Cancertope
In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer
Personalized immunotherapy or Vaccine against Cancer
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The result page of search shows exclusive peptide/epitopes generated due to mutation [Neoepitope], the tissue of origin [Tissue], position of peptide in protein [Position], number of mismatches counted by aligning mutated and normal protein sequence [Num Mismatch, percentage of cell lines with this peptide over total number of cell lines [Promiscuity %]. The immune information include CTL epitopes (Yes/No), MHC I binders, MHC II binders (both given as number of alleles) and B cell epitopes (Yes/No). For more information, please click |
| Result | Search: | |||||||||||||||||||||||||
| Protein | Neoepitopes | Tissue | Position | Prot Mutation | cDNA Mutation | Mutation Type | Num Mismatch | Promiscuity (%) | Cell Line | CTL | MHC I | NHLApred | MHC II | Bcell | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MEN1 | AARLRCQHP | PROSTATE | 537 | p.R521fs | c.1561_1561delC | Frame_Shift_Del | 5 | 0.11 | 22RV1 | N | 1 | 0 | 0 | N | ||||||||||||
| MEN1 | ALKVAARLR | PROSTATE | 533 | p.R521fs | c.1561_1561delC | Frame_Shift_Del | 4 | 0.11 | 22RV1 | Y | 3 | 10 | 0 | N | ||||||||||||
| MEN1 | AQPEALKVA | PROSTATE | 529 | p.R521fs | c.1561_1561delC | Frame_Shift_Del | 5 | 0.11 | 22RV1 | N | 4 | 0 | 0 | N | ||||||||||||
| MEN1 | ARLRCQHPQ | PROSTATE | 538 | p.R521fs | c.1561_1561delC | Frame_Shift_Del | 6 | 0.11 | 22RV1 | N | 1 | 0 | 0 | N | ||||||||||||
| MEN1 | AVSGPPGSL | PROSTATE | 515 | p.R521fs | c.1561_1561delC | Frame_Shift_Del | 3 | 0.11 | 22RV1 | N | 5 | 0 | 0 | N | ||||||||||||
| MEN1 | CQHPQHHHR | PROSTATE | 542 | p.R521fs | c.1561_1561delC | Frame_Shift_Del | 7 | 0.11 | 22RV1 | N | 5 | 0 | 0 | N | ||||||||||||
| MEN1 | EALKVAARL | PROSTATE | 532 | p.R521fs | c.1561_1561delC | Frame_Shift_Del | 4 | 0.11 | 22RV1 | N | 15 | 0 | 0 | N | ||||||||||||
| MEN1 | GLSLAQPEA | PROSTATE | 525 | p.R521fs | c.1561_1561delC | Frame_Shift_Del | 4 | 0.11 | 22RV1 | N | 4 | 0 | 0 | N | ||||||||||||
| MEN1 | GPPGSLLGL | PROSTATE | 518 | p.R521fs | c.1561_1561delC | Frame_Shift_Del | 5 | 0.11 | 22RV1 | N | 20 | 0 | 0 | N | ||||||||||||
| MEN1 | GSLLGLSLA | PROSTATE | 521 | p.R521fs | c.1561_1561delC | Frame_Shift_Del | 5 | 0.11 | 22RV1 | N | 3 | 0 | 0 | N | ||||||||||||
| MEN1 | HHHRRRVQC | PROSTATE | 547 | p.R521fs | c.1561_1561delC | Frame_Shift_Del | 6 | 0.11 | 22RV1 | N | 2 | 0 | 0 | N | ||||||||||||
| MEN1 | HHRRRVQCS | PROSTATE | 548 | p.R521fs | c.1561_1561delC | Frame_Shift_Del | 6 | 0.11 | 22RV1 | N | 1 | 0 | 0 | N | ||||||||||||
| MEN1 | HPQHHHRRR | PROSTATE | 544 | p.R521fs | c.1561_1561delC | Frame_Shift_Del | 6 | 0.11 | 22RV1 | N | 4 | 0 | 0 | N | ||||||||||||
