dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: EHMT1 |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 2334192 LUNG c.2015G>A p.G672E COSMIC CANCER Benign 2 587278 LARGE INTESTINE c.94G>A p.A32T COSMIC NP NP 3 587342 LARGE INTESTINE c.2761T>C p.Y921H COSMIC NP NP 4 587376 LARGE INTESTINE c.1858G>A p.V620M COSMIC NP NP 5 587376 LARGE INTESTINE c.3433G>T p.D1145Y COSMIC PASSENGER/OTHER Probably Damaging 6 BB13T BREAST c.35C>T p.A12V COSMIC NP NP 7 BN24T LIVER c.1920G>A p.T640T COSMIC NP NP 8 DU-145 PROSTATE c.1557G>T p.L519F COSMIC CANCER Probably Damaging 9 ESO-0950 OESOPHAGUS c.2725G>A p.D909N COSMIC NP NP 10 ESO-173 OESOPHAGUS c.1649G>A p.R550H COSMIC NP NP 11 ESO-805 OESOPHAGUS c.3149G>A p.R1050H COSMIC NP NP 12 ESO-859 OESOPHAGUS c.2299A>G p.N767D COSMIC NP NP 13 H1672 LUNG c.2015G>A p.G672E COSMIC CANCER Benign 14 H2009 LUNG c.2293G>T p.G765C COSMIC NP NP 15 HCC2218 BREAST c.3425A>T p.Y1142F COSMIC NP NP 16 HCC60T LIVER c.745G>T p.V249F COSMIC NP NP 17 HN_00313 UPPER AERODIGESTIVE TRACT c.1027G>A p.D343N COSMIC NP NP 18 HN_63021 UPPER AERODIGESTIVE TRACT c.38G>C p.G13A COSMIC CANCER Benign 19 LC_C21 LUNG c.3677G>T p.R1226L COSMIC NP NP 20 LC_C9 LUNG c.1074G>T p.Q358H COSMIC NP NP 21 LC_C9 LUNG c.1700G>T p.G567V COSMIC NP NP 22 LC_S18 LUNG c.3641G>T p.R1214L COSMIC NP NP 23 LUAD-5V8LT LUNG c.2710G>T p.V904L COSMIC NP NP 24 LUAD-B02077 LUNG c.2297C>T p.A766V COSMIC NP NP 25 LUAD-CHTN-Z4716A LUNG c.3529G>C p.V1177L COSMIC NP Probably Damaging 26 LUAD-E01278 LUNG c.120G>A p.K40K COSMIC NP NP 27 LUAD-RT-S01702 LUNG c.3737C>T p.A1246V COSMIC NP NP 28 ME009T SKIN c.1378G>A p.V460I COSMIC NP NP 29 P01-28 PROSTATE c.2102C>T p.P701L COSMIC CANCER Benign 30 Pa08C PANCREAS c.1939C>G p.P647A COSMIC NP NP 31 S00836 LUNG c.116C>A p.A39E COSMIC CANCER Benign 32 SF539 CENTRAL NERVOUS SYSTEM c.1A>G p.M1V COSMIC CANCER Benign 33 SJMB008 CENTRAL NERVOUS SYSTEM c.3402C>T p.A1134A COSMIC NP NP 34 TCGA-05-4395-01 LUNG c.264C>G p.V88V COSMIC NP NP 35 TCGA-05-4405-01 LUNG c.988G>T p.G330C COSMIC NP NP 36 TCGA-13-2057-01 OVARY c.3045G>C p.V1015V COSMIC NP NP 37 TCGA-22-5477-01 LUNG c.485C>A p.A162D COSMIC NP NP 38 TCGA-24-1431-01 OVARY c.1848C>T p.T616T COSMIC NP NP 39 TCGA-38-4632-01 LUNG c.285C>G p.I95M COSMIC NP NP 40 TCGA-43-5668-01 LUNG c.230A>T p.H77L COSMIC NP NP 41 TCGA-44-3918-01 LUNG c.3743A>C p.Q1248P COSMIC NP NP 42 TCGA-46-3765-01 LUNG c.801G>T p.L267L COSMIC NP NP 43 TCGA-51-4079-01 LUNG c.3409C>T p.R1137* COSMIC NP NP 44 TCGA-60-2698-01 LUNG c.2333C>T p.P778L COSMIC NP NP 45 TCGA-69-7979-01 LUNG c.2913G>T p.R971S COSMIC NP NP 46 TCGA-86-6851-01 LUNG c.868C>G p.H290D COSMIC NP NP 47 TCGA-95-7039-01 LUNG c.1854G>A p.S618S