dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: HDAC6 |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 2313287 STOMACH c.2247_2247delG p.L749fs CCLE NP NP 2 BCP1 HAEMATOPOIETIC AND LYMPHOID TISSUE c.2513_splice p.K838_splice CCLE NP NP 3 BECKER CENTRAL NERVOUS SYSTEM c.2242C>A p.P748T CCLE CANCER Probably Damaging 4 CCK81 LARGE INTESTINE c.356T>C p.L119P CCLE PASSENGER/OTHER Probably Damaging 5 COLO679 SKIN c.2086G>A p.G696S CCLE CANCER Probably Damaging 6 COV434 OVARY c.2837C>G p.A946G CCLE PASSENGER/OTHER Benign 7 EFO27 OVARY c.1834G>A p.A612T CCLE CANCER Probably Damaging 8 ES2 OVARY c.337C>G p.H113D CCLE PASSENGER/OTHER Benign 9 FU97 STOMACH c.216A>G p.Q72Q CCLE NP NP 10 HEC108 ENDOMETRIUM c.3509A>G p.H1170R CCLE PASSENGER/OTHER Probably Damaging 11 HEC251 ENDOMETRIUM c.2609G>A p.R870Q CCLE PASSENGER/OTHER Benign 12 HEC265 ENDOMETRIUM c.923C>A p.P308H CCLE CANCER Probably Damaging 13 HEC6 ENDOMETRIUM c.2278G>A p.A760T CCLE CANCER Probably Damaging 14 JHUEM2 ENDOMETRIUM c.3092_3092delC p.T1031fs CCLE NP NP 15 KCL22 HAEMATOPOIETIC AND LYMPHOID TISSUE c.700G>A p.A234T CCLE CANCER Probably Damaging 16 KYSE150 OESOPHAGUS c.3203C>T p.S1068F CCLE PASSENGER/OTHER Probably Damaging 17 KYSE450 OESOPHAGUS c.133C>T p.P45S CCLE PASSENGER/OTHER Probably Damaging 18 L540 HAEMATOPOIETIC AND LYMPHOID TISSUE c.1308G>T p.E436D CCLE PASSENGER/OTHER Possibly Damaging 19 MDAMB453 BREAST c.3367_3368CC>GT p.P1123V CCLE PASSENGER/OTHER Probably Damaging 20 MELJUSO SKIN c.1791_splice p.E597_splice CCLE NP NP 21 NALM6 HAEMATOPOIETIC AND LYMPHOID TISSUE c.1688G>C p.S563T CCLE CANCER Benign 22 NCIH1184 LUNG c.2917G>C p.G973R CCLE PASSENGER/OTHER Possibly Damaging 23 NCIH2286 LUNG c.1646G>C p.R549P CCLE PASSENGER/OTHER Probably Damaging 24 OC316 OVARY c.2309C>T p.A770V CCLE CANCER Probably Damaging 25 PECAPJ41CLONED2 UPPER AERODIGESTIVE TRACT c.333G>A p.R111R CCLE NP NP 26 RCHACV HAEMATOPOIETIC AND LYMPHOID TISSUE c.400C>T p.R134W CCLE PASSENGER/OTHER Probably Damaging 27 SNU175 LARGE INTESTINE c.1168G>A p.A390T CCLE PASSENGER/OTHER Possibly Damaging 28 SNU175 LARGE INTESTINE c.1849G>A p.A617T CCLE CANCER Probably Damaging 29 SNU520 STOMACH c.3566A>G p.Y1189C CCLE PASSENGER/OTHER Probably Damaging 30 SNU620 STOMACH c.658A>G p.S220G CCLE CANCER Benign 31 SNUC2A LARGE INTESTINE c.1422G>A p.W474* CCLE NP NP 32 SW48 LARGE INTESTINE c.1183G>A p.V395I CCLE CANCER Probably Damaging 33 SW48 LARGE INTESTINE c.11C>T p.T4I CCLE PASSENGER/OTHER Probably Damaging 34 VMRCLCD LUNG c.1756G>T p.A586S CCLE PASSENGER/OTHER Benign 35 ZR7530 BREAST c.3451G>A p.V1151I CCLE PASSENGER/OTHER Possibly Damaging 36 001 KIDNEY c.1765C>A p.L589M COSMIC PASSENGER/OTHER Probably Damaging 37 56506 MENINGES c.2892G>T p.Q964H COSMIC PASSENGER/OTHER Benign 38 578 UPPER AERODIGESTIVE TRACT c.619A>T p.M207L COSMIC PASSENGER/OTHER Benign 39 587238 LARGE INTESTINE