dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: HDAC9 |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 043 HAEMATOPOIETIC AND LYMPHOID TISSUE c.3108_3109insT p.V1037fs*25 COSMIC NP NP 2 043-0094-01TD HAEMATOPOIETIC AND LYMPHOID TISSUE c.3108_3109insT p.V1037fs*25 COSMIC NP NP 3 587222 LARGE INTESTINE c.2358C>G p.H786Q COSMIC NP NP 4 587278 LARGE INTESTINE c.1801G>C p.D601H COSMIC NP NP 5 587304 LARGE INTESTINE c.1883G>A p.R628H COSMIC NP NP 6 587316 LARGE INTESTINE c.68C>A p.P23H COSMIC CANCER Probably Damaging 7 587342 LARGE INTESTINE c.28G>A p.V10M COSMIC PASSENGER/OTHER Probably Damaging 8 587376 LARGE INTESTINE c.1226G>A p.R409Q COSMIC NP NP 9 587376 LARGE INTESTINE c.183G>T p.K61N COSMIC PASSENGER/OTHER Probably Damaging 10 587376 LARGE INTESTINE c.291A>C p.K97N COSMIC NP NP 11 587376 LARGE INTESTINE c.435A>C p.E145D COSMIC NP NP 12 Br25X CENTRAL NERVOUS SYSTEM c.847A>G p.N283D COSMIC NP NP 13 Br27P CENTRAL NERVOUS SYSTEM c.49G>A p.G17S COSMIC PASSENGER/OTHER Benign 14 CHC205T LIVER c.3128T>A p.L1043Q COSMIC NP NP 15 CMML-03 HAEMATOPOIETIC AND LYMPHOID TISSUE c.1948G>A p.V650I COSMIC NP NP 16 ESO-0053 OESOPHAGUS c.1882C>T p.R628C COSMIC NP NP 17 ESO-105 OESOPHAGUS c.1398C>A p.V466V COSMIC NP NP 18 ESO-116 OESOPHAGUS c.2354A>G p.H785R COSMIC NP NP 19 ESO-160 OESOPHAGUS c.1351C>T p.R451* COSMIC NP NP 20 ESO-1733 OESOPHAGUS c.1948G>A p.V650I COSMIC NP NP 21 ESO-177 OESOPHAGUS c.2540G>A p.R847H COSMIC NP NP 22 H441 LUNG c.67C>A p.P23T COSMIC CANCER Probably Damaging 23 H650 LUNG c.102G>T p.M34I COSMIC PASSENGER/OTHER Benign 24 HCC138T LIVER c.1A>G p.M1V COSMIC PASSENGER/OTHER Probably Damaging 25 HCC6T LIVER c.2600T>A p.L867H COSMIC NP NP 26 HCC72T LIVER c.2636G>A p.G879D COSMIC NP Possibly Damaging 27 HN_0-046 UPPER AERODIGESTIVE TRACT c.486C>T p.D162D COSMIC NP NP 28 HN_62854 UPPER AERODIGESTIVE TRACT c.1551G>T p.A517A COSMIC NP NP 29 LUAD-2GUGK LUNG c.2070G>A p.L690L COSMIC NP NP 30 LUAD-5V8LT LUNG c.1541G>T p.G514V COSMIC NP NP 31 LUAD-B02077 LUNG c.1036G>C p.A346P COSMIC NP NP 32 LUAD-B02077 LUNG c.2566G>T p.G856C COSMIC NP NP 33 LUAD-B02477 LUNG c.963G>T p.L321L COSMIC NP NP 34 LUAD-B02594 LUNG c.2383delT p.F795fs*14 COSMIC NP NP 35 LUAD-CHTN-MAD06-00490 LUNG c.1106G>C p.G369A COSMIC PASSENGER/OTHER Benign 36 LUAD-CHTN-MAD06-00678 LUNG c.2586G>A p.E862E COSMIC NP NP 37 LUAD-CHTN-Z4716A LUNG c.553C>A p.H185N COSMIC NP NP 38 LUAD-E01278 LUNG c.1006G>T p.G336W COSMIC NP NP 39 LUAD-F00368 LUNG c.2514C>A p.P838P COSMIC NP NP 40 LUAD-NYU1051S LUNG c.1830C>T