dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: ACTL6B |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 587284 LARGE INTESTINE c.742C>T p.H248Y COSMIC PASSENGER/OTHER Possibly Damaging 2 587376 LARGE INTESTINE c.1012C>T p.R338C COSMIC PASSENGER/OTHER Probably Damaging 3 587376 LARGE INTESTINE c.258G>T p.K86N COSMIC PASSENGER/OTHER Probably Damaging 4 CA3 LARGE INTESTINE c.1157G>T p.R386L COSMIC PASSENGER/OTHER Probably Damaging 5 LUAD-CHTN-3090415 LUNG c.951C>G p.N317K COSMIC PASSENGER/OTHER Benign 6 LUAD-NYU408 LUNG c.780G>T p.Q260H COSMIC PASSENGER/OTHER Probably Damaging 7 LUAD-S00488 LUNG c.838C>A p.P280T COSMIC PASSENGER/OTHER Probably Damaging 8 LUAD_E01419 LUNG c.859C>T p.P287S COSMIC PASSENGER/OTHER Probably Damaging 9 S01366 LUNG c.60C>A p.S20S COSMIC NP NP 10 TARGET-30-PASYPX AUTONOMIC GANGLIA c.1231C>A p.Q411K COSMIC PASSENGER/OTHER Benign 11 TCGA-24-1423-01 OVARY c.1153G>T p.E385* COSMIC NP NP 12 TCGA-34-5236-01 LUNG c.627G>A p.E209E COSMIC NP NP 13 TCGA-60-2723-01 LUNG c.575C>T p.S192F COSMIC PASSENGER/OTHER Probably Damaging 14 TCGA-66-2800-01 LUNG c.1113G>T p.P371P COSMIC NP NP 15 TCGA-A6-4105-01 LARGE INTESTINE c.1154A>G p.E385G COSMIC PASSENGER/OTHER Probably Damaging 16 TCGA-A6-5665-01 LARGE INTESTINE c.73G>A p.A25T COSMIC PASSENGER/OTHER Probably Damaging 17 TCGA-AA-3877-01 LARGE INTESTINE c.369G>A p.P123P COSMIC NP NP 18 TCGA-AA-3977-01 LARGE INTESTINE c.297C>T p.I99I COSMIC NP NP 19 TCGA-AA-A02O-01 LARGE INTESTINE c.467C>T p.A156V COSMIC PASSENGER/OTHER Probably Damaging 20 TCGA-AD-6901-01 LARGE INTESTINE c.135C>T p.A45A COSMIC NP NP 21 TCGA-AP-A059-01 ENDOMETRIUM c.886G>A p.A296T COSMIC PASSENGER/OTHER Possibly Damaging 22 TCGA-AP-A0LM-01 ENDOMETRIUM c.714G>T p.E238D COSMIC PASSENGER/OTHER Benign 23 TCGA-AR-A24H-01 BREAST c.706A>T p.K236* COSMIC NP NP 24 TCGA-B5-A0JY-01 ENDOMETRIUM c.863A>G p.N288S COSMIC PASSENGER/OTHER Benign 25 TCGA-B6-A0RU-01 BREAST c.583delG p.A195fs*25 COSMIC NP NP 26 TCGA-BS-A0UF-01 ENDOMETRIUM c.180G>T p.K60N COSMIC PASSENGER/OTHER Benign 27 TCGA-CM-6170-01 LARGE INTESTINE c.1154A>G p.E385G COSMIC PASSENGER/OTHER Probably Damaging 28 TCGA-D1-A103-01 ENDOMETRIUM c.1176C>T p.I392I COSMIC NP NP 29 TCGA-D1-A16R-01 ENDOMETRIUM c.1156C>T p.R386C COSMIC PASSENGER/OTHER Probably Damaging 30 TCGA-D5-5539-01 LARGE INTESTINE c.1153G>A p.E385K COSMIC PASSENGER/OTHER Probably Damaging 31 TCGA-D5-6533-01 LARGE INTESTINE c.889G>A p.E297K COSMIC PASSENGER/OTHER Probably Damaging 32 TCGA-D8-A1X6-01 BREAST c.967G>C p.G323R COSMIC PASSENGER/OTHER Possibly Damaging 33 TCGA-D8-A27H-01 BREAST c.1013G>T p.R338L COSMIC PASSENGER/OTHER Benign 34 TCGA-DM-A28C-01 LARGE INTESTINE c.219C>T p.H73H COSMIC NP NP 35 TCGA-E2-A14P-01 BREAST c.786C>T p.S262S COSMIC NP NP 36 TCGA-EJ-7784-01 PROSTATE c.551T>A p.V184D COSMIC PASSENGER/OTHER Probably Damaging 37 TCGA-F4-6856-01 LARGE INTESTINE c.249G>A p.S83S COSMIC NP NP 38 TCGA-G4-6321-01 LARGE INTESTINE c.1154A>G p.E385G COSMIC PASSENGER/OTHER Probably Damaging 39 YUKLAB SKIN c.358T>C p.S120P COSMIC PASSENGER/OTHER Probably Damaging 40 YULAN SKIN c.893G>A p.R298Q COSMIC PASSENGER/OTHER Probably Damaging 41 YUMER SKIN c.1111C>T p.P371S COSMIC PASSENGER/OTHER Probably Damaging 42 YUVAIL SKIN c.674C>T p.P225L COSMIC PASSENGER/OTHER Benign 43 cSCCP7 SKIN c.233G>A p.G78E COSMIC PASSENGER/OTHER Possibly Damaging
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.Gene essentiality data is not present in COLT database!! -
Tertiary structure (+)
Users must enabled the Java in their browser to see structure.
Users can also download Java from here.Modelled Structure Structures available in PDB -
Structure Domains (+)
1. PFAM domains are not present!!2. Superfaimly domains are not present!! -
Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:4. Sequence alignment with homologus proteins: -
Sequence Profiles (+)
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Post Translational Modifications (+)
Post translational modifications are not found!!Other Databases Link (+)
