dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: HINFP |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 12T SKIN c.854A>C p.K285T COSMIC PASSENGER/OTHER Benign 2 587376 LARGE INTESTINE c.187G>T p.E63* COSMIC NP NP 3 BN37T LIVER c.453A>C p.E151D COSMIC PASSENGER/OTHER Benign 4 Capan-1 PANCREAS c.1053C>T p.D351D COSMIC NP NP 5 HCT-15 LARGE INTESTINE c.1496G>A p.G499E COSMIC PASSENGER/OTHER Benign 6 HN_62814 UPPER AERODIGESTIVE TRACT c.1220G>A p.R407Q COSMIC PASSENGER/OTHER Benign 7 LUAD-B02077 LUNG c.444G>T p.R148R COSMIC NP NP 8 LUAD-NYU184 LUNG c.846G>T p.R282R COSMIC NP NP 9 LUAD-YINHD LUNG c.1191G>C p.E397D COSMIC PASSENGER/OTHER Probably Damaging 10 ME016T SKIN c.565C>T p.H189Y COSMIC CANCER Probably Damaging 11 MOLT-4 HAEMATOPOIETIC AND LYMPHOID TISSUE c.1001G>A p.R334H COSMIC PASSENGER/OTHER Probably Damaging 12 PD6350a NS c.1409C>G p.T470S COSMIC PASSENGER/OTHER Benign 13 Pa37X PANCREAS c.1535C>T p.P512L COSMIC PASSENGER/OTHER Benign 14 Pa43X PANCREAS c.1015G>T p.G339* COSMIC NP NP 15 S00472 LUNG c.619A>T p.M207L COSMIC PASSENGER/OTHER Probably Damaging 16 TCGA-13-0800-01 OVARY c.208G>C p.E70Q COSMIC PASSENGER/OTHER Possibly Damaging 17 TCGA-18-3409-01 LUNG c.1118C>T p.P373L COSMIC PASSENGER/OTHER Probably Damaging 18 TCGA-18-3416-01 LUNG c.265C>A p.H89N COSMIC PASSENGER/OTHER Probably Damaging 19 TCGA-22-4595-01 LUNG c.1345G>C p.E449Q COSMIC PASSENGER/OTHER Benign 20 TCGA-44-7662-01 LUNG c.562G>T p.E188* COSMIC NP NP 21 TCGA-64-5775-01 LUNG c.1406A>T p.Q469L COSMIC PASSENGER/OTHER Benign 22 TCGA-86-8054-01 LUNG c.69C>T p.S23S COSMIC NP NP 23 TCGA-A3-3346-01 KIDNEY c.246C>T p.L82L COSMIC NP NP 24 TCGA-AA-3510-01 LARGE INTESTINE c.96C>A p.F32L COSMIC PASSENGER/OTHER Probably Damaging 25 TCGA-AA-3525-01 LARGE INTESTINE c.812G>A p.R271H COSMIC PASSENGER/OTHER Probably Damaging 26 TCGA-AA-3697-01 LARGE INTESTINE c.384C>A p.H128Q COSMIC PASSENGER/OTHER Possibly Damaging 27 TCGA-AA-3947-01 LARGE INTESTINE c.965G>A p.S322N COSMIC PASSENGER/OTHER Possibly Damaging 28 TCGA-AA-A00R-01 LARGE INTESTINE c.758A>G p.N253S COSMIC PASSENGER/OTHER Possibly Damaging 29 TCGA-AA-A01I-01 LARGE INTESTINE c.1067G>A p.R356Q COSMIC PASSENGER/OTHER Probably Damaging 30 TCGA-AP-A056-01 ENDOMETRIUM c.829C>T p.R277C COSMIC PASSENGER/OTHER Probably Damaging 31 TCGA-AP-A0LM-01 ENDOMETRIUM c.907C>T p.L303L COSMIC NP NP 32 TCGA-AZ-6598-01 LARGE INTESTINE c.137G>A p.G46D COSMIC PASSENGER/OTHER Benign 33 TCGA-AZ-6598-01 LARGE INTESTINE c.771C>T p.C257C COSMIC NP NP 34 TCGA-BP-4982-01 KIDNEY c.1168C>T p.R390W COSMIC PASSENGER/OTHER Probably Damaging 35 TCGA-BS-A0UF-01 ENDOMETRIUM c.96C>A p.F32L COSMIC PASSENGER/OTHER Probably Damaging 36 TCGA-BT-A20N-01 URINARY TRACT c.963C>T p.F321F COSMIC NP NP 37 TCGA-CM-5344-01 LARGE INTESTINE c.210A>G p.E70E COSMIC NP NP 38 TCGA-D1-A0ZO-01 ENDOMETRIUM c.1037A>C p.K346T COSMIC PASSENGER/OTHER Possibly Damaging 39 TCGA-D1-A103-01 ENDOMETRIUM c.1211A>G p.Q404R COSMIC PASSENGER/OTHER Probably Damaging 40 TCGA-D1-A174-01 ENDOMETRIUM c.676C>T p.Q226* COSMIC NP NP 41 TCGA-DK-A3IL-01 URINARY TRACT c.26G>A p.R9Q COSMIC PASSENGER/OTHER Benign 42 TCGA-DK-A3IS-01 URINARY TRACT c.949G>T p.E317* COSMIC NP NP 43 TCGA-EJ-5504-01 PROSTATE c.660C>G p.R220R COSMIC NP NP 44 TCGA-G2-A2EL-01 URINARY TRACT c.721G>C p.E241Q COSMIC PASSENGER/OTHER Probably Damaging 45 YUSWI SKIN c.559C>T p.R187* COSMIC NP NP 46 YUZINO SKIN c.376C>T p.P126S COSMIC PASSENGER/OTHER Possibly Damaging
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.test -
Tertiary structure (+)
Users must enabled the Java in their browser to see structure.
Users can also download Java from here.Modelled Structure Structures available in PDB Structure is not available in PDB -
Structure Domains (+)
1. PFAM Domains:Domain ID Domain Name Start Site End Site E-value PB003308 Pfam-B_3308 1 53 3.3e-08 PB017110 Pfam-B_17110 1 103 1.1e-56 PF13465 zf-H2C2_2 186 210 5.2e-05 PF13894 zf-C2H2_4 229 251 0.00056 PF00096 zf-C2H2 255 278 0.00086 PF00096 zf-C2H2 345 368 7.5e-05 2. Superfamily Domains:Domain ID Start Site End Site E-value 0052279 254 306 5.03e-10 0052279 174 219 2.62e-08 0045110 196 252 1.79e-07 0045110 309 369 1.44e-05 -
Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Variants are not present in 1000 Genomes!!2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 4. Sequence alignment with homologus proteins:
Click on button to get Sequence alignment with Coverage, Consensus and Quality -
Sequence Profiles (+)
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Post Translational Modifications (+)
Post translational modifications are not found!!Other Databases Link (+)
Proteomics DB COSMIC Gene Atlas STRING PIR HINFP HINFP HINFP ENSP00000318085 Q9BQA5 QuickGO HGNC Ensembl Genome Browser TreeFam UniProt Q9BQA5 HINFP ENSP00000318085 HINFP Q9BQA5 Expression Atlas Protein Atlas OMIM IntAct PharmGKB HINFP ENSP00000318085 607099 Q9BQA5 PA164720597
