dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: DNMT3B |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 ACCS URINARY TRACT c.1318_1319insG p.R440fs CCLE NP NP 2 AN3CA ENDOMETRIUM c.2020G>A p.E674K CCLE PASSENGER/OTHER Probably Damaging 3 BT20 BREAST c.1318_1319insG p.R440fs CCLE NP NP 4 CHL1 SKIN c.1318_1319insG p.R440fs CCLE NP NP 5 CL40 LARGE INTESTINE c.1634G>A p.R545H CCLE PASSENGER/OTHER Probably Damaging 6 COLO201 LARGE INTESTINE c.2236G>A p.V746M CCLE CANCER Possibly Damaging 7 COLO205 LARGE INTESTINE c.2236G>A p.V746M CCLE CANCER Possibly Damaging 8 CW2 LARGE INTESTINE c.1352_1353insGG p.E451fs CCLE NP NP 9 ECC10 STOMACH c.1318_1319insG p.R440fs CCLE NP NP 10 FU97 STOMACH c.1318_1319insG p.R440fs CCLE NP NP 11 GP2D LARGE INTESTINE c.248A>G p.D83G CCLE PASSENGER/OTHER Benign 12 HCC1569 BREAST c.1712G>A p.R571Q CCLE PASSENGER/OTHER Benign 13 HCT15 LARGE INTESTINE c.1318_1319insG p.R440fs CCLE NP NP 14 HEC6 ENDOMETRIUM c.1193G>A p.R398H CCLE PASSENGER/OTHER Probably Damaging 15 HEPG2 LIVER c.1318_1319insG p.R440fs CCLE NP NP 16 HS729 SOFT TISSUE c.2116G>A p.D706N CCLE PASSENGER/OTHER Probably Damaging 17 HS944T SKIN c.1318_1319insG p.R440fs CCLE NP NP 18 IGROV1 OVARY c.1753G>A p.A585T CCLE PASSENGER/OTHER Probably Damaging 19 JHUEM2 ENDOMETRIUM c.891C>A p.S297S CCLE NP NP 20 KATOIII STOMACH c.1318_1319insG p.R440fs CCLE NP NP 21 KP4 PANCREAS c.445C>T p.R149W CCLE PASSENGER/OTHER Probably Damaging 22 KYSE270 OESOPHAGUS c.2449G>T p.D817Y CCLE CANCER Probably Damaging 23 MFE319 ENDOMETRIUM c.1801T>C p.Y601H CCLE PASSENGER/OTHER Probably Damaging 24 MINO HAEMATOPOIETIC AND LYMPHOID TISSUE c.1591C>T p.R531C CCLE PASSENGER/OTHER Possibly Damaging 25 MUTZ3 HAEMATOPOIETIC AND LYMPHOID TISSUE c.1318_1319insG p.R440fs CCLE NP NP 26 NCCSTCK140 STOMACH c.2043C>T p.Y681Y CCLE NP NP 27 NCIH1930 LUNG c.1318_1319insG p.R440fs CCLE NP NP 28 NCIH1963 LUNG c.1318_1319insG p.R440fs CCLE NP NP 29 NCIH82 LUNG c.846G>A p.L282L CCLE NP NP 30 OSRC2 KIDNEY c.1318_1319insG p.R440fs CCLE NP NP 31 QGP1 PANCREAS c.1318_1319insG p.R440fs CCLE NP NP 32 REH HAEMATOPOIETIC AND LYMPHOID TISSUE c.2526C>T p.L842L CCLE NP NP 33 RKO LARGE INTESTINE c.1846G>A p.V616M CCLE PASSENGER/OTHER Possibly Damaging 34 RKO LARGE INTESTINE c.998T>C p.L333S CCLE PASSENGER/OTHER Probably Damaging 35 RPMI8226 HAEMATOPOIETIC AND LYMPHOID TISSUE c.1318_1319insG p.R440fs CCLE NP NP 36 RS411 HAEMATOPOIETIC AND LYMPHOID TISSUE c.1753G>A p.A585T CCLE PASSENGER/OTHER Probably Damaging 37 SNU1040 LARGE INTESTINE c.1193G>A p.R398H CCLE PASSENGER/OTHER Probably Damaging 38 SNU1040 LARGE INTESTINE