ApoCanD

#	Name/ID	Cell Line/Tumor sample	Tissue of Origin	Reference ID	cDNA change	Protein change	Source	FATHMM Prediction	PolyPhen2 Prediction
1	AU565	Cell Line	BREAST	NP_066961	c.1443G>C	p.K481N	CCLE	NP	NP
2	CAKI1	Cell Line	KIDNEY	NP_066961	c.74G>A	p.G25E	CCLE	NP	NP
3	DV90	Cell Line	LUNG	NP_066961	c.20_20delC	p.T7fs	CCLE	NP	NP
4	HEC108	Cell Line	ENDOMETRIUM	NP_066961	c.209C>G	p.A70G	CCLE	NP	NP
5	HEC59	Cell Line	ENDOMETRIUM	NP_066961	c.1241T>C	p.M414T	CCLE	NP	NP
6	JHUEM2	Cell Line	ENDOMETRIUM	NP_066961	c.20_20delC	p.T7fs	CCLE	NP	NP
7	MEWO	Cell Line	SKIN	NP_066961	c.556C>T	p.P186S	CCLE	NP	NP
8	NCIH1693	Cell Line	LUNG	NP_066961	c.1120C>T	p.P374S	CCLE	NP	NP
9	OVK18	Cell Line	OVARY	NP_066961	c.20_20delC	p.T7fs	CCLE	NP	NP
10	RKO	Cell Line	LARGE INTESTINE	NP_066961	c.1444A>G	p.N482D	CCLE	NP	NP
11	SKBR3	Cell Line	BREAST	NP_066961	c.1443G>C	p.K481N	CCLE	NP	NP
12	SNGM	Cell Line	ENDOMETRIUM	NP_066961	c.158A>G	p.Y53C	CCLE	NP	NP
13	SNU1040	Cell Line	LARGE INTESTINE	NP_066961	c.1267C>T	p.R423W	CCLE	NP	NP
14	SUDHL5	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_066961	c.583A>G	p.K195E	CCLE	NP	NP
15	112731	Tumour	LUNG	ENST00000536468	c.1251G>A	p.P417P	COSMIC	NP	NP
16	1946219	Tumour	LUNG	ENST00000536468	c.223G>A	p.E75K	COSMIC	NP	NP
17	E22	Tumour	EYE	ENST00000536468	c.1348G>A	p.D450N	COSMIC	NP	NP
18	ESO-859	Tumour	OESOPHAGUS	ENST00000536468	c.125G>A	p.R42H	COSMIC	NP	NP
19	ESO-859	Tumour	OESOPHAGUS	ENST00000536468	c.790G>A	p.A264T	COSMIC	NP	NP
20	HCC1954	Cell Line	BREAST	ENST00000536468	c.1370A>T	p.Q457L	COSMIC	NP	NP
21	HCT-15	Cell Line	LARGE INTESTINE	ENST00000536468	c.1159G>A	p.G387S	COSMIC	NP	NP
22	HF-23896	Tumour	LUNG	ENST00000536468	c.223G>A	p.E75K	COSMIC	NP	NP
23	HN	Tumour	62739 UPPER AERODIGESTIVE TRACT	ENST00000536468	c.600G>T	p.E200D	COSMIC	NP	NP
24	LUAD-RT-S01487	Tumour	LUNG	ENST00000536468	c.1370_1371delAG	p.R458fs*>44	COSMIC	NP	NP
25	MD-279	Tumour	CENTRAL NERVOUS SYSTEM	ENST00000536468	c.1123G>A	p.A375T	COSMIC	NP	NP
26	MOLT-4	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	ENST00000536468	c.1118T>C	p.I373T	COSMIC	NP	NP
27	MZ7-mel	Cell Line	SKIN	ENST00000536468	c.1269G>A	p.R423R	COSMIC	NP	NP
28	PC-9BRc1	Cell Line	LUNG	ENST00000536468	c.960G>T	p.K320N	COSMIC	NP	NP
29	PD4098a	Tumour	BREAST	ENST00000536468	c.1154G>C	p.R385T	COSMIC	NP	NP
30	S00841	Tumour	LUNG	ENST00000536468	c.127A>T	p.R43W	COSMIC	NP	NP
31	TCGA-09-0369-01	Tumour	OVARY	ENST00000536468	c.802C>T	p.L268F	COSMIC	NP	NP
32	TCGA-55-7281-01	Tumour	LUNG	ENST00000536468	c.757G>C	p.E253Q	COSMIC	NP	NP
33	TCGA-64-5779-01	Tumour	LUNG	ENST00000536468	c.1015G>C	p.E339Q	COSMIC	NP	NP
34	TCGA-66-2763-01	Tumour	LUNG	ENST00000536468	c.414G>T	p.A138A	COSMIC	NP	NP
35	TCGA-78-7150-01	Tumour	LUNG	ENST00000536468	c.315C>T	p.A105A	COSMIC	NP	NP
