dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: INO80 |
| Expand All | Collapse All |
-
Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 51T SKIN c.2998C>T p.R1000C COSMIC PASSENGER/OTHER Benign 2 587342 LARGE INTESTINE c.1964A>G p.Q655R COSMIC PASSENGER/OTHER Probably Damaging 3 587342 LARGE INTESTINE c.3935A>G p.D1312G COSMIC PASSENGER/OTHER Benign 4 BN17T LIVER c.2262A>G p.E754E COSMIC NP NP 5 DLBCL-PatientH HAEMATOPOIETIC AND LYMPHOID TISSUE c.526A>T p.K176* COSMIC NP NP 6 ESO-007 OESOPHAGUS c.1888A>T p.S630C COSMIC PASSENGER/OTHER Probably Damaging 7 ESO-539 OESOPHAGUS c.959G>A p.R320Q COSMIC PASSENGER/OTHER Probably Damaging 8 ESO-859 OESOPHAGUS c.4183C>T p.R1395* COSMIC NP NP 9 ESOSCC156T OESOPHAGUS c.2909C>G p.S970C COSMIC PASSENGER/OTHER Possibly Damaging 10 HCC2998 LARGE INTESTINE c.1403C>A p.S468* COSMIC NP NP 11 HCC2998 LARGE INTESTINE c.887A>C p.K296T COSMIC PASSENGER/OTHER Probably Damaging 12 HCC98T LIVER c.2324A>G p.Y775C COSMIC CANCER Probably Damaging 13 HN_62601 UPPER AERODIGESTIVE TRACT c.3635G>A p.R1212H COSMIC CANCER Probably Damaging 14 HN_62646 UPPER AERODIGESTIVE TRACT c.1940A>C p.Q647P COSMIC PASSENGER/OTHER Probably Damaging 15 KM12 LARGE INTESTINE c.3481G>A p.A1161T COSMIC PASSENGER/OTHER Probably Damaging 16 LC_C16 LUNG c.3175G>T p.A1059S COSMIC PASSENGER/OTHER Benign 17 LC_S12 LUNG c.3899_3900insT p.K1300fs*14 COSMIC NP NP 18 LUAD-5V8LT LUNG c.4363G>T p.G1455C COSMIC PASSENGER/OTHER Probably Damaging 19 LUAD-D01603 LUNG c.3813C>G p.D1271E COSMIC PASSENGER/OTHER Probably Damaging 20 LUAD-NYU263 LUNG c.2818C>T p.H940Y COSMIC PASSENGER/OTHER Benign 21 LUAD-QCHM7 LUNG c.3723G>C p.K1241N COSMIC PASSENGER/OTHER Probably Damaging 22 LUAD-S00488 LUNG c.411G>T p.E137D COSMIC PASSENGER/OTHER Benign 23 LUAD-S01315 LUNG c.81G>A p.R27R COSMIC NP NP 24 LUAD-S01405 LUNG c.3555C>A p.L1185L COSMIC NP NP 25 LUAD-YINHD LUNG c.3601A>T p.T1201S COSMIC CANCER Probably Damaging 26 ME009T SKIN c.707C>T p.S236F COSMIC PASSENGER/OTHER Benign 27 ME012T SKIN c.2448T>G p.C816W COSMIC PASSENGER/OTHER Probably Damaging 28 OV207 OVARY c.3995C>T p.S1332L COSMIC PASSENGER/OTHER Probably Damaging 29 PCSI0007 PANCREAS c.4123G>A p.E1375K COSMIC PASSENGER/OTHER Probably Damaging 30 PCSI_0007_Pa_P NS c.4123G>A p.E1375K COSMIC PASSENGER/OTHER Probably Damaging 31 PD4120a BREAST c.2182G>A p.D728N COSMIC PASSENGER/OTHER Probably Damaging 32 PD4134a BREAST c.269C>A p.S90Y COSMIC