Cancertope: In silico Platform for designing genome-based Personalized immunotherapy or Vaccine against Cancer

Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

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The result page of search shows exclusive peptide/epitopes generated due to mutation [Neoepitope], the tissue of origin [Tissue], position of peptide in protein [Position], number of mismatches counted by aligning mutated and normal protein sequence [Num Mismatch, percentage of cell lines with this peptide over total number of cell lines [Promiscuity %]. The immune information include CTL epitopes (Yes/No), MHC I binders, MHC II binders (both given as number of alleles) and B cell epitopes (Yes/No). For more information, please click HERE

Protein	Neoepitopes	Tissue	Position	Prot Mutation	cDNA Mutation	Mutation Type	Num Mismatch	Promiscuity (%)	Cell Line	CTL	MHC I	NHLApred	MHC II	Bcell
Result		Search:
SMAD4	ADCRPTTFR	BILIARY_TRACT	539	p.V539fs	c.1615_1628delGTACTTCATACCAT	Frame_Shift_Del	7	0.11	SNU245	N	1	0	0	N
SMAD4	AIFSTTRLC	PANCREAS	282	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	N	0	0	0	N
SMAD4	CRPIPDITG	PANCREAS	290	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	N	1	0	0	N
SMAD4	DCRPTTFRL	BILIARY_TRACT	540	p.V539fs	c.1615_1628delGTACTTCATACCAT	Frame_Shift_Del	6	0.11	SNU245	Y	5	10	0	N
SMAD4	EADCRPTTF	BILIARY_TRACT	538	p.V539fs	c.1615_1628delGTACTTCATACCAT	Frame_Shift_Del	6	0.11	SNU245	Y	4	9	0	N
SMAD4	EHWMGGFRW	OVARY	76	p.T63fs	c.189_189delA	Frame_Shift_Del	6	0.11	JHOM2B	N	2	0	0	N
SMAD4	ELILVNVLP	OVARY	65	p.T63fs	c.189_189delA	Frame_Shift_Del	6	0.11	JHOM2B	N	0	0	0	N
SMAD4	EMLFIRSTQ	PANCREAS	422	p.L414fs	c.1242_1245delAGAC	Frame_Shift_Del	6	0.11	KP2	N	1	0	0	N
SMAD4	EVGLHHTHL	PANCREAS	266	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	N	5	0	0	N
SMAD4	FIRSTQVHI	PANCREAS	425	p.L414fs	c.1242_1245delAGAC	Frame_Shift_Del	6	0.11	KP2	N	8	0	6	N
SMAD4	FRWLVGKDF	OVARY	82	p.T63fs	c.189_189delA	Frame_Shift_Del	6	0.11	JHOM2B	N	6	0	11	N
SMAD4	FTMSLHSSL	PANCREAS	300	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	N	14	0	2	N
SMAD4	GAAIVKDCC	UPPER_AERODIGESTIVE_TRACT	230	p.L229fs	c.687_687delG	Frame_Shift_Del	6	0.11	PECAPJ34CLONEC12	N	3	0	0	N
SMAD4	GFRWLVGKD	OVARY	81	p.T63fs	c.189_189delA	Frame_Shift_Del	6	0.11	JHOM2B	N	0	0	0	N
SMAD4	GLEVGLHHT	PANCREAS	264	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	N	2	0	0	N
SMAD4	GLFTMSLHS	PANCREAS	298	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	N	2	0	0	N
SMAD4	GLHHTHLIC	PANCREAS	268	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	N	2	0	0	N
SMAD4	GQQLVSQLL	PANCREAS	247	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	N	11	0	0	N
SMAD4	GVPLLTLKW	PANCREAS	319	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	N	1	0	0	N
SMAD4	HHTHLICLT	PANCREAS	270	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	N	1	0	0	N
SMAD4	HLEMLFIRS	PANCREAS	420	p.L414fs	c.1242_1245delAGAC	Frame_Shift_Del	6	0.11	KP2	N	1	0	0	N
SMAD4	HTHLICLTT	PANCREAS	271	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	N	1	0	0	N
SMAD4	HWMGGFRWL	OVARY	77	p.T63fs	c.189_189delA	Frame_Shift_Del	6	0.11	JHOM2B	Y	8	13	0	N
SMAD4	ICLTTKTAI	PANCREAS	275	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	N	9	0	2	N
SMAD4	IFSTTRLCR	PANCREAS	283	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	N	2	0	2	N
SMAD4	IILLLSIGV	PANCREAS	312	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	N	8	0	24	N
SMAD4	IITALPPGL	PANCREAS	257	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	N	6	0	2	N
SMAD4	ILLLSIGVP	PANCREAS	313	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	N	0	0	6	N
SMAD4	IPDITGLFT	PANCREAS	293	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	N	6	0	0	N
SMAD4	ITALPPGLE	PANCREAS	258	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	N	0	0	0	N
SMAD4	ITGLFTMSL	PANCREAS	296	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	Y	10	11	15	N
SMAD4	ITTMELILV	OVARY	61	p.T63fs	c.189_189delA	Frame_Shift_Del	6	0.11	JHOM2B	N	5	0	0	N
