dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: INO80 |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 51T SKIN c.2998C>T p.R1000C COSMIC PASSENGER/OTHER Benign 2 587342 LARGE INTESTINE c.1964A>G p.Q655R COSMIC PASSENGER/OTHER Probably Damaging 3 587342 LARGE INTESTINE c.3935A>G p.D1312G COSMIC PASSENGER/OTHER Benign 4 BN17T LIVER c.2262A>G p.E754E COSMIC NP NP 5 DLBCL-PatientH HAEMATOPOIETIC AND LYMPHOID TISSUE c.526A>T p.K176* COSMIC NP NP 6 ESO-007 OESOPHAGUS c.1888A>T p.S630C COSMIC PASSENGER/OTHER Probably Damaging 7 ESO-539 OESOPHAGUS c.959G>A p.R320Q COSMIC PASSENGER/OTHER Probably Damaging 8 ESO-859 OESOPHAGUS c.4183C>T p.R1395* COSMIC NP NP 9 ESOSCC156T OESOPHAGUS c.2909C>G p.S970C COSMIC PASSENGER/OTHER Possibly Damaging 10 HCC2998 LARGE INTESTINE c.1403C>A p.S468* COSMIC NP NP 11 HCC2998 LARGE INTESTINE c.887A>C p.K296T COSMIC PASSENGER/OTHER Probably Damaging 12 HCC98T LIVER c.2324A>G p.Y775C COSMIC CANCER Probably Damaging 13 HN_62601 UPPER AERODIGESTIVE TRACT c.3635G>A p.R1212H COSMIC CANCER Probably Damaging 14 HN_62646 UPPER AERODIGESTIVE TRACT c.1940A>C p.Q647P COSMIC PASSENGER/OTHER Probably Damaging 15 KM12 LARGE INTESTINE c.3481G>A p.A1161T COSMIC PASSENGER/OTHER Probably Damaging 16 LC_C16 LUNG c.3175G>T p.A1059S COSMIC PASSENGER/OTHER Benign 17 LC_S12 LUNG c.3899_3900insT p.K1300fs*14 COSMIC NP NP 18 LUAD-5V8LT LUNG c.4363G>T p.G1455C COSMIC PASSENGER/OTHER Probably Damaging 19 LUAD-D01603 LUNG c.3813C>G p.D1271E COSMIC PASSENGER/OTHER Probably Damaging 20 LUAD-NYU263 LUNG c.2818C>T p.H940Y COSMIC PASSENGER/OTHER Benign 21 LUAD-QCHM7 LUNG c.3723G>C p.K1241N COSMIC PASSENGER/OTHER Probably Damaging 22 LUAD-S00488 LUNG c.411G>T p.E137D COSMIC PASSENGER/OTHER Benign 23 LUAD-S01315 LUNG c.81G>A p.R27R COSMIC NP NP 24 LUAD-S01405 LUNG c.3555C>A p.L1185L COSMIC NP NP 25 LUAD-YINHD LUNG c.3601A>T p.T1201S COSMIC CANCER Probably Damaging 26 ME009T SKIN c.707C>T p.S236F COSMIC PASSENGER/OTHER Benign 27 ME012T SKIN c.2448T>G p.C816W COSMIC PASSENGER/OTHER Probably Damaging 28 OV207 OVARY c.3995C>T p.S1332L COSMIC PASSENGER/OTHER Probably Damaging 29 PCSI0007 PANCREAS c.4123G>A p.E1375K COSMIC PASSENGER/OTHER Probably Damaging 30 PCSI_0007_Pa_P NS c.4123G>A p.E1375K COSMIC PASSENGER/OTHER Probably Damaging 31 PD4120a BREAST c.2182G>A p.D728N COSMIC PASSENGER/OTHER Probably Damaging 32 PD4134a BREAST c.269C>A p.S90Y COSMIC PASSENGER/OTHER Possibly Damaging 33 PD6750a NS c.4198C>T p.P1400S COSMIC PASSENGER/OTHER Probably Damaging 34 Pa14C PANCREAS c.4324A>G p.K1442E COSMIC PASSENGER/OTHER Benign 35 SA106 BREAST c.1954G>C p.D652H COSMIC CANCER Probably Damaging 