1	c.1043C>A	p.T348K	COSMIC	NP	NP
135	SW948	Cell Line	LARGE_INTESTINE	NM_004347.1	c.648C>T	p.D216D	COSMIC	NP	NP
136	TT	Cell Line	OESOPHAGUS	NM_004347.1	c.1207A>G	p.I403V	COSMIC	NP	NP

*NP: Not Predicted

Tissue Type	Mean Expression Value	Median Expression Value	Mean CNV	Median CNV

AUTONOMIC GANGLIA	4.2181	4.1475	-0.2433	-0.1185
BILIARY TRACT	4.6044	4.5364	-0.4362	-0.3536
BONE	4.1795	4.1565	-0.0032	-0.0033
BREAST	4.2744	4.24095	-0.1577	-0.04385
CENTRAL NERVOUS SYSTEM	4.3408	4.3247	-0.1443	-0.0773
ENDOMETRIUM	4.4712	4.353	-0.0138	-0.0087
HAEMATOPOIETIC AND LYMPHOID TISSUE	4.3705	4.3727	0.0230	-0.00438
KIDNEY	4.3187	4.3092	-0.2754	-0.1976
LARGE INTESTINE	4.8976	4.5435	0.0591	-0.005012
LIVER	4.3378	4.3309	-0.0431	0.05235
LUNG	4.2719	4.2633	0.1062	0.12525
OESOPHAGUS	4.6989	4.4713	0.1250	0.24415
OVARY	4.3767	4.3853	0.0965	0.1005
PANCREAS	4.3212	4.2896	0.2031	0.2523
PLEURA	4.3322	4.3599	-0.1663	-0.1774
PROSTATE	4.2060	4.15025	0.0955	0.04605
SALIVARY GLAND	4.1629	4.1629	-0.4050	-0.405
SKIN	4.2320	4.2222	-0.3170	-0.1878
SMALL INTESTINE	4.3875	4.3875	-0.0067	-0.0067
SOFT TISSUE	4.4731	4.4323	-0.0533	-0.022675
STOMACH	4.3357	4.29585	0.0887	0.10805
THYROID	4.1815	4.19945	0.0004	-0.01511
UPPER AERODIGESTIVE TRACT	4.4736	4.41725	-0.0140	0.020045
URINARY TRACT	4.2679	4.2712	-0.0758	-0.00175

Domain ID	Domain Name	Start Site	End Site	E-value
PF00619	CARD	62	140	4e-13
PF07870	DUF1657	121	147	0.04
PF07063	DUF1338	184	264	0.029
PF00656	Peptidase_C14	193	429	1.5e-46

Domain ID	Start Site	End Site	E-value
0039807	170	433	6.43e-82
0036420	62	142	7.53e-14

Proteomics DB	COSMIC	Gene Atlas	STRING	PIR
CASP5	CASP5	CASP5	ENSP00000260315	P51878
QuickGO	HGNC	Ensembl Genome Browser	TreeFam	UniProt
P51878	CASP5	ENSP00000260315	CASP5	P51878
Expression Atlas	Protein Atlas	OMIM	IntAct	PharmGKB
CASP5	ENSP00000260315	602665	P51878	PA26089

Protein: CASP5

Mutation Data (+)

Copy number variation and expression profile (+)

Gene Essentiality Data (+)

Tertiary structure (+)

Structure Domains (+)

Sequence Alignment (+)

Sequence Profiles (+)

Post Translational Modifications (+)

Other Databases Link (+)

Modelled Structure	Structures available in PDB
	Structure is not available in PDB