Cancertope: In silico Platform for designing genome-based Personalized immunotherapy or Vaccine against Cancer

Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

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The result page of search shows exclusive peptide/epitopes generated due to mutation [Neoepitope], the tissue of origin [Tissue], position of peptide in protein [Position], number of mismatches counted by aligning mutated and normal protein sequence [Num Mismatch, percentage of cell lines with this peptide over total number of cell lines [Promiscuity %]. The immune information include CTL epitopes (Yes/No), MHC I binders, MHC II binders (both given as number of alleles) and B cell epitopes (Yes/No). For more information, please click HERE

Protein	Neoepitopes	Tissue	Position	Prot Mutation	cDNA Mutation	Mutation Type	Num Mismatch	Promiscuity (%)	Cell Line	CTL	MHC I	NHLApred	MHC II	Bcell
Result		Search:
SMAD4	AAIVKDCCR	UPPER_AERODIGESTIVE_TRACT	231	p.L229fs	c.687_687delG	Frame_Shift_Del	5	0.11	PECAPJ34CLONEC12	N	4	0	0	N
SMAD4	ADCRPTTFR	BILIARY_TRACT	539	p.V539fs	c.1615_1628delGTACTTCATACCAT	Frame_Shift_Del	7	0.11	SNU245	N	1	0	0	N
SMAD4	AIFSTTRLC	PANCREAS	282	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	N	0	0	0	N
SMAD4	AITTMELIL	OVARY	60	p.T63fs	c.189_189delA	Frame_Shift_Del	5	0.11	JHOM2B	N	5	0	0	N
SMAD4	ALPPGLEVG	PANCREAS	260	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	5	0.11	TCCPAN2	N	0	0	0	N
SMAD4	ALQLLDEAD	BILIARY_TRACT	532	p.V539fs	c.1615_1628delGTACTTCATACCAT	Frame_Shift_Del	2	0.11	SNU245	N	0	0	0	N
SMAD4	ASILGAAIV	UPPER_AERODIGESTIVE_TRACT	226	p.L229fs	c.687_687delG	Frame_Shift_Del	4	0.11	PECAPJ34CLONEC12	N	5	0	0	N
SMAD4	CLTTKTAIF	PANCREAS	276	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	5	0.11	TCCPAN2	N	5	0	0	N
SMAD4	CRPIPDITG	PANCREAS	290	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	N	1	0	0	N
SMAD4	DCRPTTFRL	BILIARY_TRACT	540	p.V539fs	c.1615_1628delGTACTTCATACCAT	Frame_Shift_Del	6	0.11	SNU245	Y	5	10	0	N
SMAD4	DEADCRPTT	BILIARY_TRACT	537	p.V539fs	c.1615_1628delGTACTTCATACCAT	Frame_Shift_Del	5	0.11	SNU245	N	5	0	0	N
SMAD4	DITGLFTMS	PANCREAS	295	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	5	0.11	TCCPAN2	N	1	0	0	N
SMAD4	EADCRPTTF	BILIARY_TRACT	538	p.V539fs	c.1615_1628delGTACTTCATACCAT	Frame_Shift_Del	6	0.11	SNU245	Y	4	9	0	N
SMAD4	EHWMGGFRW	OVARY	76	p.T63fs	c.189_189delA	Frame_Shift_Del	6	0.11	JHOM2B	N	2	0	0	N
SMAD4	EKLGVHLEM	PANCREAS	415	p.L414fs	c.1242_1245delAGAC	Frame_Shift_Del	5	0.11	KP2	N	4	0	0	N
SMAD4	ELILVNVLP	OVARY	65	p.T63fs	c.189_189delA	Frame_Shift_Del	6	0.11	JHOM2B	N	0	0	0	N
SMAD4	EMLFIRSTQ	PANCREAS	422	p.L414fs	c.1242_1245delAGAC	Frame_Shift_Del	6	0.11	KP2	N	1	0	0	N
SMAD4	EVGLHHTHL	PANCREAS	266	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	N	5	0	0	N
SMAD4	FIRSTQVHI	PANCREAS	425	p.L414fs	c.1242_1245delAGAC	Frame_Shift_Del	6	0.11	KP2	N	8	0	6	N
SMAD4	FPIILLLSI	PANCREAS	310	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	5	0.11	TCCPAN2	N	16	0	18	N
SMAD4	FRWLVGKDF	OVARY	82	p.T63fs	c.189_189delA	Frame_Shift_Del	6	0.11	JHOM2B	N	6	0	11	N
SMAD4	FSTTRLCRP	PANCREAS	284	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	5	0.11	TCCPAN2	N	2	0	0	N
SMAD4	FTMSLHSSL	PANCREAS	300	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	N	14	0	2	N
SMAD4	FVQSYYLEK	PANCREAS	408	p.L414fs	c.1242_1245delAGAC	Frame_Shift_Del	2	0.11	KP2	N	7	0	5	N
SMAD4	GAAIVKDCC	UPPER_AERODIGESTIVE_TRACT	230	p.L229fs	c.687_687delG	Frame_Shift_Del	6	0.11	PECAPJ34CLONEC12	N	3	0	0	N
SMAD4	GFRWLVGKD	OVARY	81	p.T63fs	c.189_189delA	Frame_Shift_Del	6	0.11	JHOM2B	N	0	0	0	N
SMAD4	GGFRWLVGK	OVARY	80	p.T63fs	c.189_189delA	Frame_Shift_Del	5	0.11	JHOM2B	N	2	0	0	N
SMAD4	GLEVGLHHT	PANCREAS	264	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	N	2	0	0	N
SMAD4	GLFTMSLHS	PANCREAS	298	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	N	2	0	0	N
SMAD4	GLHHTHLIC	PANCREAS	268	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	N	2	0	0	N
SMAD4	GPQPGQQLV	PANCREAS	243	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	2	0.11	TCCPAN2	N	12	0	0	N
SMAD4	GQQLVSQLL	PANCREAS	247	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	N	11	0	0	N
SMAD4	GVHLEMLFI	PANCREAS	418	p.L414fs	c.1242_1245delAGAC	Frame_Shift_Del	5	0.11	KP2	Y	6	12	0	N
SMAD4	GVPLLTLKW	PANCREAS	319	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	N	1	0	0	N
SMAD4	HHTHLICLT	PANCREAS	270	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	N	1	0	0	N
SMAD4	HLEMLFIRS	PANCREAS	420	p.L414fs	c.1242_1245delAGAC	Frame_Shift_Del	6	0.11	KP2	N	1	0	0	N
SMAD4	HLICLTTKT	PANCREAS	273	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	5	0.11	TCCPAN2	N	2	0	0	N
SMAD4	HSSLPFPII	PANCREAS	305	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	5	0.11	TCCPAN2	N	8	0	0	N
SMAD4	HTHLICLTT	PANCREAS	271	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	N	1	0	0	N
SMAD4	HWMGGFRWL	OVARY	77	p.T63fs	c.189_189delA	Frame_Shift_Del	6	0.11	JHOM2B	Y	8	13	0	N
SMAD4	ICLTTKTAI	PANCREAS	275	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	N	9	0	2	N
SMAD4	IFSTTRLCR	PANCREAS	283	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	N	2	0	2	N
SMAD4	IGVPLLTLK	PANCREAS	318	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	5	0.11	TCCPAN2	N	0	0	0	N
SMAD4	IILLLSIGV	PANCREAS	312	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	N	8	0	24	N
SMAD4	IITALPPGL	PANCREAS	257	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	N	6	0	2	N
SMAD4	ILGAAIVKD	UPPER_AERODIGESTIVE_TRACT	228	p.L229fs	c.687_687delG	Frame_Shift_Del	5	0.11	PECAPJ34CLONEC12	N	0	0	1	N
SMAD4	ILLLSIGVP	PANCREAS	313	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	N	0	0	6	N
SMAD4	ILVNVLPYR	OVARY	67	p.T63fs	c.189_189delA	Frame_Shift_Del	5	0.11	JHOM2B	N	5	0	1	N
SMAD4	IPDITGLFT	PANCREAS	293	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	N	6	0	0	N
SMAD4	ITAITTMEL	OVARY	58	p.T63fs	c.189_189delA	Frame_Shift_Del	3	0.11	JHOM2B	Y	6	13	12	N