c.1514A>C p.Q505P COSMIC PASSENGER/OTHER Probably Damaging 40 587284 LARGE INTESTINE c.649G>A p.A217T COSMIC CANCER Probably Damaging 41 8015299 PANCREAS c.144G>A p.A48A COSMIC NP NP 42 E5 URINARY TRACT c.1834G>T p.A612S COSMIC CANCER Probably Damaging 43 ESO15T OESOPHAGUS c.1924C>T p.R642W COSMIC CANCER Probably Damaging 44 HCC25T LIVER c.388T>A p.S130T COSMIC CANCER Benign 45 HCC35T LIVER c.3436C>T p.L1146F COSMIC PASSENGER/OTHER Probably Damaging 46 HCC56T LIVER c.1155C>G p.G385G COSMIC NP NP 47 HCC86T LIVER c.1973A>T p.H658L COSMIC PASSENGER/OTHER Probably Damaging 48 HCC86T LIVER c.1974C>A p.H658Q COSMIC PASSENGER/OTHER Probably Damaging 49 LC_S6 LUNG c.546_547delCT p.A184fs*18 COSMIC NP NP 50 LUAD-B01169 LUNG c.265G>T p.V89L COSMIC CANCER Benign 51 LUAD-CHTN-MAD06-00668 LUNG c.3624G>T p.G1208G COSMIC NP NP 52 LUAD-E01014 LUNG c.1381G>A p.E461K COSMIC PASSENGER/OTHER Possibly Damaging 53 LUAD-NYU508 LUNG c.3074C>T p.S1025L COSMIC PASSENGER/OTHER Benign 54 LUAD-RT-S01709 LUNG c.1527G>C p.R509R COSMIC NP NP 55 LUAD-RT-S01709 LUNG c.671G>T p.G224V COSMIC CANCER Probably Damaging 56 LUAD-S01315 LUNG c.1888G>A p.A630T COSMIC CANCER Probably Damaging 57 NB-1942 AUTONOMIC GANGLIA c.3606C>A p.A1202A COSMIC NP NP 58 PA285 PANCREAS c.2116A>G p.N706D COSMIC CANCER Probably Damaging 59 S00356 LUNG c.2800C>T p.L934L COSMIC NP NP 60 S00936 LUNG c.1585C>T p.R529C COSMIC PASSENGER/OTHER Probably Damaging 61 S00946 LUNG c.59C>G p.P20R COSMIC PASSENGER/OTHER Benign 62 S01453 LUNG c.2409A>C p.P803P COSMIC NP NP 63 TCGA-05-4405-01 LUNG c.3399T>A p.C1133* COSMIC NP NP 64 TCGA-05-5715-01 LUNG c.2513A>G p.K838R COSMIC PASSENGER/OTHER Possibly Damaging 65 TCGA-13-0904-01 OVARY c.1522T>C p.L508L COSMIC NP NP 66 TCGA-13-0904-01 OVARY c.439C>T p.L147L COSMIC NP NP 67 TCGA-24-1544-01 OVARY c.2242C>A p.P748T COSMIC CANCER Probably Damaging 68 TCGA-29-1775-01 OVARY c.2272G>A p.G758S COSMIC CANCER Probably Damaging 69 TCGA-38-4631-01 LUNG c.317C>G p.P106R COSMIC CANCER Probably Damaging 70 TCGA-42-2590-01 OVARY c.3244G>A p.G1082R COSMIC PASSENGER/OTHER Probably Damaging 71 TCGA-67-3774-01 LUNG c.2409A>C p.P803P COSMIC NP NP 72 TCGA-69-7973-01 LUNG c.2605A>T p.T869S COSMIC PASSENGER/OTHER Benign 73 TCGA-69-7974-01 LUNG c.3636C>T p.P1212P COSMIC NP NP 74 TCGA-75-5146-01 LUNG c.265G>T p.V89L COSMIC CANCER Benign 75 TCGA-A2-A0T0-01 BREAST c.3318T>C p.A1106A COSMIC NP NP 76 TCGA-A3-3324-01 KIDNEY c.1776T>A p.A592A COSMIC NP NP 77 TCGA-A6-2672-01 LARGE INTESTINE c.2274T>C p.G758G COSMIC NP NP 78 TCGA-A6-2676-01 LARGE INTESTINE c.297C>T p.C99C COSMIC NP NP 79 TCGA-A6-5657-01 LARGE INTESTINE c.2244G>T p.P748P COSMIC NP NP 80 TCGA-A8-A08T-01 BREAST c.855C>T p.P285P COSMIC NP NP 81 TCGA-AA-3492-01 LARGE INTESTINE c.2273G>T p.G758V COSMIC CANCER Probably Damaging 82 TCGA-AA-3811-01 LARGE INTESTINE c.1763G>A p.R588H COSMIC PASSENGER/OTHER Probably