dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: HR |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 22RV1 PROSTATE c.1141C>T p.H381Y CCLE NP NP 2 647V URINARY TRACT c.6122G>C p.R2041P CCLE NP NP 3 CAL120 BREAST c.317G>A p.R106Q CCLE NP NP 4 CCK81 LARGE INTESTINE c.2289G>T p.Q763H CCLE NP NP 5 CI1 HAEMATOPOIETIC AND LYMPHOID TISSUE c.682_682delC p.H228fs CCLE NP NP 6 CMLT1 HAEMATOPOIETIC AND LYMPHOID TISSUE c.868C>T p.R290C CCLE NP NP 7 COLO684 ENDOMETRIUM c.1457G>A p.R486Q CCLE NP NP 8 CORL88 LUNG c.708C>T p.H236H CCLE NP NP 9 CW2 LARGE INTESTINE c.11_11delC p.P4fs CCLE NP NP 10 DND41 HAEMATOPOIETIC AND LYMPHOID TISSUE c.394C>T p.R132W CCLE NP NP 11 DU145 PROSTATE c.850C>T p.H284Y CCLE NP NP 12 HCC15 LUNG c.125G>A p.R42Q CCLE NP NP 13 HCC2218 BREAST c.904C>T p.H302Y CCLE NP NP 14 HEC59 ENDOMETRIUM c.2410C>T p.R804C CCLE NP NP 15 HSC4 UPPER AERODIGESTIVE TRACT c.1711C>T p.R571C CCLE PASSENGER/OTHER Probably Damaging 16 HT115 LARGE INTESTINE c.3335G>T p.R1112I CCLE NP NP 17 HT115 LARGE INTESTINE c.523C>T p.H175Y CCLE PASSENGER/OTHER Benign 18 HUH28 BILIARY TRACT c.880C>T p.R294C CCLE NP NP 19 HUH7 LIVER c.3013C>T p.R1005C CCLE NP NP 20 IM95 STOMACH c.604C>T p.R202C CCLE NP NP 21 KNS60 CENTRAL NERVOUS SYSTEM c.8839C>T p.R2947C CCLE NP NP 22 KYO1 HAEMATOPOIETIC AND LYMPHOID TISSUE c.2876G>A p.R959H CCLE NP NP 23 LOVO LARGE INTESTINE c.364C>T p.R122C CCLE NP NP 24 LS180 LARGE INTESTINE c.4196G>A p.R1399H CCLE NP NP 25 MFE296 ENDOMETRIUM c.1327C>A p.R443S CCLE NP NP 26 NCIH1651 LUNG c.417G>T p.K139N CCLE NP NP 27 NCIH1793 LUNG c.901G>A p.G301S CCLE NP NP 28 NCIH2141 LUNG c.783T>G p.C261W CCLE NP NP 29 NCIH2227 LUNG c.908G>A p.R303Q CCLE NP NP 30 RKO LARGE INTESTINE c.2258G>A p.R753H CCLE NP NP 31 SF295 CENTRAL NERVOUS SYSTEM c.1222C>T p.R408C CCLE NP NP 32 SNU1040 LARGE INTESTINE c.2321G>A p.R774H CCLE NP NP 33 SNU1040 LARGE INTESTINE c.2386C>T p.Q796* CCLE NP NP 34 SNU1040 LARGE INTESTINE c.2419C>T p.R807C CCLE PASSENGER/OTHER Probably Damaging 35 SNU1040 LARGE INTESTINE c.466C>T p.R156* CCLE NP NP 36 SNU175 LARGE INTESTINE c.226C>T p.R76W CCLE NP NP 37 SNU213 PANCREAS c.3013C>T p.R1005C CCLE NP NP 38 SNU324 PANCREAS c.3053A>G p.H1018R CCLE NP NP 39 SNU387 LIVER c.1711C>T p.R571C CCLE PASSENGER/OTHER Probably Damaging 40 SNU407 LARGE INTESTINE c.4387C>T p.R1463C CCLE NP NP 41 SNU407 LARGE INTESTINE c.5507G>A p.R1836H CCLE NP NP 42 SNU423 LIVER c.226C>T p.R76W CCLE NP NP 43 SUDHL4 HAEMATOPOIETIC AND LYMPHOID TISSUE c.4468C>T p.R1490C CCLE NP NP 44 TE4 OESOPHAGUS c.317G>T p.R106L CCLE NP NP 45 VMRCLCD LUNG c.835C>G p.R279G CCLE NP NP 46 585205 LUNG c.3406G>A p.V1136I COSMIC PASSENGER/OTHER Benign 47 585208 LUNG c.765G>T p.M255I COSMIC PASSENGER/OTHER Benign 48 587234 LARGE INTESTINE c.2297C>T p.A766V COSMIC PASSENGER/OTHER Probably Damaging 49 76629543 STOMACH c.2961G>C p.Q987H COSMIC PASSENGER/OTHER Probably Damaging 50 ESO-0292 OESOPHAGUS c.1289G>A p.R430Q COSMIC PASSENGER/OTHER Probably Damaging 51 ESO-114 OESOPHAGUS c.1318G>A p.E440K COSMIC