ApoCanD

Mutation Data (+)

#	Name/ID	Cell Line/Tumor sample	Tissue of Origin	Reference ID	cDNA change	Protein change	Source	FATHMM Prediction	PolyPhen2 Prediction
1	048	Tumour	HAEMATOPOIETIC AND LYMPHOID TISSUE	ENST00000298894	c.44T>C	p.M15T	COSMIC	NP	NP
2	048-0089-01TD	Tumour	HAEMATOPOIETIC AND LYMPHOID TISSUE	ENST00000298894	c.44T>C	p.M15T	COSMIC	NP	NP
3	12T	Tumour	SKIN	ENST00000298894	c.1004C>A	p.A335D	COSMIC	NP	NP
4	12T	Tumour	SKIN	ENST00000298894	c.235C>T	p.P79S	COSMIC	NP	NP
5	1946219	Tumour	LUNG	ENST00000298894	c.1055G>C	p.*352S	COSMIC	NP	NP
6	MD-320	Tumour	CENTRAL NERVOUS SYSTEM	ENST00000298894	c.332C>G	p.A111G	COSMIC	NP	NP
7	PA285	Cell Line	PANCREAS	ENST00000298894	c.431delC	p.P144fs*7	COSMIC	NP	NP
8	TCGA-05-4430-01	Tumour	LUNG	ENST00000298894	c.946G>C	p.D316H	COSMIC	NP	NP
9	TCGA-18-3410-01	Tumour	LUNG	ENST00000298894	c.281A>G	p.K94R	COSMIC	NP	NP
10	TCGA-24-1847-01	Tumour	OVARY	ENST00000298894	c.504C>A	p.F168L	COSMIC	NP	NP
11	TCGA-61-1727-01	Tumour	OVARY	ENST00000298894	c.447_463del17	p.L150fs*8	COSMIC	NP	NP
12	TCGA-61-2016-01	Tumour	OVARY	ENST00000298894	c.299A>G	p.N100S	COSMIC	NP	NP
13	TCGA-66-2756-01	Tumour	LUNG	ENST00000298894	c.438G>A	p.L146L	COSMIC	NP	NP
14	TCGA-73-4668-01	Tumour	LUNG	ENST00000298894	c.1027C>T	p.Q343*	COSMIC	NP	NP
15	TCGA-86-6851-01	Tumour	LUNG	ENST00000298894	c.462G>T	p.Q154H	COSMIC	NP	NP
16	TCGA-A5-A0VQ-01	Tumour	ENDOMETRIUM	ENST00000298894	c.103delA	p.I35fs*9	COSMIC	NP	NP
17	TCGA-A8-A07L-01	Tumour	BREAST	ENST00000298894	c.1A>T	p.M1L	COSMIC	NP	NP
18	TCGA-AA-3713-01	Tumour	LARGE INTESTINE	ENST00000298894	c.786G>A	p.E262E	COSMIC	NP	NP
19	TCGA-AD-6889-01	Tumour	LARGE INTESTINE	ENST00000298894	c.284C>T	p.P95L	COSMIC	NP	NP
20	TCGA-AG-A002-01	Tumour	LARGE INTESTINE	ENST00000298894	c.922C>T	p.R308C	COSMIC	NP	NP
21	TCGA-AP-A0LF-01	Tumour	ENDOMETRIUM	ENST00000298894	c.149G>A	p.R50K	COSMIC	NP	NP
22	TCGA-AX-A05T-01	Tumour	ENDOMETRIUM	ENST00000298894	c.468C>G	p.A156A	COSMIC	NP	NP
23	TCGA-AX-A0J0-01	Tumour	ENDOMETRIUM	ENST00000298894	c.850G>C	p.A284P	COSMIC	NP	NP
24	TCGA-B5-A0JZ-01	Tumour	ENDOMETRIUM	ENST00000298894	c.614G>A	p.R205Q	COSMIC	NP	NP
25	TCGA-BS-A0UA-01	Tumour	ENDOMETRIUM	ENST00000298894	c.52C>T	p.R18W	COSMIC	NP	NP
26	TCGA-C8-A12Q-01	Tumour	BREAST	ENST00000298894	c.535G>T	p.E179*	COSMIC	NP	NP
27	TCGA-CF-A27C-01	Tumour	URINARY TRACT	ENST00000298894	c.538G>A	p.E180K	COSMIC	NP	NP
28	TCGA-CK-4952-01	Tumour	LARGE INTESTINE	ENST00000298894	c.298A>T	p.N100Y	COSMIC	NP	NP
29	TCGA-D1-A17Q-01	Tumour	ENDOMETRIUM	ENST00000298894	c.922C>T	p.R308C	COSMIC	NP	NP
30	TCGA-EJ-7786-01	Tumour	PROSTATE	ENST00000298894	c.674A>G	p.N225S	COSMIC	NP	NP
31	TCGA-EJ-7792-01	Tumour	PROSTATE	ENST00000298894	c.932T>G	p.L311R	COSMIC	NP	NP
32	TCGA-GD-A2C5-01	Tumour	URINARY TRACT	ENST00000298894	c.595G>T	p.D199Y	COSMIC	NP	NP
33	BV173	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000298894	c.219T>A	p.T73T	COSMIC	NP	NP
34	CORL32	Cell Line	LUNG	ENST00000298894	c.627C>A	p.S209R	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
35	FARAGE	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000298894	c.760T>C	p.Y254H	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
36	KNS62	Cell Line	LUNG	ENST00000298894	c.407G>T	p.G136V	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
37	LS180	Cell Line	LARGE_INTESTINE	ENST00000298894	c.36delG	p.M13fs*3	COSMIC	NP	NP
38	LS411N	Cell Line	LARGE_INTESTINE	ENST00000298894	c.202G>T	p.G68W	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
39	LS411N	Cell Line	LARGE_INTESTINE	ENST00000298894	c.37A>G	p.M13V	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
40	NCIH660	Cell Line	PROSTATE	ENST00000298894	c.397C>G	p.P133A	COSMIC	PASSENGER/OTHER	BENIGN
41	SNU81	Cell Line	LARGE_INTESTINE	ENST00000298894	c.922C>T	p.R308C	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
42	TGBC1TKB	Cell Line	BILIARY_TRACT	ENST00000298894	c.17T>C	p.L6S	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING

