dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: EHMT2 |
| Expand All | Collapse All |
-
Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 CLL129 HAEMATOPOIETIC AND LYMPHOID TISSUE c.1465G>T p.V489F COSMIC CANCER Probably Damaging 2 ESO-0115 OESOPHAGUS c.943G>T p.E315* COSMIC NP NP 3 ESO-114 OESOPHAGUS c.3330C>A p.F1110L COSMIC PASSENGER/OTHER Probably Damaging 4 H1155 LUNG c.2617C>T p.R873C COSMIC CANCER Probably Damaging 5 HCC51T LIVER c.613A>G p.I205V COSMIC PASSENGER/OTHER Benign 6 HN_63080 UPPER AERODIGESTIVE TRACT c.980C>T p.S327L COSMIC CANCER Possibly Damaging 7 LC_S19 LUNG c.1034delA p.K345fs*9 COSMIC NP NP 8 LUAD-CHTN-MAD06-00668 LUNG c.1348G>A p.E450K COSMIC CANCER Probably Damaging 9 LUAD_E00522 LUNG c.1897G>C p.E633Q COSMIC CANCER Benign 10 MD-324 CENTRAL NERVOUS SYSTEM c.1971C>A p.S657S COSMIC NP NP 11 TCGA-13-0887-01 OVARY c.356C>T p.S119F COSMIC PASSENGER/OTHER Benign 12 TCGA-18-3406-01 LUNG c.194C>A p.S65* COSMIC NP NP 13 TCGA-20-0991-01 OVARY c.1854T>G p.L618L COSMIC NP NP 14 TCGA-22-5480-01 LUNG c.2113C>T p.L705L COSMIC NP NP 15 TCGA-29-1784-01 OVARY c.231G>T p.E77D COSMIC PASSENGER/OTHER Benign 16 TCGA-44-6777-01 LUNG c.931G>C p.E311Q COSMIC PASSENGER/OTHER Probably Damaging 17 TCGA-55-1594-01 LUNG c.1983C>T p.G661G COSMIC NP NP 18 TCGA-55-7727-01 LUNG c.1932G>A p.R644R COSMIC NP NP 19 TCGA-55-7911-01 LUNG c.3409G>A p.A1137T COSMIC PASSENGER/OTHER Probably Damaging 20 TCGA-75-7027-01 LUNG c.2421G>A p.R807R COSMIC NP NP 21 TCGA-95-7944-01 LUNG c.92G>C p.R31T COSMIC CANCER Possibly Damaging 22 TCGA-A3-3316-01 KIDNEY c.232G>A p.G78R COSMIC PASSENGER/OTHER Possibly Damaging 23 TCGA-A6-6653-01 LARGE INTESTINE c.317G>A p.R106Q COSMIC PASSENGER/OTHER Probably Damaging 24 TCGA-AA-3558-01 LARGE INTESTINE c.2818G>A p.G940S COSMIC PASSENGER/OTHER Benign 25 TCGA-AG-3999-01 LARGE INTESTINE c.845G>A p.R282H COSMIC CANCER Benign 26 TCGA-AG-A02N-01 LARGE INTESTINE c.2218C>T p.R740C COSMIC CANCER Benign 27 TCGA-AP-A056-01 ENDOMETRIUM c.995A>C p.D332A COSMIC CANCER Benign 28 TCGA-AX-A0J1-01 ENDOMETRIUM c.2876C>T p.T959M COSMIC CANCER Probably Damaging 29 TCGA-AX-A0J1-01 ENDOMETRIUM c.663C>A p.T221T COSMIC NP NP 30 TCGA-B0-5096-01 KIDNEY c.1979A>G p.Q660R COSMIC CANCER Benign 31 TCGA-CH-5768-01 PROSTATE c.50C>A p.A17D COSMIC CANCER Benign 32 TCGA-CK-5915-01 LARGE INTESTINE c.2549A>G p.H850R COSMIC CANCER Probably Damaging 33 TCGA-CM-4743-01 LARGE INTESTINE c.1471C>A p.H491N COSMIC CANCER Probably Damaging 34 TCGA-CM-4746-01 LARGE INTESTINE c.1861G>A p.V621M COSMIC CANCER Benign 35 TCGA-CM-6674-01 LARGE INTESTINE c.733C>T p.R245C COSMIC CANCER Possibly Damaging 36 TCGA-CZ-5459-01 KIDNEY c.3395G>A p.R1132Q COSMIC PASSENGER/OTHER Probably Damaging 37 TCGA-DR-A0ZM-01 CERVIX c.781G>A p.E261K COSMIC CANCER Possibly Damaging 38 TCGA-DS-A0VL-01 CERVIX c.3476G>T p.W1159L COSMIC PASSENGER/OTHER Probably Damaging 39 TCGA-EJ-5498-01 PROSTATE c.3054C>A p.N1018K COSMIC PASSENGER/OTHER Probably Damaging 40 TCGA-G4-6588-01 LARGE INTESTINE c.1635G>T p.E545D COSMIC CANCER Probably Damaging 41 TCGA-GD-A2C5-01 URINARY TRACT c.3601G>C p.E1201Q COSMIC CANCER Possibly Damaging 42 TCGA-GV-A3JX-01 URINARY TRACT c.1687C>G p.P563A COSMIC CANCER Possibly Damaging 43 WA56 PROSTATE c.2927G>C p.C976S COSMIC CANCER Probably Damaging
*NP: Not Predicted -
Copy number variation and expression profile (+)
-
Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.test -
Tertiary structure (+)
-
Structure Domains (+)
-
Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:4. Sequence alignment with homologus proteins: -
Sequence Profiles (+)
-
Post Translational Modifications (+)
Post translational modifications are not found!!Other Databases Link (+)
