Cancertope: In silico Platform for designing genome-based Personalized immunotherapy or Vaccine against Cancer

Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

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The result page of search shows exclusive peptide/epitopes generated due to mutation [Neoepitope], the tissue of origin [Tissue], position of peptide in protein [Position], number of mismatches counted by aligning mutated and normal protein sequence [Num Mismatch, percentage of cell lines with this peptide over total number of cell lines [Promiscuity %]. The immune information include CTL epitopes (Yes/No), MHC I binders, MHC II binders (both given as number of alleles) and B cell epitopes (Yes/No). For more information, please click HERE

Protein	Neoepitopes	Tissue	Position	Prot Mutation	cDNA Mutation	Mutation Type	Num Mismatch	Promiscuity (%)	Cell Line	CTL	MHC I	NHLApred	MHC II	Bcell
Result		Search:
TNFAIP3	ALFCSVRPL	ENDOMETRIUM	466	p.G455fs	c.1363_1363delG	Frame_Shift_Del	6	0.11	MFE319	Y	16	9	0	N
TNFAIP3	CVSSSTEKT	LARGE_INTESTINE	626	p.F623fs	c.1867_1867delT	Frame_Shift_Del	6	0.11	LOVO	N	0	0	0	N
TNFAIP3	DFMRPKGQK	LARGE_INTESTINE	685	p.F623fs	c.1867_1867delT	Frame_Shift_Del	6	0.11	LOVO	N	0	0	0	N
TNFAIP3	FMRPKGQKS	LARGE_INTESTINE	686	p.F623fs	c.1867_1867delT	Frame_Shift_Del	6	0.11	LOVO	N	2	0	0	N
TNFAIP3	FRAWGGNAA	LARGE_INTESTINE	655	p.F623fs	c.1867_1867delT	Frame_Shift_Del	6	0.11	LOVO	Y	5	10	9	N
TNFAIP3	GFAHCVSSS	LARGE_INTESTINE	622	p.F623fs	c.1867_1867delT	Frame_Shift_Del	6	0.11	LOVO	N	0	0	0	N
TNFAIP3	GGLIRPHRQ	ENDOMETRIUM	455	p.G455fs	c.1363_1363delG	Frame_Shift_Del	6	0.11	MFE319	N	0	0	0	N
TNFAIP3	GLIRPHRQH	ENDOMETRIUM	456	p.G455fs	c.1363_1363delG	Frame_Shift_Del	6	0.11	MFE319	N	0	0	0	N
TNFAIP3	GSRTPFRAW	LARGE_INTESTINE	650	p.F623fs	c.1867_1867delT	Frame_Shift_Del	6	0.11	LOVO	Y	3	9	0	N
TNFAIP3	HPALFCSVR	ENDOMETRIUM	464	p.G455fs	c.1363_1363delG	Frame_Shift_Del	6	0.11	MFE319	Y	4	9	0	N
TNFAIP3	ILLLPQGKS	LARGE_INTESTINE	636	p.F623fs	c.1867_1867delT	Frame_Shift_Del	6	0.11	LOVO	N	0	0	11	N
TNFAIP3	IRDFMRPKG	LARGE_INTESTINE	683	p.F623fs	c.1867_1867delT	Frame_Shift_Del	6	0.11	LOVO	N	1	0	5	Y
TNFAIP3	KGFAHCVSS	LARGE_INTESTINE	621	p.F623fs	c.1867_1867delT	Frame_Shift_Del	6	0.11	LOVO	N	1	0	0	N
TNFAIP3	LEAPCLKDT	LARGE_INTESTINE	665	p.F623fs	c.1867_1867delT	Frame_Shift_Del	6	0.11	LOVO	N	5	0	0	N
TNFAIP3	LIRPHRQHP	ENDOMETRIUM	457	p.G455fs	c.1363_1363delG	Frame_Shift_Del	6	0.11	MFE319	N	0	0	0	N
TNFAIP3	LKDTARSVS	LARGE_INTESTINE	670	p.F623fs	c.1867_1867delT	Frame_Shift_Del	6	0.11	LOVO	N	1	0	0	N
TNFAIP3	LLLPQGKSV	LARGE_INTESTINE	637	p.F623fs	c.1867_1867delT	Frame_Shift_Del	6	0.11	LOVO	N	7	0	0	N
TNFAIP3	MRPKGQKSN	LARGE_INTESTINE	687	p.F623fs	c.1867_1867delT	Frame_Shift_Del	6	0.11	LOVO	N	2	0	6	N
TNFAIP3	PLEAPCLKD	LARGE_INTESTINE	664	p.F623fs	c.1867_1867delT	Frame_Shift_Del	6	0.11	LOVO	N	0	0	0	N
TNFAIP3	QHPALFCSV	ENDOMETRIUM	463	p.G455fs	c.1363_1363delG	Frame_Shift_Del	6	0.11	MFE319	N	4	0	0	N
TNFAIP3	RDFMRPKGQ	LARGE_INTESTINE	684	p.F623fs	c.1867_1867delT	Frame_Shift_Del	6	0.11	LOVO	N	0	0	0	Y
TNFAIP3	RIRDFMRPK	LARGE_INTESTINE	682	p.F623fs	c.1867_1867delT	Frame_Shift_Del	6	0.11	LOVO	Y	2	10	0	Y
TNFAIP3	RQHPALFCS	ENDOMETRIUM	462	p.G455fs	c.1363_1363delG	Frame_Shift_Del	6	0.11	MFE319	N	2	0	0	N
TNFAIP3	SSSTEKTNI	LARGE_INTESTINE	628	p.F623fs	c.1867_1867delT	Frame_Shift_Del	6	0.11	LOVO	N	4	0	0	N
TNFAIP3	SSTEKTNIL	LARGE_INTESTINE	629	p.F623fs	c.1867_1867delT	Frame_Shift_Del	6	0.11	LOVO	N	10	0	0	N
TNFAIP3	STEKTNILL	LARGE_INTESTINE	630	p.F623fs	c.1867_1867delT	Frame_Shift_Del	6	0.11	LOVO	Y	7	11	0	N
TNFAIP3	TEKTNILLL	LARGE_INTESTINE	631	p.F623fs	c.1867_1867delT	Frame_Shift_Del	6	0.11	LOVO	Y	9	10	0	N
TNFAIP3	TGGLIRPHR	ENDOMETRIUM	454	p.G455fs	c.1363_1363delG	Frame_Shift_Del	6	0.11	MFE319	N	1	0	0	N
TNFAIP3	TPFRAWGGN	LARGE_INTESTINE	653	p.F623fs	c.1867_1867delT	Frame_Shift_Del	6	0.11	LOVO	N	5	0	0	N
TNFAIP3	VSSSTEKTN	LARGE_INTESTINE	627	p.F623fs	c.1867_1867delT	Frame_Shift_Del	6	0.11	LOVO	N	0	0	0	N