dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: DNMT1 |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 22RV1 PROSTATE c.1345C>T p.L449F CCLE PASSENGER/OTHER Possibly Damaging 2 A375 SKIN c.2683C>T p.P895S CCLE NP Probably Damaging 3 CALU6 LUNG c.3797C>T p.S1266F CCLE NP NP 4 GP2D LARGE INTESTINE c.248A>G p.D83G CCLE NP NP 5 GP2D LARGE INTESTINE c.3029G>A p.G1010D CCLE NP NP 6 HEC251 ENDOMETRIUM c.1315G>A p.D439N CCLE NP NP 7 HS944T SKIN c.1694C>T p.S565F CCLE NP NP 8 JHUEM2 ENDOMETRIUM c.891C>A p.S297S CCLE NP NP 9 KLE ENDOMETRIUM c.4894G>C p.D1632H CCLE NP NP 10 KP4 PANCREAS c.445C>T p.R149W CCLE NP NP 11 KYSE180 OESOPHAGUS c.954_954delA p.K318fs CCLE NP NP 12 LP1 HAEMATOPOIETIC AND LYMPHOID TISSUE c.919A>G p.K307E CCLE NP NP 13 LU99 LUNG c.4001C>T p.A1334V CCLE NP NP 14 MFE319 ENDOMETRIUM c.2135T>C p.M712T CCLE PASSENGER/OTHER Benign 15 MFE319 ENDOMETRIUM c.3553A>G p.M1185V CCLE NP NP 16 MOLT13 HAEMATOPOIETIC AND LYMPHOID TISSUE c.3697G>A p.V1233M CCLE NP NP 17 NALM6 HAEMATOPOIETIC AND LYMPHOID TISSUE c.3467G>A p.R1156Q CCLE NP NP 18 NCIH196 LUNG c.4293_splice p.K1431_splice CCLE NP NP 19 NCIH2106 LUNG c.981T>G p.I327M CCLE NP NP 20 NCIH2110 LUNG c.4174G>C p.E1392Q CCLE NP NP 21 NCIH82 LUNG c.846G>A p.L282L CCLE NP NP 22 NIHOVCAR3 OVARY c.341G>A p.R114K CCLE PASSENGER/OTHER Benign 23 NUGC3 STOMACH c.4223C>A p.P1408H CCLE NP NP 24 ONCODG1 OVARY c.341G>A p.R114K CCLE PASSENGER/OTHER Benign 25 PECAPJ49 UPPER AERODIGESTIVE TRACT c.981T>G p.I327M CCLE NP NP 26 REH HAEMATOPOIETIC AND LYMPHOID TISSUE c.328G>A p.G110R CCLE PASSENGER/OTHER Probably Damaging 27 SKES1 BONE c.2811_2815delCCTCT p.V937fs CCLE NP NP 28 SNU886 LIVER c.410C>G p.T137R CCLE PASSENGER/OTHER Benign 29 SW620 LARGE INTESTINE c.1807C>A p.L603M CCLE NP NP 30 VMRCLCP LUNG c.710A>T p.E237V CCLE NP NP 31 WM1799 SKIN c.3343C>T p.P1115S CCLE NP NP 32 100843 LUNG c.2339C>T p.T780M COSMIC PASSENGER/OTHER Possibly Damaging 33 103812 BREAST c.4652G>A p.R1551Q COSMIC PASSENGER/OTHER Probably Damaging 34 112032 PROSTATE c.1848G>A p.T616T COSMIC NP NP 35 587222 LARGE INTESTINE c.737G>A p.R246Q COSMIC PASSENGER/OTHER Benign 36 587226 LARGE INTESTINE c.2873G>A p.R958H COSMIC PASSENGER/OTHER Probably Damaging 37 587342 LARGE INTESTINE c.2105A>T p.D702V COSMIC PASSENGER/OTHER Probably Damaging 38 587342 LARGE INTESTINE c.3937G>A p.A1313T COSMIC PASSENGER/OTHER Possibly Damaging 39 587376 LARGE INTESTINE c.2975G>A p.R992Q COSMIC PASSENGER/OTHER Probably Damaging 40 587376 LARGE INTESTINE c.4283T>A p.I1428N COSMIC PASSENGER/OTHER Probably Damaging 41 B2 KIDNEY c.860G>A p.R287K COSMIC PASSENGER/OTHER Possibly Damaging 42 BN40T LIVER c.4273A>G p.M1425V COSMIC PASSENGER/OTHER Possibly Damaging 43 CP66-MEL SKIN