dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: ING2 |
| Expand All | Collapse All |
-
Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 585208 LUNG c.469A>T p.T157S COSMIC CANCER Benign 2 HCT-116 LARGE INTESTINE c.457C>A p.R153S COSMIC CANCER Probably Damaging 3 NB-0478 AUTONOMIC GANGLIA c.412G>C p.A138P COSMIC CANCER Benign 4 S00943 LUNG c.200A>G p.Y67C COSMIC CANCER Benign 5 SA228 BREAST c.278G>C p.S93T COSMIC CANCER Benign 6 TCGA-13-0760-01 OVARY c.759G>T p.W253C COSMIC CANCER Probably Damaging 7 TCGA-46-3769-01 LUNG c.610G>C p.E204Q COSMIC CANCER Probably Damaging 8 TCGA-AA-3663-01 LARGE INTESTINE c.445T>C p.S149P COSMIC CANCER Possibly Damaging 9 TCGA-AD-5900-01 LARGE INTESTINE c.819delA p.K275fs*>6 COSMIC NP NP 10 TCGA-AG-A002-01 LARGE INTESTINE c.202G>A p.E68K COSMIC CANCER Probably Damaging 11 TCGA-AZ-4315-01 LARGE INTESTINE c.679G>A p.G227R COSMIC CANCER Probably Damaging 12 TCGA-AZ-5407-01 LARGE INTESTINE c.759G>C p.W253C COSMIC CANCER Probably Damaging 13 TCGA-B5-A0JR-01 ENDOMETRIUM c.605C>T p.P202L COSMIC CANCER Probably Damaging 14 TCGA-B5-A11E-01 ENDOMETRIUM c.760T>C p.Y254H COSMIC CANCER Probably Damaging 15 TCGA-BS-A0UV-01 ENDOMETRIUM c.325G>T p.E109* COSMIC NP NP 16 TCGA-D1-A103-01 ENDOMETRIUM c.266C>T p.A89V COSMIC CANCER Probably Damaging 17 TCGA-E2-A15F-01 BREAST c.39C>T p.A13A COSMIC NP NP 18 TCGA-F4-6703-01 LARGE INTESTINE c.758G>A p.W253* COSMIC NP NP 19 TCGA-G4-6586-01 LARGE INTESTINE c.758G>A p.W253* COSMIC NP NP 20 YUKLAB SKIN c.116_117CC>TT p.P39L COSMIC CANCER Probably Damaging
*NP: Not Predicted -
Copy number variation and expression profile (+)
-
Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score. -
Tertiary structure (+)
Users must enabled the Java in their browser to see structure.
Users can also download Java from here.Modelled Structure Structures available in PDB -
Structure Domains (+)
1. PFAM domains are not present!!2. Superfaimly domains are not present!! -
Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:4. Sequence alignment with homologus proteins: -
Sequence Profiles (+)
-
Post Translational Modifications (+)
Post translational modifications are not found!!Other Databases Link (+)
