dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: CDYL |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 2334194 LUNG c.143T>C p.V48A COSMIC PASSENGER/OTHER Benign 2 2334194 LUNG c.179C>G p.A60G COSMIC PASSENGER/OTHER Benign 3 2334194 LUNG c.25T>C p.S9P COSMIC PASSENGER/OTHER Benign 4 2334194 LUNG c.4A>G p.T2A COSMIC PASSENGER/OTHER Benign 5 587222 LARGE INTESTINE c.985C>T p.R329C COSMIC PASSENGER/OTHER Benign 6 587284 LARGE INTESTINE c.478G>A p.E160K COSMIC PASSENGER/OTHER Benign 7 587304 LARGE INTESTINE c.745G>A p.A249T COSMIC PASSENGER/OTHER Benign 8 587374 LARGE INTESTINE c.946A>T p.I316F COSMIC PASSENGER/OTHER Benign 9 ESO-114 OESOPHAGUS c.1065C>G p.I355M COSMIC PASSENGER/OTHER Probably Damaging 10 ESO03T OESOPHAGUS c.847G>A p.G283R COSMIC PASSENGER/OTHER Benign 11 GC8_T STOMACH c.25T>C p.S9P COSMIC PASSENGER/OTHER Benign 12 GC8_T STOMACH c.4A>G p.T2A COSMIC PASSENGER/OTHER Benign 13 HCC90T LIVER c.763G>A p.G255R COSMIC PASSENGER/OTHER Benign 14 HX4T LIVER c.694G>T p.A232S COSMIC PASSENGER/OTHER Benign 15 LUAD_E00522 LUNG c.639G>C p.Q213H COSMIC PASSENGER/OTHER Benign 16 TARGET-30-PARDIW AUTONOMIC GANGLIA c.341C>T p.T114M COSMIC PASSENGER/OTHER Benign 17 TARGET-30-PATEPF AUTONOMIC GANGLIA c.1714G>T p.E572* COSMIC NP NP 18 TCGA-05-4397-01 LUNG c.803C>T p.P268L COSMIC PASSENGER/OTHER Benign 19 TCGA-05-4415-01 LUNG c.24G>T p.R8S COSMIC PASSENGER/OTHER Benign 20 TCGA-05-4424-01 LUNG c.160G>C p.G54R COSMIC PASSENGER/OTHER Benign 21 TCGA-22-1002-01 LUNG c.1544G>T p.C515F COSMIC PASSENGER/OTHER Benign 22 TCGA-50-5066-01 LUNG c.1061A>G p.H354R COSMIC PASSENGER/OTHER Probably Damaging 23 TCGA-53-7624-01 LUNG c.676G>T p.G226C COSMIC PASSENGER/OTHER Probably Damaging 24 TCGA-55-6972-01 LUNG c.1717G>A p.V573M COSMIC PASSENGER/OTHER Benign 25 TCGA-55-6982-01 LUNG c.478G>T p.E160* COSMIC NP NP 26 TCGA-67-3771-01 LUNG c.652G>T p.E218* COSMIC NP NP 27 TCGA-69-7979-01 LUNG c.654G>T p.E218D COSMIC PASSENGER/OTHER Benign 28 TCGA-73-4662-01 LUNG c.592G>T p.V198L COSMIC PASSENGER/OTHER Possibly Damaging 29 TCGA-73-4670-01 LUNG c.371G>A p.R124K COSMIC PASSENGER/OTHER Benign 30 TCGA-86-6851-01 LUNG c.1450G>T p.G484C COSMIC PASSENGER/OTHER Probably Damaging 31 TCGA-97-7937-01 LUNG c.135C>A p.S45R COSMIC PASSENGER/OTHER Benign 32 TCGA-99-7458-01 LUNG c.763G>T p.G255W COSMIC PASSENGER/OTHER Probably Damaging 33 TCGA-A2-A0CT-01 BREAST c.1447G>A p.D483N COSMIC PASSENGER/OTHER Probably Damaging 34 TCGA-A6-6781-01 LARGE INTESTINE c.1625C>T p.S542L COSMIC PASSENGER/OTHER Benign 35 TCGA-AA-3864-01 LARGE INTESTINE c.1161C>A p.S387R COSMIC PASSENGER/OTHER Probably Damaging 36 TCGA-AA-3977-01 LARGE INTESTINE c.1290C>T p.F430F COSMIC NP NP 37 TCGA-AA-A00N-01 LARGE INTESTINE c.1290C>T p.F430F COSMIC NP NP 38 TCGA-AA-A00N-01 LARGE INTESTINE c.951C>T p.D317D COSMIC NP NP 39 TCGA-AA-A01R-01 LARGE INTESTINE c.986G>A p.R329H COSMIC PASSENGER/OTHER Benign 40 TCGA-AD-6889-01 LARGE INTESTINE c.1179C>T p.S393S COSMIC NP NP 41 TCGA-AG-A002-01 LARGE INTESTINE c.1290C>T p.F430F COSMIC NP NP 42 TCGA-AG-A002-01 LARGE INTESTINE c.1393G>T p.A465S COSMIC PASSENGER/OTHER Probably Damaging 43 TCGA-AG-A002-01 LARGE INTESTINE c.951C>T p.D317D COSMIC NP NP 44 TCGA-AP-A056-01 