ApoCanD

#	Name/ID	Cell Line/Tumor sample	Tissue of Origin	Reference ID	cDNA change	Protein change	Source	FATHMM Prediction	PolyPhen2 Prediction
1	EB2	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_000034	c.948G>A	p.K316K	CCLE	NP	NP
2	GCT	Cell Line	SOFT TISSUE	NP_000034	c.305G>A	p.R102K	CCLE	PASSENGER/OTHER	Probably Damaging
3	HEC151	Cell Line	ENDOMETRIUM	NP_000034	c.870G>A	p.A290A	CCLE	NP	NP
4	HEC59	Cell Line	ENDOMETRIUM	NP_000034	c.397_397delT	p.F133fs	CCLE	NP	NP
5	JHUEM7	Cell Line	ENDOMETRIUM	NP_000034	c.748C>T	p.R250*	CCLE	NP	NP
6	KYO1	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_000034	c.38C>T	p.T13M	CCLE	PASSENGER/OTHER	Probably Damaging
7	KYSE150	Cell Line	OESOPHAGUS	NP_000034	c.836G>A	p.R279H	CCLE	PASSENGER/OTHER	Probably Damaging
8	L1236	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_000034	c.651_splice	p.P217_splice	CCLE	NP	NP
9	LS411N	Cell Line	LARGE INTESTINE	NP_000034	c.711T>C	p.A237A	CCLE	NP	NP
10	NCIH1573	Cell Line	LUNG	NP_000034	c.495C>T	p.C165C	CCLE	NP	NP
11	NCIH1755	Cell Line	LUNG	NP_000034	c.880T>C	p.L294L	CCLE	NP	NP
12	NCIH1838	Cell Line	LUNG	NP_000034	c.799G>T	p.V267F	CCLE	PASSENGER/OTHER	Benign
13	OCILY10	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_000034	c.526T>G	p.W176G	CCLE	PASSENGER/OTHER	Probably Damaging
14	P3HR1	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_000034	c.818A>G	p.Q273R	CCLE	CANCER	Probably Damaging
15	SNU407	Cell Line	LARGE INTESTINE	NP_000034	c.176G>A	p.C59Y	CCLE	CANCER	Probably Damaging
16	SNU81	Cell Line	LARGE INTESTINE	NP_000034	c.568_splice	p.V190_splice	CCLE	NP	NP
17	SUDHL8	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_000034	c.680_684delTTGAC	p.V227fs	CCLE	NP	NP
18	06-25470	Tumour	HAEMATOPOIETIC AND LYMPHOID TISSUE	NM_000043.3	c.696T>G	p.Y232*	COSMIC	NP	NP
19	105307	Tumour	BREAST	NM_000043.3	c.381C>T	p.C127C	COSMIC	NP	NP
20	BB49-HNC	Cell Line	UPPER AERODIGESTIVE TRACT	NM_000043.3	c.805G>A	p.D269N	COSMIC	NP	NP
21	DLBCL-PatientM	Tumour	HAEMATOPOIETIC AND LYMPHOID TISSUE	NM_000043.3	c.733G>C	p.V245L	COSMIC	NP	NP
22	DLBCL-PatientM	Tumour	HAEMATOPOIETIC AND LYMPHOID TISSUE	NM_000043.3	c.794A>G	p.D265G	COSMIC	NP	NP
23	FL-PatientA	Tumour	HAEMATOPOIETIC AND LYMPHOID TISSUE	NM_000043.3	c.826C>T	p.Q276*	COSMIC	NP	NP
24	HCC137T	Tumour	LIVER	NM_000043.3	c.165T>C	p.D55D	COSMIC	NP	NP
25	HCC20T	Tumour	LIVER	NM_000043.3	c.657A>G	p.T219T	COSMIC	NP	NP
26	HCC73T	Tumour	LIVER	NM_000043.3	c.249G>C	p.V83V	COSMIC	NP	NP
27	HN	Tumour	62374 UPPER AERODIGESTIVE TRACT	NM_000043.3	c.631G>T	p.E211*	COSMIC	NP	NP
28	LUAD-5V8LT	Tumour	LUNG	NM_000043.3	c.493T>A	p.C165S	COSMIC	NP	NP
29	LUAD-NYU1021	Tumour	LUNG	NM_000043.3	c.870G>A	p.A290A	COSMIC	NP	NP
30	TCGA-18-3409-01	Tumour	LUNG	NM_000043.3	c.59C>T	p.S20F	COSMIC	NP	NP
