dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: ING1 |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 AN3CA ENDOMETRIUM c.112_113insT p.L38fs CCLE NP NP 2 EFO27 OVARY c.740G>A p.R247Q CCLE CANCER Probably Damaging 3 HARA LUNG c.485G>C p.R162P CCLE CANCER Possibly Damaging 4 HEC108 ENDOMETRIUM c.310G>T p.G104C CCLE CANCER Probably Damaging 5 HEC151 ENDOMETRIUM c.609C>T p.R203R CCLE NP NP 6 HS888T BONE c.165C>A p.N55K CCLE PASSENGER/OTHER Benign 7 KATOIII STOMACH c.242G>A p.R81Q CCLE PASSENGER/OTHER Possibly Damaging 8 KMS12BM HAEMATOPOIETIC AND LYMPHOID TISSUE c.859A>C p.K287Q CCLE CANCER Probably Damaging 9 NCIH1734 LUNG c.1199G>T p.R400L CCLE PASSENGER/OTHER Probably Damaging 10 NCIH1793 LUNG c.157G>A p.D53N CCLE PASSENGER/OTHER Possibly Damaging 11 NCIH23 LUNG c.520G>T p.A174S CCLE CANCER Benign 12 NCIH650 LUNG c.502C>T p.R168W CCLE CANCER Possibly Damaging 13 NCIH660 PROSTATE c.334C>T p.P112S CCLE CANCER Benign 14 RAJI HAEMATOPOIETIC AND LYMPHOID TISSUE c.325_326insC p.S109fs CCLE NP NP 15 REH HAEMATOPOIETIC AND LYMPHOID TISSUE c.823G>A p.D275N CCLE CANCER Benign 16 RKO LARGE INTESTINE c.923A>C p.N308T CCLE CANCER Possibly Damaging 17 SKMEL1 SKIN c.993_994delGC p.K331fs CCLE NP NP 18 SKOV3 OVARY c.1169C>A p.P390H CCLE CANCER Probably Damaging 19 SNU1040 LARGE INTESTINE c.1184A>G p.Y395C CCLE CANCER Probably Damaging 20 SNU1040 LARGE INTESTINE c.668G>A p.R223H CCLE CANCER Probably Damaging 21 SNUC4 LARGE INTESTINE c.485G>C p.R162P CCLE CANCER Possibly Damaging 22 T98G CENTRAL NERVOUS SYSTEM c.165C>A p.N55K CCLE PASSENGER/OTHER Benign 23 TOV21G OVARY c.1108G>A p.D370N CCLE CANCER Probably Damaging 24 587234 LARGE INTESTINE c.674G>A p.G225D COSMIC NP NP 25 CCRF-CEM HAEMATOPOIETIC AND LYMPHOID TISSUE c.202C>T p.R68W COSMIC NP NP 26 ESO-0071 OESOPHAGUS c.767G>A p.C256Y COSMIC NP NP 27 ESO-859 OESOPHAGUS c.770G>A p.R257Q COSMIC NP NP 28 NB07C AUTONOMIC GANGLIA c.154G>T p.D52Y COSMIC NP NP 29 SK-OV-3 OVARY c.740C>A p.P247H COSMIC NP NP 30 TCGA-24-1424-01 OVARY c.705G>T p.W235C COSMIC NP NP 31 TCGA-44-7671-01 LUNG c.576C>T p.A192A COSMIC NP NP 32 TCGA-53-7624-01 LUNG c.630C>G p.P210P COSMIC NP NP 33 TCGA-69-7974-01 LUNG c.253G>A p.G85S COSMIC NP NP 34 TCGA-A5-A0VP-01 ENDOMETRIUM c.274G>A p.V92M COSMIC NP NP 35 TCGA-A6-2672-01 LARGE INTESTINE c.484G>A p.A162T COSMIC NP NP 36 TCGA-AA-3492-01 LARGE INTESTINE c.657C>A p.S219S COSMIC NP NP 37 TCGA-AA-3502-01 LARGE INTESTINE c.679G>T p.D227Y COSMIC NP NP 38 TCGA-AA-3949-01 LARGE INTESTINE c.703T>C p.W235R COSMIC NP NP 39 TCGA-AA-A010-01 LARGE INTESTINE c.505G>A p.D169N COSMIC NP NP 40 TCGA-AA-A01F-01 LARGE INTESTINE c.700G>A p.E234K COSMIC NP NP 41 TCGA-AA-A03F-01 LARGE INTESTINE c.586C>T p.R196* COSMIC NP NP 42 TCGA-AF-3913-01 LARGE INTESTINE c.586C>T p.R196* COSMIC NP NP 43 TCGA-AP-A056-01 ENDOMETRIUM c.305G>A p.R102H COSMIC NP NP 44 TCGA-AP-A059-01 ENDOMETRIUM c.345G>A p.A115A COSMIC NP NP 45 TCGA-AP-A059-01 ENDOMETRIUM c.705G>A p.W235* COSMIC NP NP 46 TCGA-AR-A1AH-01 BREAST c.514G>T p.A172S COSMIC NP NP 47 TCGA-B5-A0JY-01 ENDOMETRIUM c.625G>T p.E209* COSMIC NP NP 48 TCGA-B5-A0JZ-01 ENDOMETRIUM c.678C>T p.C226C COSMIC NP NP 49 TCGA-B5-A11E-01 ENDOMETRIUM c.514G>A p.A172T COSMIC NP NP 50 TCGA-BG-A0M9-01 ENDOMETRIUM c.688G>T p.E230* COSMIC NP NP 51 TCGA-BS-A0TC-01 ENDOMETRIUM c.625G>A p.E209K COSMIC NP NP 52 TCGA-D1-A168-01 ENDOMETRIUM c.586C>T p.R196* COSMIC NP NP 53 TCGA-D1-A17C-01 ENDOMETRIUM c.679G>T p.D227Y COSMIC NP NP 54 TCGA-D1-A17Q-01 ENDOMETRIUM c.512G>A p.G171D COSMIC NP NP 55 TCGA-D8-A1JN-01 BREAST c.435C>T p.P145P COSMIC NP NP 56 TCGA-DY-A1DD-01 LARGE INTESTINE c.703T>C p.W235R COSMIC NP NP 57 TCGA-F4-6570-01 LARGE INTESTINE c.763A>T p.K255* COSMIC NP NP 58 TCGA-G4-6586-01 LARGE INTESTINE c.770delG p.E259fs*>21 COSMIC NP NP 59 YUDAB SKIN c.475C>A p.R159S COSMIC CANCER Benign
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.Gene essentiality data is not present in COLT database!! -
Tertiary structure (+)
Users must enabled the Java in their browser to see structure.
Users can also download Java from here.Modelled Structure Structures available in PDB -
Structure Domains (+)
1. PFAM domains are not present!!2. Superfaimly domains are not present!! -
Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Variants are not present in 1000 Genomes!!2. Sequence alignment with CCLE mutants:3. Sequence alignment with COSMIC mutants:4. Sequence alignment with homologus proteins: -
Sequence Profiles (+)
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Post Translational Modifications (+)
Post translational modifications are not found!!Other Databases Link (+)