PASSENGER/OTHER Benign 52 ESO-409 OESOPHAGUS c.3421delC p.L1141fs*38 COSMIC NP NP 53 FRO95-HR LARGE INTESTINE c.742C>T p.R248W COSMIC NP NP 54 H1155 LUNG c.1934C>T p.A645V COSMIC PASSENGER/OTHER Benign 55 HCC137T LIVER c.1064C>A p.A355D COSMIC PASSENGER/OTHER Benign 56 HN_62505 UPPER AERODIGESTIVE TRACT c.1212G>A p.P404P COSMIC NP NP 57 LUAD-CHTN-3090346 LUNG c.3444C>G p.L1148L COSMIC NP NP 58 LUAD-NYU803 LUNG c.2678C>T p.A893V COSMIC PASSENGER/OTHER Possibly Damaging 59 Mx41 LARGE INTESTINE c.1898G>A p.R633Q COSMIC PASSENGER/OTHER Possibly Damaging 60 NCI-H23 LUNG c.3107C>G p.S1036* COSMIC NP NP 61 PGBM20PT CENTRAL NERVOUS SYSTEM c.2986C>T p.P996S COSMIC PASSENGER/OTHER Benign 62 PR-00-1165 PROSTATE c.1186G>A p.G396S COSMIC PASSENGER/OTHER Possibly Damaging 63 PR-2916 PROSTATE c.2179C>T p.H727Y COSMIC PASSENGER/OTHER Possibly Damaging 64 PR-3048 PROSTATE c.1587G>T p.E529D COSMIC PASSENGER/OTHER Benign 65 SJMB020 CENTRAL NERVOUS SYSTEM c.3012G>T p.K1004N COSMIC PASSENGER/OTHER Probably Damaging 66 TCGA-13-1481-01 OVARY c.1764C>T p.A588A COSMIC NP NP 67 TCGA-18-5595-01 LUNG c.1592A>C p.D531A COSMIC PASSENGER/OTHER Benign 68 TCGA-25-2400-01 OVARY c.883G>T p.A295S COSMIC PASSENGER/OTHER Benign 69 TCGA-37-4135-01 LUNG c.2218G>T p.A740S COSMIC PASSENGER/OTHER Benign 70 TCGA-44-4112-01 LUNG c.2699C>T p.A900V COSMIC PASSENGER/OTHER Benign 71 TCGA-44-4112-01 LUNG c.3039G>C p.L1013L COSMIC NP NP 72 TCGA-50-5946-01 LUNG c.345C>G p.C115W COSMIC PASSENGER/OTHER Probably Damaging 73 TCGA-50-5946-02 LUNG c.345C>G p.C115W COSMIC PASSENGER/OTHER Probably Damaging 74 TCGA-53-7624-01 LUNG c.3345G>A p.E1115E COSMIC NP NP 75 TCGA-60-2722-01 LUNG c.1078G>T p.E360* COSMIC NP NP 76 TCGA-61-1738-01 OVARY c.3165C>G p.H1055Q COSMIC PASSENGER/OTHER Probably Damaging 77 TCGA-64-1681-01 LUNG c.2889C>T p.C963C COSMIC NP NP 78 TCGA-73-4670-01 LUNG c.1146A>T p.T382T COSMIC NP NP 79 TCGA-78-7155-01 LUNG c.109C>A p.H37N COSMIC PASSENGER/OTHER Benign 80 TCGA-78-7542-01 LUNG c.2220T>A p.A740A COSMIC NP NP 81 TCGA-85-6561-01 LUNG c.1219C>A p.R407R COSMIC NP NP 82 TCGA-95-7039-01 LUNG c.2311T>C p.L771L COSMIC NP NP 83 TCGA-A2-A0SV-01 BREAST c.1010G>A p.G337D COSMIC PASSENGER/OTHER Benign 84 TCGA-A2-A0SW-01 BREAST c.2240G>A p.R747H COSMIC PASSENGER/OTHER Possibly Damaging 85 TCGA-A5-A0GB-01 ENDOMETRIUM c.3033C>T p.A1011A COSMIC NP NP 86 TCGA-A5-A0GQ-01 ENDOMETRIUM c.2181C>A p.H727Q COSMIC PASSENGER/OTHER Benign 87 TCGA-AA-3672-01 LARGE INTESTINE c.170C>T p.P57L COSMIC PASSENGER/OTHER Probably Damaging 88 TCGA-AA-3976-01 LARGE INTESTINE c.2060G>A p.R687Q COSMIC PASSENGER/OTHER Probably Damaging 89 TCGA-AF-5654-01 LARGE INTESTINE c.1186G>A p.G396S COSMIC PASSENGER/OTHER Possibly Damaging 90 TCGA-AO-A12A-01 BREAST c.1305T>C p.F435F COSMIC NP NP 91 TCGA-AP-A059-01 ENDOMETRIUM c.1240G>A p.A414T COSMIC PASSENGER/OTHER Possibly Damaging 92 TCGA-AP-A059-01 ENDOMETRIUM c.2988G>A p.P996P COSMIC NP NP 93 TCGA-AP-A059-01 ENDOMETRIUM c.3197G>A p.R1066H COSMIC PASSENGER/OTHER Probably Damaging 94 