36	TCGA-AA-3502-01	Tumour	LARGE INTESTINE	ENST00000536468	c.538G>A	p.E180K	COSMIC	NP	NP
37	TCGA-AA-3662-01	Tumour	LARGE INTESTINE	ENST00000536468	c.803T>C	p.L268P	COSMIC	NP	NP
38	TCGA-AA-3715-01	Tumour	LARGE INTESTINE	ENST00000536468	c.449G>A	p.R150H	COSMIC	NP	NP
39	TCGA-AG-3727-01	Tumour	LARGE INTESTINE	ENST00000536468	c.1002G>A	p.A334A	COSMIC	NP	NP
40	TCGA-AG-A02N-01	Tumour	LARGE INTESTINE	ENST00000536468	c.1197C>T	p.D399D	COSMIC	NP	NP
41	TCGA-AP-A059-01	Tumour	ENDOMETRIUM	ENST00000536468	c.1219C>A	p.L407M	COSMIC	NP	NP
42	TCGA-AX-A0J0-01	Tumour	ENDOMETRIUM	ENST00000536468	c.266C>T	p.S89L	COSMIC	NP	NP
43	TCGA-AY-6386-01	Tumour	LARGE INTESTINE	ENST00000536468	c.803T>C	p.L268P	COSMIC	NP	NP
44	TCGA-AZ-4315-01	Tumour	LARGE INTESTINE	ENST00000536468	c.861C>T	p.C287C	COSMIC	NP	NP
45	TCGA-AZ-5407-01	Tumour	LARGE INTESTINE	ENST00000536468	c.803T>C	p.L268P	COSMIC	NP	NP
46	TCGA-BS-A0TA-01	Tumour	ENDOMETRIUM	ENST00000536468	c.537C>T	p.H179H	COSMIC	NP	NP
47	TCGA-BS-A0UF-01	Tumour	ENDOMETRIUM	ENST00000536468	c.1396G>A	p.A466T	COSMIC	NP	NP
48	TCGA-BT-A0YX-01	Tumour	URINARY TRACT	ENST00000536468	c.457G>C	p.E153Q	COSMIC	NP	NP
49	TCGA-CA-6718-01	Tumour	LARGE INTESTINE	ENST00000536468	c.340T>C	p.W114R	COSMIC	NP	NP
50	TCGA-CA-6718-01	Tumour	LARGE INTESTINE	ENST00000536468	c.358G>T	p.E120*	COSMIC	NP	NP
51	TCGA-D1-A163-01	Tumour	ENDOMETRIUM	ENST00000536468	c.1158C>T	p.Y386Y	COSMIC	NP	NP
52	TCGA-D5-6540-01	Tumour	LARGE INTESTINE	ENST00000536468	c.1250C>T	p.P417L	COSMIC	NP	NP
53	TCGA-G4-6304-01	Tumour	LARGE INTESTINE	ENST00000536468	c.1326C>T	p.H442H	COSMIC	NP	NP
54	647V	Cell Line	URINARY_TRACT	ENST00000536468	c.366+3_366+21del19	p.?	COSMIC	NP	NP
55	A253	Cell Line	SALIVARY_GLAND	ENST00000536468	c.367-8G>A	p.?	COSMIC	NP	NP
56	AU565	Cell Line	BREAST	ENST00000536468	c.1443G>C	p.K481N	COSMIC	NP	NP
57	BFTC909	Cell Line	KIDNEY	ENST00000536468	c.1203C>T	p.T401T	COSMIC	NP	NP
58	CAKI1	Cell Line	KIDNEY	ENST00000536468	c.74G>A	p.G25E	COSMIC	NP	NP
59	CHL1	Cell Line	SKIN	ENST00000536468	c.309G>A	p.L103L	COSMIC	NP	NP
60	EFO27	Cell Line	OVARY	ENST00000536468	c.20delC	p.P9fs*77	COSMIC	NP	NP
61	EW12	Cell Line	BONE	ENST00000536468	c.43C>T	p.L15L	COSMIC	NP	NP
62	FARAGE	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000536468	c.838G>T	p.A280S	COSMIC	NP	NP
63	HCC1954	Cell Line	BREAST	ENST00000536468	c.1370A>T	p.Q457L	COSMIC	NP	NP
64	HCC2998	Cell Line	LARGE_INTESTINE	ENST00000536468	c.749C>T	p.S250L	COSMIC	NP	NP
65	IALM	Cell Line	LUNG	ENST00000536468	c.1239G>C	p.V413V	COSMIC	NP	NP
66	IPC298	Cell Line	SKIN	ENST00000536468	c.506C>T	p.P169L	COSMIC	NP	NP
67	JHH7	Cell Line	LIVER	ENST00000536468	c.491G>A	p.R164Q	COSMIC	NP	NP
68	JURKAT	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000536468	c.647G>A	p.C216Y	COSMIC	NP	NP
69	KARPAS45	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000536468	c.1250C>T	p.P417L	COSMIC	NP	NP
