dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: CHD4 |
| Expand All | Collapse All |
-
Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 31231321 STOMACH c.4698A>G p.I1566M COSMIC PASSENGER/OTHER Benign 2 Br27P CENTRAL NERVOUS SYSTEM c.1935G>A p.R645R COSMIC NP NP 3 Br27P CENTRAL NERVOUS SYSTEM c.4601G>A p.G1534E COSMIC PASSENGER/OTHER Benign 4 ESO-085 OESOPHAGUS c.5402G>A p.R1801Q COSMIC CANCER Probably Damaging 5 ESO-117 OESOPHAGUS c.3119A>G p.Y1040C COSMIC PASSENGER/OTHER Probably Damaging 6 ESO-175 OESOPHAGUS c.5339A>C p.K1780T COSMIC CANCER Probably Damaging 7 HCC30T LIVER c.687G>T p.A229A COSMIC NP NP 8 HCC33T LIVER c.2288T>G p.V763G COSMIC PASSENGER/OTHER Probably Damaging 9 HCC39T LIVER c.5084G>A p.R1695H COSMIC PASSENGER/OTHER Probably Damaging 10 HCC58T LIVER c.4375T>C p.Y1459H COSMIC CANCER Probably Damaging 11 HCC60T LIVER c.3709_3725del17 p.D1237fs*2 COSMIC NP NP 12 HCT-116 LARGE INTESTINE c.3484C>T p.R1162W COSMIC CANCER Probably Damaging 13 ICGC_MB40 CENTRAL NERVOUS SYSTEM c.340_358>16 p.K119delK COSMIC NP NP 14 KM12 LARGE INTESTINE c.3250G>A p.D1084N COSMIC CANCER Probably Damaging 15 MN-1041 MENINGES c.2867G>A p.R956Q COSMIC CANCER Probably Damaging 16 MOLT-4 HAEMATOPOIETIC AND LYMPHOID TISSUE c.2554T>C p.Y852H COSMIC CANCER Probably Damaging 17 RK062_C01 LIVER c.1702C>T p.Q568* COSMIC NP NP 18 RK177_C01 LIVER c.3696T>A p.T1232T COSMIC NP NP 19 TCGA-05-4390-01 LUNG c.2448C>G p.I816M COSMIC PASSENGER/OTHER Probably Damaging 20 TCGA-05-4396-01 LUNG c.4905C>A p.P1635P COSMIC NP NP 21 TCGA-05-4424-01 LUNG c.1096G>C p.E366Q COSMIC CANCER Probably Damaging 22 TCGA-05-5428-01 LUNG c.1625A>C p.Q542P COSMIC PASSENGER/OTHER Possibly Damaging 23 TCGA-09-1674-01 OVARY c.846T>C p.D282D COSMIC NP NP 24 TCGA-18-3414-01 LUNG c.3659A>G p.K1220R COSMIC PASSENGER/OTHER Benign 25 TCGA-18-3417-01 LUNG c.1821G>A p.E607E COSMIC NP NP 26 TCGA-34-5928-01 LUNG c.3775G>C p.D1259H COSMIC PASSENGER/OTHER Possibly Damaging 27 TCGA-38-4625-01 LUNG c.1804G>T p.D602Y COSMIC PASSENGER/OTHER Probably Damaging 28 TCGA-39-5019-01 LUNG c.3319G>C p.E1107Q COSMIC PASSENGER/OTHER Probably Damaging 29 TCGA-43-5668-01 LUNG c.2280G>C p.Q760H COSMIC PASSENGER/OTHER Probably Damaging 30 TCGA-44-2668-01 LUNG c.3559G>C p.V1187L COSMIC CANCER Benign 31 TCGA-44-4112-01 LUNG c.1314G>T p.G438G COSMIC NP NP 32 TCGA-44-8119-01 LUNG c.2335C>T p.L779L COSMIC NP NP 33 TCGA-55-6968-01 LUNG c.637A>G p.S213G COSMIC PASSENGER/OTHER Probably Damaging 34 TCGA-61-1741-01 OVARY c.2924G>A p.R975H COSMIC PASSENGER/OTHER Probably Damaging 35 TCGA-63-5131-01 LUNG c.2197G>T p.G733C COSMIC PASSENGER/OTHER Probably Damaging 36 TCGA-66-2777-01 LUNG c.4615A>G p.K1539E COSMIC PASSENGER/OTHER Benign 37 TCGA-75-5125-01 LUNG