A Database of Epigenetic Modifiers
Protein: HDAC2 |
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# | Cell Line/Tumor sample | Tissue of Origin | cDNA change | Protein change | Source | FATHMM Prediction | PolyPhen2 Prediction |
---|---|---|---|---|---|---|---|
1 | 2313287 | STOMACH | c.315_315delA | p.K105fs | CCLE | NP | NP |
2 | 2313287 | STOMACH | c.761C>T | p.A254V | CCLE | NP | NP |
3 | AN3CA | ENDOMETRIUM | c.315_315delA | p.K105fs | CCLE | NP | NP |
4 | COLO829 | SKIN | c.1507C>T | p.R503* | CCLE | NP | NP |
5 | CORL279 | LUNG | c.146C>T | p.P49L | CCLE | NP | NP |
6 | COV318 | OVARY | c.243_245delCAG | p.S81del | CCLE | NP | NP |
7 | DAOY | CENTRAL NERVOUS SYSTEM | c.245_246insCAG | p.81_82insS | CCLE | NP | NP |
8 | DKMG | CENTRAL NERVOUS SYSTEM | c.245_246insCAG | p.81_82insS | CCLE | NP | NP |
9 | DV90 | LUNG | c.315_315delA | p.K105fs | CCLE | NP | NP |
10 | EB2 | HAEMATOPOIETIC AND LYMPHOID TISSUE | c.13C>T | p.P5S | CCLE | NP | NP |
11 | EFO27 | OVARY | c.315_315delA | p.K105fs | CCLE | NP | NP |
12 | EM2 | HAEMATOPOIETIC AND LYMPHOID TISSUE | c.245_246insCAG | p.81_82insS | CCLE | NP | NP |
13 | EN | ENDOMETRIUM | c.1409A>G | p.H470R | CCLE | NP | NP |
14 | GP2D | LARGE INTESTINE | c.315_315delA | p.K105fs | CCLE | NP | NP |
15 | HEC108 | ENDOMETRIUM | c.1062A>T | p.L354F | CCLE | NP | NP |
16 | HEC108 | ENDOMETRIUM | c.300A>C | p.G100G | CCLE | NP | NP |
17 | HEC108 | ENDOMETRIUM | c.315_315delA | p.K105fs | CCLE | NP | NP |
18 | HEC59 | ENDOMETRIUM | c.315_315delA | p.K105fs | CCLE | NP | NP |
19 | HEC6 | ENDOMETRIUM | c.150C>A | p.A50A | CCLE | NP | NP |
20 | HGC27 | STOMACH | c.641_splice | p.A214_splice | CCLE | NP | NP |
21 | ISHIKAWAHERAKLIO02ER | ENDOMETRIUM | c.1641A>C | p.E547D | CCLE | NP | NP |
22 | ISHIKAWAHERAKLIO02ER | ENDOMETRIUM | c.315_315delA | p.K105fs | CCLE | NP | NP |
23 | JHUEM7 | ENDOMETRIUM | c.859C>T | p.R287C | CCLE | NP | NP |
24 | KCL22 | HAEMATOPOIETIC AND LYMPHOID TISSUE | c.315_315delA | p.K105fs | CCLE | NP | NP |
25 | KM12 | LARGE INTESTINE | c.1657_1657delA | p.T553fs | CCLE | NP | NP |
26 | KYSE270 | OESOPHAGUS | c.835G>T | p.E279* | CCLE | NP | NP |
27 | L363 | HAEMATOPOIETIC AND LYMPHOID TISSUE | c.245_246insCAG | p.81_82insS | CCLE | NP | NP |
28 | LNCAPCLONEFGC | PROSTATE | c.467C>T | p.A156V | CCLE | NP | NP |
29 | LS1034 | LARGE INTESTINE | c.245_246insCAG | p.81_82insS | CCLE | NP | NP |
30 | LS411N | LARGE INTESTINE | c.694G>A | p.G232R | CCLE | PASSENGER/OTHER | Probably Damaging |
