dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: HDAC11 |
| Expand All | Collapse All |
-
Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 587228 LARGE INTESTINE c.285delC p.V98fs*14 COSMIC NP NP 2 LC_S15 LUNG c.793G>C p.G265R COSMIC PASSENGER/OTHER Probably Damaging 3 LUAD-S01315 LUNG c.729G>C p.K243N COSMIC PASSENGER/OTHER Benign 4 LUAD-S01315 LUNG c.967G>T p.G323W COSMIC PASSENGER/OTHER Probably Damaging 5 MEL-JWCI-WGS-22 SKIN c.197delC p.S67fs*45 COSMIC NP NP 6 OV207 OVARY c.503G>A p.R168H COSMIC PASSENGER/OTHER Benign 7 PD4120a BREAST c.955C>T p.L319L COSMIC NP NP 8 TCGA-05-4432-01 LUNG c.657C>G p.I219M COSMIC CANCER Probably Damaging 9 TCGA-24-0980-01 OVARY c.716A>T p.E239V COSMIC PASSENGER/OTHER Benign 10 TCGA-59-2348-01 OVARY c.288C>T p.P96P COSMIC NP NP 11 TCGA-97-7937-01 LUNG c.955C>G p.L319V COSMIC CANCER Probably Damaging 12 TCGA-99-7458-01 LUNG c.931A>G p.I311V COSMIC PASSENGER/OTHER Benign 13 TCGA-A6-5661-01 LARGE INTESTINE c.285delC p.V98fs*14 COSMIC NP NP 14 TCGA-A6-5666-01 LARGE INTESTINE c.288C>T p.P96P COSMIC NP NP 15 TCGA-A8-A08Z-01 BREAST c.753C>T p.P251P COSMIC NP NP 16 TCGA-AA-3516-01 LARGE INTESTINE c.970C>A p.L324I COSMIC PASSENGER/OTHER Probably Damaging 17 TCGA-AF-6672-01 LARGE INTESTINE c.468G>A p.A156A COSMIC NP NP 18 TCGA-AP-A0LE-01 ENDOMETRIUM c.781G>A p.D261N COSMIC CANCER Probably Damaging 19 TCGA-AX-A0J1-01 ENDOMETRIUM c.233G>A p.R78H COSMIC CANCER Probably Damaging 20 TCGA-AY-6197-01 LARGE INTESTINE c.68G>A p.R23H COSMIC CANCER Benign 21 TCGA-AZ-6601-01 LARGE INTESTINE c.716A>G p.E239G COSMIC PASSENGER/OTHER Benign 22 TCGA-B5-A0JY-01 ENDOMETRIUM c.44G>A p.R15H COSMIC CANCER Possibly Damaging 23 TCGA-BH-A0AU-01 BREAST c.672G>T p.E224D COSMIC PASSENGER/OTHER Possibly Damaging 24 TCGA-BS-A0UF-01 ENDOMETRIUM c.538C>A p.L180I COSMIC PASSENGER/OTHER Probably Damaging 25 TCGA-CF-A3MG-01 URINARY TRACT c.617G>A p.R206H COSMIC CANCER Possibly Damaging 26 TCGA-CH-5766-01 PROSTATE c.447C>T p.G149G COSMIC NP NP 27 TCGA-CK-6746-01 LARGE INTESTINE c.285delC p.V98fs*14 COSMIC NP NP 28 TCGA-CM-5860-01 LARGE INTESTINE c.291C>A p.P97P COSMIC NP NP 29 TCGA-CM-5861-01 LARGE INTESTINE c.1019C>T p.P340L COSMIC PASSENGER/OTHER Benign 30 TCGA-CM-5862-01 LARGE INTESTINE c.716A>G p.E239G COSMIC PASSENGER/OTHER Benign 31 TCGA-D1-A103-01 ENDOMETRIUM c.638G>A p.R213H COSMIC CANCER Benign 32 TCGA-D1-A167-01 ENDOMETRIUM c.66G>A p.P22P COSMIC NP NP 33 TCGA-D1-A174-01 ENDOMETRIUM c.827C>T p.A276V COSMIC PASSENGER/OTHER Benign 34 TCGA-D8-A1Y1-01 BREAST c.900C>A p.T300T COSMIC NP NP 35 TCGA-DK-A3IM-01 URINARY TRACT c.139A>C p.N47H COSMIC CANCER Benign 36 TCGA-G4-6628-01 LARGE INTESTINE c.560G>T p.G187V COSMIC CANCER Probably Damaging 37 WA14 PROSTATE c.67C>T p.R23C COSMIC CANCER Probably Damaging 38 WA19 PROSTATE c.448G>A p.G150R COSMIC CANCER Probably Damaging
*NP: Not Predicted -
Copy number variation and expression profile (+)
-
Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.Gene essentiality data is not present in COLT database!! -
Tertiary structure (+)
Users must enabled the Java in their browser to see structure.
Users can also download Java from here.Modelled Structure Structures available in PDB -
Structure Domains (+)
1. PFAM domains are not present!!2. Superfaimly domains are not present!! -
Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:4. Sequence alignment with homologus proteins: -
Sequence Profiles (+)
-
Post Translational Modifications (+)
Post translational modifications are not found!!Other Databases Link (+)