c.1202C>T p.T401I CCLE PASSENGER/OTHER Probably Damaging 39 SNU1040 LARGE INTESTINE c.1382G>A p.R461H CCLE PASSENGER/OTHER Probably Damaging 40 SNU1079 BILIARY TRACT c.1318_1319insG p.R440fs CCLE NP NP 41 SNU324 PANCREAS c.2236G>A p.V746M CCLE CANCER Possibly Damaging 42 SNU520 STOMACH c.1318_1319insG p.R440fs CCLE NP NP 43 SNU81 LARGE INTESTINE c.2020G>A p.E674K CCLE PASSENGER/OTHER Probably Damaging 44 SNU81 LARGE INTESTINE c.2481G>T p.Q827H CCLE CANCER Probably Damaging 45 SNUC2A LARGE INTESTINE c.1613G>A p.R538H CCLE PASSENGER/OTHER Probably Damaging 46 SUDHL1 HAEMATOPOIETIC AND LYMPHOID TISSUE c.1231G>A p.G411R CCLE PASSENGER/OTHER Benign 47 SUDHL1 HAEMATOPOIETIC AND LYMPHOID TISSUE c.1727G>A p.R576Q CCLE PASSENGER/OTHER Probably Damaging 48 SW1271 LUNG c.2349G>T p.Q783H CCLE CANCER Possibly Damaging 49 SW403 LARGE INTESTINE c.1318_1319insG p.R440fs CCLE NP NP 50 SW48 LARGE INTESTINE c.1318_1319insG p.R440fs CCLE NP NP 51 SW48 LARGE INTESTINE c.2272G>A p.D758N CCLE CANCER Probably Damaging 52 TE159T SOFT TISSUE c.1318_1319insG p.R440fs CCLE NP NP 53 TGBC11TKB STOMACH c.1318_1319insG p.R440fs CCLE NP NP 54 TOV21G OVARY c.1952G>A p.C651Y CCLE CANCER Probably Damaging 55 UMUC1 URINARY TRACT c.1318_1319insG p.R440fs CCLE NP NP 56 YD38 UPPER AERODIGESTIVE TRACT c.1318_1319insG p.R440fs CCLE NP NP 57 105225 LUNG c.113T>C p.L38P COSMIC PASSENGER/OTHER Probably Damaging 58 112140 LUNG c.813G>A p.E271E COSMIC NP NP 59 1731645 SKIN c.158C>T p.S53L COSMIC PASSENGER/OTHER Benign 60 587256 LARGE INTESTINE c.1609C>T p.R537W COSMIC PASSENGER/OTHER Benign 61 587284 LARGE INTESTINE c.2048G>A p.R683H COSMIC PASSENGER/OTHER Probably Damaging 62 587332 LARGE INTESTINE c.1647C>A p.F549L COSMIC PASSENGER/OTHER Possibly Damaging 63 587342 LARGE INTESTINE c.43G>A p.G15S COSMIC PASSENGER/OTHER Benign 64 DLBCL-PatientB HAEMATOPOIETIC AND LYMPHOID TISSUE c.2072C>T p.P691L COSMIC CANCER Probably Damaging 65 ESO-0009 OESOPHAGUS c.1755G>A p.A585A COSMIC NP NP 66 ESO-1145 OESOPHAGUS c.1454G>A p.R485Q COSMIC PASSENGER/OTHER Benign 67 ESO-717 OESOPHAGUS c.1125C>T p.Y375Y COSMIC NP NP 68 ESO-859 OESOPHAGUS c.1183G>A p.A395T COSMIC PASSENGER/OTHER Benign 69 H23 LUNG c.14C>G p.T5S COSMIC PASSENGER/OTHER Benign 70 HCC119T LIVER c.1718G>T p.R573L COSMIC PASSENGER/OTHER Probably Damaging 71 HCC2998 LARGE INTESTINE c.2020G>A p.E674K COSMIC PASSENGER/OTHER Probably Damaging 72 HCC32T LIVER c.96C>T p.S32S COSMIC NP NP 73 HCC76T LIVER c.1641G>A p.Q547Q COSMIC NP NP 74 HN_62739 UPPER AERODIGESTIVE TRACT c.2197C>T p.R733* COSMIC NP NP 75 IGROV-1 OVARY c.1753G>A p.A585T COSMIC PASSENGER/OTHER