dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: HSPBAP1 |
| Expand All | Collapse All |
-
Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 587332 LARGE INTESTINE c.773A>G p.Y258C COSMIC PASSENGER/OTHER Probably Damaging 2 587376 LARGE INTESTINE c.719C>T p.A240V COSMIC PASSENGER/OTHER Benign 3 587376 LARGE INTESTINE c.93G>T p.E31D COSMIC PASSENGER/OTHER Possibly Damaging 4 970010 STOMACH c.191C>T p.S64L COSMIC PASSENGER/OTHER Probably Damaging 5 HCC94T LIVER c.719C>A p.A240E COSMIC PASSENGER/OTHER Benign 6 LC_S11 LUNG c.58G>C p.E20Q COSMIC PASSENGER/OTHER Benign 7 NCI-H2009 LUNG c.1410G>A p.V470V COSMIC NP NP 8 PD4127a BREAST c.1333G>A p.E445K COSMIC PASSENGER/OTHER Benign 9 TCGA-13-0913-01 OVARY c.342A>T p.P114P COSMIC NP NP 10 TCGA-18-5592-01 LUNG c.91G>T p.E31* COSMIC NP NP 11 TCGA-50-5049-01 LUNG c.845G>T p.R282L COSMIC PASSENGER/OTHER Probably Damaging 12 TCGA-66-2757-01 LUNG c.315C>T p.N105N COSMIC NP NP 13 TCGA-66-2792-01 LUNG c.4G>C p.A2P COSMIC PASSENGER/OTHER Possibly Damaging 14 TCGA-A5-A0GA-01 ENDOMETRIUM c.419C>T p.T140I COSMIC PASSENGER/OTHER Possibly Damaging 15 TCGA-A6-6142-01 LARGE INTESTINE c.341C>T p.P114L COSMIC PASSENGER/OTHER Possibly Damaging 16 TCGA-A8-A07O-01 BREAST c.989C>T p.S330F COSMIC PASSENGER/OTHER Possibly Damaging 17 TCGA-AA-A00N-01 LARGE INTESTINE c.424C>A p.L142I COSMIC PASSENGER/OTHER Benign 18 TCGA-AD-6889-01 LARGE INTESTINE c.217C>T p.R73* COSMIC NP NP 19 TCGA-AH-6644-01 LARGE INTESTINE c.866G>A p.R289H COSMIC PASSENGER/OTHER Probably Damaging 20 TCGA-AZ-6598-01 LARGE INTESTINE c.218G>A p.R73Q COSMIC PASSENGER/OTHER Probably Damaging 21 TCGA-B5-A11E-01 ENDOMETRIUM c.1342A>G p.I448V COSMIC PASSENGER/OTHER Benign 22 TCGA-B5-A11E-01 ENDOMETRIUM c.999T>C p.F333F COSMIC NP NP 23 TCGA-B5-A11R-01 ENDOMETRIUM c.820G>C p.E274Q COSMIC PASSENGER/OTHER Probably Damaging 24 TCGA-BK-A0C9-01 ENDOMETRIUM c.1361C>T p.T454M COSMIC PASSENGER/OTHER Benign 25 TCGA-BS-A0UF-01 ENDOMETRIUM c.103G>T p.E35* COSMIC NP NP 26 TCGA-BS-A0UJ-01 ENDOMETRIUM c.1370A>C p.Q457P COSMIC PASSENGER/OTHER Benign 27 TCGA-BT-A20O-01 URINARY TRACT c.1000G>A p.D334N COSMIC PASSENGER/OTHER Benign 28 TCGA-CK-5913-01 LARGE INTESTINE c.1056G>T p.E352D COSMIC PASSENGER/OTHER Benign 29 TCGA-E2-A14X-01 BREAST c.902C>T p.P301L COSMIC PASSENGER/OTHER Benign 30 TCGA-F4-6459-01 LARGE INTESTINE c.1409T>C p.V470A COSMIC PASSENGER/OTHER Probably Damaging 31 TCGA-FI-A2EW-01 ENDOMETRIUM c.438G>A p.V146V COSMIC NP NP
*NP: Not Predicted -
Copy number variation and expression profile (+)
-
Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.Gene essentiality data is not present in COLT database!! -
Tertiary structure (+)
Users must enabled the Java in their browser to see structure.
Users can also download Java from here.Modelled Structure Structures available in PDB Structure is not available in PDB -
Structure Domains (+)
-
Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 4. Sequence alignment with homologus proteins:
Click on button to get Sequence alignment with Coverage, Consensus and Quality -
Sequence Profiles (+)
-
Post Translational Modifications (+)
S. No. Position Amino acid Type 1 147 K Ubiquitylation 2 219 K Ubiquitylation 3 228 K Ubiquitylation -
Other Databases Link (+)
Proteomics DB COSMIC Gene Atlas STRING PIR HSPBAP1 HSPBAP1 HSPBAP1 ENSP00000302562 Q96EW2 QuickGO HGNC Ensembl Genome Browser TreeFam UniProt Q96EW2 HSPBAP1 ENSP00000302562 HSPBAP1 Q96EW2 Expression Atlas Protein Atlas OMIM IntAct PharmGKB HSPBAP1 ENSP00000302562 608263 Q96EW2 PA29515