SMAD4	ITALPPGLE	PANCREAS	258	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	N	0	0	0	N
SMAD4	ITGLFTMSL	PANCREAS	296	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	Y	10	11	15	N
SMAD4	ITTMELILV	OVARY	61	p.T63fs	c.189_189delA	Frame_Shift_Del	6	0.11	JHOM2B	N	5	0	0	N
SMAD4	KLGVHLEML	PANCREAS	416	p.L414fs	c.1242_1245delAGAC	Frame_Shift_Del	5	0.11	KP2	Y	16	12	0	N
SMAD4	KTAIFSTTR	PANCREAS	280	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	5	0.11	TCCPAN2	Y	6	9	0	N
SMAD4	LCRPIPDIT	PANCREAS	289	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	5	0.11	TCCPAN2	N	1	0	0	N
SMAD4	LDEADCRPT	BILIARY_TRACT	536	p.V539fs	c.1615_1628delGTACTTCATACCAT	Frame_Shift_Del	5	0.11	SNU245	N	1	0	0	N
SMAD4	LEKLGVHLE	PANCREAS	414	p.L414fs	c.1242_1245delAGAC	Frame_Shift_Del	5	0.11	KP2	N	0	0	4	N
SMAD4	LEMLFIRST	PANCREAS	421	p.L414fs	c.1242_1245delAGAC	Frame_Shift_Del	6	0.11	KP2	N	5	0	11	N
SMAD4	LEVGLHHTH	PANCREAS	265	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	N	1	0	0	N
SMAD4	LFIRSTQVH	PANCREAS	424	p.L414fs	c.1242_1245delAGAC	Frame_Shift_Del	6	0.11	KP2	N	0	0	19	N
SMAD4	LFTMSLHSS	PANCREAS	299	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	N	0	0	22	N
SMAD4	LGAAIVKDC	UPPER_AERODIGESTIVE_TRACT	229	p.L229fs	c.687_687delG	Frame_Shift_Del	6	0.11	PECAPJ34CLONEC12	N	0	0	0	N
SMAD4	LGVHLEMLF	PANCREAS	417	p.L414fs	c.1242_1245delAGAC	Frame_Shift_Del	5	0.11	KP2	N	8	0	0	N
SMAD4	LHHTHLICL	PANCREAS	269	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	N	8	0	2	N
SMAD4	LHSSLPFPI	PANCREAS	304	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	N	6	0	7	N
SMAD4	LICLTTKTA	PANCREAS	274	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	N	1	0	19	N
SMAD4	LILVNVLPY	OVARY	66	p.T63fs	c.189_189delA	Frame_Shift_Del	5	0.11	JHOM2B	N	11	0	40	N
SMAD4	LITAITTME	OVARY	57	p.T63fs	c.189_189delA	Frame_Shift_Del	2	0.11	JHOM2B	N	0	0	3	N
SMAD4	LLDEADCRP	BILIARY_TRACT	535	p.V539fs	c.1615_1628delGTACTTCATACCAT	Frame_Shift_Del	5	0.11	SNU245	N	0	0	0	N
SMAD4	LLLSIGVPL	PANCREAS	314	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	5	0.11	TCCPAN2	N	19	0	4	N
SMAD4	LLSIGVPLL	PANCREAS	315	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	5	0.11	TCCPAN2	N	12	0	14	N
SMAD4	LLTIITALP	PANCREAS	254	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	5	0.11	TCCPAN2	N	0	0	6	N
SMAD4	LLTLKWMFR	PANCREAS	322	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	N	6	0	0	N
SMAD4	LPFPIILLL	PANCREAS	308	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	Y	30	10	0	N
SMAD4	LPPGLEVGL	PANCREAS	261	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	5	0.11	TCCPAN2	N	19	0	0	N
SMAD4	LPYREHWMG	OVARY	72	p.T63fs	c.189_189delA	Frame_Shift_Del	6	0.11	JHOM2B	N	3	0	0	N
SMAD4	LQLLDEADC	BILIARY_TRACT	533	p.V539fs	c.1615_1628delGTACTTCATACCAT	Frame_Shift_Del	3	0.11	SNU245	N	4	0	2	N
SMAD4	LSIGVPLLT	PANCREAS	316	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	5	0.11	TCCPAN2	N	1	0	0	N
SMAD4	LTIITALPP	PANCREAS	255	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	N	0	0	8	N
SMAD4	LTTKTAIFS	PANCREAS	277	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	5	0.11	TCCPAN2	N	0	0	4	N
SMAD4	LVNVLPYRE	OVARY	68	p.T63fs	c.189_189delA	Frame_Shift_Del	5	0.11	JHOM2B	N	0	0	10	N
SMAD4	LVSQLLTII	PANCREAS	250	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	N	8	0	14	N
SMAD4	MELILVNVL	OVARY	64	p.T63fs	c.189_189delA	Frame_Shift_Del	6	0.11	JHOM2B	Y	13	9	13	N
SMAD4	MGGFRWLVG	OVARY	79	p.T63fs	c.189_189delA	Frame_Shift_Del	5	0.11	JHOM2B	N	0	0	2	N
SMAD4	MLFIRSTQV	PANCREAS	423	p.L414fs	c.1242_1245delAGAC	Frame_Shift_Del	6	0.11	KP2	Y	15	9	15	N
SMAD4	MSLHSSLPF	PANCREAS	302	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	N	9	0	12	N
SMAD4	NVLPYREHW	OVARY	70	p.T63fs	c.189_189delA	Frame_Shift_Del	6	0.11	JHOM2B	Y	1	9	0	N
SMAD4	PASILGAAI	UPPER_AERODIGESTIVE_TRACT	225	p.L229fs	c.687_687delG	Frame_Shift_Del	3	0.11	PECAPJ34CLONEC12	N	3	0	0	N
SMAD4	PDITGLFTM	PANCREAS	294	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	N	1	0	0	N
SMAD4	PFPIILLLS	PANCREAS	309	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	5	0.11	TCCPAN2	N	0	0	0	N
SMAD4	PGLEVGLHH	PANCREAS	263	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	N	0	0	0	N
SMAD4	PGQQLVSQL	PANCREAS	246	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	5	0.11	TCCPAN2	N	1	0	0	N
SMAD4	PIILLLSIG	PANCREAS	311	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	N	0	0	0	N
SMAD4	PIPDITGLF	PANCREAS	292	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	5	0.11	TCCPAN2	N	1	0	0	N
SMAD4	PLLTLKWMF	PANCREAS	321	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	N	3	0	0	N
SMAD4	PPGLEVGLH	PANCREAS	262	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	5	0.11	TCCPAN2	N	0	0	0	N
SMAD4	PQPGQQLVS	PANCREAS	244	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	3	0.11	TCCPAN2	N	0	0	0	N
SMAD4	PYREHWMGG	OVARY	73	p.T63fs	c.189_189delA	Frame_Shift_Del	6	0.11	JHOM2B	N	0	0	0	N
SMAD4	QLLDEADCR	BILIARY_TRACT	534	p.V539fs	c.1615_1628delGTACTTCATACCAT	Frame_Shift_Del	4	0.11	SNU245	N	5	0	0	N
SMAD4	QLLTIITAL	PANCREAS	253	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	5	0.11	TCCPAN2	N	18	0	0	N
SMAD4	QLVSQLLTI	PANCREAS	249	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	Y	11	11	0	N
SMAD4	QPASILGAA	UPPER_AERODIGESTIVE_TRACT	224	p.L229fs	c.687_687delG	Frame_Shift_Del	2	0.11	PECAPJ34CLONEC12	N	9	0	0	N
SMAD4	QPGQQLVSQ	PANCREAS	245	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	4	0.11	TCCPAN2	N	0	0	0	N
SMAD4	QQLVSQLLT	PANCREAS	248	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	5	0.11	TCCPAN2	N	3	0	0	N
SMAD4	QSYYLEKLG	PANCREAS	410	p.L414fs	c.1242_1245delAGAC	Frame_Shift_Del	4	0.11	KP2	N	0	0	0	N
SMAD4	RALQLLDEA	BILIARY_TRACT	531	p.V539fs	c.1615_1628delGTACTTCATACCAT	Frame_Shift_Del	1	0.11	SNU245	N	5	0	0	N
SMAD4	REHWMGGFR	OVARY	75	p.T63fs	c.189_189delA	Frame_Shift_Del	6	0.11	JHOM2B	N	1	0	0	N
SMAD4	RLCRPIPDI	PANCREAS	288	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	Y	9	15	0	N