31 | MFE296 | ENDOMETRIUM | c.245_246insCAG | p.81_82insS | CCLE | NP | NP |
32 | MKN74 | STOMACH | c.245_246insCAG | p.81_82insS | CCLE | NP | NP |
33 | ML1 | THYROID | c.245_246insCAG | p.81_82insS | CCLE | NP | NP |
34 | MOLT13 | HAEMATOPOIETIC AND LYMPHOID TISSUE | c.243_245delCAG | p.S81del | CCLE | NP | NP |
35 | NCIH1048 | LUNG | c.315_315delA | p.K105fs | CCLE | NP | NP |
36 | NCIH1944 | LUNG | c.716A>C | p.K239T | CCLE | NP | NP |
37 | NCIH2023 | LUNG | c.243_245delCAG | p.S81del | CCLE | NP | NP |
38 | NCIH2126 | LUNG | c.245_246insCAG | p.81_82insS | CCLE | NP | NP |
39 | NCIH510 | LUNG | c.245_246insCAG | p.81_82insS | CCLE | NP | NP |
40 | NCIH526 | LUNG | c.243_245delCAG | p.S81del | CCLE | NP | NP |
41 | OCILY3 | HAEMATOPOIETIC AND LYMPHOID TISSUE | c.245_246insCAG | p.81_82insS | CCLE | NP | NP |
42 | OVCAR8 | OVARY | c.245_246insCAG | p.81_82insS | CCLE | NP | NP |
43 | OVK18 | OVARY | c.315_315delA | p.K105fs | CCLE | NP | NP |
44 | PANC0213 | PANCREAS | c.245_246insCAG | p.81_82insS | CCLE | NP | NP |
45 | RKO | LARGE INTESTINE | c.315_315delA | p.K105fs | CCLE | NP | NP |
46 | RL952 | ENDOMETRIUM | c.315_315delA | p.K105fs | CCLE | NP | NP |
47 | RS411 | HAEMATOPOIETIC AND LYMPHOID TISSUE | c.1657_1657delA | p.T553fs | CCLE | NP | NP |
48 | SKUT1 | SOFT TISSUE | c.315_315delA | p.K105fs | CCLE | NP | NP |
49 | SNGM | ENDOMETRIUM | c.303C>T | p.G101G | CCLE | NP | NP |
50 | SNU1040 | LARGE INTESTINE | c.392G>A | p.R131H | CCLE | NP | NP |
51 | SNU1040 | LARGE INTESTINE | c.514C>T | p.R172W | CCLE | NP | NP |
52 | SNU175 | LARGE INTESTINE | c.1111C>A | p.L371I | CCLE | PASSENGER/OTHER | Possibly Damaging |
53 | SNU324 | PANCREAS | c.1657_1657delA | p.T553fs | CCLE | NP | NP |
54 | SNU324 | PANCREAS | c.315_315delA | p.K105fs | CCLE | NP | NP |
55 | SNU81 | LARGE INTESTINE | c.1507C>T | p.R503* | CCLE | NP | NP |
56 | SNUC2A | LARGE INTESTINE | c.315_315delA | p.K105fs | CCLE | NP | NP |
57 | SNUC4 | LARGE INTESTINE | c.243_245delCAG | p.S81del | CCLE | NP | NP |
58 | SW48 | LARGE INTESTINE | c.315_316insA | p.K105fs | CCLE | NP | NP |
59 | SW780 | URINARY TRACT | c.245_246insCAG | p.81_82insS | CCLE | NP | NP |
60 | TGBC11TKB | STOMACH | c.315_315delA | p.K105fs | CCLE | NP | NP |
61 | 1946219 | LUNG | c.82G>T | p.G28C | COSMIC | PASSENGER/OTHER | Probably Damaging |
62 | 587256 | LARGE INTESTINE | c.453C>A | p.F151L | COSMIC | CANCER | Benign |
63 | 587342 | LARGE INTESTINE | c.1213A>G | p.R405G | COSMIC | PASSENGER/OTHER | Possibly Damaging |
