Cancertope
In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer
Personalized immunotherapy or Vaccine against Cancer
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The result page of search shows exclusive peptide/epitopes generated due to mutation [Neoepitope], the tissue of origin [Tissue], position of peptide in protein [Position], number of mismatches counted by aligning mutated and normal protein sequence [Num Mismatch, percentage of cell lines with this peptide over total number of cell lines [Promiscuity %]. The immune information include CTL epitopes (Yes/No), MHC I binders, MHC II binders (both given as number of alleles) and B cell epitopes (Yes/No). For more information, please click |
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| Protein | Neoepitopes | Tissue | Position | Prot Mutation | cDNA Mutation | Mutation Type | Num Mismatch | Promiscuity (%) | Cell Line | CTL | MHC I | NHLApred | MHC II | Bcell | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| RB1 | DIFHMSLLA | BREAST | 479 | p.N480del | c.1436_1438delACA | In_Frame_Del | 1 | 0.11 | HCC70 | N | 2 | 0 | 0 | N | ||||||||||||
| RB1 | DLSFPWNVL | THYROID | 511 | p.IL517del | c.1548_1553delGATTCT | In_Frame_Del | 3 | 0.11 | FTC133 | Y | 5 | 11 | 0 | N | ||||||||||||
| RB1 | FPWNVLNLK | THYROID | 514 | p.IL517del | c.1548_1553delGATTCT | In_Frame_Del | 3 | 0.11 | FTC133 | N | 7 | 0 | 0 | Y | ||||||||||||
| RB1 | FSKLLNDIF | BREAST | 473 | p.N480del | c.1436_1438delACA | In_Frame_Del | 2 | 0.11 | HCC70 | N | 8 | 0 | 1 | N | ||||||||||||
| RB1 | GTDLSFPWN | THYROID | 509 | p.IL517del | c.1548_1553delGATTCT | In_Frame_Del | 1 | 0.11 | FTC133 | N | 1 | 0 | 0 | N | ||||||||||||
| RB1 | KLLNDIFHM | BREAST | 475 | p.N480del | c.1436_1438delACA | In_Frame_Del | 4 | 0.11 | HCC70 | Y | 9 | 9 | 0 | N | ||||||||||||
| RB1 | LLNDIFHMS | BREAST | 476 | p.N480del | c.1436_1438delACA | In_Frame_Del | 3 | 0.11 | HCC70 | N | 0 | 0 | 6 | N | ||||||||||||
| RB1 | LNDIFHMSL | BREAST | 477 | p.N480del | c.1436_1438delACA | In_Frame_Del | 3 | 0.11 | HCC70 | N | 10 | 0 | 1 | N | ||||||||||||
| RB1 | LSFPWNVLN | THYROID | 512 | p.IL517del | c.1548_1553delGATTCT | In_Frame_Del | 4 | 0.11 | FTC133 | N | 0 | 0 | 0 | N | ||||||||||||
| RB1 | NDIFHMSLL | BREAST | 478 | p.N480del | c.1436_1438delACA | In_Frame_Del | 2 | 0.11 | HCC70 | N | 7 | 0 | 0 | N | ||||||||||||
| RB1 | NFSKLLNDI | BREAST | 472 | p.N480del | c.1436_1438delACA | In_Frame_Del | 1 | 0.11 | HCC70 | N | 5 | 0 | 0 | N | ||||||||||||
| RB1 | PWNVLNLKA | THYROID | 515 | p.IL517del | c.1548_1553delGATTCT | In_Frame_Del | 2 | 0.11 | FTC133 | N | 0 | 0 | 0 | N | ||||||||||||
| RB1 | SFPWNVLNL | THYROID | 513 | p.IL517del | c.1548_1553delGATTCT | In_Frame_Del | 4 | 0.11 | FTC133 | Y | 10 | 13 | 0 | N | ||||||||||||
| RB1 | SKLLNDIFH | BREAST | 474 | p.N480del | c.1436_1438delACA | In_Frame_Del | 3 | 0.11 | HCC70 | N | 2 | 0 | 0 | N | ||||||||||||
| RB1 | TDLSFPWNV | THYROID | 510 | p.IL517del | c.1548_1553delGATTCT | In_Frame_Del | 2 | 0.11 | FTC133 | Y | 7 | 10 | 0 | N | ||||||||||||
| RB1 | WNVLNLKAF | THYROID | 516 | p.IL517del | c.1548_1553delGATTCT | In_Frame_Del | 1 | 0.11 | FTC133 | Y | 6 | 14 | 9 | N | ||||||||||||
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