dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: ARID1B |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 587234 LARGE INTESTINE c.6581G>A p.R2194H COSMIC PASSENGER/OTHER Probably Damaging 2 587256 LARGE INTESTINE c.3349A>C p.S1117R COSMIC NP NP 3 587256 LARGE INTESTINE c.5118G>T p.L1706F COSMIC NP NP 4 587278 LARGE INTESTINE c.1528G>A p.G510R COSMIC NP NP 5 587302 LARGE INTESTINE c.5822C>T p.P1941L COSMIC NP NP 6 587316 LARGE INTESTINE c.1640C>T p.P547L COSMIC NP NP 7 587316 LARGE INTESTINE c.4250C>T p.P1417L COSMIC NP NP 8 587316 LARGE INTESTINE c.797G>C p.G266A COSMIC NP NP 9 587316 LARGE INTESTINE c.803G>C p.G268A COSMIC NP NP 10 8012854 PANCREAS c.3281G>A p.G1094D COSMIC NP NP 11 BN40T LIVER c.1062G>T p.P354P COSMIC NP NP 12 ESO-0061 OESOPHAGUS c.3463A>T p.K1155* COSMIC NP NP 13 ESO-859 OESOPHAGUS c.6345G>A p.A2115A COSMIC NP NP 14 H322T LUNG c.2812G>T p.A938S COSMIC NP NP 15 HCC123T LIVER c.3277G>A p.G1093R COSMIC NP NP 16 HCC1395 BREAST c.2267G>C p.G756A COSMIC NP NP 17 HCC20T LIVER c.3504G>A p.S1168S COSMIC NP NP 18 HCC41T LIVER c.3348A>G p.S1116S COSMIC NP NP 19 HCT-15 LARGE INTESTINE c.4816C>T p.R1606* COSMIC NP NP 20 HX12T LIVER c.6211C>G p.L2071V COSMIC NP NP 21 ICGC_0029 PANCREAS c.3281G>A p.G1094D COSMIC NP NP 22 LC_C21 LUNG c.1606C>T p.Q536* COSMIC NP NP 23 LC_C21 LUNG c.3658G>C p.D1220H COSMIC NP NP 24 LC_C32 LUNG c.1996C>T p.P666S COSMIC PASSENGER/OTHER Probably Damaging 25 LUAD-F00368 LUNG c.1659A>G p.P553P COSMIC NP NP 26 LUAD-NYU1219 LUNG c.5873G>T p.G1958V COSMIC NP NP 27 LUAD-RT-S01813 LUNG c.6196G>T p.E2066* COSMIC NP NP 28 LUAD-S00484 LUNG c.2013T>C p.S671S COSMIC NP NP 29 LUAD-S01345 LUNG c.1973C>T p.S658F COSMIC NP NP 30 LUAD-S01356 LUNG c.5089G>T p.A1697S COSMIC PASSENGER/OTHER Benign 31 LUAD-S01356 LUNG c.769_789del21 p.G257_G263delGGGGGSG COSMIC NP NP 32 LUAD-YINHD LUNG c.5377G>T p.E1793* COSMIC NP NP 33 LUAD-YINHD LUNG c.6505C>T p.L2169L COSMIC NP NP 34 MBRep_T29 CENTRAL NERVOUS SYSTEM c.5896G>A p.E1966K COSMIC NP NP 35 MBRep_T92 CENTRAL NERVOUS SYSTEM c.5914C>T p.R1972* COSMIC NP NP 36 MD-317 CENTRAL NERVOUS SYSTEM c.5587_5588delCT p.S1864fs*8 COSMIC NP NP 37 MD-324 CENTRAL NERVOUS SYSTEM c.2181A>G p.R727R COSMIC NP NP 38 ME009T SKIN c.4051C>T p.Q1351* COSMIC NP NP 39 ME011T SKIN c.5988G>A p.W1996* COSMIC NP NP 40 MS4 LARGE INTESTINE c.3873G>A p.M1291I COSMIC NP NP 41 NB_69 AUTONOMIC GANGLIA c.4307C>T p.S1436L COSMIC NP NP 42 