dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: CHRAC1 |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 TCGA-09-2050-01 OVARY c.81C>A p.I27I COSMIC NP NP 2 TCGA-57-1582-01 OVARY c.39G>A p.E13E COSMIC NP NP 3 TCGA-78-7146-01 LUNG c.359A>G p.N120S COSMIC PASSENGER/OTHER Benign 4 TCGA-D5-6538-01 LARGE INTESTINE c.80T>C p.I27T COSMIC PASSENGER/OTHER Probably Damaging 5 TCGA-D5-6928-01 LARGE INTESTINE c.80T>C p.I27T COSMIC PASSENGER/OTHER Probably Damaging 6 TCGA-GV-A3QI-01 URINARY TRACT c.190G>T p.G64C COSMIC PASSENGER/OTHER Probably Damaging 7 YUAVEY SKIN c.73C>T p.R25W COSMIC PASSENGER/OTHER Probably Damaging
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.test -
Tertiary structure (+)
Users must enabled the Java in their browser to see structure.
Users can also download Java from here.Modelled Structure Structures available in PDB Structure is not available in PDB -
Structure Domains (+)
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Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 4. Sequence alignment with homologus proteins:
Click on button to get Sequence alignment with Coverage, Consensus and Quality -
Sequence Profiles (+)
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Post Translational Modifications (+)
S. No. Position Amino acid Type 1 102 K Acetylation 2 102 K Acetylation 3 124 S Phosphorylation 4 124 S Phosphorylation 5 2 A Acetylation -
Other Databases Link (+)
Proteomics DB COSMIC Gene Atlas STRING PIR CHRAC1 CHRAC1 CHRAC1 ENSP00000220913 Q9NRG0 QuickGO HGNC Ensembl Genome Browser TreeFam UniProt Q9NRG0 CHRAC1 ENSP00000220913 CHRAC1 Q9NRG0 Expression Atlas Protein Atlas OMIM IntAct PharmGKB CHRAC1 ENSP00000220913 607268 Q9NRG0 PA26481