SMAD4	RPIPDITGL	PANCREAS	291	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	5	0.11	TCCPAN2	Y	22	9	0	N
SMAD4	RWLVGKDFL	OVARY	83	p.T63fs	c.189_189delA	Frame_Shift_Del	6	0.11	JHOM2B	N	9	0	0	N
SMAD4	SGPQPGQQL	PANCREAS	242	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	1	0.11	TCCPAN2	N	12	0	0	N
SMAD4	SIGVPLLTL	PANCREAS	317	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	5	0.11	TCCPAN2	Y	5	9	0	N
SMAD4	SILGAAIVK	UPPER_AERODIGESTIVE_TRACT	227	p.L229fs	c.687_687delG	Frame_Shift_Del	5	0.11	PECAPJ34CLONEC12	N	4	0	0	N
SMAD4	SLHSSLPFP	PANCREAS	303	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	N	0	0	0	N
SMAD4	SLITAITTM	OVARY	56	p.T63fs	c.189_189delA	Frame_Shift_Del	1	0.11	JHOM2B	Y	7	9	0	N
SMAD4	SLPFPIILL	PANCREAS	307	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	Y	15	10	0	N
SMAD4	SQLLTIITA	PANCREAS	252	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	5	0.11	TCCPAN2	Y	4	9	0	N
SMAD4	SQPASILGA	UPPER_AERODIGESTIVE_TRACT	223	p.L229fs	c.687_687delG	Frame_Shift_Del	1	0.11	PECAPJ34CLONEC12	N	3	0	0	N
SMAD4	SSLPFPIIL	PANCREAS	306	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	5	0.11	TCCPAN2	Y	18	9	0	N
SMAD4	STTRLCRPI	PANCREAS	285	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	5	0.11	TCCPAN2	N	3	0	0	N
SMAD4	SYYLEKLGV	PANCREAS	411	p.L414fs	c.1242_1245delAGAC	Frame_Shift_Del	5	0.11	KP2	N	5	0	0	N
SMAD4	TAIFSTTRL	PANCREAS	281	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	5	0.11	TCCPAN2	Y	16	10	0	N
SMAD4	TAITTMELI	OVARY	59	p.T63fs	c.189_189delA	Frame_Shift_Del	4	0.11	JHOM2B	N	9	0	0	N
SMAD4	TALPPGLEV	PANCREAS	259	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	5	0.11	TCCPAN2	N	7	0	0	N
SMAD4	TGLFTMSLH	PANCREAS	297	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	N	0	0	0	N
SMAD4	THLICLTTK	PANCREAS	272	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	N	0	0	0	N
SMAD4	TIITALPPG	PANCREAS	256	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	N	0	0	0	N
SMAD4	TKTAIFSTT	PANCREAS	279	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	5	0.11	TCCPAN2	N	1	0	0	N
SMAD4	TMELILVNV	OVARY	63	p.T63fs	c.189_189delA	Frame_Shift_Del	6	0.11	JHOM2B	N	6	0	0	N
SMAD4	TMSLHSSLP	PANCREAS	301	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	5	0.11	TCCPAN2	N	0	0	0	N
SMAD4	TRLCRPIPD	PANCREAS	287	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	N	2	0	0	N
SMAD4	TTKTAIFST	PANCREAS	278	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	5	0.11	TCCPAN2	N	1	0	0	N
SMAD4	TTMELILVN	OVARY	62	p.T63fs	c.189_189delA	Frame_Shift_Del	6	0.11	JHOM2B	N	1	0	0	N
SMAD4	TTRLCRPIP	PANCREAS	286	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	N	0	0	0	N
SMAD4	VGLHHTHLI	PANCREAS	267	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	N	11	0	20	N
SMAD4	VHLEMLFIR	PANCREAS	419	p.L414fs	c.1242_1245delAGAC	Frame_Shift_Del	5	0.11	KP2	N	2	0	2	N
SMAD4	VLPYREHWM	OVARY	71	p.T63fs	c.189_189delA	Frame_Shift_Del	6	0.11	JHOM2B	N	7	0	2	N
SMAD4	VNVLPYREH	OVARY	69	p.T63fs	c.189_189delA	Frame_Shift_Del	5	0.11	JHOM2B	N	0	0	1	N
SMAD4	VPLLTLKWM	PANCREAS	320	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	N	13	0	0	N
SMAD4	VQSYYLEKL	PANCREAS	409	p.L414fs	c.1242_1245delAGAC	Frame_Shift_Del	3	0.11	KP2	N	13	0	2	N
SMAD4	VSQLLTIIT	PANCREAS	251	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	5	0.11	TCCPAN2	N	1	0	0	N
SMAD4	WLVGKDFLM	OVARY	84	p.T63fs	c.189_189delA	Frame_Shift_Del	6	0.11	JHOM2B	Y	10	9	0	N
SMAD4	WMGGFRWLV	OVARY	78	p.T63fs	c.189_189delA	Frame_Shift_Del	6	0.11	JHOM2B	Y	8	10	1	N
SMAD4	YLEKLGVHL	PANCREAS	413	p.L414fs	c.1242_1245delAGAC	Frame_Shift_Del	6	0.11	KP2	Y	13	11	0	N
SMAD4	YREHWMGGF	OVARY	74	p.T63fs	c.189_189delA	Frame_Shift_Del	6	0.11	JHOM2B	N	6	0	0	N
SMAD4	YYLEKLGVH	PANCREAS	412	p.L414fs	c.1242_1245delAGAC	Frame_Shift_Del	6	0.11	KP2	N	2	0	1	N
SMAD4	VFVQSYYLE	PANCREAS	407	p.L414fs	c.1242_1245delAGAC	Frame_Shift_Del	1	0.22	KP2	N	0	0	0	N
SMAD4	CQYAFDLKM	PANCREAS	115	p.L121fs	c.362_363insA	Frame_Shift_Ins	1	0.11	PANC0813	N	10	0	0	N
SMAD4	AAGIGVDDP	OVARY	487	p.L495P	c.1484T>C	Missense_Mutation	1	0.11	IGROV1	N	0	0	0	N
SMAD4	AATAQASAA	AUTONOMIC_GANGLIA	451	p.A457S	c.1369G>T	Missense_Mutation	1	0.11	NB1	N	1	0	0	N
SMAD4	AGIGVDDPR	OVARY	488	p.L495P	c.1484T>C	Missense_Mutation	1	0.11	IGROV1	N	1	0	0	N
SMAD4	ALQLLGEVL	BILIARY_TRACT	532	p.D537G	c.1610A>G	Missense_Mutation	1	0.11	SNU308	Y	14	12	0	N
SMAD4	ALQLLYEVL	LARGE_INTESTINE	532	p.D537Y	c.1609G>T	Missense_Mutation	1	0.11	SW948	Y	15	10	0	Y
SMAD4	ANFPNISVA	ENDOMETRIUM	212	p.P218S	c.652C>T	Missense_Mutation	1	0.11	JHUEM1	Y	4	12	0	N
SMAD4	APEHWCSIA	ENDOMETRIUM	319	p.Y322H	c.964T>C	Missense_Mutation	1	0.11	HEC108	N	6	0	0	N
SMAD4	APSESNATN	ENDOMETRIUM	202	p.S210N	c.629G>A	Missense_Mutation	1	0.11	JHUEM1	N	3	0	0	N
SMAD4	AQASAAAQA	AUTONOMIC_GANGLIA	454	p.A457S	c.1369G>T	Missense_Mutation	1	0.11	NB1	N	2	0	0	N
SMAD4	ARLHIGKSV	LARGE_INTESTINE	379	p.G386S	c.1156G>A	Missense_Mutation	1	0.11	SNU175	N	4	0	0	N
SMAD4	ARLWTWPDL	PANCREAS	96	p.R100T	c.299G>C	Missense_Mutation	1	0.11	ASPC1	Y	7	9	0	N
SMAD4	ASAAAQAAA	AUTONOMIC_GANGLIA	456	p.A457S	c.1369G>T	Missense_Mutation	1	0.11	NB1	N	2	0	0	N
SMAD4	ASAISLSAA	CENTRAL_NERVOUS_SYSTEM	479	p.P480S	c.1438C>T	Missense_Mutation	1	0.11	SNU1105	Y	2	11	0	Y
SMAD4	ATAQASAAA	AUTONOMIC_GANGLIA	452	p.A457S	c.1369G>T	Missense_Mutation	1	0.11	NB1	N	2	0	0	N
SMAD4	ATNTANFPN	ENDOMETRIUM	208	p.S210N	c.629G>A	Missense_Mutation	1	0.11	JHUEM1	N	0	0	0	N
SMAD4	AYIKVFDSR	ENDOMETRIUM	433	p.L440S	c.1319T>C	Missense_Mutation	1	0.11	HEC1A	Y	2	10	0	N
SMAD4	CEGDVWVRC	LUNG	393	p.G393C	c.1177G>T	Missense_Mutation	1	0.11	MORCPR	Y	6	9	0	N
SMAD4	CFCLGQLSN	LARGE_INTESTINE	361	p.R361C	c.1081C>T	Missense_Mutation	1	0.11	SNU175	N	0	0	0	N
SMAD4	CILRMRFVK	OVARY	499	p.S504R	c.1512T>A	Missense_Mutation	1	0.11	MCAS	Y	4	10	0	N
SMAD4	CKCEGDVWV	LUNG	391	p.G393C	c.1177G>T	Missense_Mutation	1	0.11	MORCPR	N	2	0	0	N
SMAD4	CLGQPSNVH	AUTONOMIC_GANGLIA	363	p.L367P	c.1100T>C	Missense_Mutation	1	0.11	NB1	N	0	0	0	N