NCI-H322M LUNG c.2812G>T p.A938S COSMIC NP NP 43 OCC02PT OVARY c.6496_6497insC p.P2168fs*6 COSMIC NP NP 44 P04-2740 PROSTATE c.1159_1160insCGC p.P392_S393insP COSMIC NP NP 45 PA285 PANCREAS c.6576A>C p.E2192D COSMIC NP NP 46 PD3199a NS c.4390delG p.G1464fs*12 COSMIC NP NP 47 PD3999a BREAST c.5409_5444del36 p.G1804_H1815del12 COSMIC NP NP 48 PD4120a BREAST c.2535G>A p.M845I COSMIC NP NP 49 PD4125a BREAST c.4829C>T p.S1610F COSMIC NP NP 50 PD4252a NS c.3390C>G p.Y1130* COSMIC NP NP 51 PD4844a NS c.5632delC p.Q1879fs*77 COSMIC NP NP 52 PR-00-1165 PROSTATE c.4270G>A p.G1424R COSMIC NP NP 53 PR-3026 PROSTATE c.5265C>A p.D1755E COSMIC NP NP 54 RK004_C01 LIVER c.1936C>T p.Q646* COSMIC NP NP 55 RK026_C01 LIVER c.2191A>G p.M731V COSMIC NP Probably Damaging 56 S00539 LUNG c.2693A>C p.Q898P COSMIC NP NP 57 S00827 LUNG c.3679G>T p.D1227Y COSMIC NP NP 58 S00833 LUNG c.2493T>A p.A831A COSMIC NP NP 59 S00837 LUNG c.3285G>T p.L1095F COSMIC NP NP 60 TCGA-05-4410-01 LUNG c.3415G>A p.E1139K COSMIC NP NP 61 TCGA-13-0717-01 OVARY c.5667_5668insT p.Q1890fs*36 COSMIC NP NP 62 TCGA-13-0717-01 OVARY c.5672A>C p.Q1891P COSMIC NP Possibly Damaging 63 TCGA-18-3406-01 LUNG c.6018G>T p.T2006T COSMIC NP NP 64 TCGA-18-3409-01 LUNG c.1519C>T p.R507W COSMIC NP NP 65 TCGA-38-4629-01 LUNG c.3223G>C p.V1075L COSMIC NP NP 66 TCGA-38-4631-01 LUNG c.1588G>T p.G530C COSMIC PASSENGER/OTHER Probably Damaging 67 TCGA-43-2578-01 LUNG c.4197G>A p.R1399R COSMIC NP NP 68 TCGA-43-3920-01 LUNG c.4193G>T p.R1398L COSMIC NP NP 69 TCGA-49-6743-01 LUNG c.6681G>C p.Q2227H COSMIC NP NP 70 TCGA-50-6590-01 LUNG c.2694G>C p.Q898H COSMIC NP NP 71 TCGA-51-4080-01 LUNG c.4978G>T p.G1660* COSMIC NP NP 72 TCGA-51-4080-01 LUNG c.5264A>C p.D1755A COSMIC NP NP 73 TCGA-55-6982-01 LUNG c.5760_5761GG>TT p.Q1920_D1921>HY COSMIC NP NP 74 TCGA-55-8089-01 LUNG c.3542G>C p.G1181A COSMIC NP NP 75 TCGA-60-2698-01 LUNG c.3797G>T p.G1266V COSMIC NP NP 76 TCGA-60-2698-01 LUNG c.5347G>C p.D1783H COSMIC NP NP 77 TCGA-60-2708-01 LUNG c.4353T>C p.N1451N COSMIC NP NP 78 TCGA-66-2744-01 LUNG c.3190G>A p.E1064K COSMIC NP NP 79 TCGA-66-2754-01 LUNG c.5260G>A p.A1754T COSMIC PASSENGER/OTHER Benign 80 TCGA-66-2795-01 LUNG c.4686G>T p.M1562I COSMIC NP NP 81 TCGA-69-7765-01 LUNG c.5751G>T p.A1917A COSMIC NP NP 82 TCGA-69-7980-01 LUNG c.4443G>C p.M1481I COSMIC NP NP 83 TCGA-78-7145-01 LUNG c.4217C>T p.P1406L COSMIC NP NP 84 TCGA-99-7458-01 LUNG c.5118G>T