dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: ING2 |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 585208 LUNG c.469A>T p.T157S COSMIC CANCER Benign 2 HCT-116 LARGE INTESTINE c.457C>A p.R153S COSMIC CANCER Probably Damaging 3 NB-0478 AUTONOMIC GANGLIA c.412G>C p.A138P COSMIC CANCER Benign 4 S00943 LUNG c.200A>G p.Y67C COSMIC CANCER Benign 5 SA228 BREAST c.278G>C p.S93T COSMIC CANCER Benign 6 TCGA-13-0760-01 OVARY c.759G>T p.W253C COSMIC CANCER Probably Damaging 7 TCGA-46-3769-01 LUNG c.610G>C p.E204Q COSMIC CANCER Probably Damaging 8 TCGA-AA-3663-01 LARGE INTESTINE c.445T>C p.S149P COSMIC CANCER Possibly Damaging 9 TCGA-AD-5900-01 LARGE INTESTINE c.819delA p.K275fs*>6 COSMIC NP NP 10 TCGA-AG-A002-01 LARGE INTESTINE c.202G>A p.E68K COSMIC CANCER Probably Damaging 11 TCGA-AZ-4315-01 LARGE INTESTINE c.679G>A p.G227R COSMIC CANCER Probably Damaging 12 TCGA-AZ-5407-01 LARGE INTESTINE c.759G>C p.W253C COSMIC CANCER Probably Damaging 13 TCGA-B5-A0JR-01 ENDOMETRIUM c.605C>T p.P202L COSMIC CANCER Probably Damaging 14 TCGA-B5-A11E-01 ENDOMETRIUM c.760T>C p.Y254H COSMIC CANCER Probably Damaging 15 TCGA-BS-A0UV-01 ENDOMETRIUM c.325G>T p.E109* COSMIC NP NP 16 TCGA-D1-A103-01 ENDOMETRIUM c.266C>T p.A89V COSMIC CANCER Probably Damaging 17 TCGA-E2-A15F-01 BREAST c.39C>T p.A13A COSMIC NP NP 18 TCGA-F4-6703-01 LARGE INTESTINE c.758G>A p.W253* COSMIC NP NP 19 TCGA-G4-6586-01 LARGE INTESTINE c.758G>A p.W253* COSMIC NP NP 20 YUKLAB SKIN c.116_117CC>TT p.P39L COSMIC CANCER Probably Damaging
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.test -
Tertiary structure (+)
Users must enabled the Java in their browser to see structure.
Users can also download Java from here.Modelled Structure Structures available in PDB Structure is not available in PDB -
Structure Domains (+)
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Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 4. Sequence alignment with homologus proteins:
Click on button to get Sequence alignment with Coverage, Consensus and Quality -
Sequence Profiles (+)
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Post Translational Modifications (+)
S. No. Position Amino acid Type 1 56 Y Phosphorylation -
Other Databases Link (+)
Proteomics DB COSMIC Gene Atlas STRING PIR ING2 ING2 ING2 ENSP00000307183 Q9H160 QuickGO HGNC Ensembl Genome Browser TreeFam UniProt Q9H160 ING2 ENSP00000307183 ING2 Q9H160 Expression Atlas Protein Atlas OMIM IntAct PharmGKB ING2 ENSP00000307183 604215 Q9H160 PA29873