64 | 90624 | HAEMATOPOIETIC AND LYMPHOID TISSUE | c.323_324delTT | p.F108fs*1 | COSMIC | NP | NP |
65 | Br03X | CENTRAL NERVOUS SYSTEM | c.498G>C | p.K166N | COSMIC | PASSENGER/OTHER | Benign |
66 | COLO-829 | SKIN | c.1225C>T | p.R409* | COSMIC | NP | NP |
67 | ESO-752 | OESOPHAGUS | c.1273G>C | p.E425Q | COSMIC | PASSENGER/OTHER | Possibly Damaging |
68 | H322T | LUNG | c.1276G>T | p.D426Y | COSMIC | PASSENGER/OTHER | Probably Damaging |
69 | HCC2998 | LARGE INTESTINE | c.461T>C | p.V154A | COSMIC | PASSENGER/OTHER | Benign |
70 | HCC2998 | LARGE INTESTINE | c.562T>G | p.F188V | COSMIC | PASSENGER/OTHER | Probably Damaging |
71 | HF-23896 | LUNG | c.82G>T | p.G28C | COSMIC | PASSENGER/OTHER | Probably Damaging |
72 | LUAD-F00257 | LUNG | c.193A>G | p.M65V | COSMIC | PASSENGER/OTHER | Benign |
73 | LUAD-NYU160 | LUNG | c.413delG | p.G138fs*28 | COSMIC | NP | NP |
74 | LUAD-S01320 | LUNG | c.1375_1376insA | p.T459fs*4 | COSMIC | NP | NP |
75 | MD-336 | CENTRAL NERVOUS SYSTEM | c.1364_1365delAG | p.E455fs*7 | COSMIC | NP | NP |
76 | MD-336 | CENTRAL NERVOUS SYSTEM | c.73_75delTAT | p.Y25delY | COSMIC | NP | NP |
77 | NB-1110 | AUTONOMIC GANGLIA | c.941C>A | p.T314K | COSMIC | PASSENGER/OTHER | Probably Damaging |
78 | NCI-H322M | LUNG | c.1276G>T | p.D426Y | COSMIC | PASSENGER/OTHER | Probably Damaging |
79 | OCC06PT | OVARY | c.325G>C | p.E109Q | COSMIC | PASSENGER/OTHER | Probably Damaging |
80 | OLID15 | CENTRAL NERVOUS SYSTEM | c.542G>T | p.G181V | COSMIC | CANCER | Probably Damaging |
81 | OLID15 | CENTRAL NERVOUS SYSTEM | c.782A>C | p.Q261P | COSMIC | PASSENGER/OTHER | Possibly Damaging |
82 | P03-1334 | PROSTATE | c.1240C>T | p.R414W | COSMIC | PASSENGER/OTHER | Probably Damaging |
83 | TCGA-05-4432-01 | LUNG | c.82G>C | p.G28R | COSMIC | PASSENGER/OTHER | Probably Damaging |
84 | TCGA-44-2656-01 | LUNG | c.769G>A | p.A257T | COSMIC | PASSENGER/OTHER | Possibly Damaging |
85 | TCGA-55-1592-01 | LUNG | c.304C>G | p.P102A | COSMIC | PASSENGER/OTHER | Probably Damaging |
86 | TCGA-55-7910-01 | LUNG | c.126G>T | p.L42F | COSMIC | PASSENGER/OTHER | Probably Damaging |
87 | TCGA-64-5815-01 | LUNG | c.1464C>T | p.P488P | COSMIC | NP | NP |
88 | TCGA-75-5126-01 | LUNG | c.207C>T | p.H69H | COSMIC | NP | NP |
89 | TCGA-91-6831-01 | LUNG | c.1366G>A | p.D456N | COSMIC | PASSENGER/OTHER | Possibly Damaging |
90 | TCGA-A7-A0DA-01 | BREAST | c.502C>T | p.H168Y | COSMIC | PASSENGER/OTHER | Probably Damaging |
91 | TCGA-AA-A010-01 | LARGE INTESTINE | c.1225C>T | p.R409* | COSMIC | NP | NP |