p.L1706F COSMIC NP NP 85 TCGA-99-7458-01 LUNG c.5989G>T p.D1997Y COSMIC PASSENGER/OTHER Probably Damaging 86 TCGA-99-8025-01 LUNG c.3866A>T p.Q1289L COSMIC NP NP 87 TCGA-A3-3363-01 KIDNEY c.3708G>A p.M1236I COSMIC NP NP 88 TCGA-A5-A0G3-01 ENDOMETRIUM c.5410G>A p.G1804S COSMIC NP NP 89 TCGA-A5-A0G9-01 ENDOMETRIUM c.4945A>T p.T1649S COSMIC NP NP 90 TCGA-A6-2672-01 LARGE INTESTINE c.4435_4442delGACGATAT p.D1480fs*9 COSMIC NP NP 91 TCGA-A6-6653-01 LARGE INTESTINE c.4704G>A p.T1568T COSMIC NP NP 92 TCGA-A8-A07L-01 BREAST c.5294A>C p.K1765T COSMIC NP NP 93 TCGA-AA-3710-01 LARGE INTESTINE c.1546C>T p.Q516* COSMIC NP NP 94 TCGA-AA-3864-01 LARGE INTESTINE c.2791G>A p.A931T COSMIC NP NP 95 TCGA-AA-3864-01 LARGE INTESTINE c.4901C>T p.T1634M COSMIC NP NP 96 TCGA-AA-3977-01 LARGE INTESTINE c.3235C>T p.P1079S COSMIC NP NP 97 TCGA-AA-3984-01 LARGE INTESTINE c.4642C>T p.R1548C COSMIC PASSENGER/OTHER Probably Damaging 98 TCGA-AA-3984-01 LARGE INTESTINE c.5804G>A p.R1935H COSMIC NP NP 99 TCGA-AA-A00E-01 LARGE INTESTINE c.3123G>T p.K1041N COSMIC NP NP 100 TCGA-AA-A00J-01 LARGE INTESTINE c.6266G>A p.R2089H COSMIC NP NP 101 TCGA-AD-6895-01 LARGE INTESTINE c.4429C>T p.R1477C COSMIC NP NP 102 TCGA-AF-6136-01 LARGE INTESTINE c.3712C>T p.P1238S COSMIC NP NP 103 TCGA-AG-3575-01 LARGE INTESTINE c.6328C>T p.R2110* COSMIC NP NP 104 TCGA-AG-A002-01 LARGE INTESTINE c.2084C>T p.P695L COSMIC NP NP 105 TCGA-AK-3455-01 KIDNEY c.6293T>G p.V2098G COSMIC NP NP 106 TCGA-AO-A0J2-01 BREAST c.2739C>G p.N913K COSMIC NP NP 107 TCGA-AO-A0JL-01 BREAST c.6232G>T p.V2078L COSMIC NP NP 108 TCGA-AP-A0LM-01 ENDOMETRIUM c.198G>A p.Q66Q COSMIC NP NP 109 TCGA-AP-A0LM-01 ENDOMETRIUM c.5577C>T p.I1859I COSMIC NP NP 110 TCGA-AX-A05Z-01 ENDOMETRIUM c.5298C>T p.F1766F COSMIC NP NP 111 TCGA-AX-A060-01 ENDOMETRIUM c.5982G>A p.W1994* COSMIC NP NP 112 TCGA-AX-A060-01 ENDOMETRIUM c.6606C>T p.G2202G COSMIC NP NP 113 TCGA-AX-A0J1-01 ENDOMETRIUM c.5634C>T p.P1878P COSMIC NP NP 114 TCGA-AZ-4315-01 LARGE INTESTINE c.1934C>T p.A645V COSMIC PASSENGER/OTHER Possibly Damaging 115 TCGA-AZ-6601-01 LARGE INTESTINE c.5920C>T p.P1974S COSMIC NP NP 116 TCGA-B0-5098-01 KIDNEY c.4114G>A p.D1372N COSMIC NP NP 117 TCGA-B5-A0JY-01 ENDOMETRIUM c.5178C>T p.D1726D COSMIC NP NP 118 TCGA-B5-A11E-01 ENDOMETRIUM c.3510C>A p.S1170S COSMIC NP NP 119 TCGA-B5-A11E-01 ENDOMETRIUM c.6621C>A p.I2207I COSMIC NP NP 120 TCGA-B5-A11H-01 ENDOMETRIUM c.3359C>T p.A1120V