dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: HDAC2 |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 2313287 STOMACH c.315_315delA p.K105fs CCLE NP NP 2 2313287 STOMACH c.761C>T p.A254V CCLE NP NP 3 AN3CA ENDOMETRIUM c.315_315delA p.K105fs CCLE NP NP 4 COLO829 SKIN c.1507C>T p.R503* CCLE NP NP 5 CORL279 LUNG c.146C>T p.P49L CCLE NP NP 6 COV318 OVARY c.243_245delCAG p.S81del CCLE NP NP 7 DAOY CENTRAL NERVOUS SYSTEM c.245_246insCAG p.81_82insS CCLE NP NP 8 DKMG CENTRAL NERVOUS SYSTEM c.245_246insCAG p.81_82insS CCLE NP NP 9 DV90 LUNG c.315_315delA p.K105fs CCLE NP NP 10 EB2 HAEMATOPOIETIC AND LYMPHOID TISSUE c.13C>T p.P5S CCLE NP NP 11 EFO27 OVARY c.315_315delA p.K105fs CCLE NP NP 12 EM2 HAEMATOPOIETIC AND LYMPHOID TISSUE c.245_246insCAG p.81_82insS CCLE NP NP 13 EN ENDOMETRIUM c.1409A>G p.H470R CCLE NP NP 14 GP2D LARGE INTESTINE c.315_315delA p.K105fs CCLE NP NP 15 HEC108 ENDOMETRIUM c.1062A>T p.L354F CCLE NP NP 16 HEC108 ENDOMETRIUM c.300A>C p.G100G CCLE NP NP 17 HEC108 ENDOMETRIUM c.315_315delA p.K105fs CCLE NP NP 18 HEC59 ENDOMETRIUM c.315_315delA p.K105fs CCLE NP NP 19 HEC6 ENDOMETRIUM c.150C>A p.A50A CCLE NP NP 20 HGC27 STOMACH c.641_splice p.A214_splice CCLE NP NP 21 ISHIKAWAHERAKLIO02ER ENDOMETRIUM c.1641A>C p.E547D CCLE NP NP 22 ISHIKAWAHERAKLIO02ER ENDOMETRIUM c.315_315delA p.K105fs CCLE NP NP 23 JHUEM7 ENDOMETRIUM c.859C>T p.R287C CCLE NP NP 24 KCL22 HAEMATOPOIETIC AND LYMPHOID TISSUE c.315_315delA p.K105fs CCLE NP NP 25 KM12 LARGE INTESTINE c.1657_1657delA p.T553fs CCLE NP NP 26 KYSE270 OESOPHAGUS c.835G>T p.E279* CCLE NP NP 27 L363 HAEMATOPOIETIC AND LYMPHOID TISSUE c.245_246insCAG p.81_82insS CCLE NP NP 28 LNCAPCLONEFGC PROSTATE c.467C>T p.A156V CCLE NP NP 29 LS1034 LARGE INTESTINE c.245_246insCAG p.81_82insS CCLE NP NP 30 LS411N LARGE INTESTINE c.694G>A p.G232R CCLE PASSENGER/OTHER Probably Damaging 31 MFE296 ENDOMETRIUM c.245_246insCAG p.81_82insS CCLE NP NP 32 MKN74 STOMACH c.245_246insCAG p.81_82insS CCLE NP NP 33 ML1 THYROID c.245_246insCAG p.81_82insS CCLE NP NP 34 MOLT13 HAEMATOPOIETIC AND LYMPHOID TISSUE c.243_245delCAG p.S81del CCLE NP NP 35 NCIH1048 LUNG c.315_315delA p.K105fs CCLE NP NP 36 NCIH1944 LUNG c.716A>C p.K239T CCLE NP NP 37 NCIH2023 LUNG c.243_245delCAG p.S81del CCLE NP NP 38 NCIH2126 LUNG c.245_246insCAG p.81_82insS CCLE NP NP 39 NCIH510 LUNG c.245_246insCAG p.81_82insS CCLE NP NP 40 NCIH526 LUNG c.243_245delCAG p.S81del CCLE NP NP 41 OCILY3 HAEMATOPOIETIC AND LYMPHOID TISSUE c.245_246insCAG p.81_82insS CCLE NP NP 42 OVCAR8 OVARY c.245_246insCAG p.81_82insS CCLE NP NP 43 OVK18 OVARY c.315_315delA p.K105fs CCLE NP NP 44 PANC0213 PANCREAS c.245_246insCAG p.81_82insS CCLE NP NP 45 RKO LARGE INTESTINE c.315_315delA p.K105fs CCLE NP NP 46 RL952 ENDOMETRIUM c.315_315delA p.K105fs CCLE NP NP 47 RS411 HAEMATOPOIETIC AND LYMPHOID TISSUE c.1657_1657delA p.T553fs CCLE NP NP 48 SKUT1 SOFT