ENDOMETRIUM c.974A>G p.D325G COSMIC PASSENGER/OTHER Possibly Damaging 45 TCGA-AP-A059-01 ENDOMETRIUM c.478G>A p.E160K COSMIC PASSENGER/OTHER Benign 46 TCGA-AP-A0LM-01 ENDOMETRIUM c.1380C>T p.C460C COSMIC NP NP 47 TCGA-AP-A0LM-01 ENDOMETRIUM c.912T>C p.S304S COSMIC NP NP 48 TCGA-AX-A0J1-01 ENDOMETRIUM c.1191C>T p.S397S COSMIC NP NP 49 TCGA-AX-A0J1-01 ENDOMETRIUM c.1500C>T p.N500N COSMIC NP NP 50 TCGA-AX-A0J1-01 ENDOMETRIUM c.245G>A p.R82Q COSMIC PASSENGER/OTHER Probably Damaging 51 TCGA-AX-A0J1-01 ENDOMETRIUM c.724G>A p.G242R COSMIC PASSENGER/OTHER Possibly Damaging 52 TCGA-AZ-6598-01 LARGE INTESTINE c.313T>C p.Y105H COSMIC PASSENGER/OTHER Probably Damaging 53 TCGA-B0-5698-01 KIDNEY c.184C>G p.Q62E COSMIC PASSENGER/OTHER Benign 54 TCGA-B4-5832-01 KIDNEY c.859T>C p.S287P COSMIC PASSENGER/OTHER Benign 55 TCGA-B5-A11E-01 ENDOMETRIUM c.667G>A p.V223I COSMIC PASSENGER/OTHER Benign 56 TCGA-BH-A0DQ-01 BREAST c.686A>G p.D229G COSMIC PASSENGER/OTHER Probably Damaging 57 TCGA-BP-5185-01 KIDNEY c.806G>A p.G269D COSMIC PASSENGER/OTHER Benign 58 TCGA-BS-A0UV-01 ENDOMETRIUM c.134G>A p.S45N COSMIC PASSENGER/OTHER Benign 59 TCGA-BT-A0YX-01 URINARY TRACT c.1364C>G p.S455C COSMIC PASSENGER/OTHER Probably Damaging 60 TCGA-CK-6746-01 LARGE INTESTINE c.217delA p.K76fs*25 COSMIC NP NP 61 TCGA-D1-A103-01 ENDOMETRIUM c.1192G>A p.V398I COSMIC PASSENGER/OTHER Benign 62 TCGA-D5-6928-01 LARGE INTESTINE c.219A>G p.K73K COSMIC NP NP 63 TCGA-DK-A1AD-01 URINARY TRACT c.1156G>A p.D386N COSMIC PASSENGER/OTHER Possibly Damaging 64 TCGA-DM-A28K-01 LARGE INTESTINE c.216_217insA p.G75fs*13 COSMIC NP NP 65 TCGA-EW-A1IZ-01 BREAST c.1452C>T p.G484G COSMIC NP NP 66 TCGA-G2-A3IE-01 URINARY TRACT c.1335C>T p.V445V COSMIC NP NP 67 YUDAB SKIN c.1634C>T p.P545L COSMIC PASSENGER/OTHER Benign 68 cSCCP1 SKIN c.1739C>T p.S580L COSMIC PASSENGER/OTHER Probably Damaging
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.test -
Tertiary structure (+)
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Structure Domains (+)
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Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 4. Sequence alignment with homologus proteins:
Click on button to get Sequence alignment with Coverage, Consensus and Quality -
Sequence Profiles (+)
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Post Translational Modifications (+)
S. No. Position Amino acid Type 1 135 K Methylation 2 135 K Methylation 3 135 K Methylation 4 135 K Methylation 5 135 K Methylation 6 135 K Methylation 7 149 S Phosphorylation 8 172 K Ubiquitylation 9 201 S Phosphorylation 10 201 S Phosphorylation 11 207 T Phosphorylation 12 214 S Phosphorylation 13 216 S Phosphorylation 14 216 S Phosphorylation 15 230 T Phosphorylation 16 538 K Ubiquitylation 17 576 K Ubiquitylation 18 589 K Ubiquitylation 19 86 Y Phosphorylation 20 88 S Phosphorylation 21 88 S Phosphorylation 22 92 T Phosphorylation -
Other Databases Link (+)
Proteomics DB COSMIC Gene Atlas STRING PIR CDYL CDYL CDYL ENSP00000330512 Q9Y232 QuickGO HGNC Ensembl Genome Browser TreeFam UniProt Q9Y232 CDYL ENSP00000330512 CDYL Q9Y232 Expression Atlas Protein Atlas OMIM IntAct PharmGKB CDYL ENSP00000330512 603778 Q9Y232 PA26356
