Cancertope
In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer
Personalized immunotherapy or Vaccine against Cancer
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The result page of search shows exclusive peptide/epitopes generated due to mutation [Neoepitope], the tissue of origin [Tissue], position of peptide in protein [Position], number of mismatches counted by aligning mutated and normal protein sequence [Num Mismatch, percentage of cell lines with this peptide over total number of cell lines [Promiscuity %]. The immune information include CTL epitopes (Yes/No), MHC I binders, MHC II binders (both given as number of alleles) and B cell epitopes (Yes/No). For more information, please click |
| Result | Search: | |||||||||||||||||||||||||
| Protein | Neoepitopes | Tissue | Position | Prot Mutation | cDNA Mutation | Mutation Type | Num Mismatch | Promiscuity (%) | Cell Line | CTL | MHC I | NHLApred | MHC II | Bcell | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MLH1 | AHTFCLLNI | KIDNEY | 725 | p.S711fs | c.2132_2132delC | Frame_Shift_Del | 6 | 0.11 | SNU349 | Y | 3 | 13 | 0 | N | ||||||||||||
| MLH1 | AYRASSQME | LARGE_INTESTINE | 125 | p.Y130fs | c.389_389delA | Frame_Shift_Del | 4 | 0.11 | CW2 | N | 0 | 0 | 0 | N | ||||||||||||
| MLH1 | CAHTFCLLN | KIDNEY | 724 | p.S711fs | c.2132_2132delC | Frame_Shift_Del | 6 | 0.11 | SNU349 | N | 1 | 0 | 0 | N | ||||||||||||
| MLH1 | CAYRASSQM | LARGE_INTESTINE | 124 | p.Y130fs | c.389_389delA | Frame_Shift_Del | 3 | 0.11 | CW2 | N | 8 | 0 | 0 | N | ||||||||||||
| MLH1 | CLIYTKSLR | KIDNEY | 746 | p.S711fs | c.2132_2132delC | Frame_Shift_Del | 5 | 0.11 | SNU349 | N | 5 | 0 | 0 | N | ||||||||||||
| MLH1 | CLLNISQKM | KIDNEY | 729 | p.S711fs | c.2132_2132delC | Frame_Shift_Del | 6 | 0.11 | SNU349 | N | 5 | 0 | 0 | N | ||||||||||||
| MLH1 | CSLLTCLIY | KIDNEY | 741 | p.S711fs | c.2132_2132delC | Frame_Shift_Del | 6 | 0.11 | SNU349 | N | 6 | 0 | 0 | N | ||||||||||||
| MLH1 | EISCSLLTC | KIDNEY | 738 | p.S711fs | c.2132_2132delC | Frame_Shift_Del | 5 | 0.11 | SNU349 | N | 1 | 0 | 0 | N | ||||||||||||
| MLH1 | FCLLNISQK | KIDNEY | 728 | p.S711fs | c.2132_2132delC | Frame_Shift_Del | 6 | 0.11 | SNU349 | N | 5 | 0 | 6 | N | ||||||||||||
| MLH1 | FSVKNKERQ | ENDOMETRIUM | 192 | p.K195fs | c.583_583delA | Frame_Shift_Del | 5 | 0.11 | HEC265 | N | 2 | 0 | 6 | N | ||||||||||||
| MLH1 | GLWNTLSIK | KIDNEY | 714 | p.S711fs | c.2132_2132delC | Frame_Shift_Del | 6 | 0.11 | SNU349 | N | 6 | 0 | 0 | N | ||||||||||||
| MLH1 | GSGLWNTLS | KIDNEY | 712 | p.S711fs | c.2132_2132delC | Frame_Shift_Del | 6 | 0.11 | SNU349 | N | 0 | 0 | 0 | N | ||||||||||||
| MLH1 | GSIPNSGSG | KIDNEY | 706 | p.S711fs | c.2132_2132delC | Frame_Shift_Del | 3 | 0.11 | SNU349 | N | 1 | 0 | 0 | N | ||||||||||||
