dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: HDAC1 |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 BICR18 UPPER AERODIGESTIVE TRACT c.81C>G p.G27G CCLE NP NP 2 BICR18 UPPER AERODIGESTIVE TRACT c.87A>C p.P29P CCLE NP NP 3 CL34 LARGE INTESTINE c.1323G>T p.K441N CCLE PASSENGER/OTHER Possibly Damaging 4 CMLT1 HAEMATOPOIETIC AND LYMPHOID TISSUE c.907T>C p.Y303H CCLE PASSENGER/OTHER Probably Damaging 5 DND41 HAEMATOPOIETIC AND LYMPHOID TISSUE c.495_splice p.K165_splice CCLE NP NP 6 GP2D LARGE INTESTINE c.1397_1399delAGG p.E468del CCLE NP NP 7 GP2D LARGE INTESTINE c.199T>C p.Y67H CCLE PASSENGER/OTHER Probably Damaging 8 HEC151 ENDOMETRIUM c.1397_1399delAGG p.E468del CCLE NP NP 9 HEC6 ENDOMETRIUM c.235A>G p.I79V CCLE PASSENGER/OTHER Probably Damaging 10 HT HAEMATOPOIETIC AND LYMPHOID TISSUE c.629A>G p.D210G CCLE PASSENGER/OTHER Probably Damaging 11 ISHIKAWAHERAKLIO02ER ENDOMETRIUM c.1360_1362delGAG p.E455del CCLE NP NP 12 JHH5 LIVER c.607G>A p.E203K CCLE PASSENGER/OTHER Possibly Damaging 13 KM12 LARGE INTESTINE c.1381G>A p.E461K CCLE PASSENGER/OTHER Benign 14 LNCAPCLONEFGC PROSTATE c.1360_1362delGAG p.E455del CCLE NP NP 15 MOLT16 HAEMATOPOIETIC AND LYMPHOID TISSUE c.1292G>A p.R431H CCLE PASSENGER/OTHER Probably Damaging 16 SKMEL28 SKIN c.1426A>C p.K476Q CCLE PASSENGER/OTHER Possibly Damaging 17 SNU1040 LARGE INTESTINE c.748G>A p.E250K CCLE PASSENGER/OTHER Possibly Damaging 18 SNU175 LARGE INTESTINE c.1264G>A p.D422N CCLE PASSENGER/OTHER Probably Damaging 19 SNU81 LARGE INTESTINE c.1381G>A p.E461K CCLE PASSENGER/OTHER Benign 20 SW48 LARGE INTESTINE c.232T>C p.S78P CCLE PASSENGER/OTHER Probably Damaging 21 SW48 LARGE INTESTINE c.844G>A p.A282T CCLE PASSENGER/OTHER Possibly Damaging 22 TEN ENDOMETRIUM c.356_splice p.A119_splice CCLE NP NP 23 107094 BREAST c.1094G>A p.R365Q COSMIC PASSENGER/OTHER Probably Damaging 24 112140 LUNG c.1291C>T p.R431C COSMIC PASSENGER/OTHER Probably Damaging 25 CRC-6 LARGE INTESTINE c.1292G>A p.R431H COSMIC PASSENGER/OTHER Probably Damaging 26 H322T LUNG c.229C>T p.R77C COSMIC PASSENGER/OTHER Probably Damaging 27 HCC128T LIVER c.183T>A p.A61A COSMIC NP NP 28 ME009T SKIN c.1363G>A p.E455K COSMIC PASSENGER/OTHER Possibly Damaging 29 NCI-H322M LUNG c.229C>T p.R77C COSMIC PASSENGER/OTHER Probably Damaging 30 PD4076a BREAST c.1192G>A p.E398K COSMIC PASSENGER/OTHER Benign 31 PD4601a NS c.468C>T p.I156I COSMIC NP NP 32 SA218 BREAST c.418C>T p.H140Y COSMIC CANCER Probably Damaging 33 TCGA-23-1122-01 OVARY c.74G>C p.G25A COSMIC PASSENGER/OTHER Probably Damaging 34 TCGA-60-2721-01 LUNG c.1188G>C p.E396D COSMIC PASSENGER/OTHER Benign 35 TCGA-70-6722-01 