dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: ACTR8 |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 587376 LARGE INTESTINE c.11C>G p.A4G COSMIC PASSENGER/OTHER Benign 2 Br27P CENTRAL NERVOUS SYSTEM c.1190C>T p.T397I COSMIC CANCER Benign 3 ESO-003 OESOPHAGUS c.1174T>G p.L392V COSMIC CANCER Possibly Damaging 4 ESO-732 OESOPHAGUS c.1168A>G p.M390V COSMIC CANCER Benign 5 N608T AUTONOMIC GANGLIA c.866C>A p.T289K COSMIC CANCER Probably Damaging 6 TARGET-30-PATDWN AUTONOMIC GANGLIA c.1307C>A p.A436E COSMIC PASSENGER/OTHER Benign 7 TCGA-04-1338-01 OVARY c.591T>A p.P197P COSMIC NP NP 8 TCGA-23-1120-01 OVARY c.1573G>C p.D525H COSMIC PASSENGER/OTHER Probably Damaging 9 TCGA-33-6737-01 LUNG c.230G>A p.R77Q COSMIC PASSENGER/OTHER Probably Damaging 10 TCGA-39-5019-01 LUNG c.996C>G p.C332W COSMIC PASSENGER/OTHER Probably Damaging 11 TCGA-55-8089-01 LUNG c.937G>C p.D313H COSMIC CANCER Probably Damaging 12 TCGA-67-3771-01 LUNG c.1055A>G p.H352R COSMIC CANCER Probably Damaging 13 TCGA-99-7458-01 LUNG c.1597A>T p.S533C COSMIC CANCER Probably Damaging 14 TCGA-A2-A25A-01 BREAST c.997C>A p.Q333K COSMIC PASSENGER/OTHER Benign 15 TCGA-AA-3510-01 LARGE INTESTINE c.1042G>T p.E348* COSMIC NP NP 16 TCGA-AA-3821-01 LARGE INTESTINE c.383G>A p.R128H COSMIC PASSENGER/OTHER Probably Damaging 17 TCGA-AG-A002-01 LARGE INTESTINE c.1138C>T p.R380* COSMIC NP NP 18 TCGA-AG-A002-01 LARGE INTESTINE c.901C>T p.R301W COSMIC PASSENGER/OTHER Probably Damaging 19 TCGA-AP-A0LM-01 ENDOMETRIUM c.1102C>T p.R368* COSMIC NP NP 20 TCGA-B0-5085-01 KIDNEY c.1024C>T p.L342F COSMIC PASSENGER/OTHER Probably Damaging 21 TCGA-B0-5085-01 KIDNEY c.1027C>T p.L343L COSMIC NP NP 22 TCGA-B0-5117-01 KIDNEY c.441T>G p.I147M COSMIC PASSENGER/OTHER Benign 23 TCGA-B5-A0K9-01 ENDOMETRIUM c.1368T>C p.R456R COSMIC NP NP 24 TCGA-B5-A11E-01 ENDOMETRIUM c.1797G>T p.Q599H COSMIC CANCER Possibly Damaging 25 TCGA-B5-A11N-01 ENDOMETRIUM c.164C>T p.S55L COSMIC PASSENGER/OTHER Probably Damaging 26 TCGA-BK-A0C9-01 ENDOMETRIUM c.545T>A p.I182N COSMIC PASSENGER/OTHER Probably Damaging 27 TCGA-BS-A0UV-01 ENDOMETRIUM c.645G>A p.A215A COSMIC NP NP 28 TCGA-CH-5739-01 PROSTATE c.1516G>T p.G506* COSMIC NP NP 29 TCGA-D1-A177-01 ENDOMETRIUM c.1695A>G p.R565R COSMIC NP NP 30 TCGA-D8-A142-01 BREAST c.1047T>G p.T349T COSMIC NP NP 31 TCGA-DK-A3IS-01 URINARY TRACT c.971G>A p.R324Q COSMIC PASSENGER/OTHER Probably Damaging 32 TCGA-F4-6856-01 LARGE INTESTINE c.591T>C p.P197P COSMIC NP NP 33 TCGA-G4-6321-01 LARGE INTESTINE c.1828C>T p.R610C COSMIC PASSENGER/OTHER Probably Damaging 34 TCGA-GV-A3JZ-01 URINARY TRACT c.1443G>T p.L481L COSMIC NP NP 35 YUKIL SKIN c.1366C>T p.R456C COSMIC PASSENGER/OTHER Probably Damaging 36 ccRCC-21 KIDNEY c.1410G>T p.E470D COSMIC PASSENGER/OTHER Benign 37 ccRCC-50 KIDNEY c.1559A>G p.D520G COSMIC PASSENGER/OTHER Benign
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.test -
Tertiary structure (+)
Users must enabled the Java in their browser to see structure.
Users can also download Java from here.Modelled Structure Structures available in PDB -
Structure Domains (+)
1. PFAM domains are not present!!2. Superfaimly domains are not present!! -
Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:4. Sequence alignment with homologus proteins: -
Sequence Profiles (+)
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Post Translational Modifications (+)
Post translational modifications are not found!!Other Databases Link (+)