TCGA-AP-A0LM-01 ENDOMETRIUM c.2047A>G p.K683E COSMIC PASSENGER/OTHER Probably Damaging 95 TCGA-AP-A0LM-01 ENDOMETRIUM c.2340C>T p.F780F COSMIC NP NP 96 TCGA-AP-A0LM-01 ENDOMETRIUM c.321G>A p.P107P COSMIC NP NP 97 TCGA-AX-A063-01 ENDOMETRIUM c.1200C>T p.V400V COSMIC NP NP 98 TCGA-AZ-6601-01 LARGE INTESTINE c.2333T>C p.M778T COSMIC PASSENGER/OTHER Possibly Damaging 99 TCGA-B0-5110-01 KIDNEY c.730G>T p.E244* COSMIC NP NP 100 TCGA-B5-A11E-01 ENDOMETRIUM c.1552C>T p.R518W COSMIC PASSENGER/OTHER Benign 101 TCGA-B5-A11E-01 ENDOMETRIUM c.549G>A p.P183P COSMIC NP NP 102 TCGA-CA-6717-01 LARGE INTESTINE c.3061G>A p.D1021N COSMIC PASSENGER/OTHER Benign 103 TCGA-CK-5913-01 LARGE INTESTINE c.2340C>T p.F780F COSMIC NP NP 104 TCGA-CZ-4853-01 KIDNEY c.371C>A p.P124H COSMIC PASSENGER/OTHER Probably Damaging 105 TCGA-D1-A0ZS-01 ENDOMETRIUM c.1157G>T p.R386L COSMIC PASSENGER/OTHER Probably Damaging 106 TCGA-D1-A103-01 ENDOMETRIUM c.2172C>T p.G724G COSMIC NP NP 107 TCGA-D1-A103-01 ENDOMETRIUM c.2989C>T p.H997Y COSMIC CANCER Possibly Damaging 108 TCGA-D1-A15X-01 ENDOMETRIUM c.1830C>T p.T610T COSMIC NP NP 109 TCGA-D1-A163-01 ENDOMETRIUM c.2568G>A p.R856R COSMIC NP NP 110 TCGA-D1-A167-01 ENDOMETRIUM c.3183C>T p.D1061D COSMIC NP NP 111 TCGA-D5-6928-01 LARGE INTESTINE c.2446C>T p.P816S COSMIC PASSENGER/OTHER Probably Damaging 112 TCGA-D5-6930-01 LARGE INTESTINE c.1358C>T p.S453L COSMIC PASSENGER/OTHER Benign 113 TCGA-DK-A1A6-01 URINARY TRACT c.2375G>T p.R792L COSMIC PASSENGER/OTHER Probably Damaging 114 TCGA-G4-6309-01 LARGE INTESTINE c.518delC p.P173fs*9 COSMIC NP NP 115 TCGA-J2-8192-01 LUNG c.2776C>T p.L926F COSMIC PASSENGER/OTHER Possibly Damaging 116 YUSWI SKIN c.2779C>T p.R927C COSMIC PASSENGER/OTHER Probably Damaging 117 ccRCC-55 KIDNEY c.3401T>C p.V1134A COSMIC PASSENGER/OTHER Possibly Damaging
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.test -
Tertiary structure (+)
Users must enabled the Java in their browser to see structure.
Users can also download Java from here.Modelled Structure Structures available in PDB Structure is not available in PDB -
Structure Domains (+)
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Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 2. Sequence alignment with CCLE mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 3. Sequence alignment with COSMIC mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 4. Sequence alignment with homologus proteins:
Click on button to get Sequence alignment with Coverage, Consensus and Quality -
Sequence Profiles (+)
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Post Translational Modifications (+)
S. No. Position Amino acid Type 1 416 S Phosphorylation 2 425 S Phosphorylation 3 6 S Phosphorylation -
Other Databases Link (+)
Proteomics DB COSMIC Gene Atlas STRING PIR HR HR HR ENSP00000326765 O43593 QuickGO HGNC Ensembl Genome Browser TreeFam UniProt O43593 HR ENSP00000326765 HR O43593 Expression Atlas Protein Atlas OMIM IntAct PharmGKB HR ENSP00000326765 602302 O43593 PA29443