p.S610S COSMIC NP NP 41 LUAD-NYU195 LUNG c.2404G>T p.A802S COSMIC CANCER Probably Damaging 42 LUAD-NYU575 LUNG c.105C>A p.P35P COSMIC NP NP 43 LUAD-RT-S01487 LUNG c.3080G>C p.G1027A COSMIC NP NP 44 LUAD-RT-S01774 LUNG c.2866G>T p.E956* COSMIC NP NP 45 LUAD-RT-S01777 LUNG c.3123C>A p.A1041A COSMIC NP NP 46 LUAD-S01315 LUNG c.3120G>T p.L1040L COSMIC NP NP 47 LUAD-S01357 LUNG c.1551G>A p.A517A COSMIC NP NP 48 LUAD-S01357 LUNG c.963G>T p.L321L COSMIC NP NP 49 LUAD-S01409 LUNG c.1541G>A p.G514E COSMIC NP NP 50 LUAD-S01409 LUNG c.57G>T p.E19D COSMIC PASSENGER/OTHER Benign 51 LUAD-S01478 LUNG c.54G>C p.L18L COSMIC NP NP 52 LUAD-YINHD LUNG c.1270C>G p.Q424E COSMIC NP NP 53 ME002T SKIN c.2045G>A p.R682Q COSMIC NP NP 54 NCI-H1437 LUNG c.1594A>C p.S532R COSMIC PASSENGER/OTHER Possibly Damaging 55 NCI-H2126 LUNG c.1344C>A p.P448P COSMIC NP NP 56 PACA116 PANCREAS c.1103C>T p.P368L COSMIC NP NP 57 PD2127a KIDNEY c.2770C>A p.P924T COSMIC NP NP 58 PD3890a BREAST c.2819C>T p.T940M COSMIC NP NP 59 SJMB008 CENTRAL NERVOUS SYSTEM c.277C>A p.L93I COSMIC NP Benign 60 SJMB043 CENTRAL NERVOUS SYSTEM c.628C>A p.Q210K COSMIC NP Probably Damaging 61 T162 ENDOMETRIUM c.1934T>C p.L645P COSMIC NP NP 62 TCGA-05-4250-01 LUNG c.2379_2380GG>TT p.M793_G794>IW COSMIC NP NP 63 TCGA-05-4410-01 LUNG c.2235G>A p.W745* COSMIC NP NP 64 TCGA-05-5423-01 LUNG c.230G>T p.R77L COSMIC PASSENGER/OTHER Probably Damaging 65 TCGA-18-3409-01 LUNG c.2469T>G p.D823E COSMIC NP NP 66 TCGA-18-3409-01 LUNG c.949G>T p.D317Y COSMIC NP NP 67 TCGA-21-1070-01 LUNG c.1448A>C p.Q483P COSMIC NP NP 68 TCGA-21-1070-01 LUNG c.2776C>A p.L926I COSMIC NP NP 69 TCGA-22-5472-01 LUNG c.1916C>T p.A639V COSMIC NP NP 70 TCGA-22-5478-01 LUNG c.1963A>T p.T655S COSMIC NP NP 71 TCGA-33-4533-01 LUNG c.1589C>T p.T530I COSMIC NP NP 72 TCGA-33-4566-01 LUNG c.2698C>A p.P900T COSMIC NP NP 73 TCGA-34-2596-01 LUNG c.1801G>C p.D601H COSMIC NP NP 74 TCGA-34-5240-01 LUNG c.830G>T p.G277V COSMIC NP NP 75 TCGA-35-4123-01 LUNG c.1600A>T p.S534C COSMIC NP Benign 76 TCGA-38-4632-01 LUNG c.1551G>T p.A517A COSMIC NP NP 77 TCGA-43-3394-01 LUNG c.1766C>T p.S589F COSMIC NP NP 78 TCGA-44-2659-01 LUNG c.1382C>G p.T461R COSMIC NP NP 79 TCGA-44-5644-01 LUNG c.1367C>A p.P456H COSMIC NP NP 80 TCGA-44-7662-01 LUNG c.2356C>T p.H786Y COSMIC NP NP 81 TCGA-44-7667-01 LUNG c.114C>A p.D38E COSMIC PASSENGER/OTHER Possibly Damaging 82 TCGA-44-7667-01 LUNG c.1218A>G p.E406E COSMIC NP NP 83 TCGA-46-3769-01 LUNG c.1551G>C p.A517A COSMIC NP NP 84 TCGA-49-6743-01 LUNG c.1527G>A p.E509E COSMIC