31	TCGA-22-5472-01	Tumour	LUNG	NM_000043.3	c.474A>T	p.T158T	COSMIC	NP	NP
32	TCGA-44-6145-01	Tumour	LUNG	NM_000043.3	c.341A>T	p.E114V	COSMIC	NP	NP
33	TCGA-50-5930-01	Tumour	LUNG	NM_000043.3	c.428G>T	p.C143F	COSMIC	NP	NP
34	TCGA-95-7944-01	Tumour	LUNG	NM_000043.3	c.781G>A	p.E261K	COSMIC	NP	NP
35	TCGA-A6-6780-01	Tumour	LARGE INTESTINE	NM_000043.3	c.397delT	p.C135fs*52	COSMIC	NP	NP
36	TCGA-AD-6889-01	Tumour	LARGE INTESTINE	NM_000043.3	c.894_895insA	p.A301fs*20	COSMIC	NP	NP
37	TCGA-AG-3598-01	Tumour	LARGE INTESTINE	NM_000043.3	c.536T>A	p.L179H	COSMIC	NP	NP
38	TCGA-AG-3892-01	Tumour	LARGE INTESTINE	NM_000043.3	c.312T>C	p.C104C	COSMIC	NP	NP
39	TCGA-AG-3892-01	Tumour	LARGE INTESTINE	NM_000043.3	c.925A>C	p.K309Q	COSMIC	NP	NP
40	TCGA-AP-A051-01	Tumour	ENDOMETRIUM	NM_000043.3	c.653A>G	p.E218G	COSMIC	NP	NP
41	TCGA-AP-A051-01	Tumour	ENDOMETRIUM	NM_000043.3	c.869C>T	p.A290V	COSMIC	NP	NP
42	TCGA-AP-A056-01	Tumour	ENDOMETRIUM	NM_000043.3	c.444-1G>T	p.?	COSMIC	NP	NP
43	TCGA-AP-A059-01	Tumour	ENDOMETRIUM	NM_000043.3	c.286C>T	p.H96Y	COSMIC	NP	NP
44	TCGA-AP-A0LM-01	Tumour	ENDOMETRIUM	NM_000043.3	c.608G>T	p.R203I	COSMIC	NP	NP
45	TCGA-AX-A05Z-01	Tumour	ENDOMETRIUM	NM_000043.3	c.189T>C	p.C63C	COSMIC	NP	NP
46	TCGA-AX-A0J1-01	Tumour	ENDOMETRIUM	NM_000043.3	c.870G>A	p.A290A	COSMIC	NP	NP
47	TCGA-AZ-4315-01	Tumour	LARGE INTESTINE	NM_000043.3	c.362G>A	p.R121Q	COSMIC	NP	NP
48	TCGA-B0-5713-01	Tumour	KIDNEY	NM_000043.3	c.835C>A	p.R279S	COSMIC	NP	NP
49	TCGA-B5-A0JY-01	Tumour	ENDOMETRIUM	NM_000043.3	c.801C>A	p.V267V	COSMIC	NP	NP
50	TCGA-B5-A11E-01	Tumour	ENDOMETRIUM	NM_000043.3	c.370A>C	p.N124H	COSMIC	NP	NP
51	TCGA-B8-4154-01	Tumour	KIDNEY	NM_000043.3	c.434C>A	p.P145H	COSMIC	NP	NP
52	TCGA-BS-A0TC-01	Tumour	ENDOMETRIUM	NM_000043.3	c.559A>C	p.I187L	COSMIC	NP	NP
53	TCGA-C8-A12T-01	Tumour	BREAST	NM_000043.3	c.682G>A	p.D228N	COSMIC	NP	NP
54	TCGA-CA-6717-01	Tumour	LARGE INTESTINE	NM_000043.3	c.340G>A	p.E114K	COSMIC	NP	NP
55	TCGA-CK-4947-01	Tumour	LARGE INTESTINE	NM_000043.3	c.542T>C	p.L181P	COSMIC	NP	NP
56	TCGA-CM-5862-01	Tumour	LARGE INTESTINE	NM_000043.3	c.806A>G	p.D269G	COSMIC	NP	NP
57	TCGA-CW-5581-01	Tumour	KIDNEY	NM_000043.3	c.119C>T	p.T40I	COSMIC	NP	NP
58	TCGA-D1-A103-01	Tumour	ENDOMETRIUM	NM_000043.3	c.20T>C	p.L7P	COSMIC	NP	NP
59	TCGA-D1-A16J-01	Tumour	ENDOMETRIUM	NM_000043.3	c.503delA	p.G169fs*18	COSMIC	NP	NP
60	TCGA-D5-6927-01	Tumour	LARGE INTESTINE	NM_000043.3	c.396_397insT	p.C135fs*2	COSMIC	NP	NP
61	YUAVEY	Tumour	SKIN	NM_000043.3	c.739G>A	p.G247S	COSMIC	NP	NP
62	tumor	Tumour	4163639 HAEMATOPOIETIC AND LYMPHOID TISSUE	NM_000043.3	c.656_658CAG>C	p.V220fs*6	COSMIC	NP	NP
63	tumor	Tumour	4163639 HAEMATOPOIETIC AND LYMPHOID TISSUE	NM_000043.3	c.802C>G	p.Q268E	COSMIC	NP	NP
