dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: CHRAC1 |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 TCGA-09-2050-01 OVARY c.81C>A p.I27I COSMIC NP NP 2 TCGA-57-1582-01 OVARY c.39G>A p.E13E COSMIC NP NP 3 TCGA-78-7146-01 LUNG c.359A>G p.N120S COSMIC PASSENGER/OTHER Benign 4 TCGA-D5-6538-01 LARGE INTESTINE c.80T>C p.I27T COSMIC PASSENGER/OTHER Probably Damaging 5 TCGA-D5-6928-01 LARGE INTESTINE c.80T>C p.I27T COSMIC PASSENGER/OTHER Probably Damaging 6 TCGA-GV-A3QI-01 URINARY TRACT c.190G>T p.G64C COSMIC PASSENGER/OTHER Probably Damaging 7 YUAVEY SKIN c.73C>T p.R25W COSMIC PASSENGER/OTHER Probably Damaging
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.Gene essentiality data is not present in COLT database!! -
Tertiary structure (+)
Users must enabled the Java in their browser to see structure.
Users can also download Java from here.Modelled Structure Structures available in PDB -
Structure Domains (+)
1. PFAM domains are not present!!2. Superfaimly domains are not present!! -
Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:4. Sequence alignment with homologus proteins: -
Sequence Profiles (+)
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Post Translational Modifications (+)
Post translational modifications are not found!!Other Databases Link (+)
