dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: ING4 |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 HCT-15 LARGE INTESTINE c.695C>A p.P232H COSMIC NP NP 2 PD6343a NS c.705A>T p.K235N COSMIC NP NP 3 TARGET-30-PASEGA AUTONOMIC GANGLIA c.628G>A p.G210S COSMIC NP NP 4 TCGA-02-0083-01 CENTRAL NERVOUS SYSTEM c.700G>A p.G234R COSMIC NP Possibly Damaging 5 TCGA-02-0114-01 CENTRAL NERVOUS SYSTEM c.660G>A p.W220* COSMIC NP NP 6 TCGA-06-0148-01 CENTRAL NERVOUS SYSTEM c.309C>T p.D103D COSMIC NP NP 7 TCGA-13-0891-01 OVARY c.316C>T p.R106C COSMIC CANCER Probably Damaging 8 TCGA-39-5031-01 LUNG c.505G>C p.E169Q COSMIC NP NP 9 TCGA-53-7624-01 LUNG c.12G>C p.G4G COSMIC NP NP 10 TCGA-66-2768-01 LUNG c.730G>C p.E244Q COSMIC NP Benign 11 TCGA-73-4668-01 LUNG c.730G>C p.E244Q COSMIC NP Benign 12 TCGA-91-6849-01 LUNG c.629G>T p.G210V COSMIC NP NP 13 TCGA-A6-6781-01 LARGE INTESTINE c.395G>A p.R132Q COSMIC NP NP 14 TCGA-A8-A092-01 BREAST c.349G>A p.E117K COSMIC CANCER Possibly Damaging 15 TCGA-AA-3864-01 LARGE INTESTINE c.460C>A p.P154T COSMIC NP NP 16 TCGA-AA-A00K-01 LARGE INTESTINE c.376A>T p.S126C COSMIC CANCER Probably Damaging 17 TCGA-AP-A051-01 ENDOMETRIUM c.307G>T p.D103Y COSMIC CANCER Probably Damaging 18 TCGA-AZ-6608-01 LARGE INTESTINE c.308A>G p.D103G COSMIC CANCER Probably Damaging 19 TCGA-B5-A11E-01 ENDOMETRIUM c.494G>A p.R165H COSMIC NP NP 20 TCGA-B5-A11J-01 ENDOMETRIUM c.251A>G p.Q84R COSMIC CANCER Probably Damaging 21 TCGA-BS-A0TE-01 ENDOMETRIUM c.118G>A p.A40T COSMIC CANCER Benign 22 TCGA-D5-6536-01 LARGE INTESTINE c.658T>C p.W220R COSMIC NP NP 23 TCGA-D5-6930-01 LARGE INTESTINE c.604C>T p.Q202* COSMIC NP NP 24 YUGLIDE SKIN c.586A>C p.T196P COSMIC NP Probably Damaging 25 YUHEF SKIN c.446C>T p.S149L COSMIC NP NP 26 YULAN SKIN c.446C>T p.S149L COSMIC NP NP 27 YUSEL SKIN c.595C>T p.L199F COSMIC NP NP 28 pfg019T STOMACH c.295C>T p.R99W COSMIC CANCER Probably Damaging
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.test -
Tertiary structure (+)
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Structure Domains (+)
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Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 4. Sequence alignment with homologus proteins:
Click on button to get Sequence alignment with Coverage, Consensus and Quality -
Sequence Profiles (+)
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Post Translational Modifications (+)
S. No. Position Amino acid Type 1 112 K Acetylation 2 112 K Acetylation 3 114 K Acetylation 4 127 K Acetylation 5 127 K Acetylation 6 129 K Acetylation 7 129 K Acetylation 8 146 K Acetylation 9 146 K Acetylation 10 148 K Acetylation 11 148 K Acetylation 12 150 S Phosphorylation 13 156 K Acetylation 14 156 K Acetylation 15 236 K Acetylation 16 52 S Phosphorylation 17 66 K Ubiquitylation -
Other Databases Link (+)
Proteomics DB COSMIC Gene Atlas STRING PIR ING4 ING4 ING4 ENSP00000343396 Q9UNL4 QuickGO HGNC Ensembl Genome Browser TreeFam UniProt Q9UNL4 ING4 ENSP00000343396 ING4 Q9UNL4 Expression Atlas Protein Atlas OMIM IntAct PharmGKB ING4 ENSP00000343396 608524 Q9UNL4 PA134976283