c.4804_4805TC>CT p.S1602L COSMIC PASSENGER/OTHER Benign 38 TCGA-78-7152-01 LUNG c.3482A>G p.H1161R COSMIC PASSENGER/OTHER Benign 39 TCGA-A2-A04W-01 BREAST c.4933G>T p.E1645* COSMIC NP NP 40 TCGA-A6-3809-01 LARGE INTESTINE c.1536G>A p.Q512Q COSMIC NP NP 41 TCGA-A6-5665-01 LARGE INTESTINE c.417G>T p.E139D COSMIC PASSENGER/OTHER Benign 42 TCGA-A6-6781-01 LARGE INTESTINE c.1039C>T p.R347* COSMIC NP NP 43 TCGA-A8-A07O-01 BREAST c.2574C>T p.D858D COSMIC NP NP 44 TCGA-A8-A07R-01 BREAST c.1863G>A p.W621* COSMIC NP NP 45 TCGA-AA-3713-01 LARGE INTESTINE c.699G>A p.A233A COSMIC NP NP 46 TCGA-AA-3815-01 LARGE INTESTINE c.5635C>G p.P1879A COSMIC PASSENGER/OTHER Probably Damaging 47 TCGA-AA-A02K-01 LARGE INTESTINE c.3334T>C p.F1112L COSMIC CANCER Probably Damaging 48 TCGA-AB-2878-03 HAEMATOPOIETIC AND LYMPHOID TISSUE c.3517C>T p.R1173W COSMIC CANCER Probably Damaging 49 TCGA-AB-2949-03 HAEMATOPOIETIC AND LYMPHOID TISSUE c.2924G>A p.R975H COSMIC PASSENGER/OTHER Probably Damaging 50 TCGA-AD-5900-01 LARGE INTESTINE c.4214C>T p.A1405V COSMIC PASSENGER/OTHER Possibly Damaging 51 TCGA-AH-6643-01 LARGE INTESTINE c.4602G>A p.G1534G COSMIC NP NP 52 TCGA-AO-A12E-01 BREAST c.2710C>A p.P904T COSMIC CANCER Probably Damaging 53 TCGA-AP-A051-01 ENDOMETRIUM c.3803C>T p.T1268I COSMIC PASSENGER/OTHER Benign 54 TCGA-AP-A056-01 ENDOMETRIUM c.4013G>T p.R1338I COSMIC CANCER Probably Damaging 55 TCGA-AP-A059-01 ENDOMETRIUM c.151C>A p.L51I COSMIC PASSENGER/OTHER Benign 56 TCGA-AP-A059-01 ENDOMETRIUM c.3672G>T p.E1224D COSMIC CANCER Benign 57 TCGA-AP-A059-01 ENDOMETRIUM c.4467C>A p.R1489R COSMIC NP NP 58 TCGA-AP-A059-01 ENDOMETRIUM c.4866G>T p.E1622D COSMIC PASSENGER/OTHER Benign 59 TCGA-AP-A059-01 ENDOMETRIUM c.783G>T p.K261N COSMIC PASSENGER/OTHER Probably Damaging 60 TCGA-AQ-A1H3-01 BREAST c.2630G>A p.R877Q COSMIC PASSENGER/OTHER Probably Damaging 61 TCGA-AX-A06L-01 ENDOMETRIUM c.2630G>A p.R877Q COSMIC PASSENGER/OTHER Probably Damaging 62 TCGA-AX-A0J0-01 ENDOMETRIUM c.423T>G p.D141E COSMIC PASSENGER/OTHER Benign 63 TCGA-AX-A0J1-01 ENDOMETRIUM c.5441C>A p.P1814H COSMIC PASSENGER/OTHER Probably Damaging 64 TCGA-AZ-4315-01 LARGE INTESTINE c.1429A>G p.N477D COSMIC PASSENGER/OTHER Probably Damaging 65 TCGA-AZ-6599-01 LARGE INTESTINE c.1933C>T p.R645W COSMIC PASSENGER/OTHER Probably Damaging 66 TCGA-AZ-6601-01 LARGE INTESTINE c.4409C>T p.P1470L COSMIC PASSENGER/OTHER Probably Damaging 67 TCGA-B0-5077-01 KIDNEY c.2911G>C p.E971Q COSMIC PASSENGER/OTHER Probably Damaging 68 TCGA-B0-5098-01 KIDNEY c.529A>G p.N177D COSMIC PASSENGER/OTHER Probably Damaging 69 TCGA-B0-5121-01 KIDNEY c.4703A>C p.E1568A COSMIC PASSENGER/OTHER Benign 70 TCGA-B5-A0JY-01 ENDOMETRIUM c.2655C>A p.F885L COSMIC PASSENGER/OTHER Probably Damaging 71 