COSMIC NP NP 48 TCGA-A2-A04U-01 BREAST c.2237T>G p.L746R COSMIC NP NP 49 TCGA-A2-A1FZ-01 BREAST c.3231G>A p.A1077A COSMIC NP NP 50 TCGA-A5-A0GD-01 ENDOMETRIUM c.745G>T p.V249F COSMIC NP NP 51 TCGA-A6-6781-01 LARGE INTESTINE c.950C>T p.S317L COSMIC NP NP 52 TCGA-A8-A09M-01 BREAST c.755C>T p.A252V COSMIC NP NP 53 TCGA-AA-3672-01 LARGE INTESTINE c.3439G>A p.D1147N COSMIC NP NP 54 TCGA-AA-3715-01 LARGE INTESTINE c.3095T>C p.V1032A COSMIC NP NP 55 TCGA-AA-3811-01 LARGE INTESTINE c.1161G>A p.S387S COSMIC NP NP 56 TCGA-AA-3968-01 LARGE INTESTINE c.3425A>G p.Y1142C COSMIC NP NP 57 TCGA-AA-A022-01 LARGE INTESTINE c.1014G>A p.A338A COSMIC NP NP 58 TCGA-AP-A051-01 ENDOMETRIUM c.2648C>T p.A883V COSMIC NP NP 59 TCGA-AP-A056-01 ENDOMETRIUM c.2416G>A p.A806T COSMIC NP NP 60 TCGA-AP-A059-01 ENDOMETRIUM c.1012G>A p.A338T COSMIC NP NP 61 TCGA-AP-A059-01 ENDOMETRIUM c.112G>A p.A38T COSMIC NP NP 62 TCGA-AP-A059-01 ENDOMETRIUM c.3003G>T p.E1001D COSMIC NP Benign 63 TCGA-AP-A059-01 ENDOMETRIUM c.3283G>A p.A1095T COSMIC NP NP 64 TCGA-AP-A0LM-01 ENDOMETRIUM c.1348G>A p.E450K COSMIC NP Benign 65 TCGA-AP-A0LM-01 ENDOMETRIUM c.3103G>A p.D1035N COSMIC NP NP 66 TCGA-AP-A0LM-01 ENDOMETRIUM c.3149G>A p.R1050H COSMIC NP NP 67 TCGA-AP-A0LM-01 ENDOMETRIUM c.531G>A p.P177P COSMIC NP NP 68 TCGA-AP-A0LV-01 ENDOMETRIUM c.745G>T p.V249F COSMIC NP NP 69 TCGA-AX-A0J1-01 ENDOMETRIUM c.176G>A p.R59Q COSMIC NP NP 70 TCGA-AX-A0J1-01 ENDOMETRIUM c.1777G>A p.A593T COSMIC NP NP 71 TCGA-AX-A0J1-01 ENDOMETRIUM c.2707G>A p.A903T COSMIC NP NP 72 TCGA-AX-A0J1-01 ENDOMETRIUM c.2759G>A p.R920H COSMIC NP NP 73 TCGA-AZ-4315-01 LARGE INTESTINE c.1182A>C p.K394N COSMIC NP NP 74 TCGA-AZ-6598-01 LARGE INTESTINE c.2025G>A p.R675R COSMIC NP NP 75 TCGA-AZ-6601-01 LARGE INTESTINE c.3450C>T p.D1150D COSMIC NP NP 76 TCGA-B5-A0JY-01 ENDOMETRIUM c.3417A>C p.E1139D COSMIC NP NP 77 TCGA-B5-A0JY-01 ENDOMETRIUM c.581G>A p.R194Q COSMIC NP NP 78 TCGA-B5-A0JY-01 ENDOMETRIUM c.886A>G p.K296E COSMIC NP NP 79 TCGA-B5-A11E-01 ENDOMETRIUM c.244G>A p.D82N COSMIC NP NP 80 TCGA-B5-A11Y-01 ENDOMETRIUM c.1067G>A p.R356H COSMIC NP NP 81 TCGA-BL-A0C8-01 URINARY TRACT c.3068G>A p.R1023K COSMIC NP NP 82 TCGA-BS-A0UJ-01 ENDOMETRIUM c.114T>C p.A38A COSMIC NP NP 83 TCGA-BS-A0UV-01 ENDOMETRIUM c.241G>A p.D81N COSMIC NP NP 84 TCGA-CK-6746-01 LARGE INTESTINE c.1796G>A p.C599Y COSMIC NP NP 85 TCGA-CK-6746-01 LARGE INTESTINE c.2398C>A p.L800M COSMIC NP NP 86 TCGA-D1-A103-01 ENDOMETRIUM c.1012G>A p.A338T COSMIC NP NP 87 TCGA-D1-A103-01 ENDOMETRIUM c.1284G>T p.E428D COSMIC NP NP 88 TCGA-D1-A103-01 ENDOMETRIUM c.2094G>A p.S698S COSMIC NP NP 89 TCGA-D1-A16N-01 ENDOMETRIUM c.761T>C p.V254A COSMIC NP NP 90 TCGA-D1-A17Q-01 ENDOMETRIUM