dbEM

Protein: HDAC8

Mutation Data (+)

# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction

*NP: Not Predicted

Tissue Type	Mean Expression Value	Median Expression Value	Mean CNV	Median CNV

AUTONOMIC GANGLIA	6.5743	6.4847	-0.0073	0.0014
BILIARY TRACT	6.5026	6.7716	0.0895	0.007
BONE	6.2544	6.2587	0.0119	0.002074
BREAST	6.5394	6.4922	0.0185	0.00275
CENTRAL NERVOUS SYSTEM	6.7338	6.6743	0.0345	-5e-04
ENDOMETRIUM	6.7868	6.6919	0.0217	0.0042
HAEMATOPOIETIC AND LYMPHOID TISSUE	6.6995	6.6339	0.0078	0.0106
KIDNEY	6.2778	6.3315	0.0591	0.0028
LARGE INTESTINE	6.6845	6.6222	0.0486	0.012655
LIVER	6.6222	6.5984	0.0700	0.0169
LUNG	6.5888	6.578	0.0320	0.0036915
OESOPHAGUS	6.5000	6.6372	0.1277	0.026865
OVARY	6.6327	6.6164	0.1244	0.0047
PANCREAS	6.6152	6.7773	0.0112	0.007389
PLEURA	6.6243	6.6444	-0.0645	-0.023
PROSTATE	6.6483	6.6443	0.0100	0.00655
SALIVARY GLAND	6.9325	6.9325	0.4591	0.4591
SKIN	6.8339	6.8177	0.0533	0.003011
SMALL INTESTINE	6.3121	6.3121	0.0433	0.0433
SOFT TISSUE	6.4783	6.5623	0.0763	0.0165
STOMACH	6.7284	6.76935	0.0075	0.007395
THYROID	6.6086	6.71025	0.2078	0.02455
UPPER AERODIGESTIVE TRACT	6.2478	6.2365	0.0572	0.01325

Gene Essentiality Data (+)

Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.

Gene essentiality data is not present in COLT database!!

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Modelled Structure	Structures available in PDB
	1T64, 1T67, 1T69, 1VKG, 1W22, 2V5W, 2V5X, 3EW8, 3EWF, 3EZP, 3EZT, 3F06, 3F07, 3F0R, 3MZ3, 3MZ4, 3MZ6, 3MZ7, 3RQD, 3SFF, 3SFH, 4QA0, 4QA1, 4QA2, 4QA3, 4QA4, 4QA5, 4QA6, 4QA7,

Structure Domains (+)

1. PFAM domains are not present!!

2. Superfaimly domains are not present!!

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1. Variants are not present in 1000 Genomes!!

2. Sequence alignment with CCLE mutants:

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3. Sequence alignment with COSMIC mutants:

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4. Sequence alignment with homologus proteins:

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  Sequence Profiles (+)

HMM
  With Uniprot database     With Mutants      With 1000 Genome Variants
PSSM
  With Uniprot database     With Mutants      With 1000 Genome Variant
Post Translational Modifications (+)

Post translational modifications are not found!!