dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: EHMT2 |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 CLL129 HAEMATOPOIETIC AND LYMPHOID TISSUE c.1465G>T p.V489F COSMIC CANCER Probably Damaging 2 ESO-0115 OESOPHAGUS c.943G>T p.E315* COSMIC NP NP 3 ESO-114 OESOPHAGUS c.3330C>A p.F1110L COSMIC PASSENGER/OTHER Probably Damaging 4 H1155 LUNG c.2617C>T p.R873C COSMIC CANCER Probably Damaging 5 HCC51T LIVER c.613A>G p.I205V COSMIC PASSENGER/OTHER Benign 6 HN_63080 UPPER AERODIGESTIVE TRACT c.980C>T p.S327L COSMIC CANCER Possibly Damaging 7 LC_S19 LUNG c.1034delA p.K345fs*9 COSMIC NP NP 8 LUAD-CHTN-MAD06-00668 LUNG c.1348G>A p.E450K COSMIC CANCER Probably Damaging 9 LUAD_E00522 LUNG c.1897G>C p.E633Q COSMIC CANCER Benign 10 MD-324 CENTRAL NERVOUS SYSTEM c.1971C>A p.S657S COSMIC NP NP 11 TCGA-13-0887-01 OVARY c.356C>T p.S119F COSMIC PASSENGER/OTHER Benign 12 TCGA-18-3406-01 LUNG c.194C>A p.S65* COSMIC NP NP 13 TCGA-20-0991-01 OVARY c.1854T>G p.L618L COSMIC NP NP 14 TCGA-22-5480-01 LUNG c.2113C>T p.L705L COSMIC NP NP 15 TCGA-29-1784-01 OVARY c.231G>T p.E77D COSMIC PASSENGER/OTHER Benign 16 TCGA-44-6777-01 LUNG c.931G>C p.E311Q COSMIC PASSENGER/OTHER Probably Damaging 17 TCGA-55-1594-01 LUNG c.1983C>T p.G661G COSMIC NP NP 18 TCGA-55-7727-01 LUNG c.1932G>A p.R644R COSMIC NP NP 19 TCGA-55-7911-01 LUNG c.3409G>A p.A1137T COSMIC PASSENGER/OTHER Probably Damaging 20 TCGA-75-7027-01 LUNG c.2421G>A p.R807R COSMIC NP NP 21 TCGA-95-7944-01 LUNG c.92G>C p.R31T COSMIC CANCER Possibly Damaging 22 TCGA-A3-3316-01 KIDNEY c.232G>A p.G78R COSMIC PASSENGER/OTHER Possibly Damaging 23 TCGA-A6-6653-01 LARGE INTESTINE c.317G>A p.R106Q COSMIC PASSENGER/OTHER Probably Damaging 24 TCGA-AA-3558-01 LARGE INTESTINE c.2818G>A p.G940S COSMIC PASSENGER/OTHER Benign 25 TCGA-AG-3999-01 LARGE INTESTINE c.845G>A p.R282H COSMIC CANCER Benign 26 TCGA-AG-A02N-01 LARGE INTESTINE c.2218C>T p.R740C COSMIC CANCER Benign 27 TCGA-AP-A056-01 ENDOMETRIUM c.995A>C p.D332A COSMIC CANCER Benign 28 TCGA-AX-A0J1-01 ENDOMETRIUM c.2876C>T p.T959M COSMIC CANCER Probably Damaging 29 TCGA-AX-A0J1-01 ENDOMETRIUM c.663C>A p.T221T COSMIC NP NP 30 TCGA-B0-5096-01 KIDNEY c.1979A>G p.Q660R COSMIC CANCER Benign 31 TCGA-CH-5768-01 PROSTATE c.50C>A p.A17D COSMIC CANCER Benign 32 TCGA-CK-5915-01 LARGE INTESTINE c.2549A>G p.H850R COSMIC CANCER Probably Damaging 33 TCGA-CM-4743-01 LARGE INTESTINE c.1471C>A p.H491N COSMIC CANCER Probably Damaging 34 TCGA-CM-4746-01 LARGE INTESTINE c.1861G>A p.V621M COSMIC CANCER Benign 35 TCGA-CM-6674-01 LARGE INTESTINE c.733C>T p.R245C COSMIC CANCER