*NP: Not Predicted

Copy number variation and expression profile (+)

Tissue Type	Mean Expression Value	Median Expression Value	Mean CNV	Median CNV

AUTONOMIC GANGLIA	10.5787	11.04	-0.1409	-0.07186
BILIARY TRACT	9.1115	9.3644	0.3661	0.366
BONE	9.3162	9.4031	-0.0311	-0.008894
BREAST	9.5237	9.5164	-0.0134	-0.0061145
CENTRAL NERVOUS SYSTEM	8.8726	8.8533	-0.1609	-0.155
ENDOMETRIUM	10.0014	10.089	0.0563	0.01539
HAEMATOPOIETIC AND LYMPHOID TISSUE	9.7067	9.6554	-0.0488	-0.01076
KIDNEY	9.6253	9.5508	-0.6064	-0.6986
LARGE INTESTINE	9.4217	9.4166	-0.0302	-0.01845
LIVER	9.1219	8.9936	-0.1923	-0.1967
LUNG	9.6277	9.5135	0.1186	0.12275
OESOPHAGUS	9.4327	9.57325	0.1293	0.1678
OVARY	9.8066	9.8937	0.0601	0.0452
PANCREAS	9.2934	9.3467	0.0685	0.124
PLEURA	8.9407	9.0678	-0.2792	-0.1482
PROSTATE	10.0776	10.5905	0.1253	0.0602
SALIVARY GLAND	8.4830	8.483	0.0004	0.000403
SKIN	9.4729	9.4672	-0.2400	-0.1625
SMALL INTESTINE	10.3870	10.387	0.0208	0.0208
SOFT TISSUE	8.9130	8.9153	-0.0065	-0.01926
STOMACH	9.4420	9.49755	0.0323	-0.010935
THYROID	9.1338	9.11855	-0.0950	0.01096
UPPER AERODIGESTIVE TRACT	9.1563	9.0261	0.3599	0.32675
URINARY TRACT	8.8253	8.8706	0.0831	0.07271

Gene Essentiality Data (+)

Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.

test

Tertiary structure (+)

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Modelled Structure	Structures available in PDB

Structure Domains (+)

1. PFAM Domains:

2. Superfaimly domains are not present!!

Sequence Alignment (+)

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1. Variants are not present in 1000 Genomes!!

2. Mutants are not present in CCLE!!

3. Sequence alignment with COSMIC mutants:

4. Sequence alignment with homologus proteins:

Sequence Profiles (+)

HMM
With Uniprot database	With Mutants	With 1000 Genome Variants

PSSM
With Uniprot database	With Mutants	With 1000 Genome Variant

Post Translational Modifications (+)

Post translational modifications are not found!!

Proteomics DB	COSMIC	Gene Atlas	STRING	PIR
MOAP1	MOAP1	MOAP1
QuickGO	HGNC	Ensembl Genome Browser	TreeFam	UniProt
	MOAP1		MOAP1
Expression Atlas	Protein Atlas	OMIM	IntAct	PharmGKB
MOAP1

Protein: MOAP1