Probably Damaging 76 LUAD-E01317 LUNG c.738G>T p.W246C COSMIC PASSENGER/OTHER Probably Damaging 77 LUAD_E00522 LUNG c.460G>T p.A154S COSMIC PASSENGER/OTHER Benign 78 RK080_C01 LIVER c.1371A>C p.T457T COSMIC NP NP 79 S00936 LUNG c.1603G>A p.V535I COSMIC PASSENGER/OTHER Benign 80 SN12C KIDNEY c.1320_1321insGC p.K441fs*150 COSMIC NP NP 81 TARGET-30-PASSRN AUTONOMIC GANGLIA c.154A>C p.S52R COSMIC PASSENGER/OTHER Probably Damaging 82 TCGA-04-1530-01 OVARY c.723C>G p.A241A COSMIC NP NP 83 TCGA-05-4433-01 LUNG c.364C>T p.R122C COSMIC PASSENGER/OTHER Probably Damaging 84 TCGA-05-5425-01 LUNG c.2152C>T p.P718S COSMIC PASSENGER/OTHER Probably Damaging 85 TCGA-22-5478-01 LUNG c.2232G>T p.R744S COSMIC CANCER Possibly Damaging 86 TCGA-23-2077-01 OVARY c.2155G>T p.V719L COSMIC CANCER Probably Damaging 87 TCGA-34-5231-01 LUNG c.584G>T p.S195I COSMIC PASSENGER/OTHER Possibly Damaging 88 TCGA-36-1571-01 OVARY c.1209C>G p.C403W COSMIC PASSENGER/OTHER Possibly Damaging 89 TCGA-37-4141-01 LUNG c.2304A>G p.L768L COSMIC NP NP 90 TCGA-50-5930-01 LUNG c.779G>C p.W260S COSMIC PASSENGER/OTHER Probably Damaging 91 TCGA-55-7907-01 LUNG c.2209G>T p.G737C COSMIC CANCER Probably Damaging 92 TCGA-64-5775-01 LUNG c.1841G>T p.G614V COSMIC PASSENGER/OTHER Possibly Damaging 93 TCGA-66-2787-01 LUNG c.1088G>A p.R363H COSMIC PASSENGER/OTHER Benign 94 TCGA-66-2789-01 LUNG c.1040G>A p.G347D COSMIC PASSENGER/OTHER Probably Damaging 95 TCGA-95-7944-01 LUNG c.1386C>T p.F462F COSMIC NP NP 96 TCGA-A6-5661-01 LARGE INTESTINE c.540G>A p.T180T COSMIC NP NP 97 TCGA-A6-5666-01 LARGE INTESTINE c.1633C>T p.R545C COSMIC PASSENGER/OTHER Probably Damaging 98 TCGA-A6-6138-01 LARGE INTESTINE c.2157G>T p.V719V COSMIC NP NP 99 TCGA-A6-6781-01 LARGE INTESTINE c.1881C>T p.D627D COSMIC NP NP 100 TCGA-AA-3492-01 LARGE INTESTINE c.1353delG p.L454fs*136 COSMIC NP NP 101 TCGA-AA-3710-01 LARGE INTESTINE c.131C>T p.P44L COSMIC PASSENGER/OTHER Benign 102 TCGA-AA-3818-01 LARGE INTESTINE c.274C>T p.R92W COSMIC PASSENGER/OTHER Probably Damaging 103 TCGA-AA-3877-01 LARGE INTESTINE c.561C>A p.P187P COSMIC NP NP 104 TCGA-AA-3986-01 LARGE INTESTINE c.1138C>T p.R380* COSMIC NP NP 105 TCGA-AA-A010-01 LARGE INTESTINE c.1941C>T p.G647G COSMIC NP NP 106 TCGA-AG-3583-01 LARGE INTESTINE c.274C>T p.R92W COSMIC PASSENGER/OTHER Probably Damaging 107 TCGA-AG-3892-01 LARGE INTESTINE c.1261G>A p.A421T COSMIC PASSENGER/OTHER Benign 108 TCGA-AG-A002-01 LARGE INTESTINE c.1347C>A p.L449L COSMIC NP NP 109 TCGA-AG-A002-01 LARGE INTESTINE c.896G>A p.R299Q COSMIC PASSENGER/OTHER Probably Damaging 110 TCGA-AG-A002-01 LARGE INTESTINE c.97G>A