Cancertope
In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer
Personalized immunotherapy or Vaccine against Cancer
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The result page of search shows exclusive peptide/epitopes generated due to mutation [Neoepitope], the tissue of origin [Tissue], position of peptide in protein [Position], number of mismatches counted by aligning mutated and normal protein sequence [Num Mismatch, percentage of cell lines with this peptide over total number of cell lines [Promiscuity %]. The immune information include CTL epitopes (Yes/No), MHC I binders, MHC II binders (both given as number of alleles) and B cell epitopes (Yes/No). For more information, please click |
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| Protein | Neoepitopes | Tissue | Position | Prot Mutation | cDNA Mutation | Mutation Type | Num Mismatch | Promiscuity (%) | Cell Line | CTL | MHC I | NHLApred | MHC II | Bcell | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PIK3CA | AKEEHLAWG | ENDOMETRIUM | 415 | p.CP420del | c.1258_1263delTGTCCA | In_Frame_Del | 4 | 0.11 | HEC6 | N | 0 | 0 | 0 | N | ||||||||||||
| PIK3CA | EEHLAWGNI | ENDOMETRIUM | 417 | p.CP420del | c.1258_1263delTGTCCA | In_Frame_Del | 3 | 0.11 | HEC6 | Y | 6 | 13 | 0 | N | ||||||||||||
| PIK3CA | EHLAWGNIN | ENDOMETRIUM | 418 | p.CP420del | c.1258_1263delTGTCCA | In_Frame_Del | 2 | 0.11 | HEC6 | N | 1 | 0 | 0 | N | ||||||||||||
| PIK3CA | EPVEEKILN | LUNG | 103 | p.GNR106del | c.316_324delGGCAACCGT | In_Frame_Del | 3 | 0.11 | NCIH69 | N | 4 | 0 | 0 | N | ||||||||||||
| PIK3CA | EPVGNREKI | LARGE_INTESTINE | 103 | p.E110del | c.325_327delGAA | In_Frame_Del | 2 | 0.11 | CL40 | Y | 15 | 12 | 0 | N | ||||||||||||
| PIK3CA | FLKVIEPVE | LUNG | 98 | p.GNR106del | c.316_324delGGCAACCGT | In_Frame_Del | 1 | 0.11 | NCIH69 | N | 2 | 0 | 0 | N | ||||||||||||
| PIK3CA | GAKEEHLAW | ENDOMETRIUM | 414 | p.CP420del | c.1258_1263delTGTCCA | In_Frame_Del | 3 | 0.11 | HEC6 | N | 3 | 0 | 0 | N | ||||||||||||
| PIK3CA | GNREKILNR | LARGE_INTESTINE | 106 | p.E110del | c.325_327delGAA | In_Frame_Del | 3 | 0.11 | CL40 | Y | 3 | 12 | 0 | N | ||||||||||||
| PIK3CA | HLAWGNINL | ENDOMETRIUM | 419 | p.CP420del | c.1258_1263delTGTCCA | In_Frame_Del | 1 | 0.11 | HEC6 | Y | 9 | 12 | 0 | N | ||||||||||||
| PIK3CA | IEPVEEKIL | LUNG | 102 | p.GNR106del | c.316_324delGGCAACCGT | In_Frame_Del | 4 | 0.11 | NCIH69 | N | 10 | 0 | 0 | N | ||||||||||||
| PIK3CA | IEPVGNREK | LARGE_INTESTINE | 102 | p.E110del | c.325_327delGAA | In_Frame_Del | 1 | 0.11 | CL40 | N | 0 | 0 | 3 | N | ||||||||||||
| PIK3CA | KEEHLAWGN | ENDOMETRIUM | 416 | p.CP420del | c.1258_1263delTGTCCA | In_Frame_Del | 4 | 0.11 | HEC6 | N | 3 | 0 | 0 | N | ||||||||||||
| PIK3CA | KGAKEEHLA | ENDOMETRIUM | 413 | p.CP420del | c.1258_1263delTGTCCA | In_Frame_Del | 2 | 0.11 | HEC6 | N | 1 | 0 | 0 | N | ||||||||||||
| PIK3CA | KVIEPVEEK | LUNG | 100 | p.GNR106del | c.316_324delGGCAACCGT | In_Frame_Del | 3 | 0.11 | NCIH69 | Y | 5 | 14 | 0 | N | ||||||||||||
| PIK3CA | LKVIEPVEE | LUNG | 99 | p.GNR106del | c.316_324delGGCAACCGT | In_Frame_Del | 2 | 0.11 | NCIH69 | N | 0 | 0 | 6 | N | ||||||||||||
| PIK3CA | NREKILNRE | LARGE_INTESTINE | 107 | p.E110del | c.325_327delGAA | In_Frame_Del | 2 | 0.11 | CL40 | N | 1 | 0 | 0 | N | ||||||||||||
| PIK3CA | PVEEKILNR | LUNG | 104 | p.GNR106del | c.316_324delGGCAACCGT | In_Frame_Del | 2 | 0.11 | NCIH69 | N | 4 | 0 | 0 | N | ||||||||||||
| PIK3CA | PVGNREKIL | LARGE_INTESTINE | 104 | p.E110del | c.325_327delGAA | In_Frame_Del | 3 | 0.11 | CL40 | N | 0 | 0 | 0 | N | ||||||||||||
| PIK3CA | REKILNREI | LARGE_INTESTINE | 108 | p.E110del | c.325_327delGAA | In_Frame_Del | 1 | 0.11 | CL40 | Y | 7 | 9 | 0 | N | ||||||||||||
| PIK3CA | RKGAKEEHL | ENDOMETRIUM | 412 | p.CP420del | c.1258_1263delTGTCCA | In_Frame_Del | 1 | 0.11 | HEC6 | N | 4 | 0 | 0 | N | ||||||||||||
| PIK3CA | VEEKILNRE | LUNG | 105 | p.GNR106del | c.316_324delGGCAACCGT | In_Frame_Del | 1 | 0.11 | NCIH69 | N | 0 | 0 | 0 | N | ||||||||||||
| PIK3CA | VGNREKILN | LARGE_INTESTINE | 105 | p.E110del | c.325_327delGAA | In_Frame_Del | 4 | 0.11 | CL40 | N | 0 | 0 | 7 | N | ||||||||||||
| PIK3CA | VIEPVEEKI | LUNG | 101 | p.GNR106del | c.316_324delGGCAACCGT | In_Frame_Del | 4 | 0.11 | NCIH69 | N | 5 | 0 | 0 | N | ||||||||||||
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