LUNG c.917G>T p.R306L COSMIC PASSENGER/OTHER Possibly Damaging 36 TCGA-73-4666-01 LUNG c.895G>T p.G299* COSMIC NP NP 37 TCGA-A3-3346-01 KIDNEY c.921C>T p.N307N COSMIC NP NP 38 TCGA-A3-3373-01 KIDNEY c.1162G>A p.A388T COSMIC PASSENGER/OTHER Benign 39 TCGA-A6-5661-01 LARGE INTESTINE c.74G>A p.G25E COSMIC PASSENGER/OTHER Probably Damaging 40 TCGA-A6-6780-01 LARGE INTESTINE c.1397_1399delAGG p.E468delE COSMIC NP NP 41 TCGA-AA-A01Q-01 LARGE INTESTINE c.1192G>A p.E398K COSMIC PASSENGER/OTHER Benign 42 TCGA-AA-A02K-01 LARGE INTESTINE c.1397_1399delAGG p.E468delE COSMIC NP NP 43 TCGA-AN-A0FJ-01 BREAST c.1135G>T p.V379F COSMIC PASSENGER/OTHER Probably Damaging 44 TCGA-AP-A051-01 ENDOMETRIUM c.767C>T p.A256V COSMIC PASSENGER/OTHER Possibly Damaging 45 TCGA-AP-A059-01 ENDOMETRIUM c.932G>A p.C311Y COSMIC PASSENGER/OTHER Probably Damaging 46 TCGA-AX-A0J0-01 ENDOMETRIUM c.1191C>T p.D397D COSMIC NP NP 47 TCGA-B0-5707-01 KIDNEY c.258G>C p.E86D COSMIC PASSENGER/OTHER Benign 48 TCGA-BH-A208-01 BREAST c.504G>A p.Q168Q COSMIC NP NP 49 TCGA-BK-A0C9-01 ENDOMETRIUM c.206G>A p.S69N COSMIC PASSENGER/OTHER Benign 50 TCGA-BS-A0U8-01 ENDOMETRIUM c.1360_1362delGAG p.E455delE COSMIC NP NP 51 TCGA-BS-A0U8-01 ENDOMETRIUM c.1397_1399delAGG p.E468delE COSMIC NP NP 52 TCGA-C8-A12X-01 BREAST c.1422G>A p.G474G COSMIC NP NP 53 TCGA-CM-4746-01 LARGE INTESTINE c.570G>A p.T190T COSMIC NP NP 54 TCGA-D1-A103-01 ENDOMETRIUM c.240T>C p.R80R COSMIC NP NP 55 TCGA-D1-A17Q-01 ENDOMETRIUM c.101G>A p.R34Q COSMIC PASSENGER/OTHER Possibly Damaging 56 TCGA-D5-6535-01 LARGE INTESTINE c.74G>A p.G25E COSMIC PASSENGER/OTHER Probably Damaging 57 TCGA-D8-A1JM-01 BREAST c.966G>T p.T322T COSMIC NP NP 58 TCGA-E9-A22G-01 BREAST c.1335_1336delAG p.E446fs*2 COSMIC NP NP 59 TCGA-G2-A2EK-01 URINARY TRACT c.1090C>T p.Q364* COSMIC NP NP 60 cSCCP6 SKIN c.1108C>T p.L370F COSMIC PASSENGER/OTHER Probably Damaging
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.test -
Tertiary structure (+)
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Structure Domains (+)
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Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 2. Sequence alignment with CCLE mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 3. Sequence alignment with COSMIC mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 4. Sequence alignment with homologus proteins:
Click on button to get Sequence alignment with Coverage, Consensus and Quality -
Sequence Profiles (+)
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Post Translational Modifications (+)
Post translational modifications are not found!!Other Databases Link (+)