COSMIC NP NP 121 TCGA-B5-A11M-01 ENDOMETRIUM c.6114G>T p.M2038I COSMIC NP NP 122 TCGA-B5-A11V-01 ENDOMETRIUM c.1980delC p.P661fs*13 COSMIC NP NP 123 TCGA-B6-A0WT-01 BREAST c.2187delT p.Q730fs*44 COSMIC NP NP 124 TCGA-B8-4153-01 KIDNEY c.4056G>C p.P1352P COSMIC NP NP 125 TCGA-BG-A0VZ-01 ENDOMETRIUM c.186G>A p.Q62Q COSMIC NP NP 126 TCGA-BH-A0W7-01 BREAST c.3670G>C p.D1224H COSMIC NP Possibly Damaging 127 TCGA-BH-A1EV-01 BREAST c.5137G>C p.E1713Q COSMIC NP NP 128 TCGA-BK-A0C9-01 ENDOMETRIUM c.4672C>T p.P1558S COSMIC NP NP 129 TCGA-BL-A13I-01 URINARY TRACT c.3928C>T p.Q1310* COSMIC NP NP 130 TCGA-BS-A0TJ-01 ENDOMETRIUM c.75_76insCAC p.H31_A32insH COSMIC NP NP 131 TCGA-BS-A0U9-01 ENDOMETRIUM c.4078G>A p.G1360S COSMIC NP NP 132 TCGA-BS-A0UJ-01 ENDOMETRIUM c.2889A>C p.E963D COSMIC NP NP 133 TCGA-BS-A0UL-01 ENDOMETRIUM c.4492G>A p.V1498I COSMIC NP NP 134 TCGA-BS-A0UV-01 ENDOMETRIUM c.5298C>T p.F1766F COSMIC NP NP 135 TCGA-BT-A3PH-01 URINARY TRACT c.1814C>G p.S605* COSMIC NP NP 136 TCGA-CK-6746-01 LARGE INTESTINE c.6229A>G p.N2077D COSMIC NP NP 137 TCGA-CK-6747-01 LARGE INTESTINE c.3268_3269delAA p.K1090fs*9 COSMIC NP NP 138 TCGA-CM-4743-01 LARGE INTESTINE c.5619C>T p.D1873D COSMIC NP NP 139 TCGA-CM-6171-01 LARGE INTESTINE c.1989delC p.P664fs*10 COSMIC NP NP 140 TCGA-CM-6171-01 LARGE INTESTINE c.4181C>T p.S1394L COSMIC NP NP 141 TCGA-CM-6674-01 LARGE INTESTINE c.5413G>T p.G1805W COSMIC NP NP 142 TCGA-CU-A0YR-01 URINARY TRACT c.4162C>G p.Q1388E COSMIC PASSENGER/OTHER Benign 143 TCGA-CZ-5457-01 KIDNEY c.2408T>A p.M803K COSMIC NP NP 144 TCGA-D1-A0ZO-01 ENDOMETRIUM c.6049C>T p.L2017L COSMIC NP NP 145 TCGA-D1-A0ZS-01 ENDOMETRIUM c.4021G>T p.G1341* COSMIC NP NP 146 TCGA-D1-A103-01 ENDOMETRIUM c.5166C>T p.D1722D COSMIC NP NP 147 TCGA-D1-A176-01 ENDOMETRIUM c.4571C>T p.T1524M COSMIC NP NP 148 TCGA-D1-A17Q-01 ENDOMETRIUM c.3836C>T p.T1279M COSMIC NP NP 149 TCGA-D1-A17R-01 ENDOMETRIUM c.3865C>T p.Q1289* COSMIC NP NP 150 TCGA-D5-6928-01 LARGE INTESTINE c.2075A>G p.Q692R COSMIC NP NP 151 TCGA-D5-6930-01 LARGE INTESTINE c.1520G>A p.R507Q COSMIC NP NP 152 TCGA-DK-A1A3-01 URINARY TRACT c.3209C>T p.S1070L COSMIC NP NP 153 TCGA-E2-A14S-01 BREAST c.1959G>A p.A653A COSMIC NP NP 154 TCGA-E2-A158-01 BREAST c.4601G>A p.R1534K COSMIC NP NP 155 TCGA-E2-A159-01 BREAST c.6566G>A p.R2189K COSMIC NP NP 156 TCGA-EI-6507-01 LARGE INTESTINE c.5872G>A p.G1958R COSMIC NP NP 157 TCGA-G4-6588-01 LARGE INTESTINE