SMAD4	CLSDHTVFV	LARGE_INTESTINE	401	p.A406T	c.1216G>A	Missense_Mutation	1	0.11	SNU175	Y	5	12	0	N
SMAD4	CPIVTVHGY	LARGE_INTESTINE	345	p.D351H	c.1051G>C	Missense_Mutation	1	0.11	C2BBE1	N	11	0	0	N
SMAD4	CPIVTVNGY	OESOPHAGUS	345	p.D351N	c.1051G>A	Missense_Mutation	1	0.11	KYSE450	N	11	0	0	N
SMAD4	CQYVFDLKC	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	115	p.A118V	c.353C>T	Missense_Mutation	1	0.11	NUDHL1	N	6	0	0	N
SMAD4	CVNPYHHER	STOMACH	127	p.Y133H	c.397T>C	Missense_Mutation	1	0.11	IM95	Y	6	10	0	N
SMAD4	CVNPYYYER	UPPER_AERODIGESTIVE_TRACT	127	p.H132Y	c.394C>T	Missense_Mutation	1	0.11	HSC3	Y	7	9	0	N
SMAD4	DCFCLGQLS	LARGE_INTESTINE	360	p.R361C	c.1081C>T	Missense_Mutation	1	0.11	SNU175	N	0	0	0	N
SMAD4	DDPRRLCIL	OVARY	493	p.L495P	c.1484T>C	Missense_Mutation	1	0.11	IGROV1	N	9	0	0	N
SMAD4	DEYVHEFEG	LARGE_INTESTINE	160	p.D165E	c.495C>A	Missense_Mutation	1	0.11	HRT18	N	1	0	0	N
SMAD4	DGFCLGQLS	LARGE_INTESTINE	360	p.R361G	c.1081C>G	Missense_Mutation	1	0.11	SW1463	N	1	0	0	N
SMAD4	DGYVDLSGG	PANCREAS	351	p.P356L	c.1067C>T	Missense_Mutation	1	0.11	L33	N	0	0	0	N
SMAD4	DGYVGPSGG	LARGE_INTESTINE	351	p.D355G	c.1064A>G	Missense_Mutation	1	0.11	SNU283	N	0	0	0	N
SMAD4	DGYVNPSGG	BREAST	351	p.D355N	c.1063G>A	Missense_Mutation	1	0.11	AU565	N	0	0	0	N
SMAD4	DHTVFVQSY	LARGE_INTESTINE	404	p.A406T	c.1216G>A	Missense_Mutation	1	0.11	SNU175	N	4	0	0	N
SMAD4	DLSGGDRFC	PANCREAS	355	p.P356L	c.1067C>T	Missense_Mutation	1	0.11	L33	N	1	0	0	N
SMAD4	DPRRLCILR	OVARY	494	p.L495P	c.1484T>C	Missense_Mutation	1	0.11	IGROV1	N	3	0	0	N
SMAD4	DPSGGDCFC	LARGE_INTESTINE	355	p.R361C	c.1081C>T	Missense_Mutation	1	0.11	SNU175	N	5	0	0	N
SMAD4	DPSGGDGFC	LARGE_INTESTINE	355	p.R361G	c.1081C>G	Missense_Mutation	1	0.11	SW1463	N	5	0	0	N
SMAD4	DPSGGDSFC	STOMACH	355	p.R361S	c.1081C>A	Missense_Mutation	1	0.11	HUG1N	N	5	0	0	N
SMAD4	DRFCLGQPS	AUTONOMIC_GANGLIA	360	p.L367P	c.1100T>C	Missense_Mutation	1	0.11	NB1	N	3	0	0	N
SMAD4	DSFCLGQLS	STOMACH	360	p.R361S	c.1081C>A	Missense_Mutation	1	0.11	HUG1N	N	1	0	0	N
SMAD4	DSRQCHRQM	ENDOMETRIUM	439	p.L440S	c.1319T>C	Missense_Mutation	1	0.11	HEC1A	N	6	0	0	N
SMAD4	DSVCVNPYY	UPPER_AERODIGESTIVE_TRACT	124	p.H132Y	c.394C>T	Missense_Mutation	1	0.11	HSC3	N	8	0	0	N
SMAD4	DVQVGETFN	LARGE_INTESTINE	332	p.K340N	c.1020G>C	Missense_Mutation	1	0.11	T84	N	0	0	0	N
SMAD4	ECKCEGDVW	LUNG	390	p.G393C	c.1177G>T	Missense_Mutation	1	0.11	MORCPR	N	2	0	0	N
SMAD4	EFEGQPSLS	LARGE_INTESTINE	165	p.D165E	c.495C>A	Missense_Mutation	1	0.11	HRT18	N	0	0	0	N
SMAD4	EGQPSLSTK	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	167	p.E175K	c.523G>A	Missense_Mutation	1	0.11	P12ICHIKAWA	N	0	0	0	N
SMAD4	EHWCSIAYF	ENDOMETRIUM	321	p.Y322H	c.964T>C	Missense_Mutation	1	0.11	HEC108	N	5	0	0	N
SMAD4	EREAGRAPG	PANCREAS	415	p.D415E	c.1245C>G	Missense_Mutation	1	0.11	SNU213	N	0	0	0	N
SMAD4	ESNATNTAN	ENDOMETRIUM	205	p.S210N	c.629G>A	Missense_Mutation	1	0.11	JHUEM1	N	0	0	0	N
SMAD4	ETFKVTSSC	STOMACH	337	p.P342T	c.1024C>A	Missense_Mutation	1	0.11	HGC27	N	1	0	0	N
SMAD4	ETFNVPSSC	LARGE_INTESTINE	337	p.K340N	c.1020G>C	Missense_Mutation	1	0.11	T84	N	1	0	0	N
SMAD4	EYVHEFEGQ	LARGE_INTESTINE	161	p.D165E	c.495C>A	Missense_Mutation	1	0.11	HRT18	N	1	0	0	N
SMAD4	FCLGQPSNV	AUTONOMIC_GANGLIA	362	p.L367P	c.1100T>C	Missense_Mutation	1	0.11	NB1	N	7	0	1	N
SMAD4	FDSRQCHRQ	ENDOMETRIUM	438	p.L440S	c.1319T>C	Missense_Mutation	1	0.11	HEC1A	N	1	0	0	N
SMAD4	FKVTSSCPI	STOMACH	339	p.P342T	c.1024C>A	Missense_Mutation	1	0.11	HGC27	N	7	0	11	N
SMAD4	FNVPSSCPI	LARGE_INTESTINE	339	p.K340N	c.1020G>C	Missense_Mutation	1	0.11	T84	N	10	0	2	N
SMAD4	FPNISVAST	ENDOMETRIUM	214	p.P218S	c.652C>T	Missense_Mutation	1	0.11	JHUEM1	N	8	0	1	N
SMAD4	FVQSYYLER	PANCREAS	408	p.D415E	c.1245C>G	Missense_Mutation	1	0.11	SNU213	N	9	0	4	N
SMAD4	GDCFCLGQL	LARGE_INTESTINE	359	p.R361C	c.1081C>T	Missense_Mutation	1	0.11	SNU175	N	4	0	0	N
SMAD4	GDGFCLGQL	LARGE_INTESTINE	359	p.R361G	c.1081C>G	Missense_Mutation	1	0.11	SW1463	N	5	0	0	N
SMAD4	GDRFCLGQP	AUTONOMIC_GANGLIA	359	p.L367P	c.1100T>C	Missense_Mutation	1	0.11	NB1	N	0	0	0	N
SMAD4	GDSFCLGQL	STOMACH	359	p.R361S	c.1081C>A	Missense_Mutation	1	0.11	HUG1N	N	4	0	0	N
SMAD4	GETFKVTSS	STOMACH	336	p.P342T	c.1024C>A	Missense_Mutation	1	0.11	HGC27	N	4	0	0	N
SMAD4	GETFNVPSS	LARGE_INTESTINE	336	p.K340N	c.1020G>C	Missense_Mutation	1	0.11	T84	N	4	0	0	N
SMAD4	GEVLHTMPI	BILIARY_TRACT	537	p.D537G	c.1610A>G	Missense_Mutation	1	0.11	SNU308	N	7	0	0	N
SMAD4	GFCLGQLSN	LARGE_INTESTINE	361	p.R361G	c.1081C>G	Missense_Mutation	1	0.11	SW1463	N	0	0	0	N
SMAD4	GGDCFCLGQ	LARGE_INTESTINE	358	p.R361C	c.1081C>T	Missense_Mutation	1	0.11	SNU175	N	1	0	0	N
SMAD4	GGDGFCLGQ	LARGE_INTESTINE	358	p.R361G	c.1081C>G	Missense_Mutation	1	0.11	SW1463	N	1	0	0	N
SMAD4	GGDSFCLGQ	STOMACH	358	p.R361S	c.1081C>A	Missense_Mutation	1	0.11	HUG1N	N	1	0	0	N
SMAD4	GGIASAISL	CENTRAL_NERVOUS_SYSTEM	476	p.P480S	c.1438C>T	Missense_Mutation	1	0.11	SNU1105	Y	12	9	0	N
SMAD4	GIASAISLS	CENTRAL_NERVOUS_SYSTEM	477	p.P480S	c.1438C>T	Missense_Mutation	1	0.11	SNU1105	N	0	0	0	N
SMAD4	GIGVDDPRR	OVARY	489	p.L495P	c.1484T>C	Missense_Mutation	1	0.11	IGROV1	N	6	0	0	N
SMAD4	GKSVQLECK	LARGE_INTESTINE	384	p.G386S	c.1156G>A	Missense_Mutation	1	0.11	SNU175	N	1	0	0	N
SMAD4	GPSGGDRFC	LARGE_INTESTINE	355	p.D355G	c.1064A>G	Missense_Mutation	1	0.11	SNU283	N	4	0	0	N
SMAD4	GQPSLSTKG	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	168	p.E175K	c.523G>A	Missense_Mutation	1	0.11	P12ICHIKAWA	N	0	0	0	N
SMAD4	GQPSNVHRT	AUTONOMIC_GANGLIA	365	p.L367P	c.1100T>C	Missense_Mutation	1	0.11	NB1	Y	4	9	0	Y
SMAD4	GSRIAPYTP	CENTRAL_NERVOUS_SYSTEM	270	p.T273I	c.818C>T	Missense_Mutation	1	0.11	SNU738	N	0	0	0	N
SMAD4	GSVGGIASA	CENTRAL_NERVOUS_SYSTEM	473	p.P480S	c.1438C>T	Missense_Mutation	1	0.11	SNU1105	N	3	0	0	N
SMAD4	GVDDPRRLC	OVARY	491	p.L495P	c.1484T>C	Missense_Mutation	1	0.11	IGROV1	Y	0	9	0	N
SMAD4	GVQLECKCE	LUNG	386	p.G393C	c.1177G>T	Missense_Mutation	1	0.11	MORCPR	N	0	0	0	N
SMAD4	GYVDLSGGD	PANCREAS	352	p.P356L	c.1067C>T	Missense_Mutation	1	0.11	L33	N	0	0	0	N
