Cancertope: In silico Platform for designing genome-based Personalized immunotherapy or Vaccine against Cancer

Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

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The result page of search shows exclusive peptide/epitopes generated due to mutation [Neoepitope], the tissue of origin [Tissue], position of peptide in protein [Position], number of mismatches counted by aligning mutated and normal protein sequence [Num Mismatch, percentage of cell lines with this peptide over total number of cell lines [Promiscuity %]. The immune information include CTL epitopes (Yes/No), MHC I binders, MHC II binders (both given as number of alleles) and B cell epitopes (Yes/No). For more information, please click HERE

Protein	Neoepitopes	Tissue	Position	Prot Mutation	cDNA Mutation	Mutation Type	Num Mismatch	Promiscuity (%)	Cell Line	CTL	MHC I	NHLApred	MHC II	Bcell
Result		Search:
RB1	CGWSIGRLY	ENDOMETRIUM	83	p.R71fs	c.211_212delAG	Frame_Shift_Del	6	0.22	COLO684	N	6	0	0	N
RB1	CGWSIGRLY	OVARY	83	p.R71fs	c.211_212delAG	Frame_Shift_Del	6	0.22	COLO704	N	6	0	0	N
RB1	EKGTVGNLY	ENDOMETRIUM	94	p.R71fs	c.211_212delAG	Frame_Shift_Del	6	0.22	COLO684	N	3	0	0	N
RB1	EKGTVGNLY	OVARY	94	p.R71fs	c.211_212delAG	Frame_Shift_Del	6	0.22	COLO704	N	3	0	0	N
RB1	FICGWSIGR	ENDOMETRIUM	81	p.R71fs	c.211_212delAG	Frame_Shift_Del	6	0.22	COLO684	N	8	0	3	N
RB1	FICGWSIGR	OVARY	81	p.R71fs	c.211_212delAG	Frame_Shift_Del	6	0.22	COLO704	N	8	0	3	N
RB1	GNLYLYCSS	ENDOMETRIUM	99	p.R71fs	c.211_212delAG	Frame_Shift_Del	6	0.22	COLO684	N	1	0	0	N
RB1	GNLYLYCSS	OVARY	99	p.R71fs	c.211_212delAG	Frame_Shift_Del	6	0.22	COLO704	N	1	0	0	N
RB1	GRLYSKEKG	ENDOMETRIUM	88	p.R71fs	c.211_212delAG	Frame_Shift_Del	6	0.22	COLO684	N	1	0	0	N
RB1	GRLYSKEKG	OVARY	88	p.R71fs	c.211_212delAG	Frame_Shift_Del	6	0.22	COLO704	N	1	0	0	N
RB1	GTVGNLYLY	ENDOMETRIUM	96	p.R71fs	c.211_212delAG	Frame_Shift_Del	6	0.22	COLO684	Y	8	13	0	N
RB1	GTVGNLYLY	OVARY	96	p.R71fs	c.211_212delAG	Frame_Shift_Del	6	0.22	COLO704	Y	8	13	0	N
RB1	GWSIGRLYS	ENDOMETRIUM	84	p.R71fs	c.211_212delAG	Frame_Shift_Del	6	0.22	COLO684	N	0	0	0	N
RB1	GWSIGRLYS	OVARY	84	p.R71fs	c.211_212delAG	Frame_Shift_Del	6	0.22	COLO704	N	0	0	0	N
RB1	ICGWSIGRL	ENDOMETRIUM	82	p.R71fs	c.211_212delAG	Frame_Shift_Del	6	0.22	COLO684	N	6	0	0	N
RB1	ICGWSIGRL	OVARY	82	p.R71fs	c.211_212delAG	Frame_Shift_Del	6	0.22	COLO704	N	6	0	0	N
RB1	KEKGTVGNL	ENDOMETRIUM	93	p.R71fs	c.211_212delAG	Frame_Shift_Del	6	0.22	COLO684	Y	9	13	0	N
RB1	KEKGTVGNL	OVARY	93	p.R71fs	c.211_212delAG	Frame_Shift_Del	6	0.22	COLO704	Y	9	13	0	N
RB1	KGTVGNLYL	ENDOMETRIUM	95	p.R71fs	c.211_212delAG	Frame_Shift_Del	6	0.22	COLO684	N	10	0	0	N
RB1	KGTVGNLYL	OVARY	95	p.R71fs	c.211_212delAG	Frame_Shift_Del	6	0.22	COLO704	N	10	0	0	N
RB1	SFICGWSIG	ENDOMETRIUM	80	p.R71fs	c.211_212delAG	Frame_Shift_Del	6	0.22	COLO684	N	0	0	0	N
RB1	SFICGWSIG	OVARY	80	p.R71fs	c.211_212delAG	Frame_Shift_Del	6	0.22	COLO704	N	0	0	0	N
RB1	SIGRLYSKE	ENDOMETRIUM	86	p.R71fs	c.211_212delAG	Frame_Shift_Del	6	0.22	COLO684	N	0	0	0	N
RB1	SIGRLYSKE	OVARY	86	p.R71fs	c.211_212delAG	Frame_Shift_Del	6	0.22	COLO704	N	0	0	0	N
RB1	SKEKGTVGN	ENDOMETRIUM	92	p.R71fs	c.211_212delAG	Frame_Shift_Del	6	0.22	COLO684	N	1	0	0	N
RB1	SKEKGTVGN	OVARY	92	p.R71fs	c.211_212delAG	Frame_Shift_Del	6	0.22	COLO704	N	1	0	0	N
RB1	TVGNLYLYC	ENDOMETRIUM	97	p.R71fs	c.211_212delAG	Frame_Shift_Del	6	0.22	COLO684	N	3	0	0	N
RB1	TVGNLYLYC	OVARY	97	p.R71fs	c.211_212delAG	Frame_Shift_Del	6	0.22	COLO704	N	3	0	0	N
RB1	VGNLYLYCS	ENDOMETRIUM	98	p.R71fs	c.211_212delAG	Frame_Shift_Del	6	0.22	COLO684	N	0	0	8	N
RB1	VGNLYLYCS	OVARY	98	p.R71fs	c.211_212delAG	Frame_Shift_Del	6	0.22	COLO704	N	0	0	8	N
RB1	WSIGRLYSK	ENDOMETRIUM	85	p.R71fs	c.211_212delAG	Frame_Shift_Del	6	0.22	COLO684	Y	5	12	2	N
RB1	WSIGRLYSK	OVARY	85	p.R71fs	c.211_212delAG	Frame_Shift_Del	6	0.22	COLO704	Y	5	12	2	N
RB1	YSKEKGTVG	ENDOMETRIUM	91	p.R71fs	c.211_212delAG	Frame_Shift_Del	6	0.22	COLO684	N	2	0	0	Y
RB1	YSKEKGTVG	OVARY	91	p.R71fs	c.211_212delAG	Frame_Shift_Del	6	0.22	COLO704	N	2	0	0	Y