c.4589C>T p.P1530L COSMIC PASSENGER/OTHER Probably Damaging 44 Case2 BREAST c.1147A>G p.N383D COSMIC PASSENGER/OTHER Benign 45 ESO-0129 OESOPHAGUS c.1601C>T p.T534M COSMIC PASSENGER/OTHER Probably Damaging 46 ESO-1060 OESOPHAGUS c.2415C>T p.L805L COSMIC NP NP 47 ESO-1096 OESOPHAGUS c.276G>T p.L92F COSMIC PASSENGER/OTHER Possibly Damaging 48 ESO-143 OESOPHAGUS c.3247T>A p.F1083I COSMIC PASSENGER/OTHER Probably Damaging 49 ESO-167 OESOPHAGUS c.3617C>T p.S1206F COSMIC PASSENGER/OTHER Possibly Damaging 50 ESO-859 OESOPHAGUS c.1696G>A p.E566K COSMIC PASSENGER/OTHER Benign 51 ESO-859 OESOPHAGUS c.2262G>A p.A754A COSMIC NP NP 52 GC8_T STOMACH c.290A>G p.H97R COSMIC PASSENGER/OTHER Possibly Damaging 53 HCC107T LIVER c.3450_3451insG p.L1151fs*12 COSMIC NP NP 54 HCC40T LIVER c.1897G>A p.A633T COSMIC PASSENGER/OTHER Benign 55 HCC61T LIVER c.417G>T p.R139S COSMIC PASSENGER/OTHER Probably Damaging 56 HCT-15 LARGE INTESTINE c.4801C>T p.R1601* COSMIC NP NP 57 HX11T LIVER c.2873G>A p.R958H COSMIC PASSENGER/OTHER Probably Damaging 58 ID14 HAEMATOPOIETIC AND LYMPHOID TISSUE c.4309C>T p.R1437C COSMIC PASSENGER/OTHER Probably Damaging 59 LAU165 SKIN c.4677C>T p.F1559F COSMIC NP NP 60 LC_C9 LUNG c.1915G>T p.D639Y COSMIC PASSENGER/OTHER Benign 61 LUAD-5V8LT LUNG c.3G>T p.M1I COSMIC PASSENGER/OTHER Possibly Damaging 62 LUAD-B00523 LUNG c.4170G>T p.G1390G COSMIC NP NP 63 LUAD-B01811 LUNG c.858C>T p.H286H COSMIC NP NP 64 LUAD-RT-S01769 LUNG c.1266C>T p.I422I COSMIC NP NP 65 LUAD-RT-S01818 LUNG c.3480C>T p.I1160I COSMIC NP NP 66 MOLT-4 HAEMATOPOIETIC AND LYMPHOID TISSUE c.2189G>A p.R730H COSMIC PASSENGER/OTHER Probably Damaging 67 NB-1977 AUTONOMIC GANGLIA c.1372C>A p.L458I COSMIC PASSENGER/OTHER Benign 68 PD3856a BREAST c.3002G>T p.C1001F COSMIC PASSENGER/OTHER Benign 69 PD4099a BREAST c.2961C>G p.A987A COSMIC NP NP 70 PD4136a BREAST c.929A>G p.Q310R COSMIC PASSENGER/OTHER Benign 71 RK159_C01 LIVER c.552T>C p.S184S COSMIC NP NP 72 S00841 LUNG c.1719G>T p.Q573H COSMIC PASSENGER/OTHER Possibly Damaging 73 S00936 LUNG c.2381C>T p.A794V COSMIC PASSENGER/OTHER Possibly Damaging 74 TCGA-05-4410-01 LUNG c.3964G>C p.E1322Q COSMIC PASSENGER/OTHER Benign 75 TCGA-09-1666-01 OVARY c.4145C>T p.S1382L COSMIC PASSENGER/OTHER Probably Damaging 76 TCGA-18-3408-01 LUNG c.1145C>G p.T382R COSMIC PASSENGER/OTHER Possibly Damaging 77 TCGA-18-3411-01 LUNG c.3303C>A p.N1101K COSMIC PASSENGER/OTHER Benign 78 TCGA-21-1077-01 LUNG c.2507A>T p.Y836F COSMIC PASSENGER/OTHER Benign 79 TCGA-24-2035-01 OVARY c.1567A>G p.T523A COSMIC PASSENGER/OTHER Benign 80 TCGA-33-4583-01 LUNG c.3386A>G p.E1129G COSMIC PASSENGER/OTHER Benign 81 TCGA-38-4628-01 LUNG c.3223T>G p.Y1075D COSMIC PASSENGER/OTHER Possibly Damaging 82 