| MEN1 | HRRRVQCSL | PROSTATE | 549 | p.R521fs | c.1561_1561delC | Frame_Shift_Del | 5 | 0.11 | 22RV1 | Y | 6 | 9 | 0 | N | ||||||||||||
| MEN1 | KVAARLRCQ | PROSTATE | 535 | p.R521fs | c.1561_1561delC | Frame_Shift_Del | 5 | 0.11 | 22RV1 | N | 0 | 0 | 0 | N | ||||||||||||
| MEN1 | LAQPEALKV | PROSTATE | 528 | p.R521fs | c.1561_1561delC | Frame_Shift_Del | 5 | 0.11 | 22RV1 | N | 6 | 0 | 0 | N | ||||||||||||
| MEN1 | LGLSLAQPE | PROSTATE | 524 | p.R521fs | c.1561_1561delC | Frame_Shift_Del | 5 | 0.11 | 22RV1 | N | 0 | 0 | 0 | N | ||||||||||||
| MEN1 | LKVAARLRC | PROSTATE | 534 | p.R521fs | c.1561_1561delC | Frame_Shift_Del | 4 | 0.11 | 22RV1 | N | 1 | 0 | 30 | N | ||||||||||||
| MEN1 | LLGLSLAQP | PROSTATE | 523 | p.R521fs | c.1561_1561delC | Frame_Shift_Del | 5 | 0.11 | 22RV1 | N | 0 | 0 | 0 | N | ||||||||||||
| MEN1 | LRCQHPQHH | PROSTATE | 540 | p.R521fs | c.1561_1561delC | Frame_Shift_Del | 6 | 0.11 | 22RV1 | N | 2 | 0 | 22 | N | ||||||||||||
| MEN1 | LSLAQPEAL | PROSTATE | 526 | p.R521fs | c.1561_1561delC | Frame_Shift_Del | 5 | 0.11 | 22RV1 | N | 12 | 0 | 0 | N | ||||||||||||
| MEN1 | PEALKVAAR | PROSTATE | 531 | p.R521fs | c.1561_1561delC | Frame_Shift_Del | 4 | 0.11 | 22RV1 | N | 0 | 0 | 0 | N | ||||||||||||
| MEN1 | PGSLLGLSL | PROSTATE | 520 | p.R521fs | c.1561_1561delC | Frame_Shift_Del | 5 | 0.11 | 22RV1 | N | 0 | 0 | 0 | N | ||||||||||||
| MEN1 | PPGSLLGLS | PROSTATE | 519 | p.R521fs | c.1561_1561delC | Frame_Shift_Del | 5 | 0.11 | 22RV1 | N | 0 | 0 | 0 | N | ||||||||||||
| MEN1 | PQHHHRRRV | PROSTATE | 545 | p.R521fs | c.1561_1561delC | Frame_Shift_Del | 6 | 0.11 | 22RV1 | N | 1 | 0 | 0 | N | ||||||||||||
| MEN1 | QCSLSRVRR | PROSTATE | 554 | p.R521fs | c.1561_1561delC | Frame_Shift_Del | 5 | 0.11 | 22RV1 | Y | 3 | 9 | 0 | N | ||||||||||||
| MEN1 | QHHHRRRVQ | PROSTATE | 546 | p.R521fs | c.1561_1561delC | Frame_Shift_Del | 6 | 0.11 | 22RV1 | N | 0 | 0 | 0 | N | ||||||||||||
| MEN1 | QHPQHHHRR | PROSTATE | 543 | p.R521fs | c.1561_1561delC | Frame_Shift_Del | 7 | 0.11 | 22RV1 | N | 1 | 0 | 0 | N | ||||||||||||
| MEN1 | QPEALKVAA | PROSTATE | 530 | p.R521fs | c.1561_1561delC | Frame_Shift_Del | 4 | 0.11 | 22RV1 | N | 6 | 0 | 0 | N | ||||||||||||
| MEN1 | RCQHPQHHH | PROSTATE | 541 | p.R521fs | c.1561_1561delC | Frame_Shift_Del | 7 | 0.11 | 22RV1 | N | 0 | 0 | 0 | N | ||||||||||||
| MEN1 | RLRCQHPQH | PROSTATE | 539 | p.R521fs | c.1561_1561delC | Frame_Shift_Del | 6 | 0.11 | 22RV1 | N | 1 | 0 | 0 | N | ||||||||||||
| MEN1 | RRRVQCSLS | PROSTATE | 550 | p.R521fs | c.1561_1561delC | Frame_Shift_Del | 5 | 0.11 | 22RV1 | N | 2 | 0 | 0 | N | ||||||||||||