SMAD4	LEMLFIRST	PANCREAS	421	p.L414fs	c.1242_1245delAGAC	Frame_Shift_Del	6	0.11	KP2	N	5	0	11	N
SMAD4	LEVGLHHTH	PANCREAS	265	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	N	1	0	0	N
SMAD4	LFIRSTQVH	PANCREAS	424	p.L414fs	c.1242_1245delAGAC	Frame_Shift_Del	6	0.11	KP2	N	0	0	19	N
SMAD4	LFTMSLHSS	PANCREAS	299	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	N	0	0	22	N
SMAD4	LGAAIVKDC	UPPER_AERODIGESTIVE_TRACT	229	p.L229fs	c.687_687delG	Frame_Shift_Del	6	0.11	PECAPJ34CLONEC12	N	0	0	0	N
SMAD4	LHHTHLICL	PANCREAS	269	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	N	8	0	2	N
SMAD4	LHSSLPFPI	PANCREAS	304	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	N	6	0	7	N
SMAD4	LICLTTKTA	PANCREAS	274	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	N	1	0	19	N
SMAD4	LLTLKWMFR	PANCREAS	322	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	N	6	0	0	N
SMAD4	LPFPIILLL	PANCREAS	308	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	Y	30	10	0	N
SMAD4	LPYREHWMG	OVARY	72	p.T63fs	c.189_189delA	Frame_Shift_Del	6	0.11	JHOM2B	N	3	0	0	N
SMAD4	LTIITALPP	PANCREAS	255	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	N	0	0	8	N
SMAD4	LVSQLLTII	PANCREAS	250	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	N	8	0	14	N
SMAD4	MELILVNVL	OVARY	64	p.T63fs	c.189_189delA	Frame_Shift_Del	6	0.11	JHOM2B	Y	13	9	13	N
SMAD4	MLFIRSTQV	PANCREAS	423	p.L414fs	c.1242_1245delAGAC	Frame_Shift_Del	6	0.11	KP2	Y	15	9	15	N
SMAD4	MSLHSSLPF	PANCREAS	302	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	N	9	0	12	N
SMAD4	NVLPYREHW	OVARY	70	p.T63fs	c.189_189delA	Frame_Shift_Del	6	0.11	JHOM2B	Y	1	9	0	N
SMAD4	PDITGLFTM	PANCREAS	294	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	N	1	0	0	N
SMAD4	PGLEVGLHH	PANCREAS	263	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	N	0	0	0	N
SMAD4	PIILLLSIG	PANCREAS	311	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	N	0	0	0	N
SMAD4	PLLTLKWMF	PANCREAS	321	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	N	3	0	0	N
SMAD4	PYREHWMGG	OVARY	73	p.T63fs	c.189_189delA	Frame_Shift_Del	6	0.11	JHOM2B	N	0	0	0	N
SMAD4	QLVSQLLTI	PANCREAS	249	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	Y	11	11	0	N
SMAD4	REHWMGGFR	OVARY	75	p.T63fs	c.189_189delA	Frame_Shift_Del	6	0.11	JHOM2B	N	1	0	0	N
SMAD4	RLCRPIPDI	PANCREAS	288	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	Y	9	15	0	N
SMAD4	RWLVGKDFL	OVARY	83	p.T63fs	c.189_189delA	Frame_Shift_Del	6	0.11	JHOM2B	N	9	0	0	N
SMAD4	SLHSSLPFP	PANCREAS	303	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	N	0	0	0	N
SMAD4	SLPFPIILL	PANCREAS	307	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	Y	15	10	0	N
SMAD4	TGLFTMSLH	PANCREAS	297	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	N	0	0	0	N
SMAD4	THLICLTTK	PANCREAS	272	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	N	0	0	0	N
SMAD4	TIITALPPG	PANCREAS	256	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	N	0	0	0	N
SMAD4	TMELILVNV	OVARY	63	p.T63fs	c.189_189delA	Frame_Shift_Del	6	0.11	JHOM2B	N	6	0	0	N
SMAD4	TRLCRPIPD	PANCREAS	287	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	N	2	0	0	N
SMAD4	TTMELILVN	OVARY	62	p.T63fs	c.189_189delA	Frame_Shift_Del	6	0.11	JHOM2B	N	1	0	0	N
SMAD4	TTRLCRPIP	PANCREAS	286	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	N	0	0	0	N
SMAD4	VGLHHTHLI	PANCREAS	267	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	N	11	0	20	N
SMAD4	VLPYREHWM	OVARY	71	p.T63fs	c.189_189delA	Frame_Shift_Del	6	0.11	JHOM2B	N	7	0	2	N
SMAD4	VPLLTLKWM	PANCREAS	320	p.Q250fs	c.748_760delCAGAATGGATTTA	Frame_Shift_Del	6	0.11	TCCPAN2	N	13	0	0	N
SMAD4	WLVGKDFLM	OVARY	84	p.T63fs	c.189_189delA	Frame_Shift_Del	6	0.11	JHOM2B	Y	10	9	0	N
SMAD4	WMGGFRWLV	OVARY	78	p.T63fs	c.189_189delA	Frame_Shift_Del	6	0.11	JHOM2B	Y	8	10	1	N
SMAD4	YLEKLGVHL	PANCREAS	413	p.L414fs	c.1242_1245delAGAC	Frame_Shift_Del	6	0.11	KP2	Y	13	11	0	N
SMAD4	YREHWMGGF	OVARY	74	p.T63fs	c.189_189delA	Frame_Shift_Del	6	0.11	JHOM2B	N	6	0	0	N
SMAD4	YYLEKLGVH	PANCREAS	412	p.L414fs	c.1242_1245delAGAC	Frame_Shift_Del	6	0.11	KP2	N	2	0	1	N