dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: ING5 |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 587342 LARGE INTESTINE c.305C>T p.A102V COSMIC CANCER Possibly Damaging 2 587376 LARGE INTESTINE c.292C>T p.R98* COSMIC NP NP 3 HCC23T LIVER c.637C>A p.H213N COSMIC CANCER Probably Damaging 4 HCT-15 LARGE INTESTINE c.40A>G p.I14V COSMIC CANCER Possibly Damaging 5 LUAD-CHTN-MAD06-00490 LUNG c.425G>A p.G142D COSMIC CANCER Possibly Damaging 6 LUAD-S01315 LUNG c.322G>A p.E108K COSMIC CANCER Probably Damaging 7 TCGA-18-3410-01 LUNG c.679T>C p.W227R COSMIC CANCER Probably Damaging 8 TCGA-86-6851-01 LUNG c.333G>A p.L111L COSMIC NP NP 9 TCGA-A6-5665-01 LARGE INTESTINE c.137C>T p.A46V COSMIC CANCER Probably Damaging 10 TCGA-AA-3713-01 LARGE INTESTINE c.155C>T p.T52M COSMIC CANCER Possibly Damaging 11 TCGA-AA-A01R-01 LARGE INTESTINE c.427C>T p.R143* COSMIC NP NP 12 TCGA-D5-6927-01 LARGE INTESTINE c.553G>A p.E185K COSMIC CANCER Probably Damaging
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.test -
Tertiary structure (+)
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Structure Domains (+)
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Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 4. Sequence alignment with homologus proteins:
Click on button to get Sequence alignment with Coverage, Consensus and Quality -
Sequence Profiles (+)
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Post Translational Modifications (+)
S. No. Position Amino acid Type 1 114 K Acetylation 2 114 K Acetylation 3 118 S Phosphorylation 4 118 S Phosphorylation 5 122 S Phosphorylation 6 148 S Phosphorylation 7 226 K Acetylation 8 226 K Acetylation -
Other Databases Link (+)
Proteomics DB COSMIC Gene Atlas STRING PIR ING5 ING5 ING5 ENSP00000322142 Q8WYH8 QuickGO HGNC Ensembl Genome Browser TreeFam UniProt Q8WYH8 ING5 ENSP00000322142 ING5 Q8WYH8 Expression Atlas Protein Atlas OMIM IntAct PharmGKB ING5 ENSP00000322142 608525 Q8WYH8 PA134935441