Damaging 83 TCGA-AA-3845-01 LARGE INTESTINE c.991G>A p.A331T COSMIC PASSENGER/OTHER Possibly Damaging 84 TCGA-AA-3864-01 LARGE INTESTINE c.943C>T p.R315W COSMIC CANCER Probably Damaging 85 TCGA-AA-A010-01 LARGE INTESTINE c.3463C>T p.R1155C COSMIC PASSENGER/OTHER Probably Damaging 86 TCGA-AG-A002-01 LARGE INTESTINE c.134C>A p.P45H COSMIC PASSENGER/OTHER Probably Damaging 87 TCGA-AG-A002-01 LARGE INTESTINE c.3129G>T p.Q1043H COSMIC PASSENGER/OTHER Benign 88 TCGA-AN-A03X-01 BREAST c.552C>A p.A184A COSMIC NP NP 89 TCGA-AO-A0J5-01 BREAST c.1699G>T p.D567Y COSMIC PASSENGER/OTHER Probably Damaging 90 TCGA-AO-A1KT-01 BREAST c.3469A>G p.I1157V COSMIC PASSENGER/OTHER Benign 91 TCGA-AP-A051-01 ENDOMETRIUM c.1716C>T p.C572C COSMIC NP NP 92 TCGA-AP-A051-01 ENDOMETRIUM c.3512C>T p.P1171L COSMIC PASSENGER/OTHER Probably Damaging 93 TCGA-AP-A051-01 ENDOMETRIUM c.853C>A p.P285T COSMIC CANCER Probably Damaging 94 TCGA-AP-A054-01 ENDOMETRIUM c.3542C>T p.A1181V COSMIC PASSENGER/OTHER Benign 95 TCGA-AP-A056-01 ENDOMETRIUM c.2532A>G p.G844G COSMIC NP NP 96 TCGA-AP-A059-01 ENDOMETRIUM c.1182C>T p.G394G COSMIC NP NP 97 TCGA-AP-A059-01 ENDOMETRIUM c.1194G>A p.S398S COSMIC NP NP 98 TCGA-AP-A059-01 ENDOMETRIUM c.2829C>T p.V943V COSMIC NP NP 99 TCGA-AP-A0LD-01 ENDOMETRIUM c.1751G>A p.G584D COSMIC CANCER Probably Damaging 100 TCGA-AP-A0LM-01 ENDOMETRIUM c.3181G>A p.E1061K COSMIC PASSENGER/OTHER Benign 101 TCGA-AR-A0TX-01 BREAST c.2518G>C p.E840Q COSMIC PASSENGER/OTHER Possibly Damaging 102 TCGA-AR-A24H-01 BREAST c.846G>T p.R282S COSMIC PASSENGER/OTHER Benign 103 TCGA-AX-A05Z-01 ENDOMETRIUM c.891C>T p.F297F COSMIC NP NP 104 TCGA-AX-A0J0-01 ENDOMETRIUM c.41G>A p.R14Q COSMIC PASSENGER/OTHER Possibly Damaging 105 TCGA-AX-A0J0-01 ENDOMETRIUM c.477G>T p.M159I COSMIC PASSENGER/OTHER Probably Damaging 106 TCGA-AX-A0J1-01 ENDOMETRIUM c.2126G>A p.R709H COSMIC CANCER Probably Damaging 107 TCGA-B0-4823-01 KIDNEY c.2562G>A p.K854K COSMIC NP NP 108 TCGA-B5-A0JY-01 ENDOMETRIUM c.1298C>T p.P433L COSMIC PASSENGER/OTHER Probably Damaging 109 TCGA-B5-A0JY-01 ENDOMETRIUM c.2611G>T p.E871* COSMIC NP NP 110 TCGA-B5-A11E-01 ENDOMETRIUM c.1121C>T p.A374V COSMIC CANCER Probably Damaging 111 TCGA-B5-A11E-01 ENDOMETRIUM c.1657A>C p.K553Q COSMIC PASSENGER/OTHER Possibly Damaging 112 TCGA-B5-A11E-01 ENDOMETRIUM c.2483G>A p.R828H COSMIC CANCER Benign 113 TCGA-B5-A11E-01 ENDOMETRIUM c.92C>T p.S31L COSMIC PASSENGER/OTHER Benign 114 TCGA-B5-A11E-01 ENDOMETRIUM c.98G>A p.R33Q COSMIC PASSENGER/OTHER Probably Damaging 115 TCGA-BG-A0M4-01 ENDOMETRIUM c.1761C>T p.C587C COSMIC NP NP 116 TCGA-BG-A0MQ-01 ENDOMETRIUM c.2370C>T p.S790S COSMIC NP NP 117 TCGA-BG-A0VZ-01 ENDOMETRIUM c.2162G>A p.R721H COSMIC PASSENGER/OTHER Possibly Damaging 118 TCGA-BH-A0BZ-01 BREAST c.208G>A p.G70R COSMIC PASSENGER/OTHER Possibly Damaging 119 TCGA-BP-5173-01 KIDNEY c.1529T>C p.I510T COSMIC CANCER Probably