Cancertope: In silico Platform for designing genome-based Personalized immunotherapy or Vaccine against Cancer

Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

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The result page of search shows exclusive peptide/epitopes generated due to mutation [Neoepitope], the tissue of origin [Tissue], position of peptide in protein [Position], number of mismatches counted by aligning mutated and normal protein sequence [Num Mismatch, percentage of cell lines with this peptide over total number of cell lines [Promiscuity %]. The immune information include CTL epitopes (Yes/No), MHC I binders, MHC II binders (both given as number of alleles) and B cell epitopes (Yes/No). For more information, please click HERE

Protein	Neoepitopes	Tissue	Position	Prot Mutation	cDNA Mutation	Mutation Type	Num Mismatch	Promiscuity (%)	Cell Line	CTL	MHC I	NHLApred	MHC II	Bcell
Result		Search:
FGFR3	AHCLGQGWH	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	70	p.P64fs	c.192_193delCG	Frame_Shift_Del	6	0.11	CMLT1	N	0	0	0	N
FGFR3	AWAPPPCTR	OVARY	407	p.S402fs	c.1206_1206delC	Frame_Shift_Del	6	0.11	TOV21G	Y	1	9	0	N
FGFR3	CAGDRRSIL	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	122	p.P64fs	c.192_193delCG	Frame_Shift_Del	6	0.11	CMLT1	Y	13	10	0	N
FGFR3	CLGQGWHRA	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	72	p.P64fs	c.192_193delCG	Frame_Shift_Del	6	0.11	CMLT1	N	2	0	0	N
FGFR3	CLPRGLRGL	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	98	p.P64fs	c.192_193delCG	Frame_Shift_Del	6	0.11	CMLT1	N	14	0	0	N
FGFR3	GDRRSILGR	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	124	p.P64fs	c.192_193delCG	Frame_Shift_Del	6	0.11	CMLT1	N	0	0	0	N
FGFR3	HCLGQGWHR	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	71	p.P64fs	c.192_193delCG	Frame_Shift_Del	6	0.11	CMLT1	N	4	0	0	N
FGFR3	LQCAGDRRS	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	120	p.P64fs	c.192_193delCG	Frame_Shift_Del	6	0.11	CMLT1	N	0	0	1	N
FGFR3	PCTRSPASR	OVARY	412	p.S402fs	c.1206_1206delC	Frame_Shift_Del	6	0.11	TOV21G	N	0	0	0	N
FGFR3	PGWSHGAHC	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	64	p.P64fs	c.192_193delCG	Frame_Shift_Del	6	0.11	CMLT1	N	0	0	0	N
FGFR3	PLQCAGDRR	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	119	p.P64fs	c.192_193delCG	Frame_Shift_Del	6	0.11	CMLT1	N	0	0	0	N
FGFR3	PPCTRSPAS	OVARY	411	p.S402fs	c.1206_1206delC	Frame_Shift_Del	6	0.11	TOV21G	N	0	0	0	N
FGFR3	PPGWSHGAH	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	63	p.P64fs	c.192_193delCG	Frame_Shift_Del	6	0.11	CMLT1	N	0	0	0	N
FGFR3	PPPCTRSPA	OVARY	410	p.S402fs	c.1206_1206delC	Frame_Shift_Del	6	0.11	TOV21G	N	4	0	0	N