36 TCGA-13-2061-01 OVARY c.3788A>T p.E1263V COSMIC PASSENGER/OTHER Probably Damaging 37 TCGA-22-4595-01 LUNG c.3817G>A p.E1273K COSMIC PASSENGER/OTHER Probably Damaging 38 TCGA-22-5492-01 LUNG c.3295G>A p.D1099N COSMIC PASSENGER/OTHER Possibly Damaging 39 TCGA-24-1552-01 OVARY c.452A>G p.N151S COSMIC PASSENGER/OTHER Benign 40 TCGA-25-2398-01 OVARY c.4137C>T p.D1379D COSMIC NP NP 41 TCGA-29-1696-01 OVARY c.2280G>C p.E760D COSMIC PASSENGER/OTHER Probably Damaging 42 TCGA-39-5024-01 LUNG c.43G>A p.E15K COSMIC PASSENGER/OTHER Benign 43 TCGA-44-7662-01 LUNG c.769G>A p.D257N COSMIC PASSENGER/OTHER Probably Damaging 44 TCGA-55-7907-01 LUNG c.285A>G p.T95T COSMIC NP NP 45 TCGA-55-8089-01 LUNG c.2322A>G p.L774L COSMIC NP NP 46 TCGA-61-1906-01 OVARY c.2044A>G p.T682A COSMIC CANCER Probably Damaging 47 TCGA-66-2759-01 LUNG c.792G>T p.K264N COSMIC PASSENGER/OTHER Probably Damaging 48 TCGA-66-2770-01 LUNG c.1799G>T p.G600V COSMIC CANCER Probably Damaging 49 TCGA-66-2770-01 LUNG c.3518T>G p.L1173R COSMIC CANCER Probably Damaging 50 TCGA-66-2771-01 LUNG c.3703C>T p.L1235L COSMIC NP NP 51 TCGA-75-7027-01 LUNG c.1771C>G p.P591A COSMIC PASSENGER/OTHER Probably Damaging 52 TCGA-95-7043-01 LUNG c.2185G>T p.E729* COSMIC NP NP 53 TCGA-AA-3543-01 LARGE INTESTINE c.1363G>A p.A455T COSMIC PASSENGER/OTHER Probably Damaging 54 TCGA-AA-3692-01 LARGE INTESTINE c.2788C>T p.R930C COSMIC PASSENGER/OTHER Probably Damaging 55 TCGA-AA-3710-01 LARGE INTESTINE c.2801C>T p.A934V COSMIC PASSENGER/OTHER Benign 56 TCGA-AA-3833-01 LARGE INTESTINE c.3896G>A p.R1299Q COSMIC PASSENGER/OTHER Probably Damaging 57 TCGA-AA-3977-01 LARGE INTESTINE c.1721C>A p.S574* COSMIC NP NP 58 TCGA-AA-A00J-01 LARGE INTESTINE c.1316A>G p.Q439R COSMIC PASSENGER/OTHER Benign 59 TCGA-AA-A010-01 LARGE INTESTINE c.3507C>A p.I1169I COSMIC NP NP 60 TCGA-AG-A002-01 LARGE INTESTINE c.2164G>A p.E722K COSMIC PASSENGER/OTHER Probably Damaging 61 TCGA-AG-A002-01 LARGE INTESTINE c.2372C>A p.S791Y COSMIC PASSENGER/OTHER Probably Damaging 62 TCGA-AG-A002-01 LARGE INTESTINE c.485G>A p.R162Q COSMIC PASSENGER/OTHER Probably Damaging 63 TCGA-AJ-A23M-01 ENDOMETRIUM c.10G>C p.E4Q COSMIC PASSENGER/OTHER Benign 64 TCGA-AN-A0XS-01 BREAST c.4322C>T p.A1441V COSMIC PASSENGER/OTHER Benign 65 TCGA-AP-A051-01 ENDOMETRIUM c.2087A>G p.H696R COSMIC PASSENGER/OTHER Probably Damaging 66 TCGA-AP-A056-01 ENDOMETRIUM c.3550A>G p.N1184D COSMIC PASSENGER/OTHER Probably Damaging 67 TCGA-AP-A059-01 ENDOMETRIUM c.1320G>T p.E440D COSMIC PASSENGER/OTHER Benign 68 TCGA-AP-A059-01 ENDOMETRIUM c.1363G>A p.A455T COSMIC PASSENGER/OTHER Probably Damaging 69 TCGA-AP-A059-01 ENDOMETRIUM