Cancertope: In silico Platform for designing genome-based Personalized immunotherapy or Vaccine against Cancer

Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

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The result page of search shows exclusive peptide/epitopes generated due to mutation [Neoepitope], the tissue of origin [Tissue], position of peptide in protein [Position], number of mismatches counted by aligning mutated and normal protein sequence [Num Mismatch, percentage of cell lines with this peptide over total number of cell lines [Promiscuity %]. The immune information include CTL epitopes (Yes/No), MHC I binders, MHC II binders (both given as number of alleles) and B cell epitopes (Yes/No). For more information, please click HERE

Protein	Neoepitopes	Tissue	Position	Prot Mutation	cDNA Mutation	Mutation Type	Num Mismatch	Promiscuity (%)	Cell Line	CTL	MHC I	NHLApred	MHC II	Bcell
Result		Search:
TNRC6B	AIRVLLVIA	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	1447	p.R1429fs	c.4286_4286delG	Frame_Shift_Del	6	0.11	DND41	N	1	0	0	N
TNRC6B	CHGKVSKTL	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	1484	p.R1429fs	c.4286_4286delG	Frame_Shift_Del	6	0.11	DND41	N	5	0	0	N
TNRC6B	CLGGVKEGR	ENDOMETRIUM	769	p.W749fs	c.2246_2246delG	Frame_Shift_Del	6	0.11	RL952	N	5	0	0	N
TNRC6B	DPQHGMRRA	ENDOMETRIUM	802	p.G795fs	c.2383_2383delG	Frame_Shift_Del	6	0.11	HEC108	Y	8	9	0	N
TNRC6B	EVCWGVQPH	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	1503	p.R1429fs	c.4286_4286delG	Frame_Shift_Del	6	0.11	DND41	N	2	0	0	N
TNRC6B	EVKLEVKAL	LARGE_INTESTINE	566	p.H544fs	c.1632_1632delC	Frame_Shift_Del	6	0.11	SNUC4	Y	7	13	0	N
TNRC6B	EVVTVITLA	LARGE_INTESTINE	581	p.H544fs	c.1632_1632delC	Frame_Shift_Del	6	0.11	SNUC4	N	2	0	0	N
TNRC6B	GEAHPHHLQ	ENDOMETRIUM	840	p.G795fs	c.2383_2383delG	Frame_Shift_Del	6	0.11	HEC108	N	1	0	0	N
TNRC6B	GLGVMVAMQ	ENDOMETRIUM	781	p.W749fs	c.2246_2246delG	Frame_Shift_Del	6	0.11	RL952	N	0	0	0	N
TNRC6B	HGKVSKTLT	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	1485	p.R1429fs	c.4286_4286delG	Frame_Shift_Del	6	0.11	DND41	N	1	0	0	N
TNRC6B	HILIVRLSC	LARGE_INTESTINE	596	p.H544fs	c.1632_1632delC	Frame_Shift_Del	6	0.11	SNUC4	N	0	0	0	N
TNRC6B	HPHHLQATF	ENDOMETRIUM	843	p.G795fs	c.2383_2383delG	Frame_Shift_Del	6	0.11	HEC108	Y	11	10	0	N
TNRC6B	HSSRRHHNQ	ENDOMETRIUM	826	p.G795fs	c.2383_2383delG	Frame_Shift_Del	6	0.11	HEC108	N	0	0	0	N
TNRC6B	HWVAIRVLL	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	1444	p.R1429fs	c.4286_4286delG	Frame_Shift_Del	6	0.11	DND41	N	9	0	0	N
TNRC6B	IKSEVNPAM	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	1465	p.R1429fs	c.4286_4286delG	Frame_Shift_Del	6	0.11	DND41	N	3	0	3	N
TNRC6B	ILIVRLSCR	LARGE_INTESTINE	597	p.H544fs	c.1632_1632delC	Frame_Shift_Del	6	0.11	SNUC4	N	5	0	3	N
TNRC6B	IPAGKRRRM	OVARY	1009	p.W997fs	c.2990_2990delG	Frame_Shift_Del	6	0.11	OVK18	Y	12	10	0	N