NP NP 85 TCGA-49-6761-01 LUNG c.1334G>A p.R445H COSMIC NP NP 86 TCGA-50-5946-01 LUNG c.1036G>C p.A346P COSMIC NP NP 87 TCGA-50-5946-01 LUNG c.1644G>C p.V548V COSMIC NP NP 88 TCGA-50-5946-02 LUNG c.1036G>C p.A346P COSMIC NP NP 89 TCGA-50-5946-02 LUNG c.1644G>C p.V548V COSMIC NP NP 90 TCGA-50-7109-01 LUNG c.1946G>T p.C649F COSMIC NP NP 91 TCGA-55-7570-01 LUNG c.652C>T p.L218F COSMIC NP NP 92 TCGA-55-7907-01 LUNG c.2116G>T p.G706C COSMIC NP NP 93 TCGA-59-2348-01 OVARY c.678C>T p.N226N COSMIC NP NP 94 TCGA-64-1679-01 LUNG c.234G>A p.Q78Q COSMIC NP NP 95 TCGA-64-5778-01 LUNG c.1203T>C p.H401H COSMIC NP NP 96 TCGA-66-2742-01 LUNG c.2823G>T p.K941N COSMIC NP NP 97 TCGA-66-2759-01 LUNG c.918G>A p.M306I COSMIC NP NP 98 TCGA-66-2791-01 LUNG c.448C>A p.L150I COSMIC NP NP 99 TCGA-67-3771-01 LUNG c.460C>T p.L154L COSMIC NP NP 100 TCGA-69-7765-01 LUNG c.1522G>T p.A508S COSMIC NP NP 101 TCGA-69-7979-01 LUNG c.2213G>T p.G738V COSMIC NP NP 102 TCGA-69-7979-01 LUNG c.3136G>T p.D1046Y COSMIC NP NP 103 TCGA-69-7979-01 LUNG c.3193G>T p.E1065* COSMIC NP NP 104 TCGA-73-4666-01 LUNG c.2401G>T p.V801F COSMIC NP NP 105 TCGA-78-7150-01 LUNG c.1766C>G p.S589C COSMIC NP NP 106 TCGA-78-7150-01 LUNG c.1791G>T p.A597A COSMIC NP NP 107 TCGA-78-7155-01 LUNG c.3129A>T p.L1043L COSMIC NP NP 108 TCGA-85-6561-01 LUNG c.1348A>G p.N450D COSMIC NP NP 109 TCGA-91-6836-01 LUNG c.1587C>A p.S529R COSMIC PASSENGER/OTHER Benign 110 TCGA-97-7552-01 LUNG c.1882C>T p.R628C COSMIC NP NP 111 TCGA-97-7554-01 LUNG c.1278C>T p.P426P COSMIC NP NP 112 TCGA-99-8028-01 LUNG c.1613T>A p.V538E COSMIC NP NP 113 TCGA-A2-A0D2-01 BREAST c.3178G>A p.G1060S COSMIC NP NP 114 TCGA-A2-A0SV-01 BREAST c.2057G>T p.R686L COSMIC NP NP 115 TCGA-A6-2671-01 LARGE INTESTINE c.1749G>A p.T583T COSMIC NP NP 116 TCGA-A6-3808-01 LARGE INTESTINE c.2540G>A p.R847H COSMIC NP NP 117 TCGA-A6-5661-01 LARGE INTESTINE c.961C>A p.L321M COSMIC CANCER Probably Damaging 118 TCGA-A6-6648-01 LARGE INTESTINE c.1073C>T p.T358M COSMIC NP NP 119 TCGA-A6-6781-01 LARGE INTESTINE c.2227A>G p.T743A COSMIC NP NP 120 TCGA-A6-6782-01 LARGE INTESTINE c.798A>G p.E266E COSMIC NP NP 121 TCGA-AA-3510-01 LARGE INTESTINE c.1041G>A p.S347S COSMIC NP NP 122 TCGA-AA-3664-01 LARGE INTESTINE c.3090G>T p.L1030F COSMIC NP NP 123 TCGA-AA-3710-01 LARGE INTESTINE c.984T>G p.P328P COSMIC NP NP 124 TCGA-AA-3713-01 LARGE INTESTINE c.1594A>G p.S532G COSMIC PASSENGER/OTHER Benign 125 TCGA-AA-3833-01 LARGE INTESTINE c.122T>A p.V41D COSMIC PASSENGER/OTHER Possibly Damaging 126 TCGA-AA-3864-01 LARGE