dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: HAT1 |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 CHC051T LIVER c.717T>G p.S239R COSMIC NP Probably Damaging 2 CRC-4 LARGE INTESTINE c.152T>C p.F51S COSMIC NP Probably Damaging 3 Co92 LARGE INTESTINE c.949G>C p.A317P COSMIC NP Probably Damaging 4 ESO-251 OESOPHAGUS c.835T>G p.S279A COSMIC NP Probably Damaging 5 ESO-708 OESOPHAGUS c.1176C>T p.S392S COSMIC NP NP 6 LC_S18 LUNG c.75delC p.Y25fs*1 COSMIC NP NP 7 LUAD-B01970 LUNG c.592A>G p.R198G COSMIC NP Probably Damaging 8 SA210 BREAST c.502T>C p.C168R COSMIC NP Possibly Damaging 9 TCGA-05-4396-01 LUNG c.692C>G p.P231R COSMIC NP Probably Damaging 10 TCGA-25-1315-01 OVARY c.1034C>T p.A345V COSMIC NP Benign 11 TCGA-29-1784-01 OVARY c.605T>G p.F202C COSMIC NP Probably Damaging 12 TCGA-39-5039-01 LUNG c.1053C>G p.Y351* COSMIC NP NP 13 TCGA-50-6594-01 LUNG c.319G>T p.V107F COSMIC NP Probably Damaging 14 TCGA-55-6985-01 LUNG c.1007G>T p.R336L COSMIC NP Probably Damaging 15 TCGA-66-2782-01 LUNG c.535C>T p.Q179* COSMIC NP NP 16 TCGA-97-7941-01 LUNG c.275C>T p.A92V COSMIC NP Benign 17 TCGA-A8-A0A7-01 BREAST c.1207C>T p.Q403* COSMIC NP NP 18 TCGA-AA-3510-01 LARGE INTESTINE c.106A>C p.K36Q COSMIC NP Probably Damaging 19 TCGA-AA-3672-01 LARGE INTESTINE c.1172T>C p.I391T COSMIC NP Benign 20 TCGA-AA-3712-01 LARGE INTESTINE c.1035C>A p.A345A COSMIC NP NP 21 TCGA-AG-A002-01 LARGE INTESTINE c.24G>T p.E8D COSMIC NP Possibly Damaging 22 TCGA-AG-A002-01 LARGE INTESTINE c.417C>T p.F139F COSMIC NP NP 23 TCGA-AP-A051-01 ENDOMETRIUM c.861C>A p.D287E COSMIC NP Probably Damaging 24 TCGA-AP-A051-01 ENDOMETRIUM c.922G>T p.G308* COSMIC NP NP 25 TCGA-AP-A059-01 ENDOMETRIUM c.975G>T p.K325N COSMIC NP Possibly Damaging 26 TCGA-AP-A0LM-01 ENDOMETRIUM c.550T>C p.W184R COSMIC NP Probably Damaging 27 TCGA-AY-6386-01 LARGE INTESTINE c.569G>C p.S190T COSMIC NP Possibly Damaging 28 TCGA-AZ-6598-01 LARGE INTESTINE c.905G>A p.R302Q COSMIC NP Benign 29 TCGA-AZ-6601-01 LARGE INTESTINE c.249G>A p.L83L COSMIC NP NP 30 TCGA-B5-A11E-01 ENDOMETRIUM c.294C>A p.N98K COSMIC NP Benign 31 TCGA-BS-A0UF-01 ENDOMETRIUM c.554T>G p.F185C COSMIC NP Probably Damaging 32 TCGA-CI-6619-01 LARGE INTESTINE c.1035C>T p.A345A COSMIC NP NP 33 TCGA-CJ-4882-01 KIDNEY c.341T>G p.I114S COSMIC NP Possibly Damaging 34 TCGA-D5-5538-01 LARGE INTESTINE c.1035C>A p.A345A COSMIC NP NP 35 TCGA-DM-A0XD-01 LARGE INTESTINE c.951A>G p.A317A COSMIC NP NP 36 TCGA-F4-6703-01 LARGE INTESTINE c.758G>A p.G253D COSMIC NP Probably Damaging 37 TCGA-G4-6588-01 LARGE INTESTINE c.1035C>T p.A345A COSMIC NP NP 38 TCGA-G4-6626-01 LARGE INTESTINE c.951A>G p.A317A COSMIC NP NP 39 WA53 PROSTATE c.272A>T p.Y91F COSMIC NP Benign
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.test -
Tertiary structure (+)
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Structure Domains (+)
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Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 4. Sequence alignment with homologus proteins:
Click on button to get Sequence alignment with Coverage, Consensus and Quality -
Sequence Profiles (+)
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Post Translational Modifications (+)
S. No. Position Amino acid Type 1 15 K Ubiquitylation 2 2 A Acetylation 3 26 K Ubiquitylation 4 280 K Ubiquitylation 5 304 K Ubiquitylation 6 320 K Ubiquitylation 7 350 S Phosphorylation 8 351 Y Phosphorylation 9 361 S Phosphorylation 10 361 S Phosphorylation 11 9 K Ubiquitylation -
Other Databases Link (+)
Proteomics DB COSMIC Gene Atlas STRING PIR HAT1 HAT1 HAT1 ENSP00000264108 O14929 QuickGO HGNC Ensembl Genome Browser TreeFam UniProt O14929 HAT1 ENSP00000264108 HAT1 O14929 Expression Atlas Protein Atlas OMIM IntAct PharmGKB HAT1 ENSP00000264108 603053 O14929 PA29197