PASSENGER/OTHER Possibly Damaging 33 PD6750a NS c.4198C>T p.P1400S COSMIC PASSENGER/OTHER Probably Damaging 34 Pa14C PANCREAS c.4324A>G p.K1442E COSMIC PASSENGER/OTHER Benign 35 SA106 BREAST c.1954G>C p.D652H COSMIC CANCER Probably Damaging 36 TCGA-13-2061-01 OVARY c.3788A>T p.E1263V COSMIC PASSENGER/OTHER Probably Damaging 37 TCGA-22-4595-01 LUNG c.3817G>A p.E1273K COSMIC PASSENGER/OTHER Probably Damaging 38 TCGA-22-5492-01 LUNG c.3295G>A p.D1099N COSMIC PASSENGER/OTHER Possibly Damaging 39 TCGA-24-1552-01 OVARY c.452A>G p.N151S COSMIC PASSENGER/OTHER Benign 40 TCGA-25-2398-01 OVARY c.4137C>T p.D1379D COSMIC NP NP 41 TCGA-29-1696-01 OVARY c.2280G>C p.E760D COSMIC PASSENGER/OTHER Probably Damaging 42 TCGA-39-5024-01 LUNG c.43G>A p.E15K COSMIC PASSENGER/OTHER Benign 43 TCGA-44-7662-01 LUNG c.769G>A p.D257N COSMIC PASSENGER/OTHER Probably Damaging 44 TCGA-55-7907-01 LUNG c.285A>G p.T95T COSMIC NP NP 45 TCGA-55-8089-01 LUNG c.2322A>G p.L774L COSMIC NP NP 46 TCGA-61-1906-01 OVARY c.2044A>G p.T682A COSMIC CANCER Probably Damaging 47 TCGA-66-2759-01 LUNG c.792G>T p.K264N COSMIC PASSENGER/OTHER Probably Damaging 48 TCGA-66-2770-01 LUNG c.1799G>T p.G600V COSMIC CANCER Probably Damaging 49 TCGA-66-2770-01 LUNG c.3518T>G p.L1173R COSMIC CANCER Probably Damaging 50 TCGA-66-2771-01 LUNG c.3703C>T p.L1235L COSMIC NP NP 51 TCGA-75-7027-01 LUNG c.1771C>G p.P591A COSMIC PASSENGER/OTHER Probably Damaging 52 TCGA-95-7043-01 LUNG c.2185G>T p.E729* COSMIC NP NP 53 TCGA-AA-3543-01 LARGE INTESTINE c.1363G>A p.A455T COSMIC PASSENGER/OTHER Probably Damaging 54 TCGA-AA-3692-01 LARGE INTESTINE c.2788C>T p.R930C COSMIC PASSENGER/OTHER Probably Damaging 55 TCGA-AA-3710-01 LARGE INTESTINE c.2801C>T p.A934V COSMIC PASSENGER/OTHER Benign 56 TCGA-AA-3833-01 LARGE INTESTINE c.3896G>A p.R1299Q COSMIC PASSENGER/OTHER Probably Damaging 57 TCGA-AA-3977-01 LARGE INTESTINE c.1721C>A p.S574* COSMIC NP NP 58 TCGA-AA-A00J-01 LARGE INTESTINE c.1316A>G p.Q439R COSMIC PASSENGER/OTHER Benign 59 TCGA-AA-A010-01 LARGE INTESTINE c.3507C>A p.I1169I COSMIC NP NP 60 TCGA-AG-A002-01 LARGE INTESTINE c.2164G>A p.E722K COSMIC PASSENGER/OTHER Probably Damaging 61 TCGA-AG-A002-01 LARGE INTESTINE c.2372C>A p.S791Y COSMIC PASSENGER/OTHER Probably Damaging 62 TCGA-AG-A002-01 LARGE INTESTINE c.485G>A p.R162Q COSMIC PASSENGER/OTHER Probably Damaging 63 TCGA-AJ-A23M-01 ENDOMETRIUM c.10G>C p.E4Q COSMIC PASSENGER/OTHER Benign 64 TCGA-AN-A0XS-01 