TCGA-B5-A11E-01 ENDOMETRIUM c.325G>A p.D109N COSMIC PASSENGER/OTHER Probably Damaging 72 TCGA-B5-A11E-01 ENDOMETRIUM c.5422T>C p.S1808P COSMIC PASSENGER/OTHER Possibly Damaging 73 TCGA-B5-A11E-01 ENDOMETRIUM c.913C>T p.R305C COSMIC PASSENGER/OTHER Probably Damaging 74 TCGA-B5-A11N-01 ENDOMETRIUM c.3644T>G p.L1215R COSMIC PASSENGER/OTHER Possibly Damaging 75 TCGA-B6-A0RS-01 BREAST c.888C>G p.I296M COSMIC PASSENGER/OTHER Probably Damaging 76 TCGA-B8-4153-01 KIDNEY c.512A>C p.D171A COSMIC CANCER Possibly Damaging 77 TCGA-BG-A2AE-01 ENDOMETRIUM c.3570_3572delGAA p.K1191delK COSMIC NP NP 78 TCGA-BH-A0DD-01 BREAST c.484G>A p.D162N COSMIC CANCER Benign 79 TCGA-BH-A0E1-01 BREAST c.2629C>T p.R877W COSMIC PASSENGER/OTHER Probably Damaging 80 TCGA-BH-A0HY-01 BREAST c.3390C>T p.G1130G COSMIC NP NP 81 TCGA-BK-A13C-01 ENDOMETRIUM c.3475A>G p.R1159G COSMIC CANCER Possibly Damaging 82 TCGA-BP-4976-01 KIDNEY c.4669G>A p.V1557I COSMIC PASSENGER/OTHER Benign 83 TCGA-BP-4989-01 KIDNEY c.4952A>C p.D1651A COSMIC PASSENGER/OTHER Benign 84 TCGA-BP-5001-01 KIDNEY c.2873T>A p.L958H COSMIC PASSENGER/OTHER Probably Damaging 85 TCGA-BS-A0TC-01 ENDOMETRIUM c.2618A>G p.D873G COSMIC CANCER Probably Damaging 86 TCGA-BS-A0TC-01 ENDOMETRIUM c.830G>A p.S277N COSMIC PASSENGER/OTHER Benign 87 TCGA-BS-A0UA-01 ENDOMETRIUM c.915T>C p.R305R COSMIC NP NP 88 TCGA-BS-A0UV-01 ENDOMETRIUM c.2140C>T p.R714* COSMIC NP NP 89 TCGA-BS-A0UV-01 ENDOMETRIUM c.2212C>T p.R738C COSMIC PASSENGER/OTHER Probably Damaging 90 TCGA-BS-A0UV-01 ENDOMETRIUM c.2953T>C p.Y985H COSMIC PASSENGER/OTHER Probably Damaging 91 TCGA-C8-A27B-01 BREAST c.269C>A p.P90Q COSMIC PASSENGER/OTHER Benign 92 TCGA-C8-A27B-01 BREAST c.703G>C p.A235P COSMIC PASSENGER/OTHER Benign 93 TCGA-CA-6717-01 LARGE INTESTINE c.1715G>A p.R572Q COSMIC PASSENGER/OTHER Probably Damaging 94 TCGA-CJ-4923-01 KIDNEY c.2108C>T p.T703M COSMIC PASSENGER/OTHER Probably Damaging 95 TCGA-CK-5912-01 LARGE INTESTINE c.4216C>G p.R1406G COSMIC PASSENGER/OTHER Probably Damaging 96 TCGA-CK-6746-01 LARGE INTESTINE c.4706delA p.N1569fs*9 COSMIC NP NP 97 TCGA-CK-6746-01 LARGE INTESTINE c.5645C>T p.A1882V COSMIC CANCER Probably Damaging 98 TCGA-CM-5861-01 LARGE INTESTINE c.3822T>C p.N1274N COSMIC NP NP 99 TCGA-CM-6170-01 LARGE INTESTINE c.1971G>A p.E657E COSMIC NP NP 100 TCGA-D1-A103-01 ENDOMETRIUM c.4013G>T p.R1338I COSMIC CANCER Probably Damaging 101 TCGA-D1-A17Q-01 ENDOMETRIUM c.1040G>A p.R347Q COSMIC CANCER Benign 102 TCGA-D8-A1JN-01 BREAST c.2965A>T p.I989F COSMIC PASSENGER/OTHER Probably Damaging 103 TCGA-DK-A2I1-01 URINARY TRACT c.3895G>C p.E1299Q COSMIC CANCER Benign 104 TCGA-DK-A2I1-01 URINARY TRACT c.4111G>C p.E1371Q COSMIC PASSENGER/OTHER Probably Damaging 105 TCGA-DM-A1D9-01 LARGE INTESTINE