SMAD4	GYVGPSGGD	LARGE_INTESTINE	352	p.D355G	c.1064A>G	Missense_Mutation	1	0.11	SNU283	N	0	0	0	N
SMAD4	GYVNPSGGD	BREAST	352	p.D355N	c.1063G>A	Missense_Mutation	1	0.11	AU565	N	0	0	0	N
SMAD4	HEFEGQPSL	LARGE_INTESTINE	164	p.D165E	c.495C>A	Missense_Mutation	1	0.11	HRT18	Y	14	9	0	N
SMAD4	HERVVSPGI	STOMACH	133	p.Y133H	c.397T>C	Missense_Mutation	1	0.11	IM95	N	7	0	0	N
SMAD4	HGYVDPSGG	LARGE_INTESTINE	351	p.D351H	c.1051G>C	Missense_Mutation	1	0.11	C2BBE1	N	0	0	0	N
SMAD4	HHERVVSPG	STOMACH	132	p.Y133H	c.397T>C	Missense_Mutation	1	0.11	IM95	N	0	0	0	N
SMAD4	HIGKSVQLE	LARGE_INTESTINE	382	p.G386S	c.1156G>A	Missense_Mutation	1	0.11	SNU175	N	0	0	0	N
SMAD4	HPAPEHWCS	ENDOMETRIUM	317	p.Y322H	c.964T>C	Missense_Mutation	1	0.11	HEC108	N	3	0	0	N
SMAD4	HRALQLLGE	BILIARY_TRACT	530	p.D537G	c.1610A>G	Missense_Mutation	1	0.11	SNU308	N	1	0	0	N
SMAD4	HRALQLLYE	LARGE_INTESTINE	530	p.D537Y	c.1609G>T	Missense_Mutation	1	0.11	SW948	N	1	0	0	N
SMAD4	HTVFVQSYY	LARGE_INTESTINE	405	p.A406T	c.1216G>A	Missense_Mutation	1	0.11	SNU175	Y	8	13	0	N
SMAD4	HVIYARLWT	PANCREAS	92	p.R100T	c.299G>C	Missense_Mutation	1	0.11	ASPC1	N	2	0	0	N
SMAD4	HVKYCQYVF	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	111	p.A118V	c.353C>T	Missense_Mutation	1	0.11	NUDHL1	Y	4	10	0	Y
SMAD4	HWCSIAYFE	ENDOMETRIUM	322	p.Y322H	c.964T>C	Missense_Mutation	1	0.11	HEC108	N	0	0	0	N
SMAD4	IAPYTPNLP	CENTRAL_NERVOUS_SYSTEM	273	p.T273I	c.818C>T	Missense_Mutation	1	0.11	SNU738	N	0	0	0	Y
SMAD4	IASAISLSA	CENTRAL_NERVOUS_SYSTEM	478	p.P480S	c.1438C>T	Missense_Mutation	1	0.11	SNU1105	N	5	0	1	N
SMAD4	IGKSVQLEC	LARGE_INTESTINE	383	p.G386S	c.1156G>A	Missense_Mutation	1	0.11	SNU175	N	0	0	0	N
SMAD4	IGVDDPRRL	OVARY	490	p.L495P	c.1484T>C	Missense_Mutation	1	0.11	IGROV1	N	17	0	0	N
SMAD4	IKVFDSRQC	ENDOMETRIUM	435	p.L440S	c.1319T>C	Missense_Mutation	1	0.11	HEC1A	N	1	0	20	N
SMAD4	ILRMRFVKG	OVARY	500	p.S504R	c.1512T>A	Missense_Mutation	1	0.11	MCAS	N	1	0	1	N
SMAD4	ISNHPAPEH	ENDOMETRIUM	314	p.Y322H	c.964T>C	Missense_Mutation	1	0.11	HEC108	N	0	0	0	N
SMAD4	ISVASTSQP	ENDOMETRIUM	217	p.P218S	c.652C>T	Missense_Mutation	1	0.11	JHUEM1	N	0	0	0	N
SMAD4	IVTVDGYVG	LARGE_INTESTINE	347	p.D355G	c.1064A>G	Missense_Mutation	1	0.11	SNU283	N	0	0	4	N
SMAD4	IVTVDGYVN	BREAST	347	p.D355N	c.1063G>A	Missense_Mutation	1	0.11	AU565	N	0	0	3	N
SMAD4	IVTVHGYVD	LARGE_INTESTINE	347	p.D351H	c.1051G>C	Missense_Mutation	1	0.11	C2BBE1	N	0	0	0	N
SMAD4	IVTVNGYVD	OESOPHAGUS	347	p.D351N	c.1051G>A	Missense_Mutation	1	0.11	KYSE450	N	2	0	0	N
SMAD4	IYARLWTWP	PANCREAS	94	p.R100T	c.299G>C	Missense_Mutation	1	0.11	ASPC1	N	0	0	0	N
SMAD4	KCEGDVWVR	LUNG	392	p.G393C	c.1177G>T	Missense_Mutation	1	0.11	MORCPR	N	6	0	0	N
SMAD4	KDEYVHEFE	LARGE_INTESTINE	159	p.D165E	c.495C>A	Missense_Mutation	1	0.11	HRT18	N	1	0	0	N
SMAD4	KGHSIQTIQ	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	175	p.E175K	c.523G>A	Missense_Mutation	1	0.11	P12ICHIKAWA	N	0	0	0	N
SMAD4	KGVQLECKC	LUNG	385	p.G393C	c.1177G>T	Missense_Mutation	1	0.11	MORCPR	N	1	0	0	N
SMAD4	KHVKYCQYV	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	110	p.A118V	c.353C>T	Missense_Mutation	1	0.11	NUDHL1	N	5	0	0	Y
SMAD4	KSVQLECKG	LARGE_INTESTINE	385	p.G386S	c.1156G>A	Missense_Mutation	1	0.11	SNU175	N	1	0	0	N
SMAD4	KVFDSRQCH	ENDOMETRIUM	436	p.L440S	c.1319T>C	Missense_Mutation	1	0.11	HEC1A	N	2	0	0	N
SMAD4	KVTSSCPIV	STOMACH	340	p.P342T	c.1024C>A	Missense_Mutation	1	0.11	HGC27	Y	6	10	0	N
SMAD4	KYCQYVFDL	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	113	p.A118V	c.353C>T	Missense_Mutation	1	0.11	NUDHL1	Y	9	10	0	N
SMAD4	LCILRMRFV	OVARY	498	p.S504R	c.1512T>A	Missense_Mutation	1	0.11	MCAS	N	6	0	1	N
SMAD4	LECKCEGDV	LUNG	389	p.G393C	c.1177G>T	Missense_Mutation	1	0.11	MORCPR	N	7	0	0	N
SMAD4	LEREAGRAP	PANCREAS	414	p.D415E	c.1245C>G	Missense_Mutation	1	0.11	SNU213	N	0	0	0	N
SMAD4	LGEVLHTMP	BILIARY_TRACT	536	p.D537G	c.1610A>G	Missense_Mutation	1	0.11	SNU308	N	0	0	0	N
SMAD4	LGQPSNVHR	AUTONOMIC_GANGLIA	364	p.L367P	c.1100T>C	Missense_Mutation	1	0.11	NB1	N	1	0	0	N
SMAD4	LHIGKSVQL	LARGE_INTESTINE	381	p.G386S	c.1156G>A	Missense_Mutation	1	0.11	SNU175	N	7	0	7	N
SMAD4	LHRALQLLG	BILIARY_TRACT	529	p.D537G	c.1610A>G	Missense_Mutation	1	0.11	SNU308	N	0	0	0	N
SMAD4	LHRALQLLY	LARGE_INTESTINE	529	p.D537Y	c.1609G>T	Missense_Mutation	1	0.11	SW948	N	3	0	0	N
SMAD4	LLGEVLHTM	BILIARY_TRACT	535	p.D537G	c.1610A>G	Missense_Mutation	1	0.11	SNU308	Y	6	9	0	Y
SMAD4	LLYEVLHTM	LARGE_INTESTINE	535	p.D537Y	c.1609G>T	Missense_Mutation	1	0.11	SW948	Y	13	9	1	Y
SMAD4	LQLLGEVLH	BILIARY_TRACT	533	p.D537G	c.1610A>G	Missense_Mutation	1	0.11	SNU308	N	1	0	0	Y
SMAD4	LQLLYEVLH	LARGE_INTESTINE	533	p.D537Y	c.1609G>T	Missense_Mutation	1	0.11	SW948	N	1	0	0	Y
SMAD4	LRMRFVKGW	OVARY	501	p.S504R	c.1512T>A	Missense_Mutation	1	0.11	MCAS	Y	5	11	28	N
SMAD4	LSDHTVFVQ	LARGE_INTESTINE	402	p.A406T	c.1216G>A	Missense_Mutation	1	0.11	SNU175	N	1	0	4	N
SMAD4	LSGGDRFCL	PANCREAS	356	p.P356L	c.1067C>T	Missense_Mutation	1	0.11	L33	N	11	0	0	N
SMAD4	LSTKGHSIQ	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	172	p.E175K	c.523G>A	Missense_Mutation	1	0.11	P12ICHIKAWA	N	0	0	1	N
SMAD4	LWTWPDLHK	PANCREAS	98	p.R100T	c.299G>C	Missense_Mutation	1	0.11	ASPC1	N	0	0	0	N
SMAD4	LYEVLHTMP	LARGE_INTESTINE	536	p.D537Y	c.1609G>T	Missense_Mutation	1	0.11	SW948	N	0	0	0	N
SMAD4	MRFVKGWGP	OVARY	503	p.S504R	c.1512T>A	Missense_Mutation	1	0.11	MCAS	N	2	0	5	N
SMAD4	MVKDEYVHE	LARGE_INTESTINE	157	p.D165E	c.495C>A	Missense_Mutation	1	0.11	HRT18	N	0	0	0	N
SMAD4	NATNTANFP	ENDOMETRIUM	207	p.S210N	c.629G>A	Missense_Mutation	1	0.11	JHUEM1	N	0	0	0	N
SMAD4	NFPNISVAS	ENDOMETRIUM	213	p.P218S	c.652C>T	Missense_Mutation	1	0.11	JHUEM1	N	0	0	0	N
SMAD4	NGYVDPSGG	OESOPHAGUS	351	p.D351N	c.1051G>A	Missense_Mutation	1	0.11	KYSE450	N	0	0	0	N
SMAD4	NHPAPEHWC	ENDOMETRIUM	316	p.Y322H	c.964T>C	Missense_Mutation	1	0.11	HEC108	N	1	0	0	N
SMAD4	NISVASTSQ	ENDOMETRIUM	216	p.P218S	c.652C>T	Missense_Mutation	1	0.11	JHUEM1	N	0	0	0	N
SMAD4	NPSGGDRFC	BREAST	355	p.D355N	c.1063G>A	Missense_Mutation	1	0.11	AU565	Y	4	9	0	N