92 | TCGA-AB-2861-03 | HAEMATOPOIETIC AND LYMPHOID TISSUE | c.523G>A | p.D175N | COSMIC | CANCER | Probably Damaging |
93 | TCGA-AP-A056-01 | ENDOMETRIUM | c.601A>G | p.K201E | COSMIC | PASSENGER/OTHER | Possibly Damaging |
94 | TCGA-AP-A059-01 | ENDOMETRIUM | c.321C>A | p.L107L | COSMIC | NP | NP |
95 | TCGA-AR-A0TU-01 | BREAST | c.459_463delCGTTA | p.Y153fs*1 | COSMIC | NP | NP |
96 | TCGA-AX-A060-01 | ENDOMETRIUM | c.884C>T | p.P295L | COSMIC | PASSENGER/OTHER | Probably Damaging |
97 | TCGA-AZ-6598-01 | LARGE INTESTINE | c.1375delA | p.T459fs*>30 | COSMIC | NP | NP |
98 | TCGA-B0-5116-01 | KIDNEY | c.231A>G | p.L77L | COSMIC | NP | NP |
99 | TCGA-B5-A0K3-01 | ENDOMETRIUM | c.744G>A | p.K248K | COSMIC | NP | NP |
100 | TCGA-BH-A0BR-01 | BREAST | c.523G>A | p.D175N | COSMIC | CANCER | Probably Damaging |
101 | TCGA-CA-6717-01 | LARGE INTESTINE | c.875T>G | p.F292C | COSMIC | PASSENGER/OTHER | Probably Damaging |
102 | TCGA-D1-A17Q-01 | ENDOMETRIUM | c.1225C>T | p.R409* | COSMIC | NP | NP |
103 | TCGA-DM-A28G-01 | LARGE INTESTINE | c.1227A>G | p.R409R | COSMIC | NP | NP |
104 | TCGA-DY-A1DG-01 | LARGE INTESTINE | c.348C>T | p.G116G | COSMIC | NP | NP |
105 | TCGA-F4-6703-01 | LARGE INTESTINE | c.1229C>T | p.A410V | COSMIC | PASSENGER/OTHER | Possibly Damaging |
106 | W012 | BILIARY TRACT | c.232C>T | p.R78W | COSMIC | PASSENGER/OTHER | Probably Damaging |
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S. No. | Position | Amino acid | Type |
1 | 11 | K | Ubiquitylation |
2 | 243 | K | Ubiquitylation |
3 | 262 | C | S-nitrosylation |
4 | 274 | C | S-nitrosylation |
5 | 304 | Y | Phosphorylation |
6 | 362 | K | Ubiquitylation |
7 | 394 | S | Phosphorylation |
8 | 394 | S | Phosphorylation |
9 | 394 | S | Phosphorylation |
10 | 407 | S | Phosphorylation |
11 | 407 | S | Phosphorylation |
12 | 411 | S | Phosphorylation |
13 | 422 | S | Phosphorylation |
14 | 422 | S | Phosphorylation |
15 | 422 | S | Phosphorylation |
16 | 424 | S | Phosphorylation |
17 | 424 | S | Phosphorylation |
18 | 424 | S | Phosphorylation |
19 | 67 | K | Ubiquitylation |
20 | 75 | K | Ubiquitylation |
21 | 75 | K | Acetylation |
22 | 75 | K | Acetylation |
23 | 90 | K | Ubiquitylation |
24 | 90 | K | Acetylation |
Proteomics DB | COSMIC | Gene Atlas | STRING | PIR |
HDAC2 | HDAC2 | HDAC2 | ENSP00000357621 | Q92769 |
QuickGO | HGNC | Ensembl Genome Browser | TreeFam | UniProt |
Q92769 | HDAC2 | ENSP00000357621 | HDAC2 | Q92769 |
Expression Atlas | Protein Atlas | OMIM | IntAct | PharmGKB |
HDAC2 | ENSP00000357621 | 605164 | Q92769 | PA29227 |