c.2296G>A p.A766T COSMIC NP NP 91 TCGA-D5-6928-01 LARGE INTESTINE c.36A>G p.A12A COSMIC NP NP 92 TCGA-D8-A1XY-01 BREAST c.2004G>A p.T668T COSMIC NP NP 93 TCGA-D8-A27T-01 BREAST c.3043G>A p.V1015M COSMIC NP NP 94 TCGA-DK-A1A5-01 URINARY TRACT c.3042C>T p.C1014C COSMIC NP NP 95 TCGA-DK-A3IT-01 URINARY TRACT c.3669C>T p.F1223F COSMIC NP NP 96 TCGA-DS-A0VL-01 CERVIX c.1689C>G p.F563L COSMIC NP NP 97 TCGA-E2-A14P-01 BREAST c.3692A>G p.K1231R COSMIC NP NP 98 TCGA-EI-6507-01 LARGE INTESTINE c.182C>T p.A61V COSMIC NP NP 99 TCGA-EU-5904-01 KIDNEY c.1908C>T p.A636A COSMIC NP NP 100 TCGA-G4-6304-01 LARGE INTESTINE c.1642C>T p.R548W COSMIC NP NP 101 TCGA-G4-6586-01 LARGE INTESTINE c.3368A>T p.E1123V COSMIC NP NP 102 TCGA-G5-6641-01 LARGE INTESTINE c.2992G>A p.V998M COSMIC NP NP 103 WA54 PROSTATE c.3558G>T p.Q1186H COSMIC NP NP 104 YURUB SKIN c.20C>T p.S7L COSMIC NP NP 105 cSCCP7 SKIN c.2188_2189GG>AA p.G730K COSMIC NP NP 106 pfg016T STOMACH c.2246C>T p.A749V COSMIC NP NP
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.test -
Tertiary structure (+)
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Structure Domains (+)
1. PFAM Domains:Domain ID Domain Name Start Site End Site E-value PB003620 Pfam-B_3620 29 124 0.00027 PB003400 Pfam-B_3400 289 419 6.3e-06 PF00023 Ank 774 800 3e-06 PF12796 Ank_2 810 903 2.2e-27 PF12796 Ank_2 910 985 1.2e-13 PF05033 Pre-SET 1013 1118 4.6e-19 PF00856 SET 1137 1243 5.6e-27 2. Superfamily Domains:Domain ID Start Site End Site E-value 0048228 1003 1258 2.07e-83 0053922 741 984 9.95e-72 -
Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 4. Sequence alignment with homologus proteins:
Click on button to get Sequence alignment with Coverage, Consensus and Quality -
Sequence Profiles (+)
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Post Translational Modifications (+)
S. No. Position Amino acid Type 1 1048 S Phosphorylation 2 209 K Ubiquitylation 3 239 K Ubiquitylation 4 322 S Phosphorylation 5 335 S Phosphorylation 6 336 S Phosphorylation 7 343 S Phosphorylation 8 348 S Phosphorylation 9 353 S Phosphorylation 10 395 S Phosphorylation 11 433 T Phosphorylation 12 435 S Phosphorylation 13 448 S Phosphorylation 14 460 S Phosphorylation 15 497 S Phosphorylation 16 497 S Phosphorylation 17 740 K Ubiquitylation 18 827 K Ubiquitylation 19 890 K Ubiquitylation 20 895 K Ubiquitylation 21 968 K Ubiquitylation -
Other Databases Link (+)
Proteomics DB COSMIC Gene Atlas STRING PIR EHMT1 EHMT1 EHMT1 ENSP00000417980 Q9H9B1 QuickGO HGNC Ensembl Genome Browser TreeFam UniProt Q9H9B1 EHMT1 ENSP00000417980 EHMT1 Q9H9B1 Expression Atlas Protein Atlas OMIM IntAct PharmGKB EHMT1 ENSP00000417980 607001 Q9H9B1 PA134941393