c.3226C>A p.L1076M COSMIC PASSENGER/OTHER Possibly Damaging 70 TCGA-AP-A059-01 ENDOMETRIUM c.4140G>A p.M1380I COSMIC PASSENGER/OTHER Possibly Damaging 71 TCGA-AP-A0LM-01 ENDOMETRIUM c.2998C>T p.R1000C COSMIC PASSENGER/OTHER Benign 72 TCGA-AP-A0LM-01 ENDOMETRIUM c.3530G>A p.R1177Q COSMIC PASSENGER/OTHER Probably Damaging 73 TCGA-AP-A0LM-01 ENDOMETRIUM c.4429G>A p.A1477T COSMIC PASSENGER/OTHER Probably Damaging 74 TCGA-AX-A0IU-01 ENDOMETRIUM c.2559C>T p.F853F COSMIC NP NP 75 TCGA-AX-A0J1-01 ENDOMETRIUM c.2040C>T p.T680T COSMIC NP NP 76 TCGA-AZ-4315-01 LARGE INTESTINE c.1786C>T p.L596L COSMIC NP NP 77 TCGA-AZ-4315-01 LARGE INTESTINE c.727C>T p.R243C COSMIC PASSENGER/OTHER Probably Damaging 78 TCGA-B5-A0JY-01 ENDOMETRIUM c.1530G>A p.Q510Q COSMIC NP NP 79 TCGA-B5-A11E-01 ENDOMETRIUM c.2691T>C p.S897S COSMIC NP NP 80 TCGA-BG-A0MG-01 ENDOMETRIUM c.3841C>T p.R1281W COSMIC PASSENGER/OTHER Probably Damaging 81 TCGA-BG-A187-01 ENDOMETRIUM c.3046C>T p.R1016* COSMIC NP NP 82 TCGA-BH-A18P-01 BREAST c.445delG p.E149fs*74 COSMIC NP NP 83 TCGA-BH-A1FL-01 BREAST c.241C>T p.L81F COSMIC PASSENGER/OTHER Probably Damaging 84 TCGA-BP-5176-01 KIDNEY c.1448C>A p.A483E COSMIC PASSENGER/OTHER Possibly Damaging 85 TCGA-BS-A0TC-01 ENDOMETRIUM c.348C>T p.F116F COSMIC NP NP 86 TCGA-BS-A0UF-01 ENDOMETRIUM c.1540T>G p.F514V COSMIC PASSENGER/OTHER Probably Damaging 87 TCGA-BT-A20R-01 URINARY TRACT c.4523C>T p.S1508L COSMIC PASSENGER/OTHER Benign 88 TCGA-C4-A0F1-01 URINARY TRACT c.236C>T p.S79L COSMIC PASSENGER/OTHER Benign 89 TCGA-CA-6718-01 LARGE INTESTINE c.1990C>A p.R664S COSMIC PASSENGER/OTHER Probably Damaging 90 TCGA-CH-5745-01 PROSTATE c.523A>C p.S175R COSMIC PASSENGER/OTHER Benign 91 TCGA-CJ-5672-01 KIDNEY c.2575A>G p.R859G COSMIC PASSENGER/OTHER Benign 92 TCGA-CJ-5676-01 KIDNEY c.3762C>T p.F1254F COSMIC NP NP 93 TCGA-CM-5861-01 LARGE INTESTINE c.453T>C p.N151N COSMIC NP NP 94 TCGA-CM-5862-01 LARGE INTESTINE c.2918T>C p.F973S COSMIC PASSENGER/OTHER Probably Damaging 95 TCGA-CU-A0YO-01 URINARY TRACT c.946A>T p.K316* COSMIC NP NP 96 TCGA-CU-A3KJ-01 URINARY TRACT c.1366G>A p.E456K COSMIC PASSENGER/OTHER Benign 97 TCGA-CZ-5462-01 KIDNEY c.1991G>A p.R664H COSMIC PASSENGER/OTHER Probably Damaging 98 TCGA-D1-A174-01 ENDOMETRIUM c.4478A>G p.Q1493R COSMIC PASSENGER/OTHER Possibly Damaging 99 TCGA-D1-A17Q-01 ENDOMETRIUM c.3814G>A p.E1272K COSMIC PASSENGER/OTHER Possibly Damaging 100 TCGA-D5-5537-01 LARGE INTESTINE c.1701G>A p.W567* COSMIC NP NP 101 TCGA-D8-A1XB-01 BREAST c.934C>T p.H312Y COSMIC PASSENGER/OTHER Possibly Damaging 102 TCGA-DC-6681-01 LARGE INTESTINE c.4136A>G p.D1379G COSMIC PASSENGER/OTHER Probably