Cytokines are the messengers of the immune system. They are small secreted proteins that mediate and regulate immune system, inflammation, and hematopoiesis. Recent studies have revealed important roles played by the cytokines in as therapeutic targets, adjuvants and in cancer therapy. In this paper an attempt has been made to predict this important class of proteins and further classify them into families and subfamilies. A PSI-BLAST + SVM based hybrid approach is adopted to develop the prediction methods. This method CytoPred is capable of distinguishing cytokines from non-cytokines with an accuracy of 98.29%. The overall accuracy of family and subfamily prediction is 96.34% and 92.64% respectively.
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Lata S, Raghava GP. CytoPred: a server for prediction and classification of cytokines.Protein Eng Des Sel. 2008;21(4):279-82.