70	KARPAS45	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000536468	c.1494G>A	p.L498L	COSMIC	NP	NP
71	KPNYN	Cell Line	AUTONOMIC_GANGLIA	ENST00000536468	c.1084G>A	p.A362T	COSMIC	NP	NP
72	LNCAPCLONEFGC	Cell Line	PROSTATE	ENST00000536468	c.16G>A	p.V6M	COSMIC	NP	NP
73	LNCAPCLONEFGC	Cell Line	PROSTATE	ENST00000536468	c.788A>G	p.H263R	COSMIC	NP	NP
74	MFM223	Cell Line	BREAST	ENST00000536468	c.49C>T	p.P17S	COSMIC	NP	NP
75	MM1S	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000536468	c.311C>T	p.P104L	COSMIC	NP	NP
76	MOLT4	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000536468	c.1118T>C	p.I373T	COSMIC	NP	NP
77	MZ7MEL	Cell Line	SKIN	ENST00000536468	c.1269G>A	p.R423R	COSMIC	NP	NP
78	NALM6	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000536468	c.658G>A	p.A220T	COSMIC	NP	NP
79	NCIH1693	Cell Line	LUNG	ENST00000536468	c.1120C>T	p.P374S	COSMIC	NP	NP
80	NCIH196	Cell Line	LUNG	ENST00000536468	c.359A>C	p.E120A	COSMIC	NP	NP
81	NCIH2452	Cell Line	PLEURA	ENST00000536468	c.1503C>G	p.L501L	COSMIC	NP	NP
82	NCIH596	Cell Line	LUNG	ENST00000536468	c.816C>T	p.C272C	COSMIC	NP	NP
83	NH12	Cell Line	AUTONOMIC_GANGLIA	ENST00000536468	c.507C>G	p.P169P	COSMIC	NP	NP
84	OVK18	Cell Line	OVARY	ENST00000536468	c.20delC	p.P9fs*77	COSMIC	NP	NP
85	PL18	Cell Line	PANCREAS	ENST00000536468	c.1203C>T	p.T401T	COSMIC	NP	NP
86	RCCAB	Cell Line	KIDNEY	ENST00000536468	c.190T>A	p.S64T	COSMIC	NP	NP
87	RKO	Cell Line	LARGE_INTESTINE	ENST00000536468	c.1444A>G	p.N482D	COSMIC	NP	NP
88	RS411	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000536468	c.889G>A	p.A297T	COSMIC	NP	NP
89	RVH421	Cell Line	SKIN	ENST00000536468	c.776G>C	p.G259A	COSMIC	NP	NP
90	SCC90	Cell Line	UPPER_AERODIGESTIVE_TRACT	ENST00000536468	c.351C>A	p.T117T	COSMIC	NP	NP
91	SCH	Cell Line	STOMACH	ENST00000536468	c.1203C>T	p.T401T	COSMIC	NP	NP
92	SKMEL31	Cell Line	SKIN	ENST00000536468	c.378A>G	p.E126E	COSMIC	NP	NP
93	SKNDZ	Cell Line	AUTONOMIC_GANGLIA	ENST00000536468	c.836C>T	p.T279M	COSMIC	NP	NP
94	SNU1040	Cell Line	LARGE_INTESTINE	ENST00000536468	c.26_27insC	p.G10fs*70	COSMIC	NP	NP
95	SNU175	Cell Line	LARGE_INTESTINE	ENST00000536468	c.313G>A	p.A105T	COSMIC	NP	NP
96	SNU81	Cell Line	LARGE_INTESTINE	ENST00000536468	c.817G>A	p.E273K	COSMIC	NP	NP
97	SUDHL5	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000536468	c.583A>G	p.K195E	COSMIC	NP	NP
98	SW1271	Cell Line	LUNG	ENST00000536468	c.189-8C>T	p.?	COSMIC	NP	NP
99	TGW	Cell Line	AUTONOMIC_GANGLIA	ENST00000536468	c.849G>T	p.E283D	COSMIC	NP	NP
100	UACC257	Cell Line	SKIN	ENST00000536468	c.905C>T	p.A302V	COSMIC	NP	NP
101	UACC257	Cell Line	SKIN	ENST00000536468	c.906C>A	p.A302A	COSMIC	NP	NP
102	WSUNHL	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000536468	c.1093C>T	p.R365C	COSMIC	NP	NP