Damaging 103 TCGA-DM-A28G-01 LARGE INTESTINE c.453T>C p.N151N COSMIC NP NP 104 TCGA-DM-A28H-01 LARGE INTESTINE c.452A>G p.N151S COSMIC PASSENGER/OTHER Benign 105 TCGA-DR-A0ZM-01 CERVIX c.4221C>T p.V1407V COSMIC NP NP 106 TCGA-EJ-7789-01 PROSTATE c.4573C>A p.P1525T COSMIC PASSENGER/OTHER Benign 107 TCGA-G2-A2ES-01 URINARY TRACT c.3711A>G p.R1237R COSMIC NP NP 108 TCGA-G2-A2ES-01 URINARY TRACT c.3721A>C p.K1241Q COSMIC PASSENGER/OTHER Probably Damaging 109 TCGA-G4-6309-01 LARGE INTESTINE c.458G>T p.S153I COSMIC PASSENGER/OTHER Possibly Damaging 110 TCGA-G4-6588-01 LARGE INTESTINE c.2189A>G p.N730S COSMIC PASSENGER/OTHER Possibly Damaging 111 TCGA-G4-6626-01 LARGE INTESTINE c.453T>C p.N151N COSMIC NP NP 112 TCGA-GV-A3JZ-01 URINARY TRACT c.2698G>C p.E900Q COSMIC PASSENGER/OTHER Probably Damaging 113 YULAN SKIN c.2671C>T p.L891F COSMIC PASSENGER/OTHER Probably Damaging 114 YULAN SKIN c.3163C>T p.P1055S COSMIC PASSENGER/OTHER Probably Damaging 115 cSCCP5 SKIN c.3461C>T p.S1154L COSMIC CANCER Probably Damaging 116 cSCCP7 SKIN c.781C>T p.P261S COSMIC PASSENGER/OTHER Probably Damaging 117 ccRCC-91 KIDNEY c.4573C>A p.P1525T COSMIC PASSENGER/OTHER Benign 118 pfg019T STOMACH c.685delA p.R229fs*45 COSMIC NP NP
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.test -
Tertiary structure (+)
Users must enabled the Java in their browser to see structure.
Users can also download Java from here.Modelled Structure Structures available in PDB Structure is not available in PDB -
Structure Domains (+)
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Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 4. Sequence alignment with homologus proteins:
Click on button to get Sequence alignment with Coverage, Consensus and Quality -
Sequence Profiles (+)
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Post Translational Modifications (+)
S. No. Position Amino acid Type 1 1136 Y Phosphorylation 2 1139 Y Phosphorylation 3 118 K Acetylation 4 118 K Acetylation 5 1487 S Phosphorylation 6 1490 S Phosphorylation 7 1490 S Phosphorylation 8 1512 S Phosphorylation 9 1512 S Phosphorylation 10 1515 S Phosphorylation 11 1516 S Phosphorylation 12 1516 S Phosphorylation 13 1550 T Phosphorylation 14 1550 T Phosphorylation 15 237 S Phosphorylation 16 47 S Phosphorylation 17 48 S Phosphorylation 18 51 S Phosphorylation -
Other Databases Link (+)
Proteomics DB COSMIC Gene Atlas STRING PIR INO80 INO80 INO80 ENSP00000355205 Q9ULG1 QuickGO HGNC Ensembl Genome Browser TreeFam UniProt Q9ULG1 INO80 ENSP00000355205 INO80 Q9ULG1 Expression Atlas Protein Atlas OMIM IntAct PharmGKB INO80 ENSP00000355205 610169 Q9ULG1 PA37445