| MLH1 | HTFCLLNIS | KIDNEY | 726 | p.S711fs | c.2132_2132delC | Frame_Shift_Del | 6 | 0.11 | SNU349 | N | 0 | 0 | 0 | N | ||||||||||||
| MLH1 | IFGMLLVEN | ENDOMETRIUM | 219 | p.G221fs | c.663_663delA | Frame_Shift_Del | 5 | 0.11 | HEC6 | N | 0 | 0 | 0 | N | ||||||||||||
| MLH1 | IKPCAHTFC | KIDNEY | 721 | p.S711fs | c.2132_2132delC | Frame_Shift_Del | 5 | 0.11 | SNU349 | N | 1 | 0 | 0 | N | ||||||||||||
| MLH1 | IPNSGSGLW | KIDNEY | 708 | p.S711fs | c.2132_2132delC | Frame_Shift_Del | 5 | 0.11 | SNU349 | N | 6 | 0 | 0 | N | ||||||||||||
| MLH1 | IRSIFGMLL | ENDOMETRIUM | 216 | p.G221fs | c.663_663delA | Frame_Shift_Del | 3 | 0.11 | HEC6 | Y | 10 | 9 | 20 | N | ||||||||||||
| MLH1 | ISCSLLTCL | KIDNEY | 739 | p.S711fs | c.2132_2132delC | Frame_Shift_Del | 6 | 0.11 | SNU349 | N | 13 | 0 | 0 | N | ||||||||||||
| MLH1 | ISFSVKNKE | ENDOMETRIUM | 190 | p.K195fs | c.583_583delA | Frame_Shift_Del | 3 | 0.11 | HEC265 | N | 0 | 0 | 1 | N | ||||||||||||
| MLH1 | ISQKMEISC | KIDNEY | 733 | p.S711fs | c.2132_2132delC | Frame_Shift_Del | 6 | 0.11 | SNU349 | N | 1 | 0 | 0 | N | ||||||||||||
| MLH1 | IYTKSLRGV | KIDNEY | 748 | p.S711fs | c.2132_2132delC | Frame_Shift_Del | 5 | 0.11 | SNU349 | N | 3 | 0 | 14 | N | ||||||||||||
| MLH1 | KMEISCSLL | KIDNEY | 736 | p.S711fs | c.2132_2132delC | Frame_Shift_Del | 6 | 0.11 | SNU349 | N | 12 | 0 | 0 | N | ||||||||||||
| MLH1 | KPCAHTFCL | KIDNEY | 722 | p.S711fs | c.2132_2132delC | Frame_Shift_Del | 5 | 0.11 | SNU349 | N | 17 | 0 | 0 | N | ||||||||||||
| MLH1 | LIYTKSLRG | KIDNEY | 747 | p.S711fs | c.2132_2132delC | Frame_Shift_Del | 5 | 0.11 | SNU349 | N | 0 | 0 | 9 | N | ||||||||||||
| MLH1 | LLNISQKME | KIDNEY | 730 | p.S711fs | c.2132_2132delC | Frame_Shift_Del | 5 | 0.11 | SNU349 | N | 0 | 0 | 1 | N | ||||||||||||
| MLH1 | LLTCLIYTK | KIDNEY | 743 | p.S711fs | c.2132_2132delC | Frame_Shift_Del | 5 | 0.11 | SNU349 | N | 6 | 0 | 2 | N | ||||||||||||
| MLH1 | LNISQKMEI | KIDNEY | 731 | p.S711fs | c.2132_2132delC | Frame_Shift_Del | 5 | 0.11 | SNU349 | N | 7 | 0 | 35 | N | ||||||||||||
| MLH1 | LSIKPCAHT | KIDNEY | 719 | p.S711fs | c.2132_2132delC | Frame_Shift_Del | 5 | 0.11 | SNU349 | N | 1 | 0 | 4 | N | ||||||||||||
| MLH1 | LTCLIYTKS | KIDNEY | 744 | p.S711fs | c.2132_2132delC | Frame_Shift_Del | 5 | 0.11 | SNU349 | N | 1 | 0 | 0 | N | ||||||||||||
| MLH1 | LWNTLSIKP | KIDNEY | 715 | p.S711fs | c.2132_2132delC | Frame_Shift_Del | 5 | 0.11 | SNU349 | N | 0 | 0 | 0 | N | ||||||||||||
| MLH1 | MEISCSLLT | KIDNEY | 737 | p.S711fs | c.2132_2132delC | Frame_Shift_Del | 5 | 0.11 | SNU349 | N | 6 | 0 | 7 | N | ||||||||||||
| MLH1 | NISQKMEIS | KIDNEY | 732 | p.S711fs | c.2132_2132delC | Frame_Shift_Del | 5 | 0.11 | SNU349 | N | 0 | 0 | 0 | N | ||||||||||||