INTESTINE c.255G>T p.E85D COSMIC PASSENGER/OTHER Probably Damaging 127 TCGA-AA-3966-01 LARGE INTESTINE c.2412C>T p.T804T COSMIC NP NP 128 TCGA-AA-3972-01 LARGE INTESTINE c.487A>C p.T163P COSMIC NP NP 129 TCGA-AA-3977-01 LARGE INTESTINE c.2557T>G p.F853V COSMIC NP NP 130 TCGA-AA-3984-01 LARGE INTESTINE c.273G>T p.Q91H COSMIC NP NP 131 TCGA-AA-3984-01 LARGE INTESTINE c.2976G>A p.P992P COSMIC NP NP 132 TCGA-AA-A00N-01 LARGE INTESTINE c.1988G>A p.R663Q COSMIC NP NP 133 TCGA-AA-A010-01 LARGE INTESTINE c.2113T>C p.Y705H COSMIC NP NP 134 TCGA-AA-A010-01 LARGE INTESTINE c.219G>T p.E73D COSMIC PASSENGER/OTHER Probably Damaging 135 TCGA-AA-A010-01 LARGE INTESTINE c.748G>T p.D250Y COSMIC NP NP 136 TCGA-AD-6964-01 LARGE INTESTINE c.33G>A p.K11K COSMIC NP NP 137 TCGA-AF-6655-01 LARGE INTESTINE c.1749G>A p.T583T COSMIC NP NP 138 TCGA-AG-3893-01 LARGE INTESTINE c.1864C>T p.P622S COSMIC NP NP 139 TCGA-AG-3902-01 LARGE INTESTINE c.1128G>A p.P376P COSMIC NP NP 140 TCGA-AG-A002-01 LARGE INTESTINE c.513C>T p.S171S COSMIC NP NP 141 TCGA-AG-A02N-01 LARGE INTESTINE c.2074G>T p.E692* COSMIC NP NP 142 TCGA-AP-A051-01 ENDOMETRIUM c.3116C>A p.A1039D COSMIC NP NP 143 TCGA-AP-A051-01 ENDOMETRIUM c.933C>T p.R311R COSMIC NP NP 144 TCGA-AP-A051-01 ENDOMETRIUM c.978C>A p.T326T COSMIC NP NP 145 TCGA-AP-A054-01 ENDOMETRIUM c.2350G>T p.G784C COSMIC NP NP 146 TCGA-AP-A056-01 ENDOMETRIUM c.1476G>A p.S492S COSMIC NP NP 147 TCGA-AP-A056-01 ENDOMETRIUM c.2045G>A p.R682Q COSMIC NP NP 148 TCGA-AP-A059-01 ENDOMETRIUM c.365G>A p.R122H COSMIC NP NP 149 TCGA-AP-A0LM-01 ENDOMETRIUM c.1225C>T p.R409* COSMIC NP NP 150 TCGA-AP-A0LM-01 ENDOMETRIUM c.199G>A p.E67K COSMIC PASSENGER/OTHER Probably Damaging 151 TCGA-AP-A0LM-01 ENDOMETRIUM c.2045G>A p.R682Q COSMIC NP NP 152 TCGA-AP-A0LM-01 ENDOMETRIUM c.2222G>C p.S741T COSMIC NP NP 153 TCGA-AR-A251-01 BREAST c.1846C>T p.P616S COSMIC NP Benign 154 TCGA-AX-A0J0-01 ENDOMETRIUM c.1352G>A p.R451Q COSMIC NP NP 155 TCGA-AX-A0J0-01 ENDOMETRIUM c.1428G>T p.E476D COSMIC NP NP 156 TCGA-AX-A0J0-01 ENDOMETRIUM c.2057G>A p.R686Q COSMIC NP NP 157 TCGA-AX-A0J0-01 ENDOMETRIUM c.2789A>C p.K930T COSMIC NP NP 158 TCGA-AZ-4315-01 LARGE INTESTINE c.1225C>T p.R409* COSMIC NP NP 159 TCGA-AZ-4315-01 LARGE INTESTINE c.1791G>A p.A597A COSMIC NP NP 160 TCGA-AZ-6598-01 LARGE INTESTINE c.2795C>T p.T932M COSMIC NP NP 161 TCGA-B0-5098-01 KIDNEY c.1569G>A p.A523A COSMIC NP NP 162 TCGA-B0-5104-01 KIDNEY c.1253G>T p.G418V COSMIC NP NP 163 TCGA-B5-A0JY-01 ENDOMETRIUM c.1216G>T p.E406* COSMIC NP NP 164 TCGA-B5-A11E-01 