Cancertope
In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer
Personalized immunotherapy or Vaccine against Cancer
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The result page of search shows exclusive peptide/epitopes generated due to mutation [Neoepitope], the tissue of origin [Tissue], position of peptide in protein [Position], number of mismatches counted by aligning mutated and normal protein sequence [Num Mismatch, percentage of cell lines with this peptide over total number of cell lines [Promiscuity %]. The immune information include CTL epitopes (Yes/No), MHC I binders, MHC II binders (both given as number of alleles) and B cell epitopes (Yes/No). For more information, please click |
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| Protein | Neoepitopes | Tissue | Position | Prot Mutation | cDNA Mutation | Mutation Type | Num Mismatch | Promiscuity (%) | Cell Line | CTL | MHC I | NHLApred | MHC II | Bcell | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MAP3K1 | AAAPAGLRW | BREAST | 156 | p.R162fs | c.485_485delG | Frame_Shift_Del | 3 | 0.11 | MDAMB415 | Y | 3 | 12 | 0 | N | ||||||||||||
| MAP3K1 | AAPAGLRWR | BREAST | 157 | p.R162fs | c.485_485delG | Frame_Shift_Del | 4 | 0.11 | MDAMB415 | N | 3 | 0 | 0 | N | ||||||||||||
| MAP3K1 | AGLRWRIKK | BREAST | 160 | p.R162fs | c.485_485delG | Frame_Shift_Del | 5 | 0.11 | MDAMB415 | Y | 0 | 11 | 0 | N | ||||||||||||
| MAP3K1 | APAGLRWRI | BREAST | 158 | p.R162fs | c.485_485delG | Frame_Shift_Del | 5 | 0.11 | MDAMB415 | Y | 13 | 14 | 0 | N | ||||||||||||
| MAP3K1 | CTRWMIVQR | BREAST | 173 | p.R162fs | c.485_485delG | Frame_Shift_Del | 6 | 0.11 | MDAMB415 | Y | 5 | 10 | 0 | N | ||||||||||||
| MAP3K1 | GCTRWMIVQ | BREAST | 172 | p.R162fs | c.485_485delG | Frame_Shift_Del | 6 | 0.11 | MDAMB415 | N | 0 | 0 | 0 | N | ||||||||||||
| MAP3K1 | GLRWRIKKL | BREAST | 161 | p.R162fs | c.485_485delG | Frame_Shift_Del | 5 | 0.11 | MDAMB415 | Y | 11 | 12 | 0 | N | ||||||||||||
| MAP3K1 | IKKLSKGCT | BREAST | 166 | p.R162fs | c.485_485delG | Frame_Shift_Del | 5 | 0.11 | MDAMB415 | N | 1 | 0 | 1 | N | ||||||||||||
| MAP3K1 | KGCTRWMIV | BREAST | 171 | p.R162fs | c.485_485delG | Frame_Shift_Del | 6 | 0.11 | MDAMB415 | N | 7 | 0 | 0 | N | ||||||||||||
| MAP3K1 | KKLSKGCTR | BREAST | 167 | p.R162fs | c.485_485delG | Frame_Shift_Del | 5 | 0.11 | MDAMB415 | N | 1 | 0 | 0 | Y | ||||||||||||
| MAP3K1 | KLSKGCTRW | BREAST | 168 | p.R162fs | c.485_485delG | Frame_Shift_Del | 5 | 0.11 | MDAMB415 | Y | 5 | 11 | 0 | N | ||||||||||||
| MAP3K1 | LRWRIKKLS | BREAST | 162 | p.R162fs | c.485_485delG | Frame_Shift_Del | 5 | 0.11 | MDAMB415 | N | 2 | 0 | 30 | N | ||||||||||||
| MAP3K1 | LSKGCTRWM | BREAST | 169 | p.R162fs | c.485_485delG | Frame_Shift_Del | 6 | 0.11 | MDAMB415 | N | 3 | 0 | 1 | N | ||||||||||||
| MAP3K1 | PAAAPAGLR | BREAST | 155 | p.R162fs | c.485_485delG | Frame_Shift_Del | 2 | 0.11 | MDAMB415 | N | 0 | 0 | 0 | N | ||||||||||||
| MAP3K1 | PAGLRWRIK | BREAST | 159 | p.R162fs | c.485_485delG | Frame_Shift_Del | 5 | 0.11 | MDAMB415 | N | 0 | 0 | 0 | N | ||||||||||||
| MAP3K1 | RIKKLSKGC | BREAST | 165 | p.R162fs | c.485_485delG | Frame_Shift_Del | 5 | 0.11 | MDAMB415 | N | 1 | 0 | 0 | N | ||||||||||||
| MAP3K1 | RWMIVQRNE | BREAST | 175 | p.R162fs | c.485_485delG | Frame_Shift_Del | 6 | 0.11 | MDAMB415 | N | 0 | 0 | 0 | N | ||||||||||||
| MAP3K1 | RWRIKKLSK | BREAST | 163 | p.R162fs | c.485_485delG | Frame_Shift_Del | 5 | 0.11 | MDAMB415 | N | 1 | 0 | 0 | N | ||||||||||||
| MAP3K1 | SKGCTRWMI | BREAST | 170 | p.R162fs | c.485_485delG | Frame_Shift_Del | 6 | 0.11 | MDAMB415 | Y | 2 | 13 | 0 | N | ||||||||||||
| MAP3K1 | TRWMIVQRN | BREAST | 174 | p.R162fs | c.485_485delG | Frame_Shift_Del | 6 | 0.11 | MDAMB415 | N | 2 | 0 | 0 | N | ||||||||||||
| MAP3K1 | WRIKKLSKG | BREAST | 164 | p.R162fs | c.485_485delG | Frame_Shift_Del | 5 | 0.11 | MDAMB415 | N | 3 | 0 | 24 | N | ||||||||||||
| MAP3K1 | KQGDPSKIA | ENDOMETRIUM | 1072 | p.S1077fs | c.3231_3231delA | Frame_Shift_Del | 2 | 0.22 | HEC1A | N | 5 | 0 | 0 | N | ||||||||||||
| MAP3K1 | KQGDPSKIA | ENDOMETRIUM | 1072 | p.S1077fs | c.3231_3231delA | Frame_Shift_Del | 2 | 0.22 | HEC1B | N | 5 | 0 | 0 | N | ||||||||||||
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