SMAD4	NPYHHERVV	STOMACH	129	p.Y133H	c.397T>C	Missense_Mutation	1	0.11	IM95	Y	13	9	0	N
SMAD4	NPYYYERVV	UPPER_AERODIGESTIVE_TRACT	129	p.H132Y	c.394C>T	Missense_Mutation	1	0.11	HSC3	N	15	0	0	N
SMAD4	NTANFPNIP	ENDOMETRIUM	210	p.S210N	c.629G>A	Missense_Mutation	1	0.11	JHUEM1	N	0	0	0	N
SMAD4	NVPSSCPIV	LARGE_INTESTINE	340	p.K340N	c.1020G>C	Missense_Mutation	1	0.11	T84	Y	4	10	0	N
SMAD4	PAPEHWCSI	ENDOMETRIUM	318	p.Y322H	c.964T>C	Missense_Mutation	1	0.11	HEC108	N	3	0	0	N
SMAD4	PEHWCSIAY	ENDOMETRIUM	320	p.Y322H	c.964T>C	Missense_Mutation	1	0.11	HEC108	N	2	0	0	N
SMAD4	PGSVGGIAS	CENTRAL_NERVOUS_SYSTEM	472	p.P480S	c.1438C>T	Missense_Mutation	1	0.11	SNU1105	N	0	0	0	Y
SMAD4	PIVTVHGYV	LARGE_INTESTINE	346	p.D351H	c.1051G>C	Missense_Mutation	1	0.11	C2BBE1	N	0	0	0	N
SMAD4	PIVTVNGYV	OESOPHAGUS	346	p.D351N	c.1051G>A	Missense_Mutation	1	0.11	KYSE450	N	2	0	0	N
SMAD4	PNISVASTS	ENDOMETRIUM	215	p.P218S	c.652C>T	Missense_Mutation	1	0.11	JHUEM1	N	0	0	0	N
SMAD4	PRRLCILRM	OVARY	495	p.L495P	c.1484T>C	Missense_Mutation	1	0.11	IGROV1	N	2	0	0	N
SMAD4	PSESNATNT	ENDOMETRIUM	203	p.S210N	c.629G>A	Missense_Mutation	1	0.11	JHUEM1	N	0	0	0	N
SMAD4	PSGGDCFCL	LARGE_INTESTINE	356	p.R361C	c.1081C>T	Missense_Mutation	1	0.11	SNU175	N	0	0	0	N
SMAD4	PSGGDGFCL	LARGE_INTESTINE	356	p.R361G	c.1081C>G	Missense_Mutation	1	0.11	SW1463	N	0	0	0	N
SMAD4	PSGGDSFCL	STOMACH	356	p.R361S	c.1081C>A	Missense_Mutation	1	0.11	HUG1N	N	0	0	0	N
SMAD4	PSLSTKGHS	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	170	p.E175K	c.523G>A	Missense_Mutation	1	0.11	P12ICHIKAWA	N	0	0	0	N
SMAD4	PSNVHRTEA	AUTONOMIC_GANGLIA	367	p.L367P	c.1100T>C	Missense_Mutation	1	0.11	NB1	N	0	0	0	N
SMAD4	PYHHERVVS	STOMACH	130	p.Y133H	c.397T>C	Missense_Mutation	1	0.11	IM95	N	0	0	0	N
SMAD4	PYYYERVVS	UPPER_AERODIGESTIVE_TRACT	130	p.H132Y	c.394C>T	Missense_Mutation	1	0.11	HSC3	N	0	0	0	N
SMAD4	QAATAQASA	AUTONOMIC_GANGLIA	450	p.A457S	c.1369G>T	Missense_Mutation	1	0.11	NB1	N	2	0	0	N
SMAD4	QASAAAQAA	AUTONOMIC_GANGLIA	455	p.A457S	c.1369G>T	Missense_Mutation	1	0.11	NB1	N	2	0	0	N
SMAD4	QLECKCEGD	LUNG	388	p.G393C	c.1177G>T	Missense_Mutation	1	0.11	MORCPR	N	0	0	0	N
SMAD4	QLLGEVLHT	BILIARY_TRACT	534	p.D537G	c.1610A>G	Missense_Mutation	1	0.11	SNU308	N	4	0	0	Y
SMAD4	QLLYEVLHT	LARGE_INTESTINE	534	p.D537Y	c.1609G>T	Missense_Mutation	1	0.11	SW948	N	4	0	0	Y
SMAD4	QPSLSTKGH	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	169	p.E175K	c.523G>A	Missense_Mutation	1	0.11	P12ICHIKAWA	N	0	0	0	N
SMAD4	QPSNVHRTE	AUTONOMIC_GANGLIA	366	p.L367P	c.1100T>C	Missense_Mutation	1	0.11	NB1	N	0	0	0	N
SMAD4	QQAATAQAS	AUTONOMIC_GANGLIA	449	p.A457S	c.1369G>T	Missense_Mutation	1	0.11	NB1	N	0	0	0	N
SMAD4	QSYYLEREA	PANCREAS	410	p.D415E	c.1245C>G	Missense_Mutation	1	0.11	SNU213	N	2	0	0	N
SMAD4	QVGETFKVT	STOMACH	334	p.P342T	c.1024C>A	Missense_Mutation	1	0.11	HGC27	N	2	0	0	N
SMAD4	QVGETFNVP	LARGE_INTESTINE	334	p.K340N	c.1020G>C	Missense_Mutation	1	0.11	T84	N	0	0	0	N
SMAD4	QYVFDLKCD	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	116	p.A118V	c.353C>T	Missense_Mutation	1	0.11	NUDHL1	N	0	0	0	N
SMAD4	RALQLLGEV	BILIARY_TRACT	531	p.D537G	c.1610A>G	Missense_Mutation	1	0.11	SNU308	Y	7	12	0	N
SMAD4	RALQLLYEV	LARGE_INTESTINE	531	p.D537Y	c.1609G>T	Missense_Mutation	1	0.11	SW948	Y	8	9	0	N
SMAD4	RARLHIGKS	LARGE_INTESTINE	378	p.G386S	c.1156G>A	Missense_Mutation	1	0.11	SNU175	N	2	0	0	N
SMAD4	RCLSDHTVF	LARGE_INTESTINE	400	p.A406T	c.1216G>A	Missense_Mutation	1	0.11	SNU175	N	8	0	0	N
SMAD4	RFCLGQPSN	AUTONOMIC_GANGLIA	361	p.L367P	c.1100T>C	Missense_Mutation	1	0.11	NB1	N	0	0	0	N
SMAD4	RFVKGWGPD	OVARY	504	p.S504R	c.1512T>A	Missense_Mutation	1	0.11	MCAS	N	1	0	0	N
SMAD4	RIAPYTPNL	CENTRAL_NERVOUS_SYSTEM	272	p.T273I	c.818C>T	Missense_Mutation	1	0.11	SNU738	Y	10	11	0	Y
SMAD4	RLCILRMRF	OVARY	497	p.S504R	c.1512T>A	Missense_Mutation	1	0.11	MCAS	Y	8	10	0	N
SMAD4	RLHIGKSVQ	LARGE_INTESTINE	380	p.G386S	c.1156G>A	Missense_Mutation	1	0.11	SNU175	N	1	0	0	N
SMAD4	RLWTWPDLH	PANCREAS	97	p.R100T	c.299G>C	Missense_Mutation	1	0.11	ASPC1	N	5	0	0	N
SMAD4	RMRFVKGWG	OVARY	502	p.S504R	c.1512T>A	Missense_Mutation	1	0.11	MCAS	N	1	0	0	N
SMAD4	RRLCILRMR	OVARY	496	p.S504R	c.1512T>A	Missense_Mutation	1	0.11	MCAS	Y	3	9	0	N
SMAD4	SAAAQAAAV	AUTONOMIC_GANGLIA	457	p.A457S	c.1369G>T	Missense_Mutation	1	0.11	NB1	N	4	0	0	N
SMAD4	SAISLSAAA	CENTRAL_NERVOUS_SYSTEM	480	p.P480S	c.1438C>T	Missense_Mutation	1	0.11	SNU1105	N	5	0	0	Y
SMAD4	SAYIKVFDS	ENDOMETRIUM	432	p.L440S	c.1319T>C	Missense_Mutation	1	0.11	HEC1A	N	4	0	0	N
SMAD4	SCPIVTVHG	LARGE_INTESTINE	344	p.D351H	c.1051G>C	Missense_Mutation	1	0.11	C2BBE1	N	0	0	0	N
SMAD4	SCPIVTVNG	OESOPHAGUS	344	p.D351N	c.1051G>A	Missense_Mutation	1	0.11	KYSE450	N	0	0	0	N
SMAD4	SDHTVFVQS	LARGE_INTESTINE	403	p.A406T	c.1216G>A	Missense_Mutation	1	0.11	SNU175	N	2	0	0	N
SMAD4	SESNATNTA	ENDOMETRIUM	204	p.S210N	c.629G>A	Missense_Mutation	1	0.11	JHUEM1	N	5	0	0	N
SMAD4	SFCLGQLSN	STOMACH	361	p.R361S	c.1081C>A	Missense_Mutation	1	0.11	HUG1N	N	0	0	0	N
SMAD4	SGGDCFCLG	LARGE_INTESTINE	357	p.R361C	c.1081C>T	Missense_Mutation	1	0.11	SNU175	N	0	0	0	N
SMAD4	SGGDGFCLG	LARGE_INTESTINE	357	p.R361G	c.1081C>G	Missense_Mutation	1	0.11	SW1463	N	0	0	0	N
SMAD4	SGGDSFCLG	STOMACH	357	p.R361S	c.1081C>A	Missense_Mutation	1	0.11	HUG1N	N	0	0	0	N
SMAD4	SLSTKGHSI	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	171	p.E175K	c.523G>A	Missense_Mutation	1	0.11	P12ICHIKAWA	Y	8	13	0	N
SMAD4	SNATNTANF	ENDOMETRIUM	206	p.S210N	c.629G>A	Missense_Mutation	1	0.11	JHUEM1	N	3	0	0	N
SMAD4	SNHPAPEHW	ENDOMETRIUM	315	p.Y322H	c.964T>C	Missense_Mutation	1	0.11	HEC108	N	2	0	0	N
SMAD4	SRIAPYTPN	CENTRAL_NERVOUS_SYSTEM	271	p.T273I	c.818C>T	Missense_Mutation	1	0.11	SNU738	N	2	0	0	N
SMAD4	SRQCHRQMQ	ENDOMETRIUM	440	p.L440S	c.1319T>C	Missense_Mutation	1	0.11	HEC1A	N	1	0	0	N
SMAD4	SSCPIVTVH	LARGE_INTESTINE	343	p.D351H	c.1051G>C	Missense_Mutation	1	0.11	C2BBE1	N	0	0	0	N
SMAD4	SSCPIVTVN	OESOPHAGUS	343	p.D351N	c.1051G>A	Missense_Mutation	1	0.11	KYSE450	N	1	0	0	N
SMAD4	STANFPNIS	ENDOMETRIUM	210	p.P218S	c.652C>T	Missense_Mutation	1	0.11	JHUEM1	N	0	0	0	N