p.D33N COSMIC PASSENGER/OTHER Possibly Damaging 111 TCGA-AP-A051-01 ENDOMETRIUM c.1249C>T p.R417* COSMIC NP NP 112 TCGA-AP-A056-01 ENDOMETRIUM c.540G>A p.T180T COSMIC NP NP 113 TCGA-AP-A059-01 ENDOMETRIUM c.438G>A p.L146L COSMIC NP NP 114 TCGA-AP-A0LM-01 ENDOMETRIUM c.211A>G p.T71A COSMIC PASSENGER/OTHER Benign 115 TCGA-AP-A0LM-01 ENDOMETRIUM c.2340G>A p.S780S COSMIC NP NP 116 TCGA-AU-6004-01 LARGE INTESTINE c.1353delG p.L454fs*136 COSMIC NP NP 117 TCGA-AX-A05Z-01 ENDOMETRIUM c.1138C>T p.R380* COSMIC NP NP 118 TCGA-AX-A06H-01 ENDOMETRIUM c.151T>C p.S51P COSMIC PASSENGER/OTHER Possibly Damaging 119 TCGA-AX-A0J0-01 ENDOMETRIUM c.895C>T p.R299* COSMIC NP NP 120 TCGA-AX-A0J1-01 ENDOMETRIUM c.1478C>T p.T493M COSMIC PASSENGER/OTHER Probably Damaging 121 TCGA-AZ-4315-01 LARGE INTESTINE c.1102A>C p.R368R COSMIC NP NP 122 TCGA-AZ-4315-01 LARGE INTESTINE c.1727G>A p.R576Q COSMIC PASSENGER/OTHER Probably Damaging 123 TCGA-AZ-4315-01 LARGE INTESTINE c.310C>T p.R104* COSMIC NP NP 124 TCGA-B0-5712-01 KIDNEY c.1243C>A p.Q415K COSMIC PASSENGER/OTHER Benign 125 TCGA-B5-A0JY-01 ENDOMETRIUM c.222C>T p.G74G COSMIC NP NP 126 TCGA-B5-A0JY-01 ENDOMETRIUM c.317G>A p.R106Q COSMIC PASSENGER/OTHER Benign 127 TCGA-B5-A11E-01 ENDOMETRIUM c.1879G>A p.D627N COSMIC CANCER Possibly Damaging 128 TCGA-B5-A11E-01 ENDOMETRIUM c.2417A>G p.E806G COSMIC CANCER Probably Damaging 129 TCGA-B5-A11E-01 ENDOMETRIUM c.285G>A p.R95R COSMIC NP NP 130 TCGA-B6-A0RG-01 BREAST c.2240T>C p.I747T COSMIC CANCER Benign 131 TCGA-BG-A0MQ-01 ENDOMETRIUM c.1532G>A p.G511D COSMIC PASSENGER/OTHER Probably Damaging 132 TCGA-BP-4801-01 KIDNEY c.2132C>A p.S711* COSMIC NP NP 133 TCGA-BS-A0UF-01 ENDOMETRIUM c.1609C>T p.R537W COSMIC PASSENGER/OTHER Benign 134 TCGA-BS-A0UJ-01 ENDOMETRIUM c.685G>A p.V229M COSMIC CANCER Probably Damaging 135 TCGA-BS-A0UV-01 ENDOMETRIUM c.1139G>A p.R380Q COSMIC PASSENGER/OTHER Benign 136 TCGA-C8-A27B-01 BREAST c.343G>A p.E115K COSMIC PASSENGER/OTHER Possibly Damaging 137 TCGA-CA-6717-01 LARGE INTESTINE c.234T>C p.D78D COSMIC NP NP 138 TCGA-CL-5917-01 LARGE INTESTINE c.1834G>A p.A612T COSMIC PASSENGER/OTHER Benign 139 TCGA-CM-4747-01 LARGE INTESTINE c.219T>C p.D73D COSMIC NP NP 140 TCGA-CM-6162-01 LARGE INTESTINE c.1846G>A p.V616M COSMIC PASSENGER/OTHER Possibly Damaging 141 TCGA-D5-6536-01 LARGE INTESTINE c.2156T>C p.V719A COSMIC CANCER Probably Damaging 142 TCGA-D5-6924-01 LARGE INTESTINE c.1716G>C p.R572S COSMIC PASSENGER/OTHER Probably Damaging 143 TCGA-D5-6930-01 LARGE INTESTINE c.2115C>T p.G705G COSMIC NP NP 144 TCGA-DI-A0WH-01 ENDOMETRIUM c.1935G>A p.V645V COSMIC NP NP 145 TCGA-DK-A1A3-01 