Cancertope
In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer
Personalized immunotherapy or Vaccine against Cancer
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The result page of search shows exclusive peptide/epitopes generated due to mutation [Neoepitope], the tissue of origin [Tissue], position of peptide in protein [Position], number of mismatches counted by aligning mutated and normal protein sequence [Num Mismatch, percentage of cell lines with this peptide over total number of cell lines [Promiscuity %]. The immune information include CTL epitopes (Yes/No), MHC I binders, MHC II binders (both given as number of alleles) and B cell epitopes (Yes/No). For more information, please click |
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| Protein | Neoepitopes | Tissue | Position | Prot Mutation | cDNA Mutation | Mutation Type | Num Mismatch | Promiscuity (%) | Cell Line | CTL | MHC I | NHLApred | MHC II | Bcell | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| GPR112 | CFKNFLTRL | ENDOMETRIUM | 2447 | p.I2415fs | c.7245_7245delA | Frame_Shift_Del | 6 | 0.11 | HEC108 | Y | 5 | 12 | 0 | N | ||||||||||||
| GPR112 | CIKMRMEMP | ENDOMETRIUM | 2414 | p.I2415fs | c.7245_7245delA | Frame_Shift_Del | 6 | 0.11 | HEC108 | N | 1 | 0 | 0 | N | ||||||||||||
| GPR112 | FKNFLTRLW | ENDOMETRIUM | 2448 | p.I2415fs | c.7245_7245delA | Frame_Shift_Del | 6 | 0.11 | HEC108 | N | 5 | 0 | 16 | N | ||||||||||||
| GPR112 | IKMRMEMPQ | ENDOMETRIUM | 2415 | p.I2415fs | c.7245_7245delA | Frame_Shift_Del | 6 | 0.11 | HEC108 | N | 0 | 0 | 15 | N | ||||||||||||
| GPR112 | KARVPFQHI | PANCREAS | 1381 | p.T1374fs | c.4122_4122delT | Frame_Shift_Del | 6 | 0.11 | ASPC1 | Y | 8 | 10 | 0 | N | ||||||||||||
| GPR112 | KMRMEMPQD | ENDOMETRIUM | 2416 | p.I2415fs | c.7245_7245delA | Frame_Shift_Del | 6 | 0.11 | HEC108 | N | 0 | 0 | 0 | N | ||||||||||||
| GPR112 | KRKARVPFQ | PANCREAS | 1379 | p.T1374fs | c.4122_4122delT | Frame_Shift_Del | 6 | 0.11 | ASPC1 | N | 2 | 0 | 0 | N | ||||||||||||
| GPR112 | LNNANCFKN | ENDOMETRIUM | 2442 | p.I2415fs | c.7245_7245delA | Frame_Shift_Del | 6 | 0.11 | HEC108 | N | 0 | 0 | 0 | N | ||||||||||||
| GPR112 | MMLLQPDIQ | BONE | 717 | p.G713fs | c.2137_2137delG | Frame_Shift_Del | 6 | 0.11 | HOS | N | 0 | 0 | 17 | N | ||||||||||||
| GPR112 | MRMEMPQDS | ENDOMETRIUM | 2417 | p.I2415fs | c.7245_7245delA | Frame_Shift_Del | 6 | 0.11 | HEC108 | N | 2 | 0 | 40 | N | ||||||||||||
| GPR112 | NANCFKNFL | ENDOMETRIUM | 2444 | p.I2415fs | c.7245_7245delA | Frame_Shift_Del | 6 | 0.11 | HEC108 | Y | 15 | 10 | 0 | N | ||||||||||||
| GPR112 | NCFKNFLTR | ENDOMETRIUM | 2446 | p.I2415fs | c.7245_7245delA | Frame_Shift_Del | 6 | 0.11 | HEC108 | N | 7 | 0 | 0 | N | ||||||||||||
| GPR112 | NNANCFKNF | ENDOMETRIUM | 2443 | p.I2415fs | c.7245_7245delA | Frame_Shift_Del | 6 | 0.11 | HEC108 | Y | 2 | 12 | 0 | N | ||||||||||||
| GPR112 | PMMLLQPDI | BONE | 716 | p.G713fs | c.2137_2137delG | Frame_Shift_Del | 6 | 0.11 | HOS | N | 2 | 0 | 0 | N | ||||||||||||
| GPR112 | QSLNNANCF | ENDOMETRIUM | 2440 | p.I2415fs | c.7245_7245delA | Frame_Shift_Del | 6 | 0.11 | HEC108 | N | 6 | 0 | 0 | N | ||||||||||||
| GPR112 | RKARVPFQH | PANCREAS | 1380 | p.T1374fs | c.4122_4122delT | Frame_Shift_Del | 6 | 0.11 | ASPC1 | N | 1 | 0 | 0 | N | ||||||||||||
| GPR112 | FRKHKDNKN | ENDOMETRIUM | 348 | p.M340fs | c.1020_1021insA | Frame_Shift_Ins | 6 | 0.11 | EN | N | 3 | 0 | 0 | N | ||||||||||||
| GPR112 | SIFRKHKDN | ENDOMETRIUM | 346 | p.M340fs | c.1020_1021insA | Frame_Shift_Ins | 6 | 0.11 | EN | N | 0 | 0 | 0 | N | ||||||||||||
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