c.5872G>T p.G1958W COSMIC NP NP 158 TCGA-G4-6628-01 LARGE INTESTINE c.3655C>T p.H1219Y COSMIC NP NP 159 TCGA-G9-6362-01 PROSTATE c.4643G>A p.R1548H COSMIC PASSENGER/OTHER Probably Damaging 160 TCGA-GV-A3QI-01 URINARY TRACT c.1650G>T p.P550P COSMIC NP NP 161 TCGA-HC-7749-01 PROSTATE c.2167G>A p.A723T COSMIC NP NP 162 YUKLAB SKIN c.64C>G p.P22A COSMIC NP NP 163 YURTHE SKIN c.3887C>T p.P1296L COSMIC NP NP 164 YUWHIM SKIN c.3481C>T p.Q1161* COSMIC NP NP 165 pfg014T STOMACH c.6331G>T p.E2111* COSMIC NP NP 166 pfg016T STOMACH c.3169C>T p.R1057* COSMIC NP NP 167 pfg016T STOMACH c.5337G>A p.L1779L COSMIC NP NP
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.test -
Tertiary structure (+)
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Structure Domains (+)
1. PFAM Domains:Domain ID Domain Name Start Site End Site E-value PB006715 Pfam-B_6715 32 132 6.6e-05 PB007257 Pfam-B_7257 371 451 4.4e-11 PB006834 Pfam-B_6834 693 984 1.5e-14 PB000165 Pfam-B_165 998 1034 3.6e-17 PF01388 ARID 1052 1140 9e-28 PF12031 DUF3518 1926 2182 3e-149 2. Superfamily Domains:Domain ID Start Site End Site E-value 0049275 1038 1151 8.37e-32 0051071 2066 2206 1.51e-04 -
Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 4. Sequence alignment with homologus proteins:
Click on button to get Sequence alignment with Coverage, Consensus and Quality -
Sequence Profiles (+)
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Post Translational Modifications (+)
S. No. Position Amino acid Type 1 1189 S Phosphorylation 2 1240 S Phosphorylation 3 1242 T Phosphorylation 4 1497 S Phosphorylation 5 1501 S Phosphorylation 6 1542 S Phosphorylation 7 1555 S Phosphorylation 8 1555 S Phosphorylation 9 1557 S Phosphorylation 10 1559 S Phosphorylation 11 1559 S Phosphorylation 12 1564 S Phosphorylation 13 1566 K Acetylation 14 1566 K Acetylation 15 1710 S Phosphorylation 16 1715 S Phosphorylation 17 1777 K Acetylation 18 1777 K Acetylation 19 2 A Acetylation 20 2097 K Ubiquitylation 21 2187 K Ubiquitylation 22 502 S Phosphorylation 23 516 S Phosphorylation 24 516 S Phosphorylation 25 632 S Phosphorylation -
Other Databases Link (+)
Proteomics DB COSMIC Gene Atlas STRING PIR ARID1B ARID1B ARID1B ENSP00000344546 Q8NFD5 QuickGO HGNC Ensembl Genome Browser TreeFam UniProt Q8NFD5 ARID1B ENSP00000344546 ARID1B Q8NFD5 Expression Atlas Protein Atlas OMIM IntAct PharmGKB ARID1B ENSP00000344546 614556 Q8NFD5 PA134909463