FGFR3	QCAGDRRSI	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	121	p.P64fs	c.192_193delCG	Frame_Shift_Del	6	0.11	CMLT1	N	1	0	0	N
FGFR3	RSSDRCPWS	OVARY	420	p.S402fs	c.1206_1206delC	Frame_Shift_Del	6	0.11	TOV21G	N	2	0	0	N
FGFR3	RTVPLQCAG	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	116	p.P64fs	c.192_193delCG	Frame_Shift_Del	6	0.11	CMLT1	N	1	0	0	N
FGFR3	SDRCPWSPT	OVARY	422	p.S402fs	c.1206_1206delC	Frame_Shift_Del	6	0.11	TOV21G	N	1	0	0	N
FGFR3	SRSSDRCPW	OVARY	419	p.S402fs	c.1206_1206delC	Frame_Shift_Del	6	0.11	TOV21G	N	4	0	0	N
FGFR3	SSDRCPWSP	OVARY	421	p.S402fs	c.1206_1206delC	Frame_Shift_Del	6	0.11	TOV21G	N	0	0	0	N
FGFR3	TVPLQCAGD	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	117	p.P64fs	c.192_193delCG	Frame_Shift_Del	6	0.11	CMLT1	N	0	0	0	N
FGFR3	VPLQCAGDR	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	118	p.P64fs	c.192_193delCG	Frame_Shift_Del	6	0.11	CMLT1	N	5	0	0	N
FGFR3	WHRAGALGA	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	77	p.P64fs	c.192_193delCG	Frame_Shift_Del	6	0.11	CMLT1	N	4	0	19	N
FGFR3	AACRPQMGA	LARGE_INTESTINE	461	p.S402fs	c.1205_1206insC	Frame_Shift_Ins	6	0.22	SNU1040	N	4	0	0	N
FGFR3	AACRPQMGA	LARGE_INTESTINE	461	p.S402fs	c.1205_1206insC	Frame_Shift_Ins	6	0.22	SNUC5	N	4	0	0	N
FGFR3	CRPQMGAVS	LARGE_INTESTINE	463	p.S402fs	c.1205_1206insC	Frame_Shift_Ins	6	0.22	SNU1040	N	3	0	0	N
FGFR3	CRPQMGAVS	LARGE_INTESTINE	463	p.S402fs	c.1205_1206insC	Frame_Shift_Ins	6	0.22	SNUC5	N	3	0	0	N
FGFR3	ELQHTTGAH	LARGE_INTESTINE	434	p.S402fs	c.1205_1206insC	Frame_Shift_Ins	6	0.22	SNU1040	N	0	0	0	N
FGFR3	ELQHTTGAH	LARGE_INTESTINE	434	p.S402fs	c.1205_1206insC	Frame_Shift_Ins	6	0.22	SNUC5	N	0	0	0	N
FGFR3	ERPGLPHRA	LARGE_INTESTINE	406	p.S402fs	c.1205_1206insC	Frame_Shift_Ins	6	0.22	SNU1040	N	2	0	0	N
FGFR3	ERPGLPHRA	LARGE_INTESTINE	406	p.S402fs	c.1205_1206insC	Frame_Shift_Ins	6	0.22	SNUC5	N	2	0	0	N
FGFR3	GGHGGGHRH	LARGE_INTESTINE	488	p.S402fs	c.1205_1206insC	Frame_Shift_Ins	6	0.22	SNU1040	N	0	0	0	N
FGFR3	GGHGGGHRH	LARGE_INTESTINE	488	p.S402fs	c.1205_1206insC	Frame_Shift_Ins	6	0.22	SNUC5	N	0	0	0	N
FGFR3	GVPGVQRVH	LARGE_INTESTINE	425	p.S402fs	c.1205_1206insC	Frame_Shift_Ins	6	0.22	SNU1040	N	0	0	0	N
FGFR3	GVPGVQRVH	LARGE_INTESTINE	425	p.S402fs	c.1205_1206insC	Frame_Shift_Ins	6	0.22	SNUC5	N	0	0	0	N
FGFR3	HELQHTTGA	LARGE_INTESTINE	433	p.S402fs	c.1205_1206insC	Frame_Shift_Ins	6	0.22	SNU1040	N	6	0	0	N
FGFR3	HELQHTTGA	LARGE_INTESTINE	433	p.S402fs	c.1205_1206insC	Frame_Shift_Ins	6	0.22	SNUC5	N	6	0	0	N
FGFR3	HTTGAHRKA	LARGE_INTESTINE	437	p.S402fs	c.1205_1206insC	Frame_Shift_Ins	6	0.22	SNU1040	N	2	0	0	N
FGFR3	HTTGAHRKA	LARGE_INTESTINE	437	p.S402fs	c.1205_1206insC	Frame_Shift_Ins	6	0.22	SNUC5	N	2	0	0	N
FGFR3	LQHTTGAHR	LARGE_INTESTINE	435	p.S402fs	c.1205_1206insC	Frame_Shift_Ins	6	0.22	SNU1040	N	5	0	2	N