Damaging 120 TCGA-BP-5187-01 KIDNEY c.1519A>G p.I507V COSMIC PASSENGER/OTHER Benign 121 TCGA-BS-A0TJ-01 ENDOMETRIUM c.1682G>A p.R561H COSMIC PASSENGER/OTHER Probably Damaging 122 TCGA-BS-A0UF-01 ENDOMETRIUM c.533C>T p.P178L COSMIC CANCER Probably Damaging 123 TCGA-BS-A0UV-01 ENDOMETRIUM c.3049G>A p.E1017K COSMIC PASSENGER/OTHER Benign 124 TCGA-BS-A0UV-01 ENDOMETRIUM c.899G>A p.G300D COSMIC CANCER Probably Damaging 125 TCGA-BT-A3PH-01 URINARY TRACT c.2409A>C p.P803P COSMIC NP NP 126 TCGA-C4-A0F1-01 URINARY TRACT c.3040G>T p.G1014W COSMIC PASSENGER/OTHER Benign 127 TCGA-C8-A12P-01 BREAST c.3181G>A p.E1061K COSMIC PASSENGER/OTHER Benign 128 TCGA-CF-A1HS-01 URINARY TRACT c.707G>T p.R236L COSMIC PASSENGER/OTHER Probably Damaging 129 TCGA-CH-5792-01 PROSTATE c.1698T>G p.F566L COSMIC CANCER Possibly Damaging 130 TCGA-CH-5792-01 PROSTATE c.1699G>C p.D567H COSMIC PASSENGER/OTHER Possibly Damaging 131 TCGA-CM-4743-01 LARGE INTESTINE c.2247delG p.G751fs*16 COSMIC NP NP 132 TCGA-CM-6162-01 LARGE INTESTINE c.1374C>T p.S458S COSMIC NP NP 133 TCGA-D1-A103-01 ENDOMETRIUM c.2512A>C p.K838Q COSMIC PASSENGER/OTHER Benign 134 TCGA-D1-A15X-01 ENDOMETRIUM c.2122C>T p.P708S COSMIC CANCER Benign 135 TCGA-D1-A17Q-01 ENDOMETRIUM c.1728C>T p.F576F COSMIC NP NP 136 TCGA-D1-A17Q-01 ENDOMETRIUM c.1867T>C p.F623L COSMIC PASSENGER/OTHER Probably Damaging 137 TCGA-DI-A1NN-01 ENDOMETRIUM c.1072G>A p.A358T COSMIC PASSENGER/OTHER Possibly Damaging 138 TCGA-DK-A3IL-01 URINARY TRACT c.3344A>G p.H1115R COSMIC PASSENGER/OTHER Probably Damaging 139 TCGA-E2-A1LK-01 BREAST c.1806T>A p.A602A COSMIC NP NP 140 TCGA-EI-6507-01 LARGE INTESTINE c.2076C>A p.G692G COSMIC NP NP 141 TCGA-EJ-5525-01 PROSTATE c.1102C>T p.H368Y COSMIC PASSENGER/OTHER Probably Damaging 142 TCGA-G4-6293-01 LARGE INTESTINE c.3040G>A p.G1014R COSMIC PASSENGER/OTHER Benign 143 YUSUBA SKIN c.2012T>G p.L671R COSMIC PASSENGER/OTHER Probably Damaging 144 cSCCP1 SKIN c.1246C>T p.P416S COSMIC CANCER Probably Damaging 145 ccRCC-78 KIDNEY c.1703C>A p.S568Y COSMIC CANCER Probably Damaging 146 pfg024T STOMACH c.649G>A p.A217T COSMIC CANCER Probably Damaging
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.Gene essentiality data is not present in COLT database!! -
Tertiary structure (+)
Users must enabled the Java in their browser to see structure.
Users can also download Java from here.Modelled Structure Structures available in PDB -
Structure Domains (+)
1. PFAM domains are not present!!2. Superfaimly domains are not present!! -
Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:2. Sequence alignment with CCLE mutants:3. Sequence alignment with COSMIC mutants:4. Sequence alignment with homologus proteins: -
Sequence Profiles (+)
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Post Translational Modifications (+)
Post translational modifications are not found!!Other Databases Link (+)