*NP: Not Predicted

Tissue Type	Mean Expression Value	Median Expression Value	Mean CNV	Median CNV

AUTONOMIC GANGLIA	5.7369	5.6727	0.0774	0.0605
BILIARY TRACT	6.4367	6.5753	-0.0097	-0.05184
BONE	5.7218	5.8206	0.0369	0.0022
BREAST	6.2411	6.2342	0.1141	0.084585
CENTRAL NERVOUS SYSTEM	5.9247	5.9164	0.0911	0.06137
ENDOMETRIUM	6.0970	6.0772	-0.0299	-0.008725
HAEMATOPOIETIC AND LYMPHOID TISSUE	6.3155	6.3744	-0.0409	-0.001125
KIDNEY	6.4165	6.4306	0.0090	0.0523
LARGE INTESTINE	6.1425	6.1371	0.1018	0.04245
LIVER	6.1258	6.1708	-0.0444	-0.0734
LUNG	6.1402	6.131	0.0090	0.04201
OESOPHAGUS	6.2981	6.3332	0.3472	0.31415
OVARY	6.0063	6.0346	-0.0644	-0.0024
PANCREAS	6.3698	6.418	0.0755	0.1431
PLEURA	6.4999	6.4759	0.1891	0.1619
PROSTATE	6.2054	6.0968	0.0028	0.042685
SALIVARY GLAND	5.3634	5.3634	0.4827	0.4827
SKIN	5.9289	5.9651	-0.0472	-0.0213
SMALL INTESTINE	6.0411	6.0411	0.0044	0.004401
SOFT TISSUE	5.9940	6.09485	0.0280	0.023675
STOMACH	6.3158	6.2357	0.0977	0.07043
THYROID	6.0518	6.2356	0.0964	0.06225
UPPER AERODIGESTIVE TRACT	6.3361	6.36435	0.3198	0.31095
URINARY TRACT	6.3588	6.31985	0.1650	0.1701

Proteomics DB	COSMIC	Gene Atlas	STRING	PIR
TRAF2	TRAF2	TRAF2
QuickGO	HGNC	Ensembl Genome Browser	TreeFam	UniProt
	TRAF2		TRAF2
Expression Atlas	Protein Atlas	OMIM	IntAct	PharmGKB
TRAF2

Protein: TRAF2

Mutation Data (+)

Copy number variation and expression profile (+)

Gene Essentiality Data (+)

Tertiary structure (+)

Structure Domains (+)

Sequence Alignment (+)

Sequence Profiles (+)

Post Translational Modifications (+)

Other Databases Link (+)

Modelled Structure	Structures available in PDB