dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: ACTR8 |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 587376 LARGE INTESTINE c.11C>G p.A4G COSMIC PASSENGER/OTHER Benign 2 Br27P CENTRAL NERVOUS SYSTEM c.1190C>T p.T397I COSMIC CANCER Benign 3 ESO-003 OESOPHAGUS c.1174T>G p.L392V COSMIC CANCER Possibly Damaging 4 ESO-732 OESOPHAGUS c.1168A>G p.M390V COSMIC CANCER Benign 5 N608T AUTONOMIC GANGLIA c.866C>A p.T289K COSMIC CANCER Probably Damaging 6 TARGET-30-PATDWN AUTONOMIC GANGLIA c.1307C>A p.A436E COSMIC PASSENGER/OTHER Benign 7 TCGA-04-1338-01 OVARY c.591T>A p.P197P COSMIC NP NP 8 TCGA-23-1120-01 OVARY c.1573G>C p.D525H COSMIC PASSENGER/OTHER Probably Damaging 9 TCGA-33-6737-01 LUNG c.230G>A p.R77Q COSMIC PASSENGER/OTHER Probably Damaging 10 TCGA-39-5019-01 LUNG c.996C>G p.C332W COSMIC PASSENGER/OTHER Probably Damaging 11 TCGA-55-8089-01 LUNG c.937G>C p.D313H COSMIC CANCER Probably Damaging 12 TCGA-67-3771-01 LUNG c.1055A>G p.H352R COSMIC CANCER Probably Damaging 13 TCGA-99-7458-01 LUNG c.1597A>T p.S533C COSMIC CANCER Probably Damaging 14 TCGA-A2-A25A-01 BREAST c.997C>A p.Q333K COSMIC PASSENGER/OTHER Benign 15 TCGA-AA-3510-01 LARGE INTESTINE c.1042G>T p.E348* COSMIC NP NP 16 TCGA-AA-3821-01 LARGE INTESTINE c.383G>A p.R128H COSMIC PASSENGER/OTHER Probably Damaging 17 TCGA-AG-A002-01 LARGE INTESTINE c.1138C>T p.R380* COSMIC NP NP 18 TCGA-AG-A002-01 LARGE INTESTINE c.901C>T p.R301W COSMIC PASSENGER/OTHER Probably Damaging 19 TCGA-AP-A0LM-01 ENDOMETRIUM c.1102C>T p.R368* COSMIC NP NP 20 TCGA-B0-5085-01 KIDNEY c.1024C>T p.L342F COSMIC PASSENGER/OTHER Probably Damaging 21 TCGA-B0-5085-01 KIDNEY c.1027C>T p.L343L COSMIC NP NP 22 TCGA-B0-5117-01 KIDNEY c.441T>G p.I147M COSMIC PASSENGER/OTHER Benign 23 TCGA-B5-A0K9-01 ENDOMETRIUM c.1368T>C p.R456R COSMIC NP NP 24 TCGA-B5-A11E-01 ENDOMETRIUM c.1797G>T p.Q599H COSMIC CANCER Possibly Damaging 25 TCGA-B5-A11N-01 ENDOMETRIUM c.164C>T p.S55L COSMIC PASSENGER/OTHER Probably Damaging 26 TCGA-BK-A0C9-01 ENDOMETRIUM c.545T>A p.I182N COSMIC PASSENGER/OTHER Probably Damaging 27 TCGA-BS-A0UV-01 ENDOMETRIUM c.645G>A p.A215A COSMIC NP NP 28 TCGA-CH-5739-01 PROSTATE c.1516G>T p.G506* COSMIC NP NP 29 TCGA-D1-A177-01 ENDOMETRIUM c.1695A>G p.R565R COSMIC NP NP 30 TCGA-D8-A142-01 BREAST c.1047T>G p.T349T COSMIC NP NP 31 TCGA-DK-A3IS-01 URINARY TRACT c.971G>A p.R324Q COSMIC PASSENGER/OTHER Probably Damaging 32 TCGA-F4-6856-01 LARGE INTESTINE c.591T>C p.P197P COSMIC NP NP 33 TCGA-G4-6321-01 LARGE INTESTINE c.1828C>T p.R610C COSMIC PASSENGER/OTHER Probably Damaging 34 TCGA-GV-A3JZ-01 URINARY TRACT c.1443G>T p.L481L COSMIC NP NP 35 YUKIL SKIN c.1366C>T p.R456C COSMIC PASSENGER/OTHER Probably Damaging 36 ccRCC-21 KIDNEY c.1410G>T p.E470D COSMIC PASSENGER/OTHER Benign 37 ccRCC-50 KIDNEY c.1559A>G p.D520G COSMIC PASSENGER/OTHER Benign
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.test -
Tertiary structure (+)
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Structure Domains (+)
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Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 4. Sequence alignment with homologus proteins:
Click on button to get Sequence alignment with Coverage, Consensus and Quality -
Sequence Profiles (+)
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Post Translational Modifications (+)
S. No. Position Amino acid Type 1 132 S Phosphorylation 2 132 S Phosphorylation 3 225 K Ubiquitylation 4 309 Y Phosphorylation 5 315 S Phosphorylation 6 412 S Phosphorylation 7 412 S Phosphorylation 8 431 K Ubiquitylation 9 444 S Phosphorylation 10 562 S Phosphorylation -
Other Databases Link (+)
Proteomics DB COSMIC Gene Atlas STRING PIR ACTR8 ACTR8 ACTR8 ENSP00000336842 Q9H981 QuickGO HGNC Ensembl Genome Browser TreeFam UniProt Q9H981 ACTR8 ENSP00000336842 ACTR8 Q9H981 Expression Atlas Protein Atlas OMIM IntAct PharmGKB ACTR8 ENSP00000336842 NA Q9H981 PA24491