FGFR3	LQHTTGAHR	LARGE_INTESTINE	435	p.S402fs	c.1205_1206insC	Frame_Shift_Ins	6	0.22	SNUC5	N	5	0	2	N
FGFR3	MGAVSGPAD	LARGE_INTESTINE	467	p.S402fs	c.1205_1206insC	Frame_Shift_Ins	6	0.22	SNU1040	N	0	0	0	N
FGFR3	MGAVSGPAD	LARGE_INTESTINE	467	p.S402fs	c.1205_1206insC	Frame_Shift_Ins	6	0.22	SNUC5	N	0	0	0	N
FGFR3	PGLPHRAQD	LARGE_INTESTINE	408	p.S402fs	c.1205_1206insC	Frame_Shift_Ins	6	0.22	SNU1040	N	0	0	0	N
FGFR3	PGLPHRAQD	LARGE_INTESTINE	408	p.S402fs	c.1205_1206insC	Frame_Shift_Ins	6	0.22	SNUC5	N	0	0	0	N
FGFR3	QAPWGGLLR	LARGE_INTESTINE	478	p.S402fs	c.1205_1206insC	Frame_Shift_Ins	6	0.22	SNU1040	Y	4	9	0	N
FGFR3	QAPWGGLLR	LARGE_INTESTINE	478	p.S402fs	c.1205_1206insC	Frame_Shift_Ins	6	0.22	SNUC5	Y	4	9	0	N
FGFR3	QERPGLPHR	LARGE_INTESTINE	405	p.S402fs	c.1205_1206insC	Frame_Shift_Ins	6	0.22	SNU1040	Y	0	9	0	N
FGFR3	QERPGLPHR	LARGE_INTESTINE	405	p.S402fs	c.1205_1206insC	Frame_Shift_Ins	6	0.22	SNUC5	Y	0	9	0	N
FGFR3	QHTTGAHRK	LARGE_INTESTINE	436	p.S402fs	c.1205_1206insC	Frame_Shift_Ins	6	0.22	SNU1040	N	0	0	0	N
FGFR3	QHTTGAHRK	LARGE_INTESTINE	436	p.S402fs	c.1205_1206insC	Frame_Shift_Ins	6	0.22	SNUC5	N	0	0	0	N
FGFR3	QRVHELQHT	LARGE_INTESTINE	430	p.S402fs	c.1205_1206insC	Frame_Shift_Ins	6	0.22	SNU1040	N	2	0	0	N
FGFR3	QRVHELQHT	LARGE_INTESTINE	430	p.S402fs	c.1205_1206insC	Frame_Shift_Ins	6	0.22	SNUC5	N	2	0	0	N
FGFR3	RPGLPHRAQ	LARGE_INTESTINE	407	p.S402fs	c.1205_1206insC	Frame_Shift_Ins	6	0.22	SNU1040	N	1	0	0	N
FGFR3	RPGLPHRAQ	LARGE_INTESTINE	407	p.S402fs	c.1205_1206insC	Frame_Shift_Ins	6	0.22	SNUC5	N	1	0	0	N
FGFR3	RPQMGAVSG	LARGE_INTESTINE	464	p.S402fs	c.1205_1206insC	Frame_Shift_Ins	6	0.22	SNU1040	N	1	0	0	N
FGFR3	RPQMGAVSG	LARGE_INTESTINE	464	p.S402fs	c.1205_1206insC	Frame_Shift_Ins	6	0.22	SNUC5	N	1	0	0	N
FGFR3	RVHELQHTT	LARGE_INTESTINE	431	p.S402fs	c.1205_1206insC	Frame_Shift_Ins	6	0.22	SNU1040	N	1	0	0	N
FGFR3	RVHELQHTT	LARGE_INTESTINE	431	p.S402fs	c.1205_1206insC	Frame_Shift_Ins	6	0.22	SNUC5	N	1	0	0	N
FGFR3	TTGAHRKAV	LARGE_INTESTINE	438	p.S402fs	c.1205_1206insC	Frame_Shift_Ins	6	0.22	SNU1040	N	1	0	0	N
FGFR3	TTGAHRKAV	LARGE_INTESTINE	438	p.S402fs	c.1205_1206insC	Frame_Shift_Ins	6	0.22	SNUC5	N	1	0	0	N
FGFR3	VHELQHTTG	LARGE_INTESTINE	432	p.S402fs	c.1205_1206insC	Frame_Shift_Ins	6	0.22	SNU1040	N	0	0	0	N
FGFR3	VHELQHTTG	LARGE_INTESTINE	432	p.S402fs	c.1205_1206insC	Frame_Shift_Ins	6	0.22	SNUC5	N	0	0	0	N
FGFR3	VPGVQRVHE	LARGE_INTESTINE	426	p.S402fs	c.1205_1206insC	Frame_Shift_Ins	6	0.22	SNU1040	N	1	0	0	N
FGFR3	VPGVQRVHE	LARGE_INTESTINE	426	p.S402fs	c.1205_1206insC	Frame_Shift_Ins	6	0.22	SNUC5	N	1	0	0	N
FGFR3	VQRVHELQH	LARGE_INTESTINE	429	p.S402fs	c.1205_1206insC	Frame_Shift_Ins	6	0.22	SNU1040	N	1	0	5	N
FGFR3	VQRVHELQH	LARGE_INTESTINE	429	p.S402fs	c.1205_1206insC	Frame_Shift_Ins	6	0.22	SNUC5	N	1	0	5	N