TCGA-49-6742-01 LUNG c.498C>T p.T166T COSMIC NP NP 83 TCGA-78-7155-01 LUNG c.3066C>T p.Y1022Y COSMIC NP NP 84 TCGA-A2-A25B-01 BREAST c.414C>T p.P138P COSMIC NP NP 85 TCGA-A5-A0GV-01 ENDOMETRIUM c.1068C>T p.C356C COSMIC NP NP 86 TCGA-A5-A0R9-01 ENDOMETRIUM c.4456G>A p.D1486N COSMIC PASSENGER/OTHER Possibly Damaging 87 TCGA-A6-2683-01 LARGE INTESTINE c.260A>G p.N87S COSMIC PASSENGER/OTHER Probably Damaging 88 TCGA-A8-A097-01 BREAST c.3792C>A p.L1264L COSMIC NP NP 89 TCGA-AA-3492-01 LARGE INTESTINE c.1591A>G p.I531V COSMIC PASSENGER/OTHER Possibly Damaging 90 TCGA-AA-3492-01 LARGE INTESTINE c.807C>T p.G269G COSMIC NP NP 91 TCGA-AA-3554-01 LARGE INTESTINE c.2553C>T p.P851P COSMIC NP NP 92 TCGA-AA-3555-01 LARGE INTESTINE c.4591G>C p.E1531Q COSMIC PASSENGER/OTHER Probably Damaging 93 TCGA-AA-3672-01 LARGE INTESTINE c.1294G>A p.E432K COSMIC PASSENGER/OTHER Benign 94 TCGA-AA-3713-01 LARGE INTESTINE c.3237C>T p.G1079G COSMIC NP NP 95 TCGA-AA-3845-01 LARGE INTESTINE c.3866G>A p.R1289H COSMIC PASSENGER/OTHER Probably Damaging 96 TCGA-AA-3864-01 LARGE INTESTINE c.2574C>T p.D858D COSMIC NP NP 97 TCGA-AA-3877-01 LARGE INTESTINE c.1660G>C p.A554P COSMIC PASSENGER/OTHER Probably Damaging 98 TCGA-AA-3956-01 LARGE INTESTINE c.1660G>A p.A554T COSMIC PASSENGER/OTHER Probably Damaging 99 TCGA-AA-3966-01 LARGE INTESTINE c.768_769delGA p.K257fs*16 COSMIC NP NP 100 TCGA-AA-A00J-01 LARGE INTESTINE c.3316C>T p.P1106S COSMIC PASSENGER/OTHER Benign 101 TCGA-AA-A00N-01 LARGE INTESTINE c.1294G>A p.E432K COSMIC PASSENGER/OTHER Benign 102 TCGA-AA-A010-01 LARGE INTESTINE c.3710C>T p.S1237L COSMIC PASSENGER/OTHER Probably Damaging 103 TCGA-AA-A01Q-01 LARGE INTESTINE c.1550A>C p.Q517P COSMIC PASSENGER/OTHER Probably Damaging 104 TCGA-AA-A01Z-01 LARGE INTESTINE c.1294G>A p.E432K COSMIC PASSENGER/OTHER Benign 105 TCGA-AB-2833-03 HAEMATOPOIETIC AND LYMPHOID TISSUE c.499A>T p.I167F COSMIC PASSENGER/OTHER Probably Damaging 106 TCGA-AF-2689-01 LARGE INTESTINE c.319C>G p.L107V COSMIC PASSENGER/OTHER Possibly Damaging 107 TCGA-AG-3609-01 LARGE INTESTINE c.4591G>C p.E1531Q COSMIC PASSENGER/OTHER Probably Damaging 108 TCGA-AG-3882-01 LARGE INTESTINE c.4097C>T p.T1366M COSMIC PASSENGER/OTHER Probably Damaging 109 TCGA-AG-A002-01 LARGE INTESTINE c.1453G>A p.E485K COSMIC PASSENGER/OTHER Probably Damaging 110 TCGA-AG-A002-01 LARGE INTESTINE c.689G>A p.R230H COSMIC PASSENGER/OTHER Benign 111 TCGA-AG-A02N-01 LARGE INTESTINE c.407G>A p.R136H COSMIC PASSENGER/OTHER Possibly Damaging 112 TCGA-AG-A02N-01 LARGE INTESTINE c.4103G>A p.R1368Q COSMIC PASSENGER/OTHER Probably Damaging 113 TCGA-AN-A0XW-01 BREAST c.2505C>T p.I835I COSMIC NP NP 114 TCGA-AP-A051-01 ENDOMETRIUM c.2787C>T p.N929N COSMIC NP NP 115 TCGA-AP-A056-01 