TISSUE c.315_315delA p.K105fs CCLE NP NP 49 SNGM ENDOMETRIUM c.303C>T p.G101G CCLE NP NP 50 SNU1040 LARGE INTESTINE c.392G>A p.R131H CCLE NP NP 51 SNU1040 LARGE INTESTINE c.514C>T p.R172W CCLE NP NP 52 SNU175 LARGE INTESTINE c.1111C>A p.L371I CCLE PASSENGER/OTHER Possibly Damaging 53 SNU324 PANCREAS c.1657_1657delA p.T553fs CCLE NP NP 54 SNU324 PANCREAS c.315_315delA p.K105fs CCLE NP NP 55 SNU81 LARGE INTESTINE c.1507C>T p.R503* CCLE NP NP 56 SNUC2A LARGE INTESTINE c.315_315delA p.K105fs CCLE NP NP 57 SNUC4 LARGE INTESTINE c.243_245delCAG p.S81del CCLE NP NP 58 SW48 LARGE INTESTINE c.315_316insA p.K105fs CCLE NP NP 59 SW780 URINARY TRACT c.245_246insCAG p.81_82insS CCLE NP NP 60 TGBC11TKB STOMACH c.315_315delA p.K105fs CCLE NP NP 61 1946219 LUNG c.82G>T p.G28C COSMIC PASSENGER/OTHER Probably Damaging 62 587256 LARGE INTESTINE c.453C>A p.F151L COSMIC CANCER Benign 63 587342 LARGE INTESTINE c.1213A>G p.R405G COSMIC PASSENGER/OTHER Possibly Damaging 64 90624 HAEMATOPOIETIC AND LYMPHOID TISSUE c.323_324delTT p.F108fs*1 COSMIC NP NP 65 Br03X CENTRAL NERVOUS SYSTEM c.498G>C p.K166N COSMIC PASSENGER/OTHER Benign 66 COLO-829 SKIN c.1225C>T p.R409* COSMIC NP NP 67 ESO-752 OESOPHAGUS c.1273G>C p.E425Q COSMIC PASSENGER/OTHER Possibly Damaging 68 H322T LUNG c.1276G>T p.D426Y COSMIC PASSENGER/OTHER Probably Damaging 69 HCC2998 LARGE INTESTINE c.461T>C p.V154A COSMIC PASSENGER/OTHER Benign 70 HCC2998 LARGE INTESTINE c.562T>G p.F188V COSMIC PASSENGER/OTHER Probably Damaging 71 HF-23896 LUNG c.82G>T p.G28C COSMIC PASSENGER/OTHER Probably Damaging 72 LUAD-F00257 LUNG c.193A>G p.M65V COSMIC PASSENGER/OTHER Benign 73 LUAD-NYU160 LUNG c.413delG p.G138fs*28 COSMIC NP NP 74 LUAD-S01320 LUNG c.1375_1376insA p.T459fs*4 COSMIC NP NP 75 MD-336 CENTRAL NERVOUS SYSTEM c.1364_1365delAG p.E455fs*7 COSMIC NP NP 76 MD-336 CENTRAL NERVOUS SYSTEM c.73_75delTAT p.Y25delY COSMIC NP NP 77 NB-1110 AUTONOMIC GANGLIA c.941C>A p.T314K COSMIC PASSENGER/OTHER Probably Damaging 78 NCI-H322M LUNG c.1276G>T p.D426Y COSMIC PASSENGER/OTHER Probably Damaging 79 OCC06PT OVARY c.325G>C p.E109Q COSMIC PASSENGER/OTHER Probably Damaging 80 OLID15 CENTRAL NERVOUS SYSTEM c.542G>T p.G181V COSMIC CANCER Probably Damaging 81 OLID15 CENTRAL NERVOUS SYSTEM c.782A>C p.Q261P COSMIC PASSENGER/OTHER Possibly Damaging 82 P03-1334 PROSTATE c.1240C>T p.R414W COSMIC PASSENGER/OTHER Probably Damaging 83 TCGA-05-4432-01 LUNG c.82G>C p.G28R COSMIC PASSENGER/OTHER Probably Damaging 84 TCGA-44-2656-01 LUNG c.769G>A p.A257T COSMIC PASSENGER/OTHER Possibly Damaging 85 TCGA-55-1592-01 LUNG c.304C>G p.P102A COSMIC PASSENGER/OTHER Probably Damaging 86 TCGA-55-7910-01 LUNG c.126G>T p.L42F COSMIC PASSENGER/OTHER Probably Damaging 87 TCGA-64-5815-01 LUNG c.1464C>T p.P488P COSMIC NP NP 88 TCGA-75-5126-01 LUNG c.207C>T p.H69H COSMIC NP NP 89 TCGA-91-6831-01 LUNG c.1366G>A p.D456N COSMIC PASSENGER/OTHER Possibly