BREAST c.4322C>T p.A1441V COSMIC PASSENGER/OTHER Benign 65 TCGA-AP-A051-01 ENDOMETRIUM c.2087A>G p.H696R COSMIC PASSENGER/OTHER Probably Damaging 66 TCGA-AP-A056-01 ENDOMETRIUM c.3550A>G p.N1184D COSMIC PASSENGER/OTHER Probably Damaging 67 TCGA-AP-A059-01 ENDOMETRIUM c.1320G>T p.E440D COSMIC PASSENGER/OTHER Benign 68 TCGA-AP-A059-01 ENDOMETRIUM c.1363G>A p.A455T COSMIC PASSENGER/OTHER Probably Damaging 69 TCGA-AP-A059-01 ENDOMETRIUM c.3226C>A p.L1076M COSMIC PASSENGER/OTHER Possibly Damaging 70 TCGA-AP-A059-01 ENDOMETRIUM c.4140G>A p.M1380I COSMIC PASSENGER/OTHER Possibly Damaging 71 TCGA-AP-A0LM-01 ENDOMETRIUM c.2998C>T p.R1000C COSMIC PASSENGER/OTHER Benign 72 TCGA-AP-A0LM-01 ENDOMETRIUM c.3530G>A p.R1177Q COSMIC PASSENGER/OTHER Probably Damaging 73 TCGA-AP-A0LM-01 ENDOMETRIUM c.4429G>A p.A1477T COSMIC PASSENGER/OTHER Probably Damaging 74 TCGA-AX-A0IU-01 ENDOMETRIUM c.2559C>T p.F853F COSMIC NP NP 75 TCGA-AX-A0J1-01 ENDOMETRIUM c.2040C>T p.T680T COSMIC NP NP 76 TCGA-AZ-4315-01 LARGE INTESTINE c.1786C>T p.L596L COSMIC NP NP 77 TCGA-AZ-4315-01 LARGE INTESTINE c.727C>T p.R243C COSMIC PASSENGER/OTHER Probably Damaging 78 TCGA-B5-A0JY-01 ENDOMETRIUM c.1530G>A p.Q510Q COSMIC NP NP 79 TCGA-B5-A11E-01 ENDOMETRIUM c.2691T>C p.S897S COSMIC NP NP 80 TCGA-BG-A0MG-01 ENDOMETRIUM c.3841C>T p.R1281W COSMIC PASSENGER/OTHER Probably Damaging 81 TCGA-BG-A187-01 ENDOMETRIUM c.3046C>T p.R1016* COSMIC NP NP 82 TCGA-BH-A18P-01 BREAST c.445delG p.E149fs*74 COSMIC NP NP 83 TCGA-BH-A1FL-01 BREAST c.241C>T p.L81F COSMIC PASSENGER/OTHER Probably Damaging 84 TCGA-BP-5176-01 KIDNEY c.1448C>A p.A483E COSMIC PASSENGER/OTHER Possibly Damaging 85 TCGA-BS-A0TC-01 ENDOMETRIUM c.348C>T p.F116F COSMIC NP NP 86 TCGA-BS-A0UF-01 ENDOMETRIUM c.1540T>G p.F514V COSMIC PASSENGER/OTHER Probably Damaging 87 TCGA-BT-A20R-01 URINARY TRACT c.4523C>T p.S1508L COSMIC PASSENGER/OTHER Benign 88 TCGA-C4-A0F1-01 URINARY TRACT c.236C>T p.S79L COSMIC PASSENGER/OTHER Benign 89 TCGA-CA-6718-01 LARGE INTESTINE c.1990C>A p.R664S COSMIC PASSENGER/OTHER Probably Damaging 90 TCGA-CH-5745-01 PROSTATE c.523A>C p.S175R COSMIC PASSENGER/OTHER Benign 91 TCGA-CJ-5672-01 KIDNEY c.2575A>G p.R859G COSMIC PASSENGER/OTHER Benign 92 TCGA-CJ-5676-01 KIDNEY c.3762C>T p.F1254F COSMIC NP NP 93 TCGA-CM-5861-01 LARGE INTESTINE c.453T>C p.N151N COSMIC NP NP 94 TCGA-CM-5862-01 LARGE INTESTINE c.2918T>C p.F973S COSMIC PASSENGER/OTHER Probably Damaging 95 TCGA-CU-A0YO-01 