dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: ACTL6B |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 587284 LARGE INTESTINE c.742C>T p.H248Y COSMIC PASSENGER/OTHER Possibly Damaging 2 587376 LARGE INTESTINE c.1012C>T p.R338C COSMIC PASSENGER/OTHER Probably Damaging 3 587376 LARGE INTESTINE c.258G>T p.K86N COSMIC PASSENGER/OTHER Probably Damaging 4 CA3 LARGE INTESTINE c.1157G>T p.R386L COSMIC PASSENGER/OTHER Probably Damaging 5 LUAD-CHTN-3090415 LUNG c.951C>G p.N317K COSMIC PASSENGER/OTHER Benign 6 LUAD-NYU408 LUNG c.780G>T p.Q260H COSMIC PASSENGER/OTHER Probably Damaging 7 LUAD-S00488 LUNG c.838C>A p.P280T COSMIC PASSENGER/OTHER Probably Damaging 8 LUAD_E01419 LUNG c.859C>T p.P287S COSMIC PASSENGER/OTHER Probably Damaging 9 S01366 LUNG c.60C>A p.S20S COSMIC NP NP 10 TARGET-30-PASYPX AUTONOMIC GANGLIA c.1231C>A p.Q411K COSMIC PASSENGER/OTHER Benign 11 TCGA-24-1423-01 OVARY c.1153G>T p.E385* COSMIC NP NP 12 TCGA-34-5236-01 LUNG c.627G>A p.E209E COSMIC NP NP 13 TCGA-60-2723-01 LUNG c.575C>T p.S192F COSMIC PASSENGER/OTHER Probably Damaging 14 TCGA-66-2800-01 LUNG c.1113G>T p.P371P COSMIC NP NP 15 TCGA-A6-4105-01 LARGE INTESTINE c.1154A>G p.E385G COSMIC PASSENGER/OTHER Probably Damaging 16 TCGA-A6-5665-01 LARGE INTESTINE c.73G>A p.A25T COSMIC PASSENGER/OTHER Probably Damaging 17 TCGA-AA-3877-01 LARGE INTESTINE c.369G>A p.P123P COSMIC NP NP 18 TCGA-AA-3977-01 LARGE INTESTINE c.297C>T p.I99I COSMIC NP NP 19 TCGA-AA-A02O-01 LARGE INTESTINE c.467C>T p.A156V COSMIC PASSENGER/OTHER Probably Damaging 20 TCGA-AD-6901-01 LARGE INTESTINE c.135C>T p.A45A COSMIC NP NP 21 TCGA-AP-A059-01 ENDOMETRIUM c.886G>A p.A296T COSMIC PASSENGER/OTHER Possibly Damaging 22 TCGA-AP-A0LM-01 ENDOMETRIUM c.714G>T p.E238D COSMIC PASSENGER/OTHER Benign 23 TCGA-AR-A24H-01 BREAST c.706A>T p.K236* COSMIC NP NP 24 TCGA-B5-A0JY-01 ENDOMETRIUM c.863A>G p.N288S COSMIC PASSENGER/OTHER Benign 25 TCGA-B6-A0RU-01 BREAST c.583delG p.A195fs*25 COSMIC NP NP 26 TCGA-BS-A0UF-01 ENDOMETRIUM c.180G>T p.K60N COSMIC PASSENGER/OTHER Benign 27 TCGA-CM-6170-01 LARGE INTESTINE c.1154A>G p.E385G COSMIC PASSENGER/OTHER Probably Damaging 28 TCGA-D1-A103-01 ENDOMETRIUM c.1176C>T p.I392I COSMIC NP NP 29 TCGA-D1-A16R-01 ENDOMETRIUM c.1156C>T p.R386C COSMIC PASSENGER/OTHER Probably Damaging 30 TCGA-D5-5539-01 LARGE INTESTINE c.1153G>A p.E385K COSMIC PASSENGER/OTHER Probably Damaging 31 TCGA-D5-6533-01 LARGE INTESTINE c.889G>A p.E297K COSMIC PASSENGER/OTHER Probably Damaging 32 TCGA-D8-A1X6-01 BREAST c.967G>C p.G323R COSMIC PASSENGER/OTHER Possibly Damaging 33 TCGA-D8-A27H-01 BREAST c.1013G>T p.R338L COSMIC PASSENGER/OTHER Benign 34 TCGA-DM-A28C-01 LARGE INTESTINE c.219C>T p.H73H COSMIC NP NP 35 TCGA-E2-A14P-01 BREAST c.786C>T p.S262S COSMIC NP NP 36 TCGA-EJ-7784-01 PROSTATE c.551T>A p.V184D COSMIC PASSENGER/OTHER Probably Damaging 37 TCGA-F4-6856-01 LARGE INTESTINE c.249G>A p.S83S COSMIC NP NP 38 TCGA-G4-6321-01 LARGE INTESTINE c.1154A>G p.E385G COSMIC PASSENGER/OTHER Probably Damaging 39 YUKLAB SKIN c.358T>C p.S120P COSMIC PASSENGER/OTHER Probably Damaging 40 YULAN SKIN c.893G>A p.R298Q COSMIC PASSENGER/OTHER Probably Damaging 41 YUMER SKIN c.1111C>T p.P371S COSMIC PASSENGER/OTHER Probably Damaging 42 YUVAIL SKIN c.674C>T p.P225L COSMIC PASSENGER/OTHER Benign 43 cSCCP7 SKIN c.233G>A p.G78E COSMIC PASSENGER/OTHER Possibly Damaging
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.test -
Tertiary structure (+)
Users must enabled the Java in their browser to see structure.
Users can also download Java from here.Modelled Structure Structures available in PDB Structure is not available in PDB -
Structure Domains (+)
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Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 4. Sequence alignment with homologus proteins:
Click on button to get Sequence alignment with Coverage, Consensus and Quality -
Sequence Profiles (+)
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Post Translational Modifications (+)
S. No. Position Amino acid Type 1 244 S Phosphorylation 2 368 K Ubiquitylation -
Other Databases Link (+)
Proteomics DB COSMIC Gene Atlas STRING PIR ACTL6B ACTL6B ACTL6B ENSP00000160382 O94805 QuickGO HGNC Ensembl Genome Browser TreeFam UniProt O94805 ACTL6B ENSP00000160382 ACTL6B O94805 Expression Atlas Protein Atlas OMIM IntAct PharmGKB ACTL6B ENSP00000160382 612458 O94805 PA24482