TNRC6B	IRQKTAIGK	ENDOMETRIUM	754	p.W749fs	c.2246_2246delG	Frame_Shift_Del	6	0.11	RL952	N	2	0	15	N
TNRC6B	IRVLLVIAG	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	1448	p.R1429fs	c.4286_4286delG	Frame_Shift_Del	6	0.11	DND41	N	1	0	48	N
TNRC6B	KRRRMEESG	OVARY	1013	p.W997fs	c.2990_2990delG	Frame_Shift_Del	6	0.11	OVK18	N	2	0	0	N
TNRC6B	LAIPAGKRR	OVARY	1007	p.W997fs	c.2990_2990delG	Frame_Shift_Del	6	0.11	OVK18	N	3	0	0	N
TNRC6B	LGGVKEGRM	ENDOMETRIUM	770	p.W749fs	c.2246_2246delG	Frame_Shift_Del	6	0.11	RL952	N	6	0	0	N
TNRC6B	LGVMVAMQA	ENDOMETRIUM	782	p.W749fs	c.2246_2246delG	Frame_Shift_Del	6	0.11	RL952	N	4	0	27	N
TNRC6B	LKTKAMPRL	LARGE_INTESTINE	547	p.H544fs	c.1632_1632delC	Frame_Shift_Del	6	0.11	SNUC4	N	5	0	0	N
TNRC6B	LVIAGYLPN	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	1452	p.R1429fs	c.4286_4286delG	Frame_Shift_Del	6	0.11	DND41	N	0	0	14	N
TNRC6B	NQECHGKVS	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	1481	p.R1429fs	c.4286_4286delG	Frame_Shift_Del	6	0.11	DND41	N	0	0	0	N
TNRC6B	PAGKRRRME	OVARY	1010	p.W997fs	c.2990_2990delG	Frame_Shift_Del	6	0.11	OVK18	N	0	0	0	N
TNRC6B	PHSSRRHHN	ENDOMETRIUM	825	p.G795fs	c.2383_2383delG	Frame_Shift_Del	6	0.11	HEC108	N	0	0	0	N
TNRC6B	PPHHLQATF	ENDOMETRIUM	843	p.P844fs	c.2530_2530delC	Frame_Shift_Del	6	0.11	SNGM	N	7	0	0	N
TNRC6B	PQEVKLEVK	LARGE_INTESTINE	564	p.H544fs	c.1632_1632delC	Frame_Shift_Del	6	0.11	SNUC4	N	0	0	0	N
TNRC6B	QAGDKEERN	OVARY	1036	p.W997fs	c.2990_2990delG	Frame_Shift_Del	6	0.11	OVK18	N	2	0	0	N
TNRC6B	QEVKLEVKA	LARGE_INTESTINE	565	p.H544fs	c.1632_1632delC	Frame_Shift_Del	6	0.11	SNUC4	N	5	0	0	N
TNRC6B	QEVVTVITL	LARGE_INTESTINE	580	p.H544fs	c.1632_1632delC	Frame_Shift_Del	6	0.11	SNUC4	Y	11	10	0	N
TNRC6B	QIKSEVNPA	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	1464	p.R1429fs	c.4286_4286delG	Frame_Shift_Del	6	0.11	DND41	N	1	0	0	N
TNRC6B	RGEAHPHHL	ENDOMETRIUM	839	p.G795fs	c.2383_2383delG	Frame_Shift_Del	6	0.11	HEC108	N	10	0	0	N
TNRC6B	RHHNQRLLV	ENDOMETRIUM	830	p.G795fs	c.2383_2383delG	Frame_Shift_Del	6	0.11	HEC108	Y	3	12	0	N
TNRC6B	RRHHNQRLL	ENDOMETRIUM	829	p.G795fs	c.2383_2383delG	Frame_Shift_Del	6	0.11	HEC108	Y	10	11	0	N
TNRC6B	RTGPHILIV	LARGE_INTESTINE	592	p.H544fs	c.1632_1632delC	Frame_Shift_Del	6	0.11	SNUC4	Y	5	11	0	N
TNRC6B	RVLLVIAGY	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	1449	p.R1429fs	c.4286_4286delG	Frame_Shift_Del	6	0.11	DND41	Y	7	11	0	N
TNRC6B	RWRPARTSQ	BILIARY_TRACT	1746	p.T1734fs	c.5201_5207delCACCTGC	Frame_Shift_Del	6	0.11	SNU308	N	1	0	0	Y
TNRC6B	SLVTHWVAI	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	1440	p.R1429fs	c.4286_4286delG	Frame_Shift_Del	6	0.11	DND41	N	11	0	0	N
TNRC6B	SRRHHNQRL	ENDOMETRIUM	828	p.G795fs	c.2383_2383delG	Frame_Shift_Del	6	0.11	HEC108	Y	5	9	0	N
TNRC6B	TGPHILIVR	LARGE_INTESTINE	593	p.H544fs	c.1632_1632delC	Frame_Shift_Del	6	0.11	SNUC4	N	2	0	0	N