SMAD4	STKGHSIQT	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	173	p.E175K	c.523G>A	Missense_Mutation	1	0.11	P12ICHIKAWA	N	1	0	0	N
SMAD4	SVASTSQPA	ENDOMETRIUM	218	p.P218S	c.652C>T	Missense_Mutation	1	0.11	JHUEM1	N	1	0	0	N
SMAD4	SVCVNPYHH	STOMACH	125	p.Y133H	c.397T>C	Missense_Mutation	1	0.11	IM95	N	2	0	0	N
SMAD4	SVCVNPYYY	UPPER_AERODIGESTIVE_TRACT	125	p.H132Y	c.394C>T	Missense_Mutation	1	0.11	HSC3	Y	5	16	0	N
SMAD4	SVGGIASAI	CENTRAL_NERVOUS_SYSTEM	474	p.P480S	c.1438C>T	Missense_Mutation	1	0.11	SNU1105	Y	5	12	0	N
SMAD4	SVQLECKGE	LARGE_INTESTINE	386	p.G386S	c.1156G>A	Missense_Mutation	1	0.11	SNU175	N	0	0	0	N
SMAD4	SYYLEREAG	PANCREAS	411	p.D415E	c.1245C>G	Missense_Mutation	1	0.11	SNU213	N	0	0	0	N
SMAD4	TANFPNISV	ENDOMETRIUM	211	p.P218S	c.652C>T	Missense_Mutation	1	0.11	JHUEM1	Y	3	9	0	N
SMAD4	TAQASAAAQ	AUTONOMIC_GANGLIA	453	p.A457S	c.1369G>T	Missense_Mutation	1	0.11	NB1	N	0	0	0	N
SMAD4	TFKVTSSCP	STOMACH	338	p.P342T	c.1024C>A	Missense_Mutation	1	0.11	HGC27	N	0	0	0	N
SMAD4	TFNVPSSCP	LARGE_INTESTINE	338	p.K340N	c.1020G>C	Missense_Mutation	1	0.11	T84	N	0	0	0	N
SMAD4	TGSRIAPYT	CENTRAL_NERVOUS_SYSTEM	269	p.T273I	c.818C>T	Missense_Mutation	1	0.11	SNU738	N	0	0	0	N
SMAD4	TKGHSIQTI	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	174	p.E175K	c.523G>A	Missense_Mutation	1	0.11	P12ICHIKAWA	Y	1	11	0	N
SMAD4	TNTANFPNI	ENDOMETRIUM	209	p.S210N	c.629G>A	Missense_Mutation	1	0.11	JHUEM1	Y	4	17	0	N
SMAD4	TSSCPIVTV	STOMACH	342	p.P342T	c.1024C>A	Missense_Mutation	1	0.11	HGC27	Y	4	10	0	N
SMAD4	TTTWTGSRI	CENTRAL_NERVOUS_SYSTEM	265	p.T273I	c.818C>T	Missense_Mutation	1	0.11	SNU738	N	3	0	0	N
SMAD4	TTWTGSRIA	CENTRAL_NERVOUS_SYSTEM	266	p.T273I	c.818C>T	Missense_Mutation	1	0.11	SNU738	N	3	0	0	N
SMAD4	TVDGYVDLS	PANCREAS	349	p.P356L	c.1067C>T	Missense_Mutation	1	0.11	L33	N	0	0	0	N
SMAD4	TVDGYVGPS	LARGE_INTESTINE	349	p.D355G	c.1064A>G	Missense_Mutation	1	0.11	SNU283	N	0	0	0	N
SMAD4	TVDGYVNPS	BREAST	349	p.D355N	c.1063G>A	Missense_Mutation	1	0.11	AU565	N	0	0	0	N
SMAD4	TVFVQSYYL	LARGE_INTESTINE	406	p.A406T	c.1216G>A	Missense_Mutation	1	0.11	SNU175	Y	15	11	0	N
SMAD4	TVHGYVDPS	LARGE_INTESTINE	349	p.D351H	c.1051G>C	Missense_Mutation	1	0.11	C2BBE1	N	0	0	0	N
SMAD4	TVNGYVDPS	OESOPHAGUS	349	p.D351N	c.1051G>A	Missense_Mutation	1	0.11	KYSE450	N	0	0	0	N
SMAD4	TWPDLHKNE	PANCREAS	100	p.R100T	c.299G>C	Missense_Mutation	1	0.11	ASPC1	N	0	0	0	N
SMAD4	TWTGSRIAP	CENTRAL_NERVOUS_SYSTEM	267	p.T273I	c.818C>T	Missense_Mutation	1	0.11	SNU738	N	0	0	0	N
SMAD4	VCVNPYHHE	STOMACH	126	p.Y133H	c.397T>C	Missense_Mutation	1	0.11	IM95	N	0	0	0	N
SMAD4	VCVNPYYYE	UPPER_AERODIGESTIVE_TRACT	126	p.H132Y	c.394C>T	Missense_Mutation	1	0.11	HSC3	N	0	0	0	N
SMAD4	VDDPRRLCI	OVARY	492	p.L495P	c.1484T>C	Missense_Mutation	1	0.11	IGROV1	N	5	0	0	N
SMAD4	VDGYVDLSG	PANCREAS	350	p.P356L	c.1067C>T	Missense_Mutation	1	0.11	L33	N	0	0	0	N
SMAD4	VDGYVGPSG	LARGE_INTESTINE	350	p.D355G	c.1064A>G	Missense_Mutation	1	0.11	SNU283	N	0	0	0	N
SMAD4	VDGYVNPSG	BREAST	350	p.D355N	c.1063G>A	Missense_Mutation	1	0.11	AU565	N	0	0	0	N
SMAD4	VDLSGGDRF	PANCREAS	354	p.P356L	c.1067C>T	Missense_Mutation	1	0.11	L33	N	6	0	0	N
SMAD4	VDPSGGDCF	LARGE_INTESTINE	354	p.R361C	c.1081C>T	Missense_Mutation	1	0.11	SNU175	N	8	0	0	N
SMAD4	VDPSGGDGF	LARGE_INTESTINE	354	p.R361G	c.1081C>G	Missense_Mutation	1	0.11	SW1463	N	7	0	0	N
SMAD4	VDPSGGDSF	STOMACH	354	p.R361S	c.1081C>A	Missense_Mutation	1	0.11	HUG1N	N	8	0	0	N
SMAD4	VFDLKCDSV	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	118	p.A118V	c.353C>T	Missense_Mutation	1	0.11	NUDHL1	N	4	0	0	N
SMAD4	VFDSRQCHR	ENDOMETRIUM	437	p.L440S	c.1319T>C	Missense_Mutation	1	0.11	HEC1A	Y	2	9	0	N
SMAD4	VGETFKVTS	STOMACH	335	p.P342T	c.1024C>A	Missense_Mutation	1	0.11	HGC27	N	0	0	0	N
SMAD4	VGETFNVPS	LARGE_INTESTINE	335	p.K340N	c.1020G>C	Missense_Mutation	1	0.11	T84	N	0	0	0	N
SMAD4	VGGIASAIS	CENTRAL_NERVOUS_SYSTEM	475	p.P480S	c.1438C>T	Missense_Mutation	1	0.11	SNU1105	N	0	0	15	N
SMAD4	VGPSGGDRF	LARGE_INTESTINE	354	p.D355G	c.1064A>G	Missense_Mutation	1	0.11	SNU283	N	6	0	0	N
SMAD4	VHEFEGQPS	LARGE_INTESTINE	163	p.D165E	c.495C>A	Missense_Mutation	1	0.11	HRT18	N	2	0	0	N
SMAD4	VHGYVDPSG	LARGE_INTESTINE	350	p.D351H	c.1051G>C	Missense_Mutation	1	0.11	C2BBE1	N	0	0	0	N
SMAD4	VIYARLWTW	PANCREAS	93	p.R100T	c.299G>C	Missense_Mutation	1	0.11	ASPC1	Y	8	9	0	N
SMAD4	VKDEYVHEF	LARGE_INTESTINE	158	p.D165E	c.495C>A	Missense_Mutation	1	0.11	HRT18	N	4	0	0	N
SMAD4	VKYCQYVFD	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	112	p.A118V	c.353C>T	Missense_Mutation	1	0.11	NUDHL1	N	0	0	0	Y
SMAD4	VNGYVDPSG	OESOPHAGUS	350	p.D351N	c.1051G>A	Missense_Mutation	1	0.11	KYSE450	N	0	0	0	N
SMAD4	VNPSGGDRF	BREAST	354	p.D355N	c.1063G>A	Missense_Mutation	1	0.11	AU565	N	5	0	0	N
SMAD4	VNPYHHERV	STOMACH	128	p.Y133H	c.397T>C	Missense_Mutation	1	0.11	IM95	N	2	0	0	N
SMAD4	VNPYYYERV	UPPER_AERODIGESTIVE_TRACT	128	p.H132Y	c.394C>T	Missense_Mutation	1	0.11	HSC3	N	6	0	2	N
SMAD4	VQLECKCEG	LUNG	387	p.G393C	c.1177G>T	Missense_Mutation	1	0.11	MORCPR	N	0	0	6	N
SMAD4	VQSYYLERE	PANCREAS	409	p.D415E	c.1245C>G	Missense_Mutation	1	0.11	SNU213	N	0	0	2	N
SMAD4	VQVGETFNV	LARGE_INTESTINE	333	p.K340N	c.1020G>C	Missense_Mutation	1	0.11	T84	Y	10	11	7	N
SMAD4	VRCLSDHTV	LARGE_INTESTINE	399	p.A406T	c.1216G>A	Missense_Mutation	1	0.11	SNU175	N	4	0	2	N
SMAD4	VTSSCPIVT	STOMACH	341	p.P342T	c.1024C>A	Missense_Mutation	1	0.11	HGC27	N	1	0	0	N
SMAD4	VTVDGYVDL	PANCREAS	348	p.P356L	c.1067C>T	Missense_Mutation	1	0.11	L33	N	17	0	0	N
SMAD4	VTVDGYVGP	LARGE_INTESTINE	348	p.D355G	c.1064A>G	Missense_Mutation	1	0.11	SNU283	N	0	0	0	N
SMAD4	VTVDGYVNP	BREAST	348	p.D355N	c.1063G>A	Missense_Mutation	1	0.11	AU565	N	0	0	0	N
SMAD4	VTVHGYVDP	LARGE_INTESTINE	348	p.D351H	c.1051G>C	Missense_Mutation	1	0.11	C2BBE1	N	0	0	0	N
SMAD4	VTVNGYVDP	OESOPHAGUS	348	p.D351N	c.1051G>A	Missense_Mutation	1	0.11	KYSE450	N	0	0	0	N
SMAD4	WTGSRIAPY	CENTRAL_NERVOUS_SYSTEM	268	p.T273I	c.818C>T	Missense_Mutation	1	0.11	SNU738	Y	9	14	0	N
