Cancertope: In silico Platform for designing genome-based Personalized immunotherapy or Vaccine against Cancer

Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

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The result page of search shows exclusive peptide/epitopes generated due to mutation [Neoepitope], the tissue of origin [Tissue], position of peptide in protein [Position], number of mismatches counted by aligning mutated and normal protein sequence [Num Mismatch, percentage of cell lines with this peptide over total number of cell lines [Promiscuity %]. The immune information include CTL epitopes (Yes/No), MHC I binders, MHC II binders (both given as number of alleles) and B cell epitopes (Yes/No). For more information, please click HERE

Protein	Neoepitopes	Tissue	Position	Prot Mutation	cDNA Mutation	Mutation Type	Num Mismatch	Promiscuity (%)	Cell Line	CTL	MHC I	NHLApred	MHC II	Bcell
Result		Search:
ALK	ENNSVLGLN	STOMACH	862	p.865_866SS>S	c.2595_2597delCTC	In_Frame_Del	2	0.11	HUG1N	N	0	0	0	N
ALK	ERLENNSVL	STOMACH	859	p.865_866SS>S	c.2595_2597delCTC	In_Frame_Del	2	0.11	HUG1N	N	7	0	0	N
ALK	LENNSVLGL	STOMACH	861	p.865_866SS>S	c.2595_2597delCTC	In_Frame_Del	3	0.11	HUG1N	N	10	0	9	N
ALK	NNSVLGLNG	STOMACH	863	p.865_866SS>S	c.2595_2597delCTC	In_Frame_Del	1	0.11	HUG1N	N	0	0	0	N
ALK	NSVLGLNGN	STOMACH	864	p.865_866SS>S	c.2595_2597delCTC	In_Frame_Del	1	0.11	HUG1N	N	0	0	0	N
ALK	PERLENNSV	STOMACH	858	p.865_866SS>S	c.2595_2597delCTC	In_Frame_Del	1	0.11	HUG1N	N	2	0	0	N
ALK	RLENNSVLG	STOMACH	860	p.865_866SS>S	c.2595_2597delCTC	In_Frame_Del	3	0.11	HUG1N	N	1	0	0	N
ALK	AKREERSPA	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	1430	p.E1435del	c.4303_4305delGAG	In_Frame_Del	3	0.33	HUT102	N	2	0	0	N
ALK	AKREERSPA	PANCREAS	1430	p.E1435del	c.4303_4305delGAG	In_Frame_Del	3	0.33	L33	N	2	0	0	N
ALK	AKREERSPA	LUNG	1430	p.E1435del	c.4303_4305delGAG	In_Frame_Del	3	0.33	NCIH1373	N	2	0	0	N
ALK	KREERSPAA	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	1431	p.E1435del	c.4303_4305delGAG	In_Frame_Del	2	0.33	HUT102	N	3	0	0	N
ALK	KREERSPAA	PANCREAS	1431	p.E1435del	c.4303_4305delGAG	In_Frame_Del	2	0.33	L33	N	3	0	0	N
ALK	KREERSPAA	LUNG	1431	p.E1435del	c.4303_4305delGAG	In_Frame_Del	2	0.33	NCIH1373	N	3	0	0	N
ALK	QAKREERSP	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	1429	p.E1435del	c.4303_4305delGAG	In_Frame_Del	3	0.33	HUT102	N	0	0	0	N
ALK	QAKREERSP	PANCREAS	1429	p.E1435del	c.4303_4305delGAG	In_Frame_Del	3	0.33	L33	N	0	0	0	N
ALK	QAKREERSP	LUNG	1429	p.E1435del	c.4303_4305delGAG	In_Frame_Del	3	0.33	NCIH1373	N	0	0	0	N
ALK	QQAKREERS	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	1428	p.E1435del	c.4303_4305delGAG	In_Frame_Del	2	0.33	HUT102	N	0	0	0	N
ALK	QQAKREERS	PANCREAS	1428	p.E1435del	c.4303_4305delGAG	In_Frame_Del	2	0.33	L33	N	0	0	0	N
ALK	QQAKREERS	LUNG	1428	p.E1435del	c.4303_4305delGAG	In_Frame_Del	2	0.33	NCIH1373	N	0	0	0	N
ALK	REERSPAAP	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	1432	p.E1435del	c.4303_4305delGAG	In_Frame_Del	1	0.33	HUT102	N	0	0	0	N
ALK	REERSPAAP	PANCREAS	1432	p.E1435del	c.4303_4305delGAG	In_Frame_Del	1	0.33	L33	N	0	0	0	N
ALK	REERSPAAP	LUNG	1432	p.E1435del	c.4303_4305delGAG	In_Frame_Del	1	0.33	NCIH1373	N	0	0	0	N
ALK	SQQAKREER	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	1427	p.E1435del	c.4303_4305delGAG	In_Frame_Del	1	0.33	HUT102	N	5	0	0	N
ALK	SQQAKREER	PANCREAS	1427	p.E1435del	c.4303_4305delGAG	In_Frame_Del	1	0.33	L33	N	5	0	0	N
ALK	SQQAKREER	LUNG	1427	p.E1435del	c.4303_4305delGAG	In_Frame_Del	1	0.33	NCIH1373	N	5	0	0	N