dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: HDAC10 |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 587284 LARGE INTESTINE c.274G>A p.A92T COSMIC CANCER Benign 2 BN01T LIVER c.1033A>C p.S345R COSMIC CANCER Benign 3 H358 LUNG c.782C>T p.S261L COSMIC PASSENGER/OTHER Probably Damaging 4 HCC122T LIVER c.1365G>T p.E455D COSMIC PASSENGER/OTHER Benign 5 KM12 LARGE INTESTINE c.1595delG p.G533fs*18 COSMIC NP NP 6 KM12 LARGE INTESTINE c.833C>T p.T278M COSMIC CANCER Probably Damaging 7 LAU63 SKIN c.750C>T p.A250A COSMIC NP NP 8 LC_C32 LUNG c.558C>G p.D186E COSMIC CANCER Possibly Damaging 9 LC_C5 LUNG c.5G>A p.G2E COSMIC CANCER Probably Damaging 10 LUAD-NYU284 LUNG c.1009C>G p.Q337E COSMIC CANCER Benign 11 LUAD-YINHD LUNG c.1231C>G p.R411G COSMIC PASSENGER/OTHER Benign 12 NB-0462 AUTONOMIC GANGLIA c.1414delG p.D472fs*4 COSMIC NP NP 13 PR-01-2382 PROSTATE c.337C>T p.L113L COSMIC NP NP 14 TCGA-23-1809-01 OVARY c.1657G>A p.G553S COSMIC PASSENGER/OTHER Possibly Damaging 15 TCGA-39-5031-01 LUNG c.1626C>G p.F542L COSMIC PASSENGER/OTHER Benign 16 TCGA-A6-5665-01 LARGE INTESTINE c.1464A>G p.A488A COSMIC NP NP 17 TCGA-AR-A0TU-01 BREAST c.336G>A p.Q112Q COSMIC NP NP 18 TCGA-B5-A11E-01 ENDOMETRIUM c.1525G>A p.V509M COSMIC PASSENGER/OTHER Probably Damaging 19 TCGA-BP-5202-01 KIDNEY c.1460C>T p.A487V COSMIC PASSENGER/OTHER Benign 20 TCGA-CJ-5686-01 KIDNEY c.1075C>T p.Q359* COSMIC NP NP 21 TCGA-D1-A163-01 ENDOMETRIUM c.1131G>A p.R377R COSMIC NP NP 22 TCGA-D1-A176-01 ENDOMETRIUM c.818G>A p.G273E COSMIC CANCER Probably Damaging 23 TCGA-FD-A3B6-01 URINARY TRACT c.1634C>G p.S545C COSMIC PASSENGER/OTHER Benign 24 TCGA-FD-A3B7-01 URINARY TRACT c.546C>G p.L182L COSMIC NP NP 25 TCGA-GV-A3QH-01 URINARY TRACT c.1301C>T p.A434V COSMIC PASSENGER/OTHER Benign
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.Gene essentiality data is not present in COLT database!! -
Tertiary structure (+)
Users must enabled the Java in their browser to see structure.
Users can also download Java from here.Modelled Structure Structures available in PDB -
Structure Domains (+)
1. PFAM domains are not present!!2. Superfaimly domains are not present!! -
Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:4. Sequence alignment with homologus proteins: -
Sequence Profiles (+)
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Post Translational Modifications (+)
Post translational modifications are not found!!Other Databases Link (+)