| MEN1 | RRVQCSLSR | PROSTATE | 551 | p.R521fs | c.1561_1561delC | Frame_Shift_Del | 5 | 0.11 | 22RV1 | N | 4 | 0 | 0 | N | ||||||||||||
| MEN1 | RVQCSLSRV | PROSTATE | 552 | p.R521fs | c.1561_1561delC | Frame_Shift_Del | 5 | 0.11 | 22RV1 | Y | 3 | 11 | 0 | N | ||||||||||||
| MEN1 | SGPPGSLLG | PROSTATE | 517 | p.R521fs | c.1561_1561delC | Frame_Shift_Del | 4 | 0.11 | 22RV1 | N | 1 | 0 | 0 | N | ||||||||||||
| MEN1 | SLAQPEALK | PROSTATE | 527 | p.R521fs | c.1561_1561delC | Frame_Shift_Del | 5 | 0.11 | 22RV1 | Y | 5 | 16 | 0 | N | ||||||||||||
| MEN1 | SLLGLSLAQ | PROSTATE | 522 | p.R521fs | c.1561_1561delC | Frame_Shift_Del | 4 | 0.11 | 22RV1 | N | 0 | 0 | 0 | N | ||||||||||||
| MEN1 | VAARLRCQH | PROSTATE | 536 | p.R521fs | c.1561_1561delC | Frame_Shift_Del | 5 | 0.11 | 22RV1 | N | 0 | 0 | 6 | N | ||||||||||||
| MEN1 | VQCSLSRVR | PROSTATE | 553 | p.R521fs | c.1561_1561delC | Frame_Shift_Del | 5 | 0.11 | 22RV1 | N | 4 | 0 | 3 | N | ||||||||||||
| MEN1 | VSGPPGSLL | PROSTATE | 516 | p.R521fs | c.1561_1561delC | Frame_Shift_Del | 4 | 0.11 | 22RV1 | N | 11 | 0 | 0 | N | ||||||||||||
| MEN1 | ASWDCRWHS | PANCREAS | 523 | p.R521fs | c.1561_1562insC | Frame_Shift_Ins | 6 | 0.11 | T3M4 | N | 0 | 0 | 0 | N | ||||||||||||
| MEN1 | AVSGPPPEA | PANCREAS | 515 | p.R521fs | c.1561_1562insC | Frame_Shift_Ins | 3 | 0.11 | T3M4 | N | 0 | 0 | 0 | N | ||||||||||||
| MEN1 | DCRWHSPRP | PANCREAS | 526 | p.R521fs | c.1561_1562insC | Frame_Shift_Ins | 6 | 0.11 | T3M4 | N | 0 | 0 | 0 | N | ||||||||||||
| MEN1 | EASWDCRWH | PANCREAS | 522 | p.R521fs | c.1561_1562insC | Frame_Shift_Ins | 6 | 0.11 | T3M4 | N | 0 | 0 | 0 | N | ||||||||||||
| MEN1 | GPPPEASWD | PANCREAS | 518 | p.R521fs | c.1561_1562insC | Frame_Shift_Ins | 5 | 0.11 | T3M4 | N | 0 | 0 | 0 | N | ||||||||||||
| MEN1 | PEASWDCRW | PANCREAS | 521 | p.R521fs | c.1561_1562insC | Frame_Shift_Ins | 6 | 0.11 | T3M4 | N | 2 | 0 | 0 | N | ||||||||||||
| MEN1 | PPEASWDCR | PANCREAS | 520 | p.R521fs | c.1561_1562insC | Frame_Shift_Ins | 6 | 0.11 | T3M4 | N | 0 | 0 | 0 | N | ||||||||||||
| MEN1 | PPPEASWDC | PANCREAS | 519 | p.R521fs | c.1561_1562insC | Frame_Shift_Ins | 5 | 0.11 | T3M4 | N | 0 | 0 | 0 | N | ||||||||||||
| MEN1 | SGPPPEASW | PANCREAS | 517 | p.R521fs | c.1561_1562insC | Frame_Shift_Ins | 5 | 0.11 | T3M4 | N | 3 | 0 | 0 | N | ||||||||||||
| MEN1 | SWDCRWHSP | PANCREAS | 524 | p.R521fs | c.1561_1562insC | Frame_Shift_Ins | 6 | 0.11 | T3M4 | N | 0 | 0 | 0 | N | ||||||||||||
| MEN1 | VSGPPPEAS | PANCREAS | 516 | p.R521fs | c.1561_1562insC | Frame_Shift_Ins | 4 | 0.11 | T3M4 | N | 0 | 0 | 0 | N | ||||||||||||
| MEN1 | WDCRWHSPR | PANCREAS | 525 | p.R521fs | c.1561_1562insC | Frame_Shift_Ins | 6 | 0.11 | T3M4 | N | 2 | 0 | 0 | N | ||||||||||||
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