Damaging 90 TCGA-A7-A0DA-01 BREAST c.502C>T p.H168Y COSMIC PASSENGER/OTHER Probably Damaging 91 TCGA-AA-A010-01 LARGE INTESTINE c.1225C>T p.R409* COSMIC NP NP 92 TCGA-AB-2861-03 HAEMATOPOIETIC AND LYMPHOID TISSUE c.523G>A p.D175N COSMIC CANCER Probably Damaging 93 TCGA-AP-A056-01 ENDOMETRIUM c.601A>G p.K201E COSMIC PASSENGER/OTHER Possibly Damaging 94 TCGA-AP-A059-01 ENDOMETRIUM c.321C>A p.L107L COSMIC NP NP 95 TCGA-AR-A0TU-01 BREAST c.459_463delCGTTA p.Y153fs*1 COSMIC NP NP 96 TCGA-AX-A060-01 ENDOMETRIUM c.884C>T p.P295L COSMIC PASSENGER/OTHER Probably Damaging 97 TCGA-AZ-6598-01 LARGE INTESTINE c.1375delA p.T459fs*>30 COSMIC NP NP 98 TCGA-B0-5116-01 KIDNEY c.231A>G p.L77L COSMIC NP NP 99 TCGA-B5-A0K3-01 ENDOMETRIUM c.744G>A p.K248K COSMIC NP NP 100 TCGA-BH-A0BR-01 BREAST c.523G>A p.D175N COSMIC CANCER Probably Damaging 101 TCGA-CA-6717-01 LARGE INTESTINE c.875T>G p.F292C COSMIC PASSENGER/OTHER Probably Damaging 102 TCGA-D1-A17Q-01 ENDOMETRIUM c.1225C>T p.R409* COSMIC NP NP 103 TCGA-DM-A28G-01 LARGE INTESTINE c.1227A>G p.R409R COSMIC NP NP 104 TCGA-DY-A1DG-01 LARGE INTESTINE c.348C>T p.G116G COSMIC NP NP 105 TCGA-F4-6703-01 LARGE INTESTINE c.1229C>T p.A410V COSMIC PASSENGER/OTHER Possibly Damaging 106 W012 BILIARY TRACT c.232C>T p.R78W COSMIC PASSENGER/OTHER Probably Damaging
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.test -
Tertiary structure (+)
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Structure Domains (+)
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Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 2. Sequence alignment with CCLE mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 3. Sequence alignment with COSMIC mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 4. Sequence alignment with homologus proteins:
Click on button to get Sequence alignment with Coverage, Consensus and Quality -
Sequence Profiles (+)
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Post Translational Modifications (+)
S. No. Position Amino acid Type 1 11 K Ubiquitylation 2 243 K Ubiquitylation 3 262 C S-nitrosylation 4 274 C S-nitrosylation 5 304 Y Phosphorylation 6 362 K Ubiquitylation 7 394 S Phosphorylation 8 394 S Phosphorylation 9 394 S Phosphorylation 10 407 S Phosphorylation 11 407 S Phosphorylation 12 411 S Phosphorylation 13 422 S Phosphorylation 14 422 S Phosphorylation 15 422 S Phosphorylation 16 424 S Phosphorylation 17 424 S Phosphorylation 18 424 S Phosphorylation 19 67 K Ubiquitylation 20 75 K Ubiquitylation 21 75 K Acetylation 22 75 K Acetylation 23 90 K Ubiquitylation 24 90 K Acetylation -
Other Databases Link (+)
Proteomics DB COSMIC Gene Atlas STRING PIR HDAC2 HDAC2 HDAC2 ENSP00000357621 Q92769 QuickGO HGNC Ensembl Genome Browser TreeFam UniProt Q92769 HDAC2 ENSP00000357621 HDAC2 Q92769 Expression Atlas Protein Atlas OMIM IntAct PharmGKB HDAC2 ENSP00000357621 605164 Q92769 PA29227