ENDOMETRIUM c.151G>A p.E51K COSMIC PASSENGER/OTHER Probably Damaging 116 TCGA-AP-A059-01 ENDOMETRIUM c.1137G>A p.Q379Q COSMIC NP NP 117 TCGA-AP-A0LM-01 ENDOMETRIUM c.4358G>T p.R1453M COSMIC PASSENGER/OTHER Possibly Damaging 118 TCGA-AP-A0LM-01 ENDOMETRIUM c.4394G>A p.G1465D COSMIC PASSENGER/OTHER Probably Damaging 119 TCGA-AR-A251-01 BREAST c.2318C>T p.P773L COSMIC PASSENGER/OTHER Probably Damaging 120 TCGA-AU-6004-01 LARGE INTESTINE c.687G>A p.T229T COSMIC NP NP 121 TCGA-AZ-4315-01 LARGE INTESTINE c.2873G>A p.R958H COSMIC PASSENGER/OTHER Probably Damaging 122 TCGA-B0-4712-01 KIDNEY c.2702A>C p.E901A COSMIC PASSENGER/OTHER Benign 123 TCGA-B0-5095-01 KIDNEY c.2088G>A p.M696I COSMIC PASSENGER/OTHER Benign 124 TCGA-B0-5709-01 KIDNEY c.647C>A p.P216Q COSMIC PASSENGER/OTHER Benign 125 TCGA-B5-A0JZ-01 ENDOMETRIUM c.2364C>T p.N788N COSMIC NP NP 126 TCGA-BG-A0LX-01 ENDOMETRIUM c.2895T>A p.D965E COSMIC PASSENGER/OTHER Probably Damaging 127 TCGA-BG-A0W1-01 ENDOMETRIUM c.2787C>T p.N929N COSMIC NP NP 128 TCGA-BH-A0GY-01 BREAST c.4036G>C p.D1346H COSMIC PASSENGER/OTHER Probably Damaging 129 TCGA-BS-A0UF-01 ENDOMETRIUM c.151G>A p.E51K COSMIC PASSENGER/OTHER Probably Damaging 130 TCGA-BS-A0UJ-01 ENDOMETRIUM c.1435T>C p.F479L COSMIC PASSENGER/OTHER Possibly Damaging 131 TCGA-BS-A0UM-01 ENDOMETRIUM c.897C>T p.P299P COSMIC NP NP 132 TCGA-BS-A0UV-01 ENDOMETRIUM c.3045A>C p.K1015N COSMIC PASSENGER/OTHER Possibly Damaging 133 TCGA-CA-6718-01 LARGE INTESTINE c.1732A>G p.T578A COSMIC PASSENGER/OTHER Benign 134 TCGA-CH-5769-01 PROSTATE c.2189G>A p.R730H COSMIC PASSENGER/OTHER Probably Damaging 135 TCGA-CJ-5682-01 KIDNEY c.3886T>C p.F1296L COSMIC PASSENGER/OTHER Possibly Damaging 136 TCGA-CK-5913-01 LARGE INTESTINE c.4721G>A p.R1574Q COSMIC PASSENGER/OTHER Probably Damaging 137 TCGA-CK-5913-01 LARGE INTESTINE c.890G>A p.R297Q COSMIC PASSENGER/OTHER Possibly Damaging 138 TCGA-CM-4743-01 LARGE INTESTINE c.2152delA p.M718fs*59 COSMIC NP NP 139 TCGA-CM-5861-01 LARGE INTESTINE c.2875C>T p.P959S COSMIC PASSENGER/OTHER Benign 140 TCGA-CM-6674-01 LARGE INTESTINE c.2619C>T p.Y873Y COSMIC NP NP 141 TCGA-CZ-5986-01 KIDNEY c.4520A>G p.H1507R COSMIC PASSENGER/OTHER Probably Damaging 142 TCGA-D1-A103-01 ENDOMETRIUM c.1073A>G p.Q358R COSMIC PASSENGER/OTHER Benign 143 TCGA-D1-A103-01 ENDOMETRIUM c.1453G>A p.E485K COSMIC PASSENGER/OTHER Probably Damaging 144 TCGA-D1-A103-01 ENDOMETRIUM c.369A>G p.A123A COSMIC NP NP 145 TCGA-D1-A103-01 ENDOMETRIUM c.4766G>A p.G1589D COSMIC PASSENGER/OTHER Probably Damaging 146 TCGA-D1-A103-01 ENDOMETRIUM c.497C>T p.T166I COSMIC PASSENGER/OTHER Benign 147 TCGA-D1-A16X-01 ENDOMETRIUM c.1770C>T p.V590V COSMIC NP NP 148 TCGA-D1-A17Q-01 ENDOMETRIUM c.151G>A p.E51K COSMIC