URINARY TRACT c.946A>T p.K316* COSMIC NP NP 96 TCGA-CU-A3KJ-01 URINARY TRACT c.1366G>A p.E456K COSMIC PASSENGER/OTHER Benign 97 TCGA-CZ-5462-01 KIDNEY c.1991G>A p.R664H COSMIC PASSENGER/OTHER Probably Damaging 98 TCGA-D1-A174-01 ENDOMETRIUM c.4478A>G p.Q1493R COSMIC PASSENGER/OTHER Possibly Damaging 99 TCGA-D1-A17Q-01 ENDOMETRIUM c.3814G>A p.E1272K COSMIC PASSENGER/OTHER Possibly Damaging 100 TCGA-D5-5537-01 LARGE INTESTINE c.1701G>A p.W567* COSMIC NP NP 101 TCGA-D8-A1XB-01 BREAST c.934C>T p.H312Y COSMIC PASSENGER/OTHER Possibly Damaging 102 TCGA-DC-6681-01 LARGE INTESTINE c.4136A>G p.D1379G COSMIC PASSENGER/OTHER Probably Damaging 103 TCGA-DM-A28G-01 LARGE INTESTINE c.453T>C p.N151N COSMIC NP NP 104 TCGA-DM-A28H-01 LARGE INTESTINE c.452A>G p.N151S COSMIC PASSENGER/OTHER Benign 105 TCGA-DR-A0ZM-01 CERVIX c.4221C>T p.V1407V COSMIC NP NP 106 TCGA-EJ-7789-01 PROSTATE c.4573C>A p.P1525T COSMIC PASSENGER/OTHER Benign 107 TCGA-G2-A2ES-01 URINARY TRACT c.3711A>G p.R1237R COSMIC NP NP 108 TCGA-G2-A2ES-01 URINARY TRACT c.3721A>C p.K1241Q COSMIC PASSENGER/OTHER Probably Damaging 109 TCGA-G4-6309-01 LARGE INTESTINE c.458G>T p.S153I COSMIC PASSENGER/OTHER Possibly Damaging 110 TCGA-G4-6588-01 LARGE INTESTINE c.2189A>G p.N730S COSMIC PASSENGER/OTHER Possibly Damaging 111 TCGA-G4-6626-01 LARGE INTESTINE c.453T>C p.N151N COSMIC NP NP 112 TCGA-GV-A3JZ-01 URINARY TRACT c.2698G>C p.E900Q COSMIC PASSENGER/OTHER Probably Damaging 113 YULAN SKIN c.2671C>T p.L891F COSMIC PASSENGER/OTHER Probably Damaging 114 YULAN SKIN c.3163C>T p.P1055S COSMIC PASSENGER/OTHER Probably Damaging 115 cSCCP5 SKIN c.3461C>T p.S1154L COSMIC CANCER Probably Damaging 116 cSCCP7 SKIN c.781C>T p.P261S COSMIC PASSENGER/OTHER Probably Damaging 117 ccRCC-91 KIDNEY c.4573C>A p.P1525T COSMIC PASSENGER/OTHER Benign 118 pfg019T STOMACH c.685delA p.R229fs*45 COSMIC NP NP
*NP: Not Predicted -
Copy number variation and expression profile (+)
-
Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.test -
Tertiary structure (+)
Users must enabled the Java in their browser to see structure.
Users can also download Java from here.Modelled Structure Structures available in PDB -
Structure Domains (+)
-
Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:4. Sequence alignment with homologus proteins: -
Sequence Profiles (+)
-
Post Translational Modifications (+)
Post translational modifications are not found!!Other Databases Link (+)