URINARY TRACT c.809C>G p.S270C COSMIC PASSENGER/OTHER Probably Damaging 146 TCGA-E9-A1N5-01 BREAST c.687G>A p.V229V COSMIC NP NP 147 TCGA-F4-6807-01 LARGE INTESTINE c.536G>T p.G179V COSMIC PASSENGER/OTHER Benign 148 TCGA-F4-6809-01 LARGE INTESTINE c.263C>T p.P88L COSMIC PASSENGER/OTHER Probably Damaging 149 TCGA-G4-6309-01 LARGE INTESTINE c.557delC p.Y188fs*4 COSMIC NP NP 150 YUHEF SKIN c.1228C>T p.R410* COSMIC NP NP 151 YUKLAB SKIN c.1447G>A p.E483K COSMIC PASSENGER/OTHER Possibly Damaging 152 YUWAND SKIN c.1750A>T p.I584F COSMIC PASSENGER/OTHER Probably Damaging 153 cSCCP4 SKIN c.59C>T p.S20L COSMIC PASSENGER/OTHER Benign 154 pfg008T STOMACH c.1006G>C p.A336P COSMIC PASSENGER/OTHER Probably Damaging
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.test -
Tertiary structure (+)
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Structure Domains (+)
1. PFAM Domains:Domain ID Domain Name Start Site End Site E-value PF00855 PWWP 224 307 2.7e-19 PB000343 Pfam-B_343 342 497 5.1e-05 PB000829 Pfam-B_829 473 645 5e-08 PF00145 DNA_methylase 575 708 1.2e-11 PB000071 Pfam-B_71 719 851 3.1e-38 2. Superfamily Domains:Domain ID Start Site End Site E-value 0045633 568 851 2.08e-38 0047802 216 351 1.68e-38 0037717 470 542 3.45e-05 -
Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 2. Sequence alignment with CCLE mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 3. Sequence alignment with COSMIC mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 4. Sequence alignment with homologus proteins:
Click on button to get Sequence alignment with Coverage, Consensus and Quality -
Sequence Profiles (+)
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Post Translational Modifications (+)
S. No. Position Amino acid Type 1 100 S Phosphorylation 2 110 S Phosphorylation 3 112 S Phosphorylation 4 113 S Phosphorylation 5 136 S Phosphorylation 6 195 S Phosphorylation 7 202 S Phosphorylation 8 209 S Phosphorylation 9 214 S Phosphorylation 10 353 T Phosphorylation 11 367 S Phosphorylation 12 383 T Phosphorylation 13 387 S Phosphorylation 14 53 S Phosphorylation 15 562 K Ubiquitylation 16 623 K Ubiquitylation 17 777 K Ubiquitylation 18 815 Y Phosphorylation 19 816 T Phosphorylation 20 819 S Phosphorylation 21 82 S Phosphorylation 22 96 T Phosphorylation -
Other Databases Link (+)
Proteomics DB COSMIC Gene Atlas STRING PIR DNMT3B DNMT3B DNMT3B ENSP00000201963 Q9UBC3 QuickGO HGNC Ensembl Genome Browser TreeFam UniProt Q9UBC3 DNMT3B ENSP00000201963 DNMT3B Q9UBC3 Expression Atlas Protein Atlas OMIM IntAct PharmGKB DNMT3B ENSP00000201963 602900 Q9UBC3 PA27446