PASSENGER/OTHER Probably Damaging 149 TCGA-D1-A17Q-01 ENDOMETRIUM c.1885G>A p.D629N COSMIC PASSENGER/OTHER Probably Damaging 150 TCGA-D1-A17U-01 ENDOMETRIUM c.4560C>T p.D1520D COSMIC NP NP 151 TCGA-D5-6540-01 LARGE INTESTINE c.566C>T p.S189L COSMIC PASSENGER/OTHER Benign 152 TCGA-DK-A3IS-01 URINARY TRACT c.1408G>A p.D470N COSMIC PASSENGER/OTHER Probably Damaging 153 TCGA-DK-A3IT-01 URINARY TRACT c.508C>G p.H170D COSMIC PASSENGER/OTHER Possibly Damaging 154 TCGA-DK-A3IT-01 URINARY TRACT c.541C>G p.Q181E COSMIC PASSENGER/OTHER Benign 155 TCGA-DM-A28F-01 LARGE INTESTINE c.957A>G p.E319E COSMIC NP NP 156 TCGA-EI-6510-01 LARGE INTESTINE c.4145C>T p.S1382L COSMIC PASSENGER/OTHER Probably Damaging 157 TCGA-EJ-5505-01 PROSTATE c.1747G>A p.D583N COSMIC PASSENGER/OTHER Possibly Damaging 158 TCGA-EW-A1PA-01 BREAST c.2575G>A p.D859N COSMIC PASSENGER/OTHER Benign 159 TCGA-F4-6856-01 LARGE INTESTINE c.4146G>A p.S1382S COSMIC NP NP 160 TCGA-F5-6571-01 LARGE INTESTINE c.3672G>C p.P1224P COSMIC NP NP 161 TCGA-FI-A2F8-01 ENDOMETRIUM c.3620G>A p.R1207H COSMIC PASSENGER/OTHER Probably Damaging 162 TCGA-G2-A2EO-01 URINARY TRACT c.3531C>T p.F1177F COSMIC NP NP 163 TCGA-G9-6332-01 PROSTATE c.1016G>C p.R339P COSMIC PASSENGER/OTHER Benign 164 TCGA-GC-A3I6-01 URINARY TRACT c.1164C>G p.I388M COSMIC PASSENGER/OTHER Benign 165 WA43-27 PROSTATE c.4039G>A p.D1347N COSMIC PASSENGER/OTHER Benign 166 WA43-27 PROSTATE c.4044G>A p.K1348K COSMIC NP NP 167 WA43-44 PROSTATE c.4039G>A p.D1347N COSMIC PASSENGER/OTHER Benign 168 WA43-44 PROSTATE c.4044G>A p.K1348K COSMIC NP NP 169 WA43-71 PROSTATE c.4039G>A p.D1347N COSMIC PASSENGER/OTHER Benign 170 WA43-71 PROSTATE c.4044G>A p.K1348K COSMIC NP NP 171 cSCCP1 SKIN c.3514C>T p.P1172S COSMIC PASSENGER/OTHER Benign 172 cSCCP6 SKIN c.2960_2961CC>TT p.A987V COSMIC PASSENGER/OTHER Possibly Damaging 173 cSCCP7 SKIN c.1609C>T p.P537S COSMIC PASSENGER/OTHER Probably Damaging 174 pfg019T STOMACH c.2152delA p.M718fs*59 COSMIC NP NP
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.Gene essentiality data is not present in COLT database!! -
Tertiary structure (+)
Users must enabled the Java in their browser to see structure.
Users can also download Java from here.Modelled Structure Structures available in PDB -
Structure Domains (+)
1. PFAM domains are not present!!2. Superfaimly domains are not present!! -
Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:2. Sequence alignment with CCLE mutants:3. Sequence alignment with COSMIC mutants:4. Sequence alignment with homologus proteins: -
Sequence Profiles (+)
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Post Translational Modifications (+)
Post translational modifications are not found!!Other Databases Link (+)