64	BB49HNC	Cell Line	UPPER_AERODIGESTIVE_TRACT	NM_000043.3	c.805G>A	p.D269N	COSMIC	CANCER	POSSIBLY DAMAGING
65	EB2	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	NM_000043.3	c.948G>A	p.K316K	COSMIC	NP	NP
66	GCT	Cell Line	SOFT_TISSUE	NM_000043.3	c.305G>A	p.R102K	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
67	H290	Cell Line	PLEURA	NM_000043.3	c.360C>T	p.T120T	COSMIC	NP	NP
68	JIYOYEP2003	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	NM_000043.3	c.818A>G	p.Q273R	COSMIC	CANCER	PROBABLY DAMAGING
69	KARPAS422	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	NM_000043.3	c.526T>G	p.W176G	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
70	KARPAS45	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	NM_000043.3	c.401T>C	p.F134S	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
71	KYSE150	Cell Line	OESOPHAGUS	NM_000043.3	c.836G>A	p.R279H	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
72	L1236	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	NM_000043.3	c.651+2T>C	p.?	COSMIC	NP	NP
73	LS411N	Cell Line	LARGE_INTESTINE	NM_000043.3	c.711T>C	p.A237A	COSMIC	NP	NP
74	MCC13	Cell Line	SKIN	NM_000043.3	c.293C>T	p.S98F	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
75	MRKNU1	Cell Line	BREAST	NM_000043.3	c.506-3C>T	p.?	COSMIC	NP	NP
76	NCIH1573	Cell Line	LUNG	NM_000043.3	c.495C>T	p.C165C	COSMIC	NP	NP
77	NCIH1755	Cell Line	LUNG	NM_000043.3	c.366C>T	p.T122T	COSMIC	NP	NP
78	NCIH1755	Cell Line	LUNG	NM_000043.3	c.880T>C	p.L294L	COSMIC	NP	NP
79	NCIH1770	Cell Line	LUNG	NM_000043.3	c.197-10C>T	p.?	COSMIC	NP	NP
80	NCIH1838	Cell Line	LUNG	NM_000043.3	c.799G>T	p.V267F	COSMIC	PASSENGER/OTHER	BENIGN
81	PL18	Cell Line	PANCREAS	NM_000043.3	c.937A>G	p.I313V	COSMIC	PASSENGER/OTHER	BENIGN
82	RAJI	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	NM_000043.3	c.575G>T	p.R192I	COSMIC	PASSENGER/OTHER	BENIGN
83	SNU407	Cell Line	LARGE_INTESTINE	NM_000043.3	c.176G>A	p.C59Y	COSMIC	CANCER	PROBABLY DAMAGING
84	SUDHL8	Cell Line	NS	NM_000043.3	c.57G>A	p.S19S	COSMIC	NP	NP
85	SUDHL8	Cell Line	NS	NM_000043.3	c.680_684delTTGAC	p.D228fs*2	COSMIC	NP	NP
86	SW48	Cell Line	LARGE_INTESTINE	NM_000043.3	c.315A>T	p.R105S	COSMIC	PASSENGER/OTHER	BENIGN

*NP: Not Predicted

Proteomics DB	COSMIC	Gene Atlas	STRING	PIR
FAS	FAS	FAS
QuickGO	HGNC	Ensembl Genome Browser	TreeFam	UniProt
	FAS		FAS
Expression Atlas	Protein Atlas	OMIM	IntAct	PharmGKB
FAS

Protein: FAS

Mutation Data (+)

Copy number variation and expression profile (+)

Gene Essentiality Data (+)

Tertiary structure (+)

Structure Domains (+)

Sequence Alignment (+)

Sequence Profiles (+)

Post Translational Modifications (+)

Other Databases Link (+)

Modelled Structure	Structures available in PDB