SMAD4	WTWPDLHKN	PANCREAS	99	p.R100T	c.299G>C	Missense_Mutation	1	0.11	ASPC1	N	3	0	0	N
SMAD4	WVRCLSDHT	LARGE_INTESTINE	398	p.A406T	c.1216G>A	Missense_Mutation	1	0.11	SNU175	N	4	0	5	N
SMAD4	YARLWTWPD	PANCREAS	95	p.R100T	c.299G>C	Missense_Mutation	1	0.11	ASPC1	N	2	0	6	N
SMAD4	YCQYVFDLK	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	114	p.A118V	c.353C>T	Missense_Mutation	1	0.11	NUDHL1	N	4	0	0	N
SMAD4	YEVLHTMPI	LARGE_INTESTINE	537	p.D537Y	c.1609G>T	Missense_Mutation	1	0.11	SW948	N	10	0	29	N
SMAD4	YHHERVVSP	STOMACH	131	p.Y133H	c.397T>C	Missense_Mutation	1	0.11	IM95	N	2	0	3	N
SMAD4	YIKVFDSRQ	ENDOMETRIUM	434	p.L440S	c.1319T>C	Missense_Mutation	1	0.11	HEC1A	N	2	0	2	N
SMAD4	YLEREAGRA	PANCREAS	413	p.D415E	c.1245C>G	Missense_Mutation	1	0.11	SNU213	N	3	0	1	N
SMAD4	YVDLSGGDR	PANCREAS	353	p.P356L	c.1067C>T	Missense_Mutation	1	0.11	L33	N	8	0	2	N
SMAD4	YVDPSGGDC	LARGE_INTESTINE	353	p.R361C	c.1081C>T	Missense_Mutation	1	0.11	SNU175	Y	2	11	0	N
SMAD4	YVDPSGGDG	LARGE_INTESTINE	353	p.R361G	c.1081C>G	Missense_Mutation	1	0.11	SW1463	N	2	0	0	N
SMAD4	YVDPSGGDS	STOMACH	353	p.R361S	c.1081C>A	Missense_Mutation	1	0.11	HUG1N	N	2	0	0	N
SMAD4	YVFDLKCDS	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	117	p.A118V	c.353C>T	Missense_Mutation	1	0.11	NUDHL1	N	2	0	35	N
SMAD4	YVGPSGGDR	LARGE_INTESTINE	353	p.D355G	c.1064A>G	Missense_Mutation	1	0.11	SNU283	N	6	0	2	N
SMAD4	YVHEFEGQP	LARGE_INTESTINE	162	p.D165E	c.495C>A	Missense_Mutation	1	0.11	HRT18	N	2	0	0	N
SMAD4	YVNPSGGDR	BREAST	353	p.D355N	c.1063G>A	Missense_Mutation	1	0.11	AU565	Y	7	9	2	N
SMAD4	YYERVVSPG	UPPER_AERODIGESTIVE_TRACT	132	p.H132Y	c.394C>T	Missense_Mutation	1	0.11	HSC3	N	1	0	2	N
SMAD4	YYLEREAGR	PANCREAS	412	p.D415E	c.1245C>G	Missense_Mutation	1	0.11	SNU213	Y	3	9	0	N
SMAD4	YYYERVVSP	UPPER_AERODIGESTIVE_TRACT	131	p.H132Y	c.394C>T	Missense_Mutation	1	0.11	HSC3	N	2	0	3	N
SMAD4	AFQPAISNH	SKIN	309	p.P313A	c.937C>G	Missense_Mutation	1	0.22	WM115	N	0	0	0	N
SMAD4	AFQPAISNH	SKIN	309	p.P313A	c.937C>G	Missense_Mutation	1	0.22	WM2664	N	0	0	0	N
SMAD4	AISNHPAPE	SKIN	313	p.P313A	c.937C>G	Missense_Mutation	1	0.22	WM115	N	0	0	0	N
SMAD4	AISNHPAPE	SKIN	313	p.P313A	c.937C>G	Missense_Mutation	1	0.22	WM2664	N	0	0	0	N
SMAD4	ELAFQPAIS	SKIN	307	p.P313A	c.937C>G	Missense_Mutation	1	0.22	WM115	N	0	0	0	N
SMAD4	ELAFQPAIS	SKIN	307	p.P313A	c.937C>G	Missense_Mutation	1	0.22	WM2664	N	0	0	0	N
SMAD4	FQPAISNHP	SKIN	310	p.P313A	c.937C>G	Missense_Mutation	1	0.22	WM115	N	2	0	5	N
SMAD4	FQPAISNHP	SKIN	310	p.P313A	c.937C>G	Missense_Mutation	1	0.22	WM2664	N	2	0	5	N
SMAD4	HNELAFQPA	SKIN	305	p.P313A	c.937C>G	Missense_Mutation	1	0.22	WM115	N	1	0	0	N
SMAD4	HNELAFQPA	SKIN	305	p.P313A	c.937C>G	Missense_Mutation	1	0.22	WM2664	N	1	0	0	N
SMAD4	LAFQPAISN	SKIN	308	p.P313A	c.937C>G	Missense_Mutation	1	0.22	WM115	N	3	0	0	N
SMAD4	LAFQPAISN	SKIN	308	p.P313A	c.937C>G	Missense_Mutation	1	0.22	WM2664	N	3	0	0	N
SMAD4	NELAFQPAI	SKIN	306	p.P313A	c.937C>G	Missense_Mutation	1	0.22	WM115	Y	9	9	0	N
SMAD4	NELAFQPAI	SKIN	306	p.P313A	c.937C>G	Missense_Mutation	1	0.22	WM2664	Y	9	9	0	N
SMAD4	PAISNHPAP	SKIN	312	p.P313A	c.937C>G	Missense_Mutation	1	0.22	WM115	N	0	0	0	N
SMAD4	PAISNHPAP	SKIN	312	p.P313A	c.937C>G	Missense_Mutation	1	0.22	WM2664	N	0	0	0	N
SMAD4	QPAISNHPA	SKIN	311	p.P313A	c.937C>G	Missense_Mutation	1	0.22	WM115	N	8	0	0	N
SMAD4	QPAISNHPA	SKIN	311	p.P313A	c.937C>G	Missense_Mutation	1	0.22	WM2664	N	8	0	0	N
SMAD4	VFVQSYYLE	PANCREAS	407	p.D415E	c.1245C>G	Missense_Mutation	1	0.22	SNU213	N	0	0	0	N
SMAD4	DHFCLGQLS	LARGE_INTESTINE	360	p.R361H	c.1082G>A	Missense_Mutation	1	0.33	RCM1	N	1	0	0	N
SMAD4	DHFCLGQLS	STOMACH	360	p.R361H	c.1082G>A	Missense_Mutation	1	0.33	SNU1	N	1	0	0	N
SMAD4	DHFCLGQLS	BILIARY_TRACT	360	p.R361H	c.1082G>A	Missense_Mutation	1	0.33	SNU869	N	1	0	0	N
SMAD4	DPSGGDHFC	LARGE_INTESTINE	355	p.R361H	c.1082G>A	Missense_Mutation	1	0.33	RCM1	Y	5	10	0	N
SMAD4	DPSGGDHFC	STOMACH	355	p.R361H	c.1082G>A	Missense_Mutation	1	0.33	SNU1	Y	5	10	0	N
SMAD4	DPSGGDHFC	BILIARY_TRACT	355	p.R361H	c.1082G>A	Missense_Mutation	1	0.33	SNU869	Y	5	10	0	N
SMAD4	GDHFCLGQL	LARGE_INTESTINE	359	p.R361H	c.1082G>A	Missense_Mutation	1	0.33	RCM1	N	5	0	0	N
SMAD4	GDHFCLGQL	STOMACH	359	p.R361H	c.1082G>A	Missense_Mutation	1	0.33	SNU1	N	5	0	0	N
SMAD4	GDHFCLGQL	BILIARY_TRACT	359	p.R361H	c.1082G>A	Missense_Mutation	1	0.33	SNU869	N	5	0	0	N
SMAD4	GGDHFCLGQ	LARGE_INTESTINE	358	p.R361H	c.1082G>A	Missense_Mutation	1	0.33	RCM1	N	1	0	0	N
SMAD4	GGDHFCLGQ	STOMACH	358	p.R361H	c.1082G>A	Missense_Mutation	1	0.33	SNU1	N	1	0	0	N
SMAD4	GGDHFCLGQ	BILIARY_TRACT	358	p.R361H	c.1082G>A	Missense_Mutation	1	0.33	SNU869	N	1	0	0	N
SMAD4	HFCLGQLSN	LARGE_INTESTINE	361	p.R361H	c.1082G>A	Missense_Mutation	1	0.33	RCM1	N	0	0	0	N
SMAD4	HFCLGQLSN	STOMACH	361	p.R361H	c.1082G>A	Missense_Mutation	1	0.33	SNU1	N	0	0	0	N
SMAD4	HFCLGQLSN	BILIARY_TRACT	361	p.R361H	c.1082G>A	Missense_Mutation	1	0.33	SNU869	N	0	0	0	N
SMAD4	PSGGDHFCL	LARGE_INTESTINE	356	p.R361H	c.1082G>A	Missense_Mutation	1	0.33	RCM1	N	0	0	0	N
SMAD4	PSGGDHFCL	STOMACH	356	p.R361H	c.1082G>A	Missense_Mutation	1	0.33	SNU1	N	0	0	0	N
SMAD4	PSGGDHFCL	BILIARY_TRACT	356	p.R361H	c.1082G>A	Missense_Mutation	1	0.33	SNU869	N	0	0	0	N
SMAD4	SGGDHFCLG	LARGE_INTESTINE	357	p.R361H	c.1082G>A	Missense_Mutation	1	0.33	RCM1	N	0	0	0	N
SMAD4	SGGDHFCLG	STOMACH	357	p.R361H	c.1082G>A	Missense_Mutation	1	0.33	SNU1	N	0	0	0	N
SMAD4	SGGDHFCLG	BILIARY_TRACT	357	p.R361H	c.1082G>A	Missense_Mutation	1	0.33	SNU869	N	0	0	0	N
SMAD4	VDPSGGDHF	LARGE_INTESTINE	354	p.R361H	c.1082G>A	Missense_Mutation	1	0.33	RCM1	N	7	0	0	N
SMAD4	VDPSGGDHF	STOMACH	354	p.R361H	c.1082G>A	Missense_Mutation	1	0.33	SNU1	N	7	0	0	N
SMAD4	VDPSGGDHF	BILIARY_TRACT	354	p.R361H	c.1082G>A	Missense_Mutation	1	0.33	SNU869	N	7	0	0	N
SMAD4	YVDPSGGDH	LARGE_INTESTINE	353	p.R361H	c.1082G>A	Missense_Mutation	1	0.33	RCM1	N	3	0	0	N
SMAD4	YVDPSGGDH	STOMACH	353	p.R361H	c.1082G>A	Missense_Mutation	1	0.33	SNU1	N	3	0	0	N
SMAD4	YVDPSGGDH	BILIARY_TRACT	353	p.R361H	c.1082G>A	Missense_Mutation	1	0.33	SNU869	N	3	0	0	N