Welcome to Sequence Card of Peptide
Details of CPPsite entry with Sequence GWTLNSAGYLLGKINLKALAALAKKIL |
| Primary information | |
|---|---|
| PEPTIDE SEQUENCE | GWTLNSAGYLLGKINLKALAALAKKIL |
| CPPsite ID | 2171, 2492, 2520, 2521, 2522, 2957, 1044, 1761, 1779, |
| PEPTIDE NAME | Transportan, Transportan, TP, TP-biot1, TP-biot13, Trans, Transportan (TP), PN64 (SEQ ID NO: 60), PN161 (SEQ ID NO: 93) |
| CHIRALITY | L, Modified, L, L, Modified, L, L, L, L |
| LINEAR/CYCLIC | Linear, Linear, Linear, Linear, Linear, Linear, Linear, Linear, Linear |
| SOURCE | Protein derived, Synthetic, Chimeric, Chimeric, Chimeric, Synthetic, Chimeric, Synthetic, Synthetic |
| CATEGORY | Amphipathic, Amphipathic, Cationic and Amphipathic, Cationic and Amphipathic, Cationic and Amphipathic, NA, Amphipathic, Unknown, Unknown |
| SUB CELLULAR LOCALIZATION | Vesicles, NA, Cytoplasm, Cytoplasm, Cytoplasm, NA, Cytoplasm and nucleus and intracellular membranous structures, Unknown, Unknown |
| N-TERMINAL MODIFICATION | Conjugation with fluorescein, Free, Conjugation with FITC labelled streptavidin, Biotinylation, Free, Conjugation with 5(6)-Carboxyfluorescein, Biotinylation, Bromoacetylation, Free |
| C-TERMINAL MODIFICATION | Amidation, Amidation, Amidation, Amidation, Amidation, Free, Free, Amidation, Amidation |
| CHEMICAL MODIFICATION | NA, Fluorescein coupled to Lys13, NA, NA, Biotinylation at Residue 13, NA, NA, NA, NA |
| UPTAKE EFFICIENCY | NA, NA, NA, High, Low, High, High, Unknown, Unknown |
| PROPOSED UPTAKE MECHANISM | Non-endocytosis, Non endocytosis pathway, Endocytosis-independent, Endocytosis-independent, Endocytosis-independent, NA, Non-receptor mediated endocytic pathway, Unknown, Unknown |
| INVITRO/INVIVO | In vitro, In vitro, In vitro, In vitro, In vitro, In vivo, In vitro, In vitro, In vitro |
| CELL LINE | RBL-2H3 cells, CHO-K1, Rat basophilic leukemia RBL-2H3 cells and CHO-K1, HT29 and HCT116, HT29 and HCT116, HT29 and HCT116, NA, Human bowes melanoma cells, 9 L/LacZ cells, Murine taile fibroblast (MTF) cells |
| In VIVO MODEL | NA, NA, NA, NA, NA, Adult zebrafish, NA, NA, NA |
| CARGO | Fluorophore (Fluorescein), Fluorophore (Fluorescein), Nucleic acid (siRNA), Protein (Streptavidin conjugated with FITC), Protein (Streptavidin conjugated with FITC), Fluorophore (5-Carboxyfluorescein), Biotin, Nucleic acid (siRNA), Nucleic acid (siRNA) |
| PMID | 25016968, 25016968, 25511292, 25511292, 25511292, 25894337, 10930519 |
| PATENT | Unknown, Unknown, Unknown, Unknown, Unknown, Unknown, Unknown, US 20060035815, US 20060035815 |
| Tertiary Structure (Technique) | 2171 (Experimentally determined structure from PDB), 2492 (Experimentally determined structure from PDB), 2520 (Experimentally determined structure from PDB), 2521 (Experimentally determined structure from PDB), 2522 (Experimentally determined structure from PDB), 2957 (Experimentally determined structure from PDB), 1044 (Experimentally determined structure from PDB), 1761 (Experimentally determined structure from PDB), 1779 (Experimentally determined structure from PDB), |