Cancertope: In silico Platform for designing genome-based Personalized immunotherapy or Vaccine against Cancer

Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

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The result page of search shows exclusive peptide/epitopes generated due to mutation [Neoepitope], the tissue of origin [Tissue], position of peptide in protein [Position], number of mismatches counted by aligning mutated and normal protein sequence [Num Mismatch, percentage of cell lines with this peptide over total number of cell lines [Promiscuity %]. The immune information include CTL epitopes (Yes/No), MHC I binders, MHC II binders (both given as number of alleles) and B cell epitopes (Yes/No). For more information, please click HERE

Protein	Neoepitopes	Tissue	Position	Prot Mutation	cDNA Mutation	Mutation Type	Num Mismatch	Promiscuity (%)	Cell Line	CTL	MHC I	NHLApred	MHC II	Bcell
Result		Search:
MAML2	CCHHYSPST	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	96	p.K88fs	c.262_269delAAAGCTGG	Frame_Shift_Del	6	0.11	BV173	N	0	0	0	N
MAML2	GHRHCCHHY	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	92	p.K88fs	c.262_269delAAAGCTGG	Frame_Shift_Del	6	0.11	BV173	N	1	0	0	N
MAML2	HCCHHYSPS	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	95	p.K88fs	c.262_269delAAAGCTGG	Frame_Shift_Del	6	0.11	BV173	N	2	0	0	N
MAML2	HQGHRHCCH	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	90	p.K88fs	c.262_269delAAAGCTGG	Frame_Shift_Del	6	0.11	BV173	N	1	0	0	Y
MAML2	HRHCCHHYS	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	93	p.K88fs	c.262_269delAAAGCTGG	Frame_Shift_Del	6	0.11	BV173	N	3	0	0	N
MAML2	RHCCHHYSP	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	94	p.K88fs	c.262_269delAAAGCTGG	Frame_Shift_Del	6	0.11	BV173	N	0	0	0	N
MAML2	THQGHRHCC	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	89	p.K88fs	c.262_269delAAAGCTGG	Frame_Shift_Del	6	0.11	BV173	N	1	0	0	Y
MAML2	AQSPRECTV	ENDOMETRIUM	26	p.A17fs	c.49_49delG	Frame_Shift_Del	6	0.22	HEC6	Y	6	11	0	Y
MAML2	AQSPRECTV	LARGE_INTESTINE	26	p.A17fs	c.49_49delG	Frame_Shift_Del	6	0.22	SNUC4	Y	6	11	0	Y
MAML2	CTVLSWSAS	ENDOMETRIUM	32	p.A17fs	c.49_49delG	Frame_Shift_Del	6	0.22	HEC6	N	0	0	0	N
MAML2	CTVLSWSAS	LARGE_INTESTINE	32	p.A17fs	c.49_49delG	Frame_Shift_Del	6	0.22	SNUC4	N	0	0	0	N
MAML2	ECTVLSWSA	ENDOMETRIUM	31	p.A17fs	c.49_49delG	Frame_Shift_Del	6	0.22	HEC6	N	0	0	0	N
MAML2	ECTVLSWSA	LARGE_INTESTINE	31	p.A17fs	c.49_49delG	Frame_Shift_Del	6	0.22	SNUC4	N	0	0	0	N
MAML2	PRECTVLSW	ENDOMETRIUM	29	p.A17fs	c.49_49delG	Frame_Shift_Del	6	0.22	HEC6	N	1	0	0	N
MAML2	PRECTVLSW	LARGE_INTESTINE	29	p.A17fs	c.49_49delG	Frame_Shift_Del	6	0.22	SNUC4	N	1	0	0	N
MAML2	QSPRECTVL	ENDOMETRIUM	27	p.A17fs	c.49_49delG	Frame_Shift_Del	6	0.22	HEC6	Y	10	9	0	Y
MAML2	QSPRECTVL	LARGE_INTESTINE	27	p.A17fs	c.49_49delG	Frame_Shift_Del	6	0.22	SNUC4	Y	10	9	0	Y
MAML2	SPRECTVLS	ENDOMETRIUM	28	p.A17fs	c.49_49delG	Frame_Shift_Del	6	0.22	HEC6	N	5	0	0	Y
MAML2	SPRECTVLS	LARGE_INTESTINE	28	p.A17fs	c.49_49delG	Frame_Shift_Del	6	0.22	SNUC4	N	5	0	0	Y
MAML2	AQCYRGAPP	STOMACH	33	p.A17fs	c.49_50insG	Frame_Shift_Ins	6	0.11	IM95	N	0	0	0	N
MAML2	CYRGAPPGS	STOMACH	35	p.A17fs	c.49_50insG	Frame_Shift_Ins	6	0.11	IM95	N	0	0	0	N
MAML2	ESAQCYRGA	STOMACH	31	p.A17fs	c.49_50insG	Frame_Shift_Ins	6	0.11	IM95	N	2	0	0	N
MAML2	HPESAQCYR	STOMACH	29	p.A17fs	c.49_50insG	Frame_Shift_Ins	6	0.11	IM95	N	5	0	0	N
MAML2	QCYRGAPPG	STOMACH	34	p.A17fs	c.49_50insG	Frame_Shift_Ins	6	0.11	IM95	N	0	0	0	N
MAML2	SAQCYRGAP	STOMACH	32	p.A17fs	c.49_50insG	Frame_Shift_Ins	6	0.11	IM95	N	0	0	0	N
MAML2	SHPESAQCY	STOMACH	28	p.A17fs	c.49_50insG	Frame_Shift_Ins	6	0.11	IM95	N	3	0	0	N