dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: ING3 |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 E22 EYE c.967T>A p.S323T COSMIC CANCER Possibly Damaging 2 ESO-1133 OESOPHAGUS c.219G>T p.L73F COSMIC CANCER Probably Damaging 3 ESO-859 OESOPHAGUS c.528G>A p.T176T COSMIC NP NP 4 ESO-887 OESOPHAGUS c.96G>T p.V32V COSMIC NP NP 5 HX17T LIVER c.593A>G p.N198S COSMIC CANCER Benign 6 LUAD-D01751 LUNG c.608A>T p.N203I COSMIC CANCER Benign 7 LUAD-RT-S01699 LUNG c.475G>T p.D159Y COSMIC CANCER Probably Damaging 8 LUAD-S01467 LUNG c.243G>T p.Q81H COSMIC CANCER Probably Damaging 9 ME020T NS c.503C>T p.S168F COSMIC CANCER Probably Damaging 10 NB07C AUTONOMIC GANGLIA c.1124G>T p.G375V COSMIC CANCER Probably Damaging 11 NB07C AUTONOMIC GANGLIA c.1154G>T p.W385L COSMIC CANCER Probably Damaging 12 T155 ENDOMETRIUM c.563G>A p.R188Q COSMIC CANCER Probably Damaging 13 TCGA-13-1504-01 OVARY c.809G>C p.R270T COSMIC CANCER Probably Damaging 14 TCGA-18-3411-01 LUNG c.118G>C p.E40Q COSMIC CANCER Probably Damaging 15 TCGA-46-6026-01 LUNG c.593A>G p.N198S COSMIC CANCER Benign 16 TCGA-64-1676-01 LUNG c.668G>C p.G223A COSMIC CANCER Probably Damaging 17 TCGA-66-2758-01 LUNG c.368C>A p.S123Y COSMIC CANCER Probably Damaging 18 TCGA-69-7765-01 LUNG c.399G>T p.V133V COSMIC NP NP 19 TCGA-AA-3542-01 LARGE INTESTINE c.72A>T p.E24D COSMIC CANCER Probably Damaging 20 TCGA-AA-A00N-01 LARGE INTESTINE c.563G>A p.R188Q COSMIC CANCER Probably Damaging 21 TCGA-AD-6895-01 LARGE INTESTINE c.706A>G p.T236A COSMIC CANCER Possibly Damaging 22 TCGA-AP-A059-01 ENDOMETRIUM c.1027C>T p.P343S COSMIC CANCER Benign 23 TCGA-AP-A059-01 ENDOMETRIUM c.49G>T p.D17Y COSMIC CANCER Probably Damaging 24 TCGA-AX-A0J0-01 ENDOMETRIUM c.872C>A p.S291* COSMIC NP NP 25 TCGA-B5-A0JY-01 ENDOMETRIUM c.739A>C p.S247R COSMIC CANCER Probably Damaging 26 TCGA-B5-A0JZ-01 ENDOMETRIUM c.630_641del12 p.Y211_G214delYNIG COSMIC NP NP 27 TCGA-CA-6718-01 LARGE INTESTINE c.542A>C p.K181T COSMIC CANCER Probably Damaging 28 TCGA-D1-A17Q-01 ENDOMETRIUM c.728G>A p.R243Q COSMIC CANCER Probably Damaging 29 TCGA-DK-A1A3-01 URINARY TRACT c.1160A>C p.H387P COSMIC CANCER Probably Damaging 30 TCGA-G2-A2EL-01 URINARY TRACT c.85G>A p.D29N COSMIC CANCER Probably Damaging 31 TCGA-G2-A2ES-01 URINARY TRACT c.966A>T p.L322F COSMIC CANCER Probably Damaging 32 ccRCC-95 KIDNEY c.337G>T p.A113S COSMIC CANCER Probably Damaging
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.test -
Tertiary structure (+)
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Structure Domains (+)
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Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 4. Sequence alignment with homologus proteins:
Click on button to get Sequence alignment with Coverage, Consensus and Quality -
Sequence Profiles (+)
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Post Translational Modifications (+)
S. No. Position Amino acid Type 1 140 S Phosphorylation 2 164 K Acetylation 3 264 K Acetylation 4 264 K Acetylation -
Other Databases Link (+)
Proteomics DB COSMIC Gene Atlas STRING PIR ING3 ING3 ING3 ENSP00000320566 Q9NXR8 QuickGO HGNC Ensembl Genome Browser TreeFam UniProt Q9NXR8 ING3 ENSP00000320566 ING3 Q9NXR8 Expression Atlas Protein Atlas OMIM IntAct PharmGKB ING3 ENSP00000320566 607493 Q9NXR8 PA29875