| MLH1 | NSGSGLWNT | KIDNEY | 710 | p.S711fs | c.2132_2132delC | Frame_Shift_Del | 6 | 0.11 | SNU349 | N | 2 | 0 | 0 | N | ||||||||||||
| MLH1 | NTLSIKPCA | KIDNEY | 717 | p.S711fs | c.2132_2132delC | Frame_Shift_Del | 5 | 0.11 | SNU349 | N | 1 | 0 | 0 | N | ||||||||||||
| MLH1 | PCAHTFCLL | KIDNEY | 723 | p.S711fs | c.2132_2132delC | Frame_Shift_Del | 6 | 0.11 | SNU349 | N | 0 | 0 | 0 | N | ||||||||||||
| MLH1 | PNSGSGLWN | KIDNEY | 709 | p.S711fs | c.2132_2132delC | Frame_Shift_Del | 6 | 0.11 | SNU349 | N | 0 | 0 | 0 | N | ||||||||||||
| MLH1 | QKMEISCSL | KIDNEY | 735 | p.S711fs | c.2132_2132delC | Frame_Shift_Del | 6 | 0.11 | SNU349 | N | 8 | 0 | 0 | N | ||||||||||||
| MLH1 | RSIFGMLLV | ENDOMETRIUM | 217 | p.G221fs | c.663_663delA | Frame_Shift_Del | 4 | 0.11 | HEC6 | Y | 5 | 11 | 0 | N | ||||||||||||
| MLH1 | SCSLLTCLI | KIDNEY | 740 | p.S711fs | c.2132_2132delC | Frame_Shift_Del | 6 | 0.11 | SNU349 | N | 2 | 0 | 0 | N | ||||||||||||
| MLH1 | SFSVKNKER | ENDOMETRIUM | 191 | p.K195fs | c.583_583delA | Frame_Shift_Del | 4 | 0.11 | HEC265 | N | 2 | 0 | 0 | N | ||||||||||||
| MLH1 | SGLWNTLSI | KIDNEY | 713 | p.S711fs | c.2132_2132delC | Frame_Shift_Del | 5 | 0.11 | SNU349 | N | 9 | 0 | 0 | N | ||||||||||||
| MLH1 | SGSGLWNTL | KIDNEY | 711 | p.S711fs | c.2132_2132delC | Frame_Shift_Del | 6 | 0.11 | SNU349 | Y | 11 | 10 | 0 | N | ||||||||||||
| MLH1 | SIFGMLLVE | ENDOMETRIUM | 218 | p.G221fs | c.663_663delA | Frame_Shift_Del | 5 | 0.11 | HEC6 | N | 0 | 0 | 0 | N | ||||||||||||
| MLH1 | SIKPCAHTF | KIDNEY | 720 | p.S711fs | c.2132_2132delC | Frame_Shift_Del | 5 | 0.11 | SNU349 | Y | 4 | 9 | 0 | N | ||||||||||||
| MLH1 | SIPNSGSGL | KIDNEY | 707 | p.S711fs | c.2132_2132delC | Frame_Shift_Del | 4 | 0.11 | SNU349 | N | 7 | 0 | 0 | N | ||||||||||||
| MLH1 | SLLTCLIYT | KIDNEY | 742 | p.S711fs | c.2132_2132delC | Frame_Shift_Del | 6 | 0.11 | SNU349 | N | 4 | 0 | 0 | N | ||||||||||||
| MLH1 | SQKMEISCS | KIDNEY | 734 | p.S711fs | c.2132_2132delC | Frame_Shift_Del | 6 | 0.11 | SNU349 | N | 1 | 0 | 0 | N | ||||||||||||
| MLH1 | TCLIYTKSL | KIDNEY | 745 | p.S711fs | c.2132_2132delC | Frame_Shift_Del | 6 | 0.11 | SNU349 | N | 7 | 0 | 0 | N | ||||||||||||
| MLH1 | TFCLLNISQ | KIDNEY | 727 | p.S711fs | c.2132_2132delC | Frame_Shift_Del | 6 | 0.11 | SNU349 | N | 0 | 0 | 0 | N | ||||||||||||
| MLH1 | TLSIKPCAH | KIDNEY | 718 | p.S711fs | c.2132_2132delC | Frame_Shift_Del | 5 | 0.11 | SNU349 | N | 0 | 0 | 0 | N | ||||||||||||
| MLH1 | WNTLSIKPC | KIDNEY | 716 | p.S711fs | c.2132_2132delC | Frame_Shift_Del | 6 | 0.11 | SNU349 | N | 1 | 0 | 8 | N | ||||||||||||
| MLH1 | YRASSQMEN | LARGE_INTESTINE | 126 | p.Y130fs | c.389_389delA | Frame_Shift_Del | 5 | 0.11 | CW2 | N | 4 | 0 | 5 | N | ||||||||||||
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