Possibly Damaging 36 TCGA-CZ-5459-01 KIDNEY c.3395G>A p.R1132Q COSMIC PASSENGER/OTHER Probably Damaging 37 TCGA-DR-A0ZM-01 CERVIX c.781G>A p.E261K COSMIC CANCER Possibly Damaging 38 TCGA-DS-A0VL-01 CERVIX c.3476G>T p.W1159L COSMIC PASSENGER/OTHER Probably Damaging 39 TCGA-EJ-5498-01 PROSTATE c.3054C>A p.N1018K COSMIC PASSENGER/OTHER Probably Damaging 40 TCGA-G4-6588-01 LARGE INTESTINE c.1635G>T p.E545D COSMIC CANCER Probably Damaging 41 TCGA-GD-A2C5-01 URINARY TRACT c.3601G>C p.E1201Q COSMIC CANCER Possibly Damaging 42 TCGA-GV-A3JX-01 URINARY TRACT c.1687C>G p.P563A COSMIC CANCER Possibly Damaging 43 WA56 PROSTATE c.2927G>C p.C976S COSMIC CANCER Probably Damaging
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.test -
Tertiary structure (+)
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Structure Domains (+)
1. PFAM Domains:Domain ID Domain Name Start Site End Site E-value PB009355 Pfam-B_9355 34 359 3.2e-117 PB004963 Pfam-B_4963 285 347 0.00016 PF12796 Ank_2 656 741 4.6e-17 PF12796 Ank_2 751 815 4.5e-17 PF12796 Ank_2 819 881 6.3e-12 PF05033 Pre-SET 925 1030 1.4e-17 PF00856 SET 1049 1155 1.6e-27 2. Superfamily Domains:Domain ID Start Site End Site E-value 0048228 912 1170 1.70e-85 0053922 653 892 1.51e-65 -
Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 4. Sequence alignment with homologus proteins:
Click on button to get Sequence alignment with Coverage, Consensus and Quality -
Sequence Profiles (+)
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Post Translational Modifications (+)
S. No. Position Amino acid Type 1 1210 T Phosphorylation 2 1210 T Phosphorylation 3 135 T Phosphorylation 4 140 S Phosphorylation 5 140 S Phosphorylation 6 146 S Phosphorylation 7 171 T Phosphorylation 8 172 T Phosphorylation 9 173 S Phosphorylation 10 173 S Phosphorylation 11 185 K Methylation 12 185 K Methylation 13 2 A Acetylation 14 211 S Phosphorylation 15 232 S Phosphorylation 16 232 S Phosphorylation 17 246 S Phosphorylation 18 246 S Phosphorylation 19 336 S Phosphorylation 20 350 S Phosphorylation 21 379 S Phosphorylation 22 40 S Phosphorylation 23 401 S Phosphorylation 24 413 S Phosphorylation 25 44 T Phosphorylation 26 555 T Phosphorylation 27 569 S Phosphorylation 28 569 S Phosphorylation 29 69 S Phosphorylation -
Other Databases Link (+)
Proteomics DB COSMIC Gene Atlas STRING PIR EHMT2 EHMT2 EHMT2 ENSP00000364680 Q96KQ7 QuickGO HGNC Ensembl Genome Browser TreeFam UniProt Q96KQ7 EHMT2 ENSP00000364680 EHMT2 Q96KQ7 Expression Atlas Protein Atlas OMIM IntAct PharmGKB EHMT2 ENSP00000364680 604599 Q96KQ7 PA25267