ENDOMETRIUM c.1720T>C p.F574L COSMIC NP NP 165 TCGA-BG-A18B-01 ENDOMETRIUM c.138G>A p.L46L COSMIC NP NP 166 TCGA-BP-4983-01 KIDNEY c.172C>A p.Q58K COSMIC PASSENGER/OTHER Benign 167 TCGA-BS-A0T9-01 ENDOMETRIUM c.2213G>T p.G738V COSMIC NP NP 168 TCGA-BS-A0UF-01 ENDOMETRIUM c.1699G>T p.E567* COSMIC NP NP 169 TCGA-BS-A0UV-01 ENDOMETRIUM c.2045G>A p.R682Q COSMIC NP NP 170 TCGA-BT-A3PH-01 URINARY TRACT c.1749G>A p.T583T COSMIC NP NP 171 TCGA-C4-A0F1-01 URINARY TRACT c.2883C>G p.L961L COSMIC NP NP 172 TCGA-CA-5254-01 LARGE INTESTINE c.1728A>T p.Q576H COSMIC NP NP 173 TCGA-CF-A1HS-01 URINARY TRACT c.2813A>T p.H938L COSMIC NP NP 174 TCGA-CI-6624-01 LARGE INTESTINE c.2909C>A p.A970D COSMIC NP NP 175 TCGA-CK-4952-01 LARGE INTESTINE c.3138T>C p.D1046D COSMIC NP NP 176 TCGA-CK-5914-01 LARGE INTESTINE c.1344C>A p.P448P COSMIC NP NP 177 TCGA-CM-5861-01 LARGE INTESTINE c.1874C>A p.A625E COSMIC NP NP 178 TCGA-CM-5864-01 LARGE INTESTINE c.2539C>T p.R847C COSMIC NP NP 179 TCGA-D1-A167-01 ENDOMETRIUM c.2493G>A p.Q831Q COSMIC NP NP 180 TCGA-D1-A176-01 ENDOMETRIUM c.2921C>T p.A974V COSMIC NP NP 181 TCGA-DK-A1AC-01 URINARY TRACT c.1494G>A p.L498L COSMIC NP NP 182 TCGA-DM-A1D9-01 LARGE INTESTINE c.1761G>A p.A587A COSMIC NP NP 183 TCGA-DR-A0ZM-01 CERVIX c.2093C>T p.S698F COSMIC NP NP 184 TCGA-EJ-7331-01 PROSTATE c.1074G>A p.T358T COSMIC NP NP 185 TCGA-F4-6570-01 LARGE INTESTINE c.213G>A p.Q71Q COSMIC NP NP 186 TCGA-FU-A23L-01 CERVIX c.1096C>T p.P366S COSMIC NP NP 187 TCGA-G4-6586-01 LARGE INTESTINE c.1661_1667delCAGTGGA p.D556fs*46 COSMIC NP NP 188 TCGA-G4-6588-01 LARGE INTESTINE c.542C>T p.T181M COSMIC NP NP 189 TCGA-G4-6628-01 LARGE INTESTINE c.2494C>T p.Q832* COSMIC NP NP 190 WA16 PROSTATE c.2795C>T p.T932M COSMIC NP NP 191 ccRCC-105 KIDNEY c.2312G>A p.G771E COSMIC NP NP 192 ccRCC-26 KIDNEY c.2776C>A p.L926I COSMIC NP NP 193 ccRCC-42 KIDNEY c.1825G>C p.V609L COSMIC NP NP
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.test -
Tertiary structure (+)
Users must enabled the Java in their browser to see structure.
Users can also download Java from here.Modelled Structure Structures available in PDB Structure is not available in PDB -
Structure Domains (+)
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Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:4. Sequence alignment with homologus proteins: -
Sequence Profiles (+)
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Post Translational Modifications (+)
Post translational modifications are not found!!Other Databases Link (+)