TNRC6B	TVITLAVGR	LARGE_INTESTINE	584	p.H544fs	c.1632_1632delC	Frame_Shift_Del	6	0.11	SNUC4	N	6	0	0	N
TNRC6B	VAIRVLLVI	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	1446	p.R1429fs	c.4286_4286delG	Frame_Shift_Del	6	0.11	DND41	N	14	0	22	N
TNRC6B	VITLAVGRT	LARGE_INTESTINE	585	p.H544fs	c.1632_1632delC	Frame_Shift_Del	6	0.11	SNUC4	N	1	0	1	N
TNRC6B	VKLEVKALE	LARGE_INTESTINE	567	p.H544fs	c.1632_1632delC	Frame_Shift_Del	6	0.11	SNUC4	N	0	0	3	N
TNRC6B	VLLVIAGYL	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	1450	p.R1429fs	c.4286_4286delG	Frame_Shift_Del	6	0.11	DND41	N	18	0	6	N
TNRC6B	VTVITLAVG	LARGE_INTESTINE	583	p.H544fs	c.1632_1632delC	Frame_Shift_Del	6	0.11	SNUC4	N	0	0	0	N
TNRC6B	VVTVITLAV	LARGE_INTESTINE	582	p.H544fs	c.1632_1632delC	Frame_Shift_Del	6	0.11	SNUC4	N	5	0	38	N
TNRC6B	WRPARTSQI	BILIARY_TRACT	1747	p.T1734fs	c.5201_5207delCACCTGC	Frame_Shift_Del	6	0.11	SNU308	Y	7	13	30	Y
TNRC6B	WVAIRVLLV	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	1445	p.R1429fs	c.4286_4286delG	Frame_Shift_Del	6	0.11	DND41	Y	8	13	43	N
TNRC6B	FDLPIPAGA	ENDOMETRIUM	851	p.G795fs	c.2383_2383delG	Frame_Shift_Del	6	0.22	HEC108	N	8	0	0	N
TNRC6B	FDLPIPAGA	ENDOMETRIUM	851	p.P844fs	c.2530_2530delC	Frame_Shift_Del	6	0.22	SNGM	N	8	0	0	N
TNRC6B	HLRMRNPVV	ENDOMETRIUM	866	p.G795fs	c.2383_2383delG	Frame_Shift_Del	6	0.22	HEC108	Y	4	12	0	N
TNRC6B	HLRMRNPVV	ENDOMETRIUM	866	p.P844fs	c.2530_2530delC	Frame_Shift_Del	6	0.22	SNGM	Y	4	12	0	N
TNRC6B	LMMALQHGE	ENDOMETRIUM	889	p.G795fs	c.2383_2383delG	Frame_Shift_Del	6	0.22	HEC108	N	0	0	3	N
TNRC6B	LMMALQHGE	ENDOMETRIUM	889	p.P844fs	c.2530_2530delC	Frame_Shift_Del	6	0.22	SNGM	N	0	0	3	N
TNRC6B	LRMRNPVVG	ENDOMETRIUM	867	p.G795fs	c.2383_2383delG	Frame_Shift_Del	6	0.22	HEC108	N	1	0	30	N
TNRC6B	LRMRNPVVG	ENDOMETRIUM	867	p.P844fs	c.2530_2530delC	Frame_Shift_Del	6	0.22	SNGM	N	1	0	30	N
TNRC6B	MMALQHGET	ENDOMETRIUM	890	p.G795fs	c.2383_2383delG	Frame_Shift_Del	6	0.22	HEC108	N	1	0	0	N
TNRC6B	MMALQHGET	ENDOMETRIUM	890	p.P844fs	c.2530_2530delC	Frame_Shift_Del	6	0.22	SNGM	N	1	0	0	N
TNRC6B	PHHLQATFD	ENDOMETRIUM	844	p.G795fs	c.2383_2383delG	Frame_Shift_Del	6	0.22	HEC108	N	0	0	0	N
TNRC6B	PHHLQATFD	ENDOMETRIUM	844	p.P844fs	c.2530_2530delC	Frame_Shift_Del	6	0.22	SNGM	N	0	0	0	N
TNRC6B	QHLRMRNPV	ENDOMETRIUM	865	p.G795fs	c.2383_2383delG	Frame_Shift_Del	6	0.22	HEC108	N	4	0	0	N
TNRC6B	QHLRMRNPV	ENDOMETRIUM	865	p.P844fs	c.2530_2530delC	Frame_Shift_Del	6	0.22	SNGM	N	4	0	0	N
TNRC6B	QLVGKWTLM	ENDOMETRIUM	882	p.G795fs	c.2383_2383delG	Frame_Shift_Del	6	0.22	HEC108	N	6	0	0	N
TNRC6B	QLVGKWTLM	ENDOMETRIUM	882	p.P844fs	c.2530_2530delC	Frame_Shift_Del	6	0.22	SNGM	N	6	0	0	N
TNRC6B	RMRNPVVGK	ENDOMETRIUM	868	p.G795fs	c.2383_2383delG	Frame_Shift_Del	6	0.22	HEC108	Y	5	14	0	N
TNRC6B	RMRNPVVGK	ENDOMETRIUM	868	p.P844fs	c.2530_2530delC	Frame_Shift_Del	6	0.22	SNGM	Y	5	14	0	N