c.4600G>T p.G1534W COSMIC PASSENGER/OTHER Possibly Damaging 106 TCGA-E2-A1B6-01 BREAST c.4812T>C p.D1604D COSMIC NP NP 107 TCGA-E9-A1NG-01 BREAST c.3484C>T p.R1162W COSMIC CANCER Probably Damaging 108 TCGA-E9-A1NI-01 BREAST c.355_357delAAG p.K119delK COSMIC NP NP 109 TCGA-F4-6570-01 LARGE INTESTINE c.4393C>T p.R1465W COSMIC PASSENGER/OTHER Probably Damaging 110 TCGA-F4-6856-01 LARGE INTESTINE c.4543C>T p.R1515C COSMIC PASSENGER/OTHER Probably Damaging 111 TCGA-FD-A3NA-01 URINARY TRACT c.1902G>C p.K634N COSMIC PASSENGER/OTHER Probably Damaging 112 TCGA-FD-A3NA-01 URINARY TRACT c.1923G>C p.L641F COSMIC PASSENGER/OTHER Probably Damaging 113 TCGA-G2-A2EC-01 URINARY TRACT c.4405G>C p.E1469Q COSMIC CANCER Probably Damaging 114 TCGA-G2-A2EJ-01 URINARY TRACT c.3997C>G p.L1333V COSMIC CANCER Probably Damaging 115 TCGA-G2-A2EJ-01 URINARY TRACT c.4621C>G p.P1541A COSMIC PASSENGER/OTHER Possibly Damaging 116 TCGA-G4-6309-01 LARGE INTESTINE c.1412A>G p.Y471C COSMIC PASSENGER/OTHER Probably Damaging 117 TCGA-G4-6309-01 LARGE INTESTINE c.218delA p.K73fs*129 COSMIC NP NP 118 TCGA-G4-6588-01 LARGE INTESTINE c.2835delA p.K945fs*28 COSMIC NP NP 119 TCGA-G9-6356-01 PROSTATE c.3778C>T p.R1260C COSMIC PASSENGER/OTHER Probably Damaging 120 TCGA-GV-A3QH-01 URINARY TRACT c.1618G>A p.E540K COSMIC PASSENGER/OTHER Possibly Damaging 121 YUDEDE SKIN c.772C>T p.R258C COSMIC PASSENGER/OTHER Probably Damaging 122 YUFOLD SKIN c.4091C>T p.S1364F COSMIC PASSENGER/OTHER Probably Damaging 123 YUFOLD SKIN c.4262G>A p.R1421Q COSMIC CANCER Possibly Damaging 124 YUGOE SKIN c.517C>T p.R173* COSMIC NP NP 125 YUKLAB SKIN c.848C>T p.A283V COSMIC PASSENGER/OTHER Benign 126 YUPER SKIN c.4622C>T p.P1541L COSMIC PASSENGER/OTHER Probably Damaging 127 YUPROST SKIN c.2170G>T p.G724* COSMIC NP NP 128 ccRCC-41 KIDNEY c.1448T>A p.I483N COSMIC PASSENGER/OTHER Probably Damaging 129 pfg008T STOMACH c.5190T>C p.H1730H COSMIC NP NP 130 pfg008T STOMACH c.5217C>T p.A1739A COSMIC NP NP 131 pfg017T STOMACH c.3380G>A p.R1127Q COSMIC CANCER Probably Damaging
*NP: Not Predicted -
Copy number variation and expression profile (+)
-
Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.Gene essentiality data is not present in COLT database!! -
Tertiary structure (+)
Users must enabled the Java in their browser to see structure.
Users can also download Java from here.Modelled Structure Structures available in PDB -
Structure Domains (+)
1. PFAM domains are not present!!2. Superfaimly domains are not present!! -
Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:4. Sequence alignment with homologus proteins: -
Sequence Profiles (+)
-
Post Translational Modifications (+)